SRGAP3 (SLIT-ROBO Rho GTPase activating protein 3) - Rat Genome Database

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Gene: SRGAP3 (SLIT-ROBO Rho GTPase activating protein 3) Chlorocebus sabaeus
Analyze
Symbol: SRGAP3
Name: SLIT-ROBO Rho GTPase activating protein 3
RGD ID: 18740140
Description: INVOLVED IN regulation of postsynapse assembly (ortholog); ASSOCIATED WITH Atrioventricular Septal Defect 2 (ortholog); Chromosome 3, Monosomy 3p25 (ortholog); genetic disease (ortholog); FOUND IN glutamatergic synapse (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: SLIT-ROBO Rho GTPase-activating protein 3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12244,979,675 - 45,355,753 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2244,984,615 - 45,246,209 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041121,319,319 - 121,586,653 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
SRGAP3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12244,979,675 - 45,355,753 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2244,984,615 - 45,246,209 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041121,319,319 - 121,586,653 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
SRGAP3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3838,980,591 - 9,363,027 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl38,980,591 - 9,363,053 (-)EnsemblGRCh38hg38GRCh38
GRCh3739,022,275 - 9,291,330 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3638,997,278 - 9,266,311 (-)NCBINCBI36Build 36hg18NCBI36
Build 3438,997,277 - 9,265,737NCBI
Celera38,956,988 - 9,226,019 (-)NCBICelera
Cytogenetic Map3p25.3NCBI
HuRef38,956,444 - 9,225,356 (-)NCBIHuRef
CHM1_138,972,526 - 9,241,578 (-)NCBICHM1_1
T2T-CHM13v2.038,971,761 - 9,354,865 (-)NCBIT2T-CHM13v2.0
Srgap3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396112,694,932 - 112,924,466 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6112,694,932 - 112,924,227 (-)EnsemblGRCm39 Ensembl
GRCm386112,717,971 - 112,947,505 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6112,717,971 - 112,947,266 (-)EnsemblGRCm38mm10GRCm38
MGSCv376112,667,965 - 112,897,260 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366112,683,748 - 112,795,398 (-)NCBIMGSCv36mm8
Celera6114,543,131 - 114,774,424 (-)NCBICelera
Cytogenetic Map6E3NCBI
cM Map652.54NCBI
Srgap3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84147,391,082 - 147,626,407 (-)NCBIGRCr8
mRatBN7.24145,839,369 - 146,070,556 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4145,840,078 - 146,070,575 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4151,232,340 - 151,460,022 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04147,013,154 - 147,240,832 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04145,634,410 - 145,862,095 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04144,638,782 - 144,869,961 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4144,638,335 - 144,869,919 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04207,938,122 - 208,167,826 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44148,562,981 - 148,798,613 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera4134,407,634 - 134,635,394 (-)NCBICelera
Cytogenetic Map4q42NCBI
Srgap3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955561617,001 - 835,221 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955561612,152 - 835,209 (-)NCBIChiLan1.0ChiLan1.0
SRGAP3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v228,994,561 - 9,374,714 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan138,999,319 - 9,379,472 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v038,935,179 - 9,315,264 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.139,178,709 - 9,445,905 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl39,183,641 - 9,327,559 (-)Ensemblpanpan1.1panPan2
SRGAP3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1208,894,150 - 9,147,060 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl208,894,155 - 9,142,066 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha208,852,211 - 9,178,887 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0208,849,280 - 9,175,822 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl208,922,985 - 9,175,803 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1208,571,174 - 8,897,035 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0208,916,552 - 9,242,890 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0208,889,935 - 9,215,979 (+)NCBIUU_Cfam_GSD_1.0
Srgap3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494214,889,669 - 15,139,397 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366023,770,259 - 4,016,536 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366023,770,323 - 4,020,043 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SRGAP3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1365,367,608 - 65,721,405 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11365,367,596 - 65,759,892 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Srgap3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247313,712,361 - 3,824,206 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247313,707,934 - 3,937,175 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 2 42
Low 34 18 18
Below cutoff 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000008857   ⟹   ENSCSAP00000006989
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl2244,984,615 - 45,246,209 (-)Ensembl
RefSeq Acc Id: XM_007985124   ⟹   XP_007983315
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12244,984,197 - 45,246,204 (-)NCBI
Vero_WHO_p1.0NW_023666041121,319,319 - 121,586,653 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007985125   ⟹   XP_007983316
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12244,979,675 - 45,246,219 (-)NCBI
Vero_WHO_p1.0NW_023666041121,319,353 - 121,585,245 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007985127   ⟹   XP_007983318
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12244,979,675 - 45,246,219 (-)NCBI
Vero_WHO_p1.0NW_023666041121,319,319 - 121,586,653 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007985129   ⟹   XP_007983320
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12244,984,913 - 45,246,202 (-)NCBI
Vero_WHO_p1.0NW_023666041121,319,319 - 121,581,448 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_007983315 (Get FASTA)   NCBI Sequence Viewer  
  XP_007983316 (Get FASTA)   NCBI Sequence Viewer  
  XP_007983318 (Get FASTA)   NCBI Sequence Viewer  
  XP_007983320 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000006989
  ENSCSAP00000006989.1
Reference Protein Sequences
RefSeq Acc Id: XP_007983318   ⟸   XM_007985127
- Peptide Label: isoform X3
- UniProtKB: A0A0D9REF0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007983316   ⟸   XM_007985125
- Peptide Label: isoform X2
RefSeq Acc Id: XP_007983315   ⟸   XM_007985124
- Peptide Label: isoform X1
RefSeq Acc Id: XP_007983320   ⟸   XM_007985129
- Peptide Label: isoform X4
RefSeq Acc Id: ENSCSAP00000006989   ⟸   ENSCSAT00000008857


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000010768 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000008857.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.555.10 UniProtKB/TrEMBL
  1.20.1270.60 UniProtKB/TrEMBL
  SH3 Domains UniProtKB/TrEMBL
InterPro AH/BAR_dom_sf UniProtKB/TrEMBL
  F_BAR UniProtKB/TrEMBL
  FCH_dom UniProtKB/TrEMBL
  Rho_GTPase_activation_prot UniProtKB/TrEMBL
  RhoGAP_dom UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/TrEMBL
  SH3_domain UniProtKB/TrEMBL
  srGAP1/2/3_SH3 UniProtKB/TrEMBL
  SrGAP3_F-BAR UniProtKB/TrEMBL
NCBI Gene SRGAP3 ENTREZGENE
PANTHER SLIT-ROBO RHO GTPASE ACTIVATING PROTEIN UniProtKB/TrEMBL
  SLIT-ROBO RHO GTPASE-ACTIVATING PROTEIN 3 UniProtKB/TrEMBL
Pfam FCH UniProtKB/TrEMBL
  RhoGAP UniProtKB/TrEMBL
  SH3_1 UniProtKB/TrEMBL
PROSITE F_BAR UniProtKB/TrEMBL
  RHOGAP UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
SMART FCH UniProtKB/TrEMBL
  RhoGAP UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
Superfamily-SCOP SSF103657 UniProtKB/TrEMBL
  SSF48350 UniProtKB/TrEMBL
  SSF50044 UniProtKB/TrEMBL
UniProt A0A0D9REF0 ENTREZGENE, UniProtKB/TrEMBL