CUL4B (cullin 4B) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: CUL4B (cullin 4B) Chlorocebus sabaeus
Analyze
Symbol: CUL4B
Name: cullin 4B
RGD ID: 18732989
Description: ENCODES a protein that exhibits damaged DNA binding (ortholog); INVOLVED IN astrocyte differentiation (ortholog); gene expression (ortholog); neuron projection development (ortholog); ASSOCIATED WITH autistic disorder (ortholog); Developmental Disabilities (ortholog); Dwarfism (ortholog); FOUND IN Cul4-RING E3 ubiquitin ligase complex (ortholog); Cul4A-RING E3 ubiquitin ligase complex (ortholog); cytosol (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: cullin-4B
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_02366606533,233,605 - 33,271,128 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
CUL4B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_02366606533,233,605 - 33,271,128 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
CUL4B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X120,523,858 - 120,575,532 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX120,505,920 - 120,604,074 (-)EnsemblGRCh38hg38GRCh38
GRCh37X119,657,713 - 119,709,387 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X119,542,472 - 119,593,712 (-)NCBINCBI36Build 36hg18NCBI36
Build 34X119,442,379 - 119,491,531NCBI
CeleraX120,122,944 - 120,174,184 (-)NCBICelera
Cytogenetic MapXq24NCBI
HuRefX109,109,003 - 109,160,669 (-)NCBIHuRef
CHM1_1X119,570,086 - 119,621,321 (-)NCBICHM1_1
T2T-CHM13v2.0X118,899,322 - 118,951,000 (-)NCBIT2T-CHM13v2.0
Cul4b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X37,620,493 - 37,665,073 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX37,622,151 - 37,665,073 (-)EnsemblGRCm39 Ensembl
GRCm38X38,531,616 - 38,576,196 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX38,533,274 - 38,576,196 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X35,884,793 - 35,929,373 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X34,777,901 - 34,820,823 (-)NCBIMGSCv36mm8
CeleraX26,177,720 - 26,222,300 (-)NCBICelera
Cytogenetic MapXA3.3NCBI
cM MapX22.81NCBI
Cul4b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X122,154,332 - 122,192,299 (-)NCBIGRCr8
mRatBN7.2X117,287,481 - 117,326,688 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX117,287,484 - 117,326,688 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX119,387,179 - 119,425,184 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X122,956,187 - 122,994,194 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X120,501,572 - 120,539,675 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X124,831,391 - 124,870,329 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX124,832,628 - 124,870,329 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X124,915,933 - 124,954,871 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X6,800,506 - 6,838,023 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX116,505,114 - 116,543,077 (-)NCBICelera
Cytogenetic MapXq35NCBI
Cul4b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555721,308,491 - 1,365,147 (+)NCBIChiLan1.0ChiLan1.0
CUL4B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X120,074,814 - 120,110,349 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X120,078,753 - 120,113,952 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X109,798,279 - 109,870,469 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X119,985,109 - 120,034,715 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX119,985,116 - 120,034,702 (-)Ensemblpanpan1.1panPan2
CUL4B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X92,489,981 - 92,538,199 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX92,491,114 - 92,537,672 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX78,521,518 - 78,569,760 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X94,236,531 - 94,284,539 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX94,236,532 - 94,283,990 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X91,685,541 - 91,733,782 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X93,448,317 - 93,496,329 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X93,223,172 - 93,271,175 (-)NCBIUU_Cfam_GSD_1.0
Cul4b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X91,451,497 - 91,509,969 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364799,479,133 - 9,534,262 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364799,490,717 - 9,535,998 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CUL4B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX98,668,953 - 98,730,565 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X98,668,945 - 98,730,582 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X112,668,459 - 112,716,028 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Cul4b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624931431,835 - 568,609 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 36 60
Low 20
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: XM_008019464   ⟹   XP_008017655
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366606533,233,605 - 33,269,519 (-)NCBI
Sequence:
RefSeq Acc Id: XM_037989092   ⟹   XP_037845020
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366606533,233,605 - 33,271,128 (-)NCBI
RefSeq Acc Id: XM_037989093   ⟹   XP_037845021
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366606533,233,605 - 33,271,128 (-)NCBI
RefSeq Acc Id: XM_037989094   ⟹   XP_037845022
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366606533,233,605 - 33,271,128 (-)NCBI
Protein Sequences
Protein RefSeqs XP_008017655 (Get FASTA)   NCBI Sequence Viewer  
  XP_037845020 (Get FASTA)   NCBI Sequence Viewer  
  XP_037845021 (Get FASTA)   NCBI Sequence Viewer  
  XP_037845022 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000014347.1
Reference Protein Sequences
RefSeq Acc Id: XP_037845021   ⟸   XM_037989093
- Peptide Label: isoform X2
- UniProtKB: A0A0D9S0F8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037845020   ⟸   XM_037989092
- Peptide Label: isoform X1
RefSeq Acc Id: XP_037845022   ⟸   XM_037989094
- Peptide Label: isoform X3
RefSeq Acc Id: XP_008017655   ⟸   XM_008019464
- Peptide Label: isoform X4


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000018338 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000016437.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.10 UniProtKB/TrEMBL
  Cullin Repeats UniProtKB/TrEMBL
InterPro Cullin UniProtKB/TrEMBL
  Cullin_CS UniProtKB/TrEMBL
  Cullin_homology UniProtKB/TrEMBL
  Cullin_homology_sf UniProtKB/TrEMBL
  Cullin_N UniProtKB/TrEMBL
  Cullin_neddylation_domain UniProtKB/TrEMBL
  Cullin_repeat-like_dom_sf UniProtKB/TrEMBL
  WH-like_DNA-bd_sf UniProtKB/TrEMBL
  WH_DNA-bd_sf UniProtKB/TrEMBL
NCBI Gene CUL4B ENTREZGENE
PANTHER PTHR11932 UniProtKB/TrEMBL
  PTHR11932:SF66 UniProtKB/TrEMBL
Pfam Cullin UniProtKB/TrEMBL
  Cullin_Nedd8 UniProtKB/TrEMBL
PROSITE CULLIN_1 UniProtKB/TrEMBL
  CULLIN_2 UniProtKB/TrEMBL
SMART CULLIN UniProtKB/TrEMBL
  Cullin_Nedd8 UniProtKB/TrEMBL
Superfamily-SCOP SSF46785 UniProtKB/TrEMBL
  SSF74788 UniProtKB/TrEMBL
  SSF75632 UniProtKB/TrEMBL
UniProt A0A0D9S0F8 ENTREZGENE, UniProtKB/TrEMBL