FGD2 (FYVE, RhoGEF and PH domain containing 2) - Rat Genome Database

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Gene: FGD2 (FYVE, RhoGEF and PH domain containing 2) Chlorocebus sabaeus
Analyze
Symbol: FGD2
Name: FYVE, RhoGEF and PH domain containing 2
RGD ID: 18708206
Description: ENCODES a protein that exhibits guanyl-nucleotide exchange factor activity (inferred); metal ion binding (inferred); phosphatidylinositol phosphate binding (inferred); INVOLVED IN cytoskeleton organization (inferred); filopodium assembly (inferred); ASSOCIATED WITH COVID-19 (ortholog); genetic disease (ortholog); ovarian cyst (ortholog); FOUND IN cytoplasm (inferred); cytoskeleton (inferred); early endosome (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: FYVE, RhoGEF and PH domain-containing protein 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11735,112,453 - 35,136,161 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1735,112,815 - 35,136,017 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604436,943,781 - 36,967,321 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)
cytoskeleton  (IEA)
early endosome  (IEA)
nucleus  (IEA)
ruffle  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
FGD2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11735,112,453 - 35,136,161 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1735,112,815 - 35,136,017 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604436,943,781 - 36,967,321 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
FGD2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38637,005,655 - 37,029,069 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl637,005,646 - 37,029,069 (+)EnsemblGRCh38hg38GRCh38
GRCh37636,973,431 - 36,996,845 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36637,081,401 - 37,104,822 (+)NCBINCBI36Build 36hg18NCBI36
Build 34637,081,400 - 37,104,822NCBI
Celera638,528,396 - 38,551,886 (+)NCBICelera
Cytogenetic Map6p21.2NCBI
HuRef636,691,770 - 36,715,184 (+)NCBIHuRef
CHM1_1636,975,223 - 36,998,669 (+)NCBICHM1_1
T2T-CHM13v2.0636,829,039 - 36,852,622 (+)NCBIT2T-CHM13v2.0
Fgd2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391729,579,878 - 29,598,509 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1729,579,888 - 29,598,635 (+)EnsemblGRCm39 Ensembl
GRCm381729,360,904 - 29,379,535 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1729,360,914 - 29,379,661 (+)EnsemblGRCm38mm10GRCm38
MGSCv371729,497,859 - 29,516,480 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361729,087,926 - 29,106,565 (+)NCBIMGSCv36mm8
Celera1729,903,505 - 29,922,630 (+)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1715.26NCBI
Fgd2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8207,426,407 - 7,443,207 (+)NCBIGRCr8
mRatBN7.2207,424,795 - 7,441,603 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl207,424,790 - 7,441,603 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx208,127,837 - 8,144,980 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0207,489,694 - 7,506,838 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0207,961,599 - 7,978,728 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0206,973,356 - 6,990,026 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl206,973,398 - 6,990,023 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0209,212,072 - 9,228,719 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4207,684,764 - 7,702,116 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1207,685,169 - 7,701,720 (+)NCBI
Celera208,967,909 - 8,984,674 (+)NCBICelera
Cytogenetic Map20p12NCBI
Fgd2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554376,024,301 - 6,038,349 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554376,026,087 - 6,038,740 (-)NCBIChiLan1.0ChiLan1.0
FGD2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2551,473,851 - 51,497,972 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1647,343,620 - 47,374,549 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0636,566,942 - 36,591,044 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1637,762,646 - 37,787,186 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl637,762,809 - 37,785,291 (+)Ensemblpanpan1.1panPan2
FGD2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1126,069,251 - 6,091,972 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl126,068,910 - 6,139,707 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha126,087,785 - 6,110,527 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0126,418,188 - 6,440,928 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl126,417,971 - 6,440,890 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1126,072,861 - 6,095,355 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0126,152,181 - 6,174,920 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0126,250,596 - 6,273,316 (+)NCBIUU_Cfam_GSD_1.0
Fgd2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494641,513,954 - 41,536,375 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647622,424,042 - 22,442,689 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647622,423,851 - 22,442,795 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FGD2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl732,648,222 - 32,674,529 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1732,648,260 - 32,674,539 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2737,551,703 - 37,577,990 (+)NCBISscrofa10.2Sscrofa10.2susScr3


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 1
Low 36 19 59
Below cutoff 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000008470   ⟹   ENSCSAP00000006614
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl1735,112,815 - 35,136,017 (-)Ensembl
RefSeq Acc Id: XM_007972755   ⟹   XP_007970946
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11735,112,453 - 35,136,160 (-)NCBI
Vero_WHO_p1.0NW_02366604436,943,781 - 36,967,321 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_007970946 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000006614
  ENSCSAP00000006614.1
Reference Protein Sequences
RefSeq Acc Id: XP_007970946   ⟸   XM_007972755
- UniProtKB: A0A0D9RDC5 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000006614   ⟸   ENSCSAT00000008470


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000010412 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000008470.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.900.10 UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/TrEMBL
  3.30.40.10 UniProtKB/TrEMBL
InterPro DBL_dom_sf UniProtKB/TrEMBL
  DH-domain UniProtKB/TrEMBL
  FGD1-4_PH2 UniProtKB/TrEMBL
  FGD2_PH1 UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
  PH_domain UniProtKB/TrEMBL
  Znf_FYVE UniProtKB/TrEMBL
  Znf_FYVE-rel UniProtKB/TrEMBL
  Znf_FYVE_PHD UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/TrEMBL
KEGG Report csab:103221575 UniProtKB/TrEMBL
NCBI Gene FGD2 ENTREZGENE
PANTHER FACIOGENITAL DYSPLASIA PROTEIN UniProtKB/TrEMBL
  FYVE, RHOGEF AND PH DOMAIN-CONTAINING PROTEIN 2 UniProtKB/TrEMBL
Pfam FYVE UniProtKB/TrEMBL
  PF00169 UniProtKB/TrEMBL
  RhoGEF UniProtKB/TrEMBL
PROSITE DH_2 UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/TrEMBL
  ZF_FYVE UniProtKB/TrEMBL
SMART FYVE UniProtKB/TrEMBL
  RhoGEF UniProtKB/TrEMBL
  SM00233 UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
  SSF48065 UniProtKB/TrEMBL
  SSF57903 UniProtKB/TrEMBL
UniProt A0A0D9RDC5 ENTREZGENE, UniProtKB/TrEMBL