UBR2 (ubiquitin protein ligase E3 component n-recognin 2) - Rat Genome Database

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Gene: UBR2 (ubiquitin protein ligase E3 component n-recognin 2) Chlorocebus sabaeus
Analyze
Symbol: UBR2
Name: ubiquitin protein ligase E3 component n-recognin 2
RGD ID: 18729685
Description: ENCODES a protein that exhibits histone ubiquitin ligase activity (inferred); L-leucine binding (inferred); metal ion binding (inferred); INVOLVED IN male meiosis I (ortholog); positive regulation of T cell receptor signaling pathway (ortholog); proteasome-mediated ubiquitin-dependent protein catabolic process (ortholog); ASSOCIATED WITH genetic disease (ortholog); infantile Refsum disease (ortholog); Zellweger syndrome (ortholog); FOUND IN chromatin (inferred); ubiquitin ligase complex (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: E3 ubiquitin-protein ligase UBR2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11729,458,388 - 29,590,706 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1729,458,374 - 29,590,687 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604442,587,479 - 42,725,323 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
UBR2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11729,458,388 - 29,590,706 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1729,458,374 - 29,590,687 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604442,587,479 - 42,725,323 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
UBR2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38642,564,029 - 42,693,505 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl642,564,029 - 42,693,505 (+)EnsemblGRCh38hg38GRCh38
GRCh37642,531,767 - 42,661,243 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36642,640,036 - 42,766,889 (+)NCBINCBI36Build 36hg18NCBI36
Celera644,084,013 - 44,213,528 (+)NCBICelera
Cytogenetic Map6p21.1NCBI
HuRef642,250,154 - 42,379,642 (+)NCBIHuRef
CHM1_1642,534,602 - 42,663,798 (+)NCBICHM1_1
T2T-CHM13v2.0642,392,486 - 42,521,935 (+)NCBIT2T-CHM13v2.0
Ubr2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391747,239,217 - 47,321,812 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1747,239,221 - 47,321,482 (-)EnsemblGRCm39 Ensembl
GRCm381746,928,291 - 47,010,886 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1746,928,295 - 47,010,556 (-)EnsemblGRCm38mm10GRCm38
MGSCv371747,065,240 - 47,147,481 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361746,391,482 - 46,473,684 (-)NCBIMGSCv36mm8
Celera1750,364,557 - 50,446,007 (-)NCBICelera
Cytogenetic Map17CNCBI
cM Map1722.91NCBI
Ubr2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8921,480,058 - 21,559,936 (+)NCBIGRCr8
mRatBN7.2913,982,427 - 14,062,315 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl913,982,329 - 14,062,139 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx922,564,690 - 22,642,065 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0927,628,725 - 27,706,075 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0925,928,057 - 26,005,432 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0916,003,058 - 16,080,152 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl916,003,058 - 16,080,152 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0914,919,790 - 14,997,035 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.499,165,363 - 9,247,261 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera911,731,361 - 11,809,500 (+)NCBICelera
Cytogenetic Map9q12NCBI
Ubr2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554378,677,801 - 8,782,120 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554378,678,212 - 8,780,700 (+)NCBIChiLan1.0ChiLan1.0
UBR2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2557,058,201 - 57,190,366 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1652,928,203 - 53,058,177 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0642,150,409 - 42,282,486 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1643,449,154 - 43,579,224 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl643,449,154 - 43,579,224 (+)Ensemblpanpan1.1panPan2
UBR2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11211,167,286 - 11,296,817 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1211,167,346 - 11,294,911 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1211,194,238 - 11,324,038 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01211,648,206 - 11,778,081 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1211,648,320 - 11,778,079 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11211,176,544 - 11,306,317 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01211,261,325 - 11,391,207 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01211,354,858 - 11,484,875 (+)NCBIUU_Cfam_GSD_1.0
