DUOXA2 (dual oxidase maturation factor 2)

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Gene: DUOXA2 (dual oxidase maturation factor 2) Chlorocebus sabaeus

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Symbol:

DUOXA2

Name:

dual oxidase maturation factor 2

RGD ID:

18717755

Description:

ENCODES a protein that exhibits enzyme binding (inferred); INVOLVED IN hydrogen peroxide metabolic process (ortholog); regulation of inflammatory response (ortholog); regulation of thyroid hormone generation (ortholog); ASSOCIATED WITH AGAT deficiency (ortholog); Bloom syndrome (ortholog); colorectal cancer (ortholog); FOUND IN apical part of cell (inferred); cell leading edge (inferred); cytosol (inferred)

Type:

protein-coding

RefSeq Status:

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	26	38,084,943 - 38,089,701 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	26	38,086,092 - 38,089,420 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666048	102,969,087 - 102,972,867 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

AGAT deficiency (ISO)

Bloom syndrome (ISO)

colorectal cancer (ISO)

congenital hypothyroidism (ISO)

genetic disease (ISO)

thyroid dyshormonogenesis 5 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

hydrogen peroxide metabolic process (IEA,ISO)

positive regulation of cell motility (IEA)

positive regulation of hydrogen peroxide biosynthetic process (IEA)

protein localization (IEA)

protein maturation (IEA)

protein transport (IEA)

regulation of inflammatory response (IEA,ISO)

regulation of thyroid hormone generation (IEA,ISO)

Cellular Component

apical part of cell (IEA)

cell leading edge (IEA)

cytosol (IEA)

endoplasmic reticulum (IEA)

endoplasmic reticulum membrane (IEA)

membrane (IEA)

plasma membrane (IEA)

Molecular Function

enzyme binding (IEA)

protein binding (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

DUOXA2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	26	38,084,943 - 38,089,701 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	26	38,086,092 - 38,089,420 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666048	102,969,087 - 102,972,867 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

DUOXA2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	15	45,114,326 - 45,118,421 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	15	45,114,326 - 45,118,421 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	15	45,406,524 - 45,410,619 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	15	43,193,816 - 43,197,596 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	15	22,297,958 - 22,301,739 (+)	NCBI		Celera
Cytogenetic Map	15	q21.1	NCBI
HuRef	15	22,230,735 - 22,234,516 (+)	NCBI		HuRef
CHM1_1	15	45,524,856 - 45,528,637 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	15	42,922,347 - 42,926,442 (+)	NCBI		T2T-CHM13v2.0

Duoxa2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	122,129,381 - 122,133,088 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	122,129,381 - 122,133,366 (+)	Ensembl		GRCm39 Ensembl
GRCm38	2	122,298,900 - 122,302,885 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	122,298,900 - 122,302,885 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	122,124,636 - 122,128,621 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	121,990,341 - 121,994,326 (+)	NCBI		MGSCv36	mm8
Celera	2	123,449,032 - 123,452,872 (+)	NCBI		Celera
Cytogenetic Map	2	E5	NCBI
cM Map	2	60.62	NCBI

Duoxa2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	129,698,938 - 129,702,656 (+)	NCBI		GRCr8
mRatBN7.2	3	109,245,337 - 109,249,055 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	109,245,476 - 109,248,968 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	112,919,191 - 112,922,563 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	121,514,712 - 121,518,084 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	119,175,086 - 119,178,458 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	114,236,718 - 114,240,086 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	114,236,718 - 114,240,086 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	120,776,164 - 120,779,532 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	109,077,891 - 109,081,259 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	3	108,143,293 - 108,146,662 (+)	NCBI		Celera
Cytogenetic Map	3	q35	NCBI

Duoxa2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955409	8,266,873 - 8,270,486 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955409	8,266,873 - 8,270,486 (-)	NCBI	ChiLan1.0	ChiLan1.0

DUOXA2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	16	34,354,178 - 34,358,614 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	15	38,532,344 - 38,536,773 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	15	24,061,922 - 24,066,016 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	15	42,415,195 - 42,418,979 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	15	42,415,195 - 42,418,974 (+)	Ensembl	panpan1.1		panPan2

DUOXA2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	30	11,541,849 - 11,546,019 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	30	11,542,078 - 11,545,811 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	30	11,597,991 - 11,602,183 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	30	11,678,623 - 11,690,210 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	30	11,678,874 - 11,682,607 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	30	11,584,860 - 11,589,033 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	30	11,707,421 - 11,711,539 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	30	11,826,699 - 11,831,334 (+)	NCBI		UU_Cfam_GSD_1.0

Duoxa2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	89,984,217 - 89,987,570 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936471	7,832,234 - 7,835,476 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936471	7,832,234 - 7,835,488 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

DUOXA2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	126,613,201 - 126,623,388 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	126,616,631 - 126,620,359 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	141,198,367 - 141,205,268 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Duoxa2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624731	14,118,426 - 14,121,928 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624731	14,118,526 - 14,121,811 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	endocrine system	hemolymphoid system	nervous system
High
Medium
Low	14	11	14
Below cutoff	12	6	5

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_008016765	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008016766	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000016	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCSAT00000008025 ⟹ ENSCSAP00000006182

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	26	38,086,092 - 38,089,420 (-)	Ensembl

RefSeq Acc Id:

XM_008016765 ⟹ XP_008014956

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	26	38,085,917 - 38,089,701 (-)	NCBI
Vero_WHO_p1.0	NW_023666048	102,969,087 - 102,972,867 (+)	NCBI

Sequence:

show sequence

CAGGGCGAACCCGCAGAACCAGGAAAGTAACGTCTACAGACAGTGAGAAGTAGTTTCGTTCGCG
GACTAGAACAACTCTCTCGGTACCAACCCCAGAGCGTTGAGAGCAGCCCACCTCCACGCTTCCT
CAGCGGAGAGGTGCAGAACTCAGACTTCACCAGCCCACTGGGTCCCGGCCTTGTACGCGAAGAG
ACGCCAAGGACGCGCTCTCCCGCGTCCAGGTGGCCCCACCTGGCTGGCTTGCCTGCCCCTCTGC
GTGCAGCTCGCGGCCGCCGTGCATCATGACCCTGTGGAACGGGGTACTGCCTTTTTACCCCCCG
CCCCGGCATGCCGCAGGCTTCAGCGTTTCACTGCTCATCGTTATTCTAGTGTTTTTGGCTTTAG
CAGCAAGCTTCCTGCTCATCCTGCCGGGGATCCGTGGCCACTCGCGCTGGTTTTGGTTGGTGAG
AGTTCTTCTCAGTCTGTTCATAGGCGCAGAAATCGTGGCTGTGCACTTCAGTGCAGAATGGTTC
GTGGGTAGAGTGAACACCAACACATCCTACAAAGCCTTCAGTGCAGCGCGCGTTACAGCCCATG
TCGGTCTGCTCGTGGGCCTGCAGGGCATTAATATTACACTCACAGGGACCCCAGTGCATCAGCT
GAACGAGACCATTGACTACAACGAGCAGTTCACCTGGCGTCTGAGAGAGAATTACGCCGCGGAG
TACGCGAACGCGCTGGAGAAGGGGCTGCCGAACCCAGTGCTCTACCTGGCGGAGAAGTTCACAC
CGAGTAGCCCTTGCGGCCTGTACCACCAGTACCACCTGGCGGGACACTACGCCTCGGCCACGCT
GTGGGTGGCGTTCTGCTTCTGGCTCCTCTCCAACGTGCTGCTCTCCACGCCGGCCCCGCTCTAC
GGAGGCCTGGCACTGCTGACCACGGGAGCCTTCGCGCTCTTCGGGATCTTCGCCTTCGCCTCCA
TCTCCAGTGTGCCGCTCTGCCCGCTCCGCCTAGGCTCCGCCGTGCTCACCGCTCAGTACGGCGC
CGCCTTCTGGGTCACGCTGGCAACCGGCATCCTGTGCCTCTTCCTCGGAGGGGCGGTAGTGAGT
CTCCACTATGTTCGGCCCAGCGCTCTTCGCACCCTTCTGGACCAAAGCGCCAAGGACTGCAGCC
AGGCAAAAGGGGGCTCACCTCTTATCCTCGGCAACCCACTGCACAAGCAGGCCGCGCTCCCGGA
CTTAAAATTCATCACCACTAACCTGTGAGGGGGACCCAATCTGGACTCCTTCCCCGCCTTGGGA
CCTGGCAGGCCGGGGAAGCAGGAGAGCTCCGGGAAGGGCACTGCGCGCAGCTGGCGCGAGGCCG
ACATCCGCAGGCACCAGGGAAAGTCTCCTGGGGCGAGCTGTAAATAAACTTGTTTTTTCTTTTG
TTTTTTAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_008014956	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000006182.1

RefSeq Acc Id:	XP_008014956 ⟸ XM_008016765
- UniProtKB:	A0A0D9RC43 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSCSAP00000006182 ⟸ ENSCSAT00000008025

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000009952	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000008025.1	UniProtKB/TrEMBL
InterPro	Dual_oxidase_maturation_fac	UniProtKB/TrEMBL
KEGG Report	csab:103245705	UniProtKB/TrEMBL
NCBI Gene	DUOXA2	ENTREZGENE
PANTHER	DUAL OXIDASE MATURATION FACTOR 2	UniProtKB/TrEMBL
	PTHR31158	UniProtKB/TrEMBL
Pfam	DuoxA	UniProtKB/TrEMBL
UniProt	A0A0D9RC43	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar

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