WIPI1 (WD repeat domain, phosphoinositide interacting 1)

Gene: WIPI1 (WD repeat domain, phosphoinositide interacting 1) Chlorocebus sabaeus

Analyze

Symbol:

WIPI1

Name:

WD repeat domain, phosphoinositide interacting 1

RGD ID:

18726565

Description:

ENCODES a protein that exhibits lipid binding (inferred); nuclear androgen receptor binding (inferred); nuclear estrogen receptor binding (inferred); INVOLVED IN autophagosome assembly (inferred); autophagy (inferred); cellular response to starvation (inferred); ASSOCIATED WITH cholestasis (ortholog); genetic disease (ortholog); lipid storage disease (ortholog); FOUND IN autophagosome membrane (inferred); cytoplasm (inferred); cytosol (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

WD repeat domain phosphoinositide-interacting protein 1

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	16	53,096,027 - 53,133,828 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	16	53,096,023 - 53,135,010 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666077	24,024,610 - 24,063,523 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

cholestasis (ISO)

genetic disease (ISO)

lipid storage disease (ISO)

neural tube defect (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

autophagosome assembly (IEA)

autophagy (IEA)

cellular response to starvation (IEA)

nucleophagy (IEA)

positive regulation of autophagosome assembly (IEA)

protein localization to phagophore assembly site (IEA)

vesicle targeting, trans-Golgi to endosome (IEA)

Cellular Component

autophagosome membrane (IEA)

cytoplasm (IEA)

cytosol (IEA)

endosome membrane (IEA)

extrinsic component of membrane (IEA)

phagophore assembly site (IEA)

phagophore assembly site membrane (IEA)

trans-Golgi network (IEA)

Molecular Function

lipid binding (IEA)

nuclear androgen receptor binding (IEA)

nuclear estrogen receptor binding (IEA)

phosphatidylinositol-3,5-bisphosphate binding (IEA)

phosphatidylinositol-3-phosphate binding (IEA)

protein binding (ISO)

protein-macromolecule adaptor activity (IEA)

signaling receptor binding (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

WIPI1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	16	53,096,027 - 53,133,828 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	16	53,096,023 - 53,135,010 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666077	24,024,610 - 24,063,523 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

WIPI1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	17	68,421,281 - 68,457,496 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	17	68,420,948 - 68,457,513 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	17	66,417,422 - 66,453,637 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	17	63,929,017 - 63,965,248 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	17	62,988,989 - 63,025,394 (-)	NCBI		Celera
Cytogenetic Map	17	q24.2	NCBI
HuRef	17	61,803,259 - 61,839,657 (-)	NCBI		HuRef
CHM1_1	17	66,482,061 - 66,518,186 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	17	69,297,798 - 69,334,178 (-)	NCBI		T2T-CHM13v2.0

Wipi1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	109,464,347 - 109,502,215 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	109,464,157 - 109,502,793 (-)	Ensembl		GRCm39 Ensembl
GRCm38	11	109,573,521 - 109,611,389 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	109,573,331 - 109,611,967 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	109,434,835 - 109,472,703 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	11	109,389,611 - 109,427,479 (-)	NCBI		MGSCv36	mm8
Celera	11	121,311,520 - 121,349,584 (-)	NCBI		Celera
Cytogenetic Map	11	E1	NCBI
cM Map	11	72.18	NCBI

Wipi1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	95,042,451 - 95,079,679 (-)	NCBI		GRCr8
mRatBN7.2	10	94,542,946 - 94,580,174 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	94,542,946 - 94,579,846 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	99,600,580 - 99,637,322 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	99,063,654 - 99,100,399 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	94,473,833 - 94,510,401 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	97,859,730 - 97,896,949 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	97,859,727 - 97,896,525 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	97,578,114 - 97,614,772 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	98,722,266 - 98,753,713 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	10	98,736,531 - 98,768,083 (+)	NCBI
Celera	10	93,202,993 - 93,239,541 (-)	NCBI		Celera
Cytogenetic Map	10	q32.1	NCBI

