RSPO4 (R-spondin 4) - Rat Genome Database

Name: RSPO4
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: RSPO4 (R-spondin 4) Chlorocebus sabaeus

Analyze

Symbol:

RSPO4

Name:

R-spondin 4

RGD ID:

18739535

Description:

ENCODES a protein that exhibits heparin binding (inferred); INVOLVED IN nail development (ortholog); PARTICIPATES IN Wnt signaling, canonical pathway; ASSOCIATED WITH genetic disease (ortholog); nonsyndromic congenital nail disorder 4 (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

R-spondin-4

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	RSPO4 (R-spondin 4)	NCBI	Ortholog
Mus musculus (house mouse):	Rspo4 (R-spondin 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Rspo4 (R-spondin 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Rspo4 (R-spondin 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	RSPO4 (R-spondin 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	RSPO4 (R-spondin 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Rspo4 (R-spondin 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	RSPO4 (R-spondin 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Rspo4 (R-spondin 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	2	55,535,042 - 55,576,807 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	2	55,568,980 - 55,576,685 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666087	1,955,133 - 1,995,968 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

nonsyndromic congenital nail disorder 4 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

nail development (IEA,ISO)

positive regulation of Wnt signaling pathway (IEA)

Wnt signaling pathway (IEA)

Molecular Function

heparin binding (IEA)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

Wnt signaling, canonical pathway (ISO)

References

Genomics

Comparative Map Data

RSPO4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	2	55,535,042 - 55,576,807 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	2	55,568,980 - 55,576,685 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666087	1,955,133 - 1,995,968 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

RSPO4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	20	958,452 - 1,002,311 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	20	958,452 - 1,002,311 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	20	939,095 - 982,954 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	20	887,095 - 930,904 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	20	1,035,254 - 1,079,064 (-)	NCBI		Celera
Cytogenetic Map	20	p13	NCBI
HuRef	20	891,402 - 934,970 (-)	NCBI		HuRef
CHM1_1	20	939,132 - 982,942 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	20	1,005,419 - 1,049,278 (-)	NCBI		T2T-CHM13v2.0

Rspo4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	151,684,571 - 151,716,588 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	151,684,847 - 151,716,588 (+)	Ensembl		GRCm39 Ensembl
GRCm38	2	151,842,647 - 151,874,668 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	151,842,927 - 151,874,668 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	151,668,663 - 151,700,404 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	151,534,368 - 151,564,918 (+)	NCBI		MGSCv36	mm8
Celera	2	157,660,543 - 157,692,549 (+)	NCBI		Celera
Cytogenetic Map	2	G3	NCBI
cM Map	2	74.83	NCBI

Rspo4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	160,817,611 - 160,852,071 (+)	NCBI		GRCr8
mRatBN7.2	3	140,357,256 - 140,391,780 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	140,357,424 - 140,388,254 (+)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	3	147,358,690 - 147,391,719 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	147,358,858 - 147,389,698 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	153,710,530 - 153,741,899 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	142,185,028 - 142,216,015 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Cytogenetic Map	3	q41	NCBI

Rspo4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955596	265,466 - 295,116 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955596	265,282 - 295,283 (-)	NCBI	ChiLan1.0	ChiLan1.0

RSPO4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	21	2,008,213 - 2,052,264 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	20	2,005,023 - 2,048,409 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	20	1,127,592 - 1,171,860 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	20	897,774 - 907,772 (-)	NCBI	panpan1.1	PanPan1.1	panPan2

RSPO4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	24	19,952,113 - 19,987,498 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	24	19,952,043 - 19,989,013 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	24	19,606,495 - 19,641,585 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	24	20,644,999 - 20,680,271 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	24	20,644,807 - 20,680,344 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	24	19,920,786 - 19,955,882 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	24	20,025,901 - 20,061,242 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	24	20,456,869 - 20,492,141 (+)	NCBI		UU_Cfam_GSD_1.0

Rspo4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	169,186,662 - 169,220,983 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936485	17,618,034 - 17,650,852 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936485	17,618,044 - 17,650,852 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

RSPO4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	17	34,268,612 - 34,309,991 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	17	34,268,702 - 34,310,073 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	17	38,815,967 - 38,857,282 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Rspo4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624741	2,252,489 - 2,255,603 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	endocrine system	hemolymphoid system	nervous system
High
Medium	4		4
Low	15	11	15
Below cutoff	6	6	12

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_007962861	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000055	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCSAT00000008615 ⟹ ENSCSAP00000006757

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	2	55,568,980 - 55,576,685 (+)	Ensembl

RefSeq Acc Id:

XM_007962861 ⟹ XP_007961052

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	2	55,535,042 - 55,576,807 (+)	NCBI
Vero_WHO_p1.0	NW_023666087	1,955,133 - 1,995,968 (+)	NCBI

Sequence:

show sequence

TGTAAAGTTCTTAGCAATGCCCACCATATATGCCTCACAAATGACAGCTAGCATTATTGTTGTT
GTTTTTGGTGGGTATAGTGACAGGAGAGGTGGGCATGCTGTTGGGTTGAAGGAGGAATTTGCTC
TGAAAGGGTTAAACTCGAATCAGCTGCTCCCAGTCCTGGTGATAAGGTTGGAGGAAACACAGTC
CAGGTCCCCAGCCCTGTCACAAGCGGATTTATGAGGTGCTGGTCACTTTGAGTCAGAGTAGATG
ATCCCCGCAGGCTGCGCAGGAAACATTGAGGGTTAGTGGCCAGAAGGGGCTCAGGACTCTGTTA
AAAGAATGAGACAGGGTAGAGAGAAAAAGAGAAAACCAGGCAGCAGGAGCCCCGCAAACACCCC
ACTCTGCAGGAGGAGAGAAGGGGAGAGATGGGGTTGAAGGGAGACACAGGGAGAAGGGAGAACT
AGAGGCCCAGCTAGGAGGAGACAGTGAGCCTGAGAGAGAGACCATCAGCAAGAGTAAAGGATGC
AGGAATAGCCAGGCAAGGTCCGGGGCAGAGCGGGGGAGCGCGGGCCGCGGAAAGACCGAGAAAG
CAGGAGCCAAGGAGTGGTCCTTAAGGGCTAGAGGGAGGAACAAACAGAGAAAGAGGGCTGGGGG
GAGGGAAAGAAAACCACAGACGCGGAGAGGGCTCAGGAGACCGTAAGGGTCTCCGGGTGTCAGT
GCATCTGTACCTGCGCGCGCTTGCGTACCTGTGCCTGGCGGTGGGCATGTACACGTGCTCTGGG
GCAGTGCCGGGGGCGGGAAAGACGCGAGACCGCGAGCTGCGAGACAGATCGAACTCGAGCACCC
TGACCCGGGCGACCCCCGGCCCCTCCCCCCGCGCTCCCGGGCCCCGAGTTGGTTAAGGCGCCAC
CCCCGCCGCGCCGGCTCCTCCCCGCCAGGGCAGTGCCCCTGCTCCGCCAACGCTGTCACTCGAC
CTGGCTGCTGGCCTCTGGGCGGACCGCGGGTCCCTGGCGGCCGTACCGACCCGCGACTGGCGGA
TGCGCCCGGCGCGCCCACAGCAGCCCCCGCGCCCTCCGCGCCGCCACCGGGCCGTCGGGCCGCC
CGGGGAGCGCCAGCCCGGACCAGGCTGCCCAGATGCGGGCGCCACTCTGCCTGCTCCTGCTCGT
CGCCCACGCCGTGGACATGCTCGCCCTGAACCGAAGGAAGAAGCAAGTGGGCACTGGCCTGGGG
GGCAACTGCACGGGCTGTATCATCTGCTCAGAGGAGAATGGCTGTTCCACCTGCCAGCAGAGGC
TCTTCCTGTTCATCCGCCGAGAAGGCATCCGCCAGTACGGCAAGTGCCTGCACGACTGTCCCCC
TGGCTACTTTGGCATCCGCGGCCAGGAGGTCAACAGGTGCAAAAAATGTGGGGCCACTTGTGAG
AGCTGCTTCAGCCAGGACTTCTGCATCCGGTGCAAGAGGCGATTTTACTTGTACAAGGGGAAGT
GTCTGCCCACCTGCCCGCCAGGCACTTTGGCCCACCAGAACACACGGGAGTGCCAGGGGCAGTG
TGAACCGGGTCCCTGGGGCGGCTGGAGCCCCTGTGCATACAACGGAAAGACCTGCGGCTCGGCT
TGGGGCCTGGAGACCCGGGTACGAGAGGCTGGCCGGGCTGGGCATGAGGAGACAACCACCTGCC
AGGTGCTTTCTGAGTCAAGGAAATGTCCCATCCAGAGGCCCTGCCCAGGAGAGAGGAGCTCCGG
CCAAAAGAAGGGCAGGAAGGACCGGCGCCCACGCAAGGACAGGAAGCTGGACCACAGGCTGGAC
GTGAGGCCGCGCCAGCCCGGCCTGCAGCCCTGACTGCCGGCTCTCCCGGCTCTCTGGTCCTAGT
CCTCGGCCCCTGCACACCTCCTCCTGCTCCTCCTCCTCTCCTCTTACCCTTCCTCCTCCATCTC
CTCCATTTGTCCTCTCTTTCTTTCCAC

hide sequence

Protein Sequences


Protein RefSeqs	XP_007961052	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000006757.1

RefSeq Acc Id:	XP_007961052 ⟸ XM_007962861
- UniProtKB:	A0A0D9RDR8 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSCSAP00000006757 ⟸ ENSCSAT00000008615

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000010537	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000008615.1	UniProtKB/TrEMBL
InterPro	Furin_repeat	UniProtKB/TrEMBL
	Growth_fac_rcpt_cys_sf	UniProtKB/TrEMBL
	Rspo_Fu-CRD_dom	UniProtKB/TrEMBL
	TSP1_rpt	UniProtKB/TrEMBL
NCBI Gene	RSPO4	ENTREZGENE
PANTHER	NEUROHYPOPHYSIAL HORMONES, N-TERMINAL DOMAIN CONTAINING PROTEIN	UniProtKB/TrEMBL
	R-SPONDIN-4	UniProtKB/TrEMBL
Pfam	Furin-like_2	UniProtKB/TrEMBL
PROSITE	TSP1	UniProtKB/TrEMBL
SMART	SM00261	UniProtKB/TrEMBL
Superfamily-SCOP	SSF57184	UniProtKB/TrEMBL
UniProt	A0A0D9RDR8	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

RGD Manual Annotations

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

RGD Manual Annotations