Ubr2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494646,637,679 - 46,781,221 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647617,181,214 - 17,322,163 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647617,178,981 - 17,322,600 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
UBR2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl737,655,926 - 37,784,359 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1737,655,808 - 37,785,301 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2743,111,597 - 43,215,426 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Ubr2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475416,701,331 - 16,798,897 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475416,701,950 - 16,798,293 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 36 18 60
Low 2
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000009529   ⟹   ENSCSAP00000007643
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl1729,458,374 - 29,590,687 (-)Ensembl
RefSeq Acc Id: XM_007972546   ⟹   XP_007970737
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11729,458,388 - 29,590,705 (-)NCBI
Vero_WHO_p1.0NW_02366604442,587,541 - 42,725,323 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007972547   ⟹   XP_007970738
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11729,458,388 - 29,590,705 (-)NCBI
Vero_WHO_p1.0NW_02366604442,587,541 - 42,724,556 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007972548   ⟹   XP_007970739
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11729,460,593 - 29,590,705 (-)NCBI
Vero_WHO_p1.0NW_02366604442,587,480 - 42,725,323 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007972550   ⟹   XP_007970741
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11729,458,388 - 29,581,078 (-)NCBI
Vero_WHO_p1.0NW_02366604442,597,062 - 42,724,556 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007972551   ⟹   XP_007970742
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11729,472,111 - 29,590,706 (-)NCBI
Vero_WHO_p1.0NW_02366604442,587,479 - 42,711,615 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007972552   ⟹   XP_007970743
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11729,484,722 - 29,590,706 (-)NCBI
Vero_WHO_p1.0NW_02366604442,587,480 - 42,699,218 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007972553   ⟹   XP_007970744
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11729,487,629 - 29,590,706 (-)NCBI
Vero_WHO_p1.0NW_02366604442,587,480 - 42,696,372 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007972558   ⟹   XP_007970749
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11729,516,432 - 29,590,703 (-)NCBI
Vero_WHO_p1.0NW_02366604442,587,480 - 42,667,551 (+)NCBI
Sequence:
RefSeq Acc Id: XR_005243027
Type: NON-CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366604442,587,480 - 42,676,453 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_007970737   ⟸   XM_007972546
- Peptide Label: isoform X1
- UniProtKB: A0A0D9RGA4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007970738   ⟸   XM_007972547
- Peptide Label: isoform X2
RefSeq Acc Id: XP_007970741   ⟸   XM_007972550
- Peptide Label: isoform X4
RefSeq Acc Id: XP_007970739   ⟸   XM_007972548
- Peptide Label: isoform X3
RefSeq Acc Id: XP_007970742   ⟸   XM_007972551
- Peptide Label: isoform X5
RefSeq Acc Id: XP_007970743   ⟸   XM_007972552
- Peptide Label: isoform X6
RefSeq Acc Id: XP_007970744   ⟸   XM_007972553
- Peptide Label: isoform X7
RefSeq Acc Id: XP_007970749   ⟸   XM_007972558
- Peptide Label: isoform X8
RefSeq Acc Id: ENSCSAP00000007643   ⟸   ENSCSAT00000009529


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000011442 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000009529.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.2670 UniProtKB/TrEMBL
  2.10.110.30 UniProtKB/TrEMBL
  3.30.1390.10 UniProtKB/TrEMBL
InterPro ClpS_core UniProtKB/TrEMBL
  E3_ELL-like UniProtKB/TrEMBL
  E3_ligase_UBR-like_C UniProtKB/TrEMBL
  Ribosomal_L7/12_C/ClpS-like UniProtKB/TrEMBL
  UBR-box_UBR2 UniProtKB/TrEMBL
  UBR1-like UniProtKB/TrEMBL
  WH_DNA-bd_sf UniProtKB/TrEMBL
  Znf_UBR UniProtKB/TrEMBL
KEGG Report csab:103221493 UniProtKB/TrEMBL
NCBI Gene UBR2 ENTREZGENE
PANTHER E3 UBIQUITIN-PROTEIN LIGASE UBR2 UniProtKB/TrEMBL
  PTHR21497 UniProtKB/TrEMBL
Pfam ClpS UniProtKB/TrEMBL
  PRT6_C UniProtKB/TrEMBL
  zf-UBR UniProtKB/TrEMBL
PROSITE ZF_UBR UniProtKB/TrEMBL
SMART ZnF_UBR1 UniProtKB/TrEMBL
Superfamily-SCOP SSF46785 UniProtKB/TrEMBL
  SSF54736 UniProtKB/TrEMBL
UniProt A0A0D9RGA4 ENTREZGENE, UniProtKB/TrEMBL