POLR2E (RNA polymerase II, I and III subunit E) - Rat Genome Database

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Gene: POLR2E (RNA polymerase II, I and III subunit E) Chlorocebus sabaeus
Analyze
Symbol: POLR2E
Name: RNA polymerase II, I and III subunit E
RGD ID: 18721376
Description: ENCODES a protein that exhibits DNA binding (inferred); DNA-directed 5'-3' RNA polymerase activity (inferred); RNA polymerase I activity (inferred); INVOLVED IN DNA-templated transcription (inferred); transcription by RNA polymerase II (inferred); PARTICIPATES IN RNA polymerase I transcription pathway; RNA polymerase II transcription pathway; RNA polymerase III transcription pathway; ASSOCIATED WITH cerebral creatine deficiency syndrome (ortholog); cyclic hematopoiesis (ortholog); Dwarfism (ortholog); FOUND IN RPAP3/R2TP/prefoldin-like complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: DNA-directed RNA polymerases I, II, and III subunit RPABC1; polymerase (RNA) II (DNA directed) polypeptide E, 25kDa; RNA polymerase II subunit E
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.16844,196 - 856,127 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl6841,615 - 855,214 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660818,003,368 - 8,013,758 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
POLR2E
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.16844,196 - 856,127 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl6841,615 - 855,214 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660818,003,368 - 8,013,758 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
POLR2E
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38191,086,574 - 1,095,375 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl191,086,574 - 1,095,380 (-)EnsemblGRCh38hg38GRCh38
GRCh37191,086,573 - 1,095,374 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36191,039,163 - 1,046,336 (-)NCBINCBI36Build 36hg18NCBI36
Build 34191,039,165 - 1,046,336NCBI
Celera191,019,553 - 1,028,363 (-)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef19860,059 - 868,869 (-)NCBIHuRef
CHM1_1191,086,181 - 1,094,986 (-)NCBICHM1_1
T2T-CHM13v2.0191,051,240 - 1,060,040 (-)NCBIT2T-CHM13v2.0
Polr2e
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391079,871,787 - 79,875,493 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1079,871,783 - 79,875,629 (-)EnsemblGRCm39 Ensembl
GRCm381080,035,953 - 80,039,659 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1080,035,949 - 80,039,795 (-)EnsemblGRCm38mm10GRCm38
MGSCv371079,498,698 - 79,502,404 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361079,439,639 - 79,442,869 (-)NCBIMGSCv36mm8
Celera1081,050,761 - 81,054,467 (-)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
Polr2e
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8710,317,332 - 10,321,280 (+)NCBIGRCr8
mRatBN7.279,666,695 - 9,670,638 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl79,666,716 - 9,670,643 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx712,549,536 - 12,553,410 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0714,424,874 - 14,428,748 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0712,285,994 - 12,289,868 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0712,532,785 - 12,536,797 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl712,532,895 - 12,536,791 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0712,702,927 - 12,706,900 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4711,179,283 - 11,183,205 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera77,842,509 - 7,846,431 (+)NCBICelera
Cytogenetic Map7q11NCBI
Polr2e
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554956,779,557 - 6,788,241 (+)NCBIChiLan1.0ChiLan1.0
POLR2E
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2205,421,085 - 5,438,308 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1194,658,825 - 4,674,825 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01932,263 - 41,992 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1191,063,296 - 1,073,379 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl191,065,421 - 1,073,379 (-)Ensemblpanpan1.1panPan2
POLR2E
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12057,649,836 - 57,653,661 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2057,649,868 - 57,654,199 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2057,452,042 - 57,455,856 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02058,391,944 - 58,395,762 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2058,392,009 - 58,395,762 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12057,447,255 - 57,451,066 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02057,926,783 - 57,930,597 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02058,129,830 - 58,133,647 (+)NCBIUU_Cfam_GSD_1.0
Polr2e
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118217,335,308 - 217,340,338 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936588494,399 - 499,952 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936588494,445 - 499,659 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
POLR2E
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl277,330,686 - 77,341,900 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1277,330,755 - 77,341,910 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2277,655,741 - 77,666,891 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Polr2e
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248287,547,460 - 7,553,282 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248287,547,401 - 7,553,282 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 36 30
Low 20 30
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000010427   ⟹   ENSCSAP00000008521
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl6841,615 - 855,214 (-)Ensembl
RefSeq Acc Id: XM_007994573   ⟹   XP_007992764
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.16844,196 - 856,127 (-)NCBI
Vero_WHO_p1.0NW_0236660818,003,371 - 8,012,212 (+)NCBI
Sequence:
RefSeq Acc Id: XM_037994561   ⟹   XP_037850489
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_0236660818,003,369 - 8,013,758 (+)NCBI
RefSeq Acc Id: XM_037994563   ⟹   XP_037850491
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_0236660818,003,368 - 8,013,758 (+)NCBI
Protein Sequences
Protein RefSeqs XP_007992764 (Get FASTA)   NCBI Sequence Viewer  
  XP_037850489 (Get FASTA)   NCBI Sequence Viewer  
  XP_037850491 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000008521
  ENSCSAP00000008521.1
Reference Protein Sequences
RefSeq Acc Id: XP_007992764   ⟸   XM_007994573
- UniProtKB: A0A0D9RIT2 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000008521   ⟸   ENSCSAT00000010427
RefSeq Acc Id: XP_037850491   ⟸   XM_037994563
- UniProtKB: A0A0D9RIT2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037850489   ⟸   XM_037994561
- UniProtKB: A0A0D9RIT2 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000012336 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000010427.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.1340.10 UniProtKB/TrEMBL
  3.90.940.20 UniProtKB/TrEMBL
InterPro DNA_RNA_pol_RPB5_euk/virus UniProtKB/TrEMBL
  RNA_pol_Rpb5_N UniProtKB/TrEMBL
  RNA_pol_Rpb5_N_sf UniProtKB/TrEMBL
  RNA_pol_subH/Rpb5_C UniProtKB/TrEMBL
  RNA_pol_subH/Rpb5_CS UniProtKB/TrEMBL
  RPB5-like_sf UniProtKB/TrEMBL
KEGG Report csab:103233592 UniProtKB/TrEMBL
NCBI Gene POLR2E ENTREZGENE
PANTHER DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1 UniProtKB/TrEMBL
  PTHR10535 UniProtKB/TrEMBL
Pfam RNA_pol_Rpb5_C UniProtKB/TrEMBL
  RNA_pol_Rpb5_N UniProtKB/TrEMBL
PIRSF RPB5 UniProtKB/TrEMBL
PROSITE RNA_POL_H_23KD UniProtKB/TrEMBL
Superfamily-SCOP SSF53036 UniProtKB/TrEMBL
  SSF55287 UniProtKB/TrEMBL
UniProt A0A0D9RIT2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-05-26 POLR2E  RNA polymerase II, I and III subunit E  POLR2E  RNA polymerase II subunit E  Symbol and/or name change 5135510 APPROVED