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Gene: TRH (thyrotropin releasing hormone) Chlorocebus sabaeus

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Symbol:

TRH

Name:

thyrotropin releasing hormone

RGD ID:

18707547

Description:

ENCODES a protein that exhibits thyrotropin-releasing hormone activity (ortholog); INVOLVED IN