SFXN1 (sideroflexin 1) - Rat Genome Database

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Gene: SFXN1 (sideroflexin 1) Chlorocebus sabaeus
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Symbol: SFXN1
Name: sideroflexin 1
RGD ID: 18734376
Description: ENCODES a protein that exhibits L-alanine transmembrane transporter activity (inferred); L-serine transmembrane transporter activity (inferred); monoatomic ion transmembrane transporter activity (inferred); INVOLVED IN erythrocyte differentiation (ortholog); iron ion transport (ortholog); one-carbon metabolic process (ortholog); ASSOCIATED WITH Animal Disease Models (ortholog); Colorectal Neoplasms (ortholog); genetic disease (ortholog); FOUND IN membrane (inferred); mitochondrial inner membrane (inferred); mitochondrial membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: sideroflexin-1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12377,625,740 - 77,675,935 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2377,625,775 - 77,674,907 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666034912,795 - 964,512 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
SFXN1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12377,625,740 - 77,675,935 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2377,625,775 - 77,674,907 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666034912,795 - 964,512 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
SFXN1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385175,478,560 - 175,529,742 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5175,477,062 - 175,529,742 (+)EnsemblGRCh38hg38GRCh38
GRCh375174,905,563 - 174,956,745 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365174,838,189 - 174,888,218 (+)NCBINCBI36Build 36hg18NCBI36
Build 345174,838,188 - 174,888,218NCBI
Celera5170,944,525 - 170,994,642 (+)NCBICelera
Cytogenetic Map5q35.2NCBI
HuRef5170,004,689 - 170,054,733 (+)NCBIHuRef
CHM1_15174,337,958 - 174,388,345 (+)NCBICHM1_1
T2T-CHM13v2.05176,022,352 - 176,073,526 (+)NCBIT2T-CHM13v2.0
Sfxn1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391354,225,675 - 54,262,365 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1354,225,888 - 54,262,361 (+)EnsemblGRCm39 Ensembl
GRCm381354,071,656 - 54,108,346 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1354,071,869 - 54,108,342 (+)EnsemblGRCm38mm10GRCm38
MGSCv371354,167,214 - 54,203,715 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361354,081,490 - 54,117,966 (+)NCBIMGSCv36mm8
Celera1355,144,580 - 55,182,917 (+)NCBICelera
Cytogenetic Map13B1NCBI
cM Map1328.4NCBI
Sfxn1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81710,491,315 - 10,527,793 (-)NCBIGRCr8
mRatBN7.21710,486,250 - 10,522,640 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1710,486,271 - 10,522,529 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1710,500,879 - 10,536,327 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01712,035,078 - 12,070,519 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01710,497,317 - 10,532,759 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01711,046,588 - 11,082,219 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1711,045,761 - 11,082,047 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01713,157,817 - 13,193,253 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41716,601,066 - 16,636,502 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11716,601,065 - 16,636,502 (-)NCBI
Celera1710,555,805 - 10,591,237 (-)NCBICelera
Cytogenetic Map17p14NCBI
Sfxn1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540828,054,211 - 28,106,175 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540828,054,211 - 28,105,294 (+)NCBIChiLan1.0ChiLan1.0
SFXN1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24170,608,863 - 170,660,457 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15168,748,446 - 168,798,866 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05170,825,507 - 170,876,741 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15177,726,518 - 177,776,344 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5177,738,961 - 177,775,212 (+)Ensemblpanpan1.1panPan2
SFXN1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1437,485,360 - 37,517,743 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl437,487,438 - 37,512,289 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha437,431,872 - 37,472,432 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0437,851,035 - 37,891,568 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl437,851,044 - 37,891,597 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1437,675,678 - 37,716,181 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0437,863,646 - 37,904,164 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0438,373,604 - 38,414,131 (-)NCBIUU_Cfam_GSD_1.0
Sfxn1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721392,004,958 - 92,032,126 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936609729,589 - 754,774 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936609727,621 - 754,806 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SFXN1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl282,025,820 - 82,057,564 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1282,025,799 - 82,057,629 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2283,647,666 - 83,679,493 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Sfxn1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473314,403,957 - 14,452,280 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473314,404,646 - 14,451,943 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 36 1 60
Low 19
Below cutoff

Sequence


RefSeq Acc Id: ENSCSAT00000007555   ⟹   ENSCSAP00000005728
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl2377,625,775 - 77,674,907 (+)Ensembl
RefSeq Acc Id: XM_008015343   ⟹   XP_008013534
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12377,625,743 - 77,675,935 (+)NCBI
Vero_WHO_p1.0NW_023666034912,795 - 964,512 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008015344   ⟹   XP_008013535
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12377,632,799 - 77,675,935 (+)NCBI
Vero_WHO_p1.0NW_023666034915,232 - 958,037 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008015345   ⟹   XP_008013536
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12377,625,742 - 77,675,935 (+)NCBI
Vero_WHO_p1.0NW_023666034915,232 - 964,421 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008015347   ⟹   XP_008013538
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12377,625,742 - 77,675,935 (+)NCBI
Vero_WHO_p1.0NW_023666034912,795 - 964,512 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008015348   ⟹   XP_008013539
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12377,625,740 - 77,675,935 (+)NCBI
Vero_WHO_p1.0NW_023666034915,232 - 964,334 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038010248   ⟹   XP_037866176
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_023666034915,232 - 964,357 (-)NCBI
RefSeq Acc Id: XM_038010251   ⟹   XP_037866179
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_023666034928,923 - 964,512 (-)NCBI
RefSeq Acc Id: XM_038010257   ⟹   XP_037866185
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_023666034915,232 - 964,413 (-)NCBI
RefSeq Acc Id: XP_008013539   ⟸   XM_008015348
- Peptide Label: isoform X3
RefSeq Acc Id: XP_008013536   ⟸   XM_008015345
- Peptide Label: isoform X1
- UniProtKB: A0A0D9RAT9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_008013538   ⟸   XM_008015347
- Peptide Label: isoform X2
RefSeq Acc Id: XP_008013534   ⟸   XM_008015343
- Peptide Label: isoform X1
- UniProtKB: A0A0D9RAT9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_008013535   ⟸   XM_008015344
- Peptide Label: isoform X1
- UniProtKB: A0A0D9RAT9 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000005728   ⟸   ENSCSAT00000007555
RefSeq Acc Id: XP_037866185   ⟸   XM_038010257
- Peptide Label: isoform X1
- UniProtKB: A0A0D9RAT9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037866176   ⟸   XM_038010248
- Peptide Label: isoform X3
RefSeq Acc Id: XP_037866179   ⟸   XM_038010251
- Peptide Label: isoform X4


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000009487 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000007555.1 UniProtKB/TrEMBL
InterPro Mtc UniProtKB/TrEMBL
KEGG Report csab:103245017 UniProtKB/TrEMBL
NCBI Gene SFXN1 ENTREZGENE
PANTHER PTHR11153 UniProtKB/TrEMBL
  SIDEROFLEXIN-1 UniProtKB/TrEMBL
Pfam Mtc UniProtKB/TrEMBL
UniProt A0A0D9RAT9 ENTREZGENE, UniProtKB/TrEMBL