Wipi1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955478	4,309,880 - 4,343,934 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955478	4,309,975 - 4,341,107 (+)	NCBI	ChiLan1.0	ChiLan1.0

WIPI1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	19	84,449,415 - 84,486,108 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	17	89,270,536 - 89,307,191 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	17	62,357,952 - 62,394,620 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	17	67,748,201 - 67,784,313 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	17	67,748,201 - 67,784,389 (-)	Ensembl	panpan1.1		panPan2

WIPI1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	9	15,115,098 - 15,147,893 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	9	15,115,315 - 15,149,147 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	9	16,007,598 - 16,040,393 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	9	16,777,725 - 16,810,214 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	9	16,777,726 - 16,810,216 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	9	15,722,376 - 15,755,139 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	9	11,778,126 - 11,810,866 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	9	11,778,427 - 11,811,230 (+)	NCBI		UU_Cfam_GSD_1.0

Wipi1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	11,382,450 - 11,411,762 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936541	7,783,322 - 7,812,054 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936541	7,782,836 - 7,812,142 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

WIPI1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	12	11,715,318 - 11,752,021 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	12	11,715,332 - 11,752,009 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	12	12,181,684 - 12,218,356 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Wipi1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624870	3,486,375 - 3,518,193 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624870	3,487,814 - 3,518,206 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	endocrine system	hemolymphoid system	nervous system
High
Medium	21	1	12
Low	15	19	48
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_008012001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008012002	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000045	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCSAT00000002265 ⟹ ENSCSAP00000000591

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	16	53,096,023 - 53,135,010 (+)	Ensembl

RefSeq Acc Id:

XM_008012001 ⟹ XP_008010192

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	16	53,096,027 - 53,133,828 (+)	NCBI
Vero_WHO_p1.0	NW_023666077	24,024,610 - 24,063,523 (+)	NCBI

Sequence:

