DOLK (dolichol kinase) - Rat Genome Database

Name: DOLK
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: DOLK (dolichol kinase) Chlorocebus sabaeus

Analyze

Symbol:

DOLK

Name:

dolichol kinase

RGD ID:

18736447

Description:

ENCODES a protein that exhibits dolichol kinase activity (inferred); transferase activity (inferred); INVOLVED IN dolichyl monophosphate biosynthetic process (inferred); ASSOCIATED WITH congenital disorder of glycosylation (ortholog); congenital disorder of glycosylation Im (ortholog); dilated cardiomyopathy (ortholog); FOUND IN endoplasmic reticulum membrane (ortholog)

Type:

protein-coding

RefSeq Status:

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	DOLK (dolichol kinase)	NCBI	Ortholog
Mus musculus (house mouse):	Dolk (dolichol kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Dolk (dolichol kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Dolk (dolichol kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	DOLK (dolichol kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	DOLK (dolichol kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Dolk (dolichol kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	DOLK (dolichol kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Dolk (dolichol kinase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	12	9,213,463 - 9,215,659 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	12	9,213,888 - 9,215,504 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666096	340,595 - 342,677 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

congenital disorder of glycosylation (ISO)

congenital disorder of glycosylation Im (ISO)

dilated cardiomyopathy (ISO)

genetic disease (ISO)

primary coenzyme Q10 deficiency 7 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

dolichyl monophosphate biosynthetic process (IEA)

Cellular Component

endoplasmic reticulum (IEA)

endoplasmic reticulum membrane (ISO)

membrane (IEA)

Molecular Function

dolichol kinase activity (IEA)

protein binding (ISO)

transferase activity (IEA)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

DOLK
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	12	9,213,463 - 9,215,659 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	12	9,213,888 - 9,215,504 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666096	340,595 - 342,677 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

DOLK
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	9	128,945,530 - 128,947,603 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	9	128,945,530 - 128,947,603 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	9	131,707,809 - 131,709,882 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	9	130,747,630 - 130,749,833 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	9	128,787,362 - 128,789,566	NCBI
Celera	9	102,359,670 - 102,361,873 (-)	NCBI		Celera
Cytogenetic Map	9	q34.11	NCBI
HuRef	9	101,315,528 - 101,317,731 (-)	NCBI		HuRef
CHM1_1	9	131,858,858 - 131,861,061 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	9	141,148,939 - 141,151,012 (-)	NCBI		T2T-CHM13v2.0

Dolk
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	30,174,241 - 30,176,366 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	30,174,243 - 30,176,346 (-)	Ensembl		GRCm39 Ensembl
GRCm38	2	30,284,229 - 30,286,354 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	30,284,231 - 30,286,334 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	30,139,749 - 30,141,874 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	30,106,271 - 30,108,088 (-)	NCBI		MGSCv36	mm8
Celera	2	29,988,986 - 29,991,111 (-)	NCBI		Celera
Cytogenetic Map	2	B	NCBI
cM Map	2	21.49	NCBI

Dolk
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	33,955,642 - 33,957,680 (-)	NCBI		GRCr8
mRatBN7.2	3	13,557,826 - 13,559,864 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	13,557,817 - 13,559,917 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	16,629,326 - 16,631,364 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	25,214,289 - 25,216,327 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	23,460,056 - 23,462,094 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	8,850,154 - 8,852,192 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	8,850,154 - 8,852,192 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	14,203,104 - 14,205,142 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	9,329,640 - 9,331,678 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	9,330,107 - 9,331,718 (-)	NCBI
Celera	3	8,324,376 - 8,326,414 (-)	NCBI		Celera
Cytogenetic Map	3	p12	NCBI

Dolk
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955570	1,311,056 - 1,312,672 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955570	1,310,894 - 1,312,952 (-)	NCBI	ChiLan1.0	ChiLan1.0

DOLK
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	11	10,404,989 - 10,406,905 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	9	10,407,463 - 10,409,253 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	9	100,067,512 - 100,069,596 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	9	128,731,590 - 128,733,787 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	9	128,731,747 - 128,733,363 (-)	Ensembl	panpan1.1		panPan2

DOLK
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	9	54,712,920 - 54,715,005 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	9	54,713,239 - 54,714,849 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	9	53,908,459 - 53,910,563 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	9	55,633,974 - 55,636,078 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	9	55,634,308 - 55,635,918 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	9	54,395,110 - 54,397,213 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	9	54,707,475 - 54,709,579 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	9	54,801,029 - 54,803,133 (+)	NCBI		UU_Cfam_GSD_1.0

Dolk
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	196,637,315 - 196,639,936 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936487	16,406,529 - 16,408,145 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936487	16,406,385 - 16,408,546 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

DOLK
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	269,257,540 - 269,259,156 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	269,257,386 - 269,259,484 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	303,273,506 - 303,275,598 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Dolk
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624760	6,107,162 - 6,108,778 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624760	6,106,890 - 6,108,939 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	endocrine system	hemolymphoid system	nervous system
High
Medium	36		32
Low		20	28
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_008005998	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000064	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCSAT00000019800 ⟹ ENSCSAP00000019206

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	12	9,213,888 - 9,215,504 (+)	Ensembl

RefSeq Acc Id:

XM_008005998 ⟹ XP_008004189

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	12	9,213,463 - 9,215,659 (+)	NCBI
Vero_WHO_p1.0	NW_023666096	340,595 - 342,677 (-)	NCBI

Sequence:

show sequence

GCCGCCATCTTCGAGCGCGCGCGCGCCCTAACCCCGCCCCCAGACGCCATGCCCACGTGACCGC
TCGCCCCCGGACCGGGAGCGTGGGCGGGGATTTCATCACGTGACGTTGCCGCGGGGCAGTGCCA
AGATGGCGAGGCCCAAAGAGGTGAGGAGCCGGCAGCGGGGGCGGCTGTAACTGAGAGGAAGGCT
GCAGAGTGGCGACGTCTACGCCGTAGGTTGGAGGCTGTGGGGGGTGGCCGGGCGCCAGCTCCCA
GGCCGCAGAGAGTGACCTGCGGTGGAGTTCCCTCCTCGCTGTTGGAGAACGGAGGGAGAAGGTT
GCTGGCCGGGTGAAAGTGCCTCCCTCTGCTTGGCGGGGCTGAGGGGCCCGAAGTCTAGGACGTC
CGTAGTCACCCCGGCCTCCGTGAAGCCCCAGGTCTAGAGACATGACCCGAGAGTGCCCATCGCC
GGCCCCGGGGCCTGGGGCTCCGCTGAGTGGATCGGTGCTGGCAGAGGCGGCAGTAGTGTTTGCA
GTGGTGCTGAGCATCCATGCAACTGTATGGGACCGATACTCGTGGTGCGCCGTGGCCCTCGCAG
TGCAGGCCTTCTACGTCCAATACAAGTGGGACCGGCTGCTACAGCAGGGAAGCGCCGTCTTCCA
GTTCCGAATGTCCGCAAACAGTGGCCTACTGCCCGCCTCCATGGTCATGCCTTTACTTGGACTA
GTCATGAAGGAACGGTGCCAGGCTGCTGGGAACCCGTTCTTTGAGCGTTTTGGCATTGTGGTGG
CAGCCACTGGCATGGCAGTGGCCCTCTTCTCATCAGTGTTGGCGCTCGGTATCACTCGCCCAGT
GCCAACCAATACTTGTGTCATCTTGGGCTTGGCTGGAGGTGTTATCATTTATATCATGAAGCAC
TCGCTGAGCGTGGGGGAGGTGATCGAAGTCCTGGAAGTCCTGCTGATCTTCGTTTATCTCAACA
TGATCCTGCTGTACCTGCTGCCCCGCTGCTTCACCCCTGGTGAGGCACTGCTGGTATTGGGTGG
CATTAGCTTTGTCCTCAACCAGCTCATCAAGCGCTCTCTGACACTGGTGGAAAGTCAGGGGGAC
CCAGTGGACTTCTTCCTGCTGGTGGTGGTAGTAGGGATGGTACTCATGGGCATCTTCTTCAGCA
CTCTCTTTGTCTTCATGGACTCAGGCACCTGGGCCTCCTCCATCTTCTTCCACCTCATGACCTG
TGTGCTGAGCCTTGGTGTGGTCCTACCCTGGCTGCACCGGCTCATCCGCAGGAATCCCCTGCTC
TGGCTTCTTCAGTTCCTCTTCCAGACGGACACCCGTATCTACCTCCTAGCCTATTGGTCTCTGC
TGGCCACCTTGGCCTGCCTGGTGGTGCTGTACCAGAATGCCAAGCGGTCATCTTCTGAGTCCAA
GAAGCACCAGGCCCCCACCATCGCCCGAAAGTATTTCCACCTCATTGTGGTAGCCACCTACATC
CCAGGTATCATCTTTGACCGGCCACTGCTCTATGTAGCTGCCACTGTATGTCTGGCGGTCTTCA
TCTTCCTGGAGTATGTGCGCTACTTCCGCATCAAGCCCTTGGGTCACACCCTGCGAAGCCTCCT
GTCCCTTTTTCTGGATGAACGAGACAGTGGACCACTCATTCTGACACACATCTACCTGCTCCTG
GGCATGTCTCTTCCCATCTGGCTGATCCCCAGACCCTGCACACAGAAGGGTAGCCTGGGGGGAG
CCAGGGCCCTCGTCCCCTATGCCGGTGTCCTGGCTGTGGGTGTGGGTGATACTGTGGCCTCCAT
CTTTGGTAGCACCATGGGGGAGATCCGCTGGCCTGGAACCAAAAAGACTTTTGAGGGGACCATG
ACATCTATATTTGCGCAGATCATTTCCGTAGCTCTGATCTTAATCTTTGACAGTGGAGTGGACC
TAAACTACAGTTACGCTTGGATTTTGGGGTCCATCAGCACTGTGTCCCTCCTGGAAGCATACAC
TACACAGATAGACAATCTCCTTCTGCCTCTCTACCTCCTGATATTGCTGATGGCCTAGCTGTTA
CAGTGCAGCAGCAGTGACAGAGGAAACACATGGGGAGGGCGAACAGTCCCCACAGCAGACAGCT
ACTTGGGCGTGAAGAGCCACGGTGTGAAAAGCAGATTTGATTTTTCAGTTGATTCAGATTTAAA
ATAAAAATCAAAGCTCTCCTA

hide sequence

Protein Sequences


Protein RefSeqs	XP_008004189	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000019206
	ENSCSAP00000019206.1

RefSeq Acc Id:	XP_008004189 ⟸ XM_008005998
- UniProtKB:	A0A0D9SEB7 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSCSAP00000019206 ⟸ ENSCSAT00000019800

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000019710	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000019800.1	UniProtKB/TrEMBL
InterPro	Polypren_kinase	UniProtKB/TrEMBL
KEGG Report	csab:103239779	UniProtKB/TrEMBL
NCBI Gene	DOLK	ENTREZGENE
PANTHER	PTHR13205	UniProtKB/TrEMBL
	PTHR13205:SF15	UniProtKB/TrEMBL
UniProt	A0A0D9SEB7	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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