show sequence

ACAGGACCGGCGACCCGTCCCGTGGAGCCGGCGCGGGCGGGCTGCTGAGGTGGCTGTCGCCGGC
TCCGAGCTGCGGCTTCCCGGGCAGAGCCCCCGATGGAGGCCGAGGCCGCGGACGCTCCCCCGGG
TGGGGTCGAGTCGGCGCTCAGCTGCTTCTCTTTCAACCAGGACTGCACGTCCCTAGCAATTGGA
ACTAAAGCCGGGTATAAGCTGTTTTCTCTGAGTTCTGTGGAGCAGCTGGATCAAGTCCACGGAA
GCAATGAAATCCCGGACGTCTACATCGTGGAGCGCCTCTTCTCCAGCAGCCTGGTGGTGGTAGT
CAGTCACACAAAACCACGGCAAATGAACGTGTATCACTTCAAGAAAGGCACAGAGATCTGTAAT
TACAGCTACTCCAGCAACATCTTGTCCATAAGGCTGAACCGGCAGAGGCTGCTGGTTTGCCTAG
AAGAGTCTATTTATATTCACAACATTAAAGACATGAAGCTGTTGAAGACCCTCCTGGATATTCC
TGCAAACCCAACAGGTCTATGTGCTCTCTCTATCAACCATTCCAATTCTTACTTGGCCTATCCT
GGAAGCCTGACTTCAGGGGAGATTGTGCTTTATGATGGAAACTCCCTGAAAACAGTCTGCACTA
TTGCTGCCCACGAGGGGACACTGGCTGCCATCACCTTCAATGCCTCAGGCTCCAAACTAGCAAG
TGCGTCTGAAAAAGGCACAGTCATCCGGGTGTTCTCTGTCCCTGACGGGCAAAAGCTCTATGAG
TTCCGGAGAGGGATGAAAAGGTATGTGACAATCAGCTCTCTAGTGTTCAGTATGGACTCACAAT
TCCTCTGCGCCTCCAGTAACACCGAGACGGTACACATCTTCAAGCTGGAGCAGGTCACCAACAG
TCGACCAGAAGAGACTTCAACCTGGAGTGGCTACGTGGGAAAGATGTTCATGGCTGCTACCAAC
TACCTCCCAAGCCAGGTGTCCGACATGATGCACCAGGACCGGGCCTTTGCCACCGCACGCTTGA
ACTTCTCCGGGCAGAGGAACATCTGTACCCTCTCAACGATCCAGAAGTTGCCACGGCTGCTAGT
TGCATCATCCAATGGACACCTTTATATCTACAATTTGGATCCTCAGGATGGAGGAGAGTGTGTC
TTAATCAAAACCCACAGCTTGCTTGGCTCAGGAACAACAGAAGAGAATAAAGAAAATGACCTCA
GACCTTCTTTACCTCAGTCTTATGCAGCAACTGTAGCCAGACCAAGTGCATCTTCAGCCTCCAC
GGTGCCAGGTTATTCCGAGGACGGCGGGGCGCTGCGAGGAGAAGTGATTCCTGAGCATGAGTTT
GCGACGGGACCAGTGTGTCTTGATGATGAGAATGAGTTTCCTCCTATAATCTTGTGCCGTGGAA
ATCAGAAGGGCAAAACGAAGCAGTCATGATGAGAAGCACACCTCAGAAATCAGGACATCCCCCT
ATCAGGTGGTTTTGGAGAAAACAAGGAAGGTGGAAGAATGGAGTGCAATTGTGTAAGCAGAAAG
GGGGGCAGGAATCCCGGGTGCTGCACTGCTTAAACCACAGGACCTGGTTAACTCCTCACCAAGC
TTCCCACGACCCTGGTTGCCAGTGGGCGTGGGAGACACTGTATACACATTATGCTATTTAAAAT
ATGTTCAAACCATAGTGTAAATGCTAATTAACCATATTGGTATGTAACCAGAATTTTTATATTA
AAAGGGGCCTCCTTTTTAAATATATGCTGTGTAAAAAATGTACCTATAGGAACATCTCTTTGAA
TTGTATTTCTTGTATATTACATACTTAGAGAAACTATTTTAGCCAGGCAAAGTCTTTTTTGGCT
GTGACTGGAATCAATCATTTATTACTGGGAGTCACATTTTGGACACTAATAATAAAATCATGGC
AATGCA

hide sequence

Protein Sequences


Protein RefSeqs	XP_008010192	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000000591
	ENSCSAP00000000591.1

RefSeq Acc Id:	XP_008010192 ⟸ XM_008012001
- UniProtKB:	A0A0D9QW52 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSCSAP00000000591 ⟸ ENSCSAT00000002265

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000004236	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000002265.1	UniProtKB/TrEMBL
Gene3D-CATH	2.130.10.10	UniProtKB/TrEMBL
InterPro	PROPPIN	UniProtKB/TrEMBL
	WD40/YVTN_repeat-like_dom_sf	UniProtKB/TrEMBL
	WD40_repeat	UniProtKB/TrEMBL
	WD40_repeat_dom_sf	UniProtKB/TrEMBL
KEGG Report	csab:103243149	UniProtKB/TrEMBL
NCBI Gene	WIPI1	ENTREZGENE
PANTHER	PTHR11227:SF23	UniProtKB/TrEMBL
	WD-REPEAT PROTEIN INTERACTING WITH PHOSPHOINOSIDES WIPI -RELATED	UniProtKB/TrEMBL
Pfam	PROPPIN	UniProtKB/TrEMBL
SMART	WD40	UniProtKB/TrEMBL
Superfamily-SCOP	SSF50978	UniProtKB/TrEMBL
UniProt	A0A0D9QW52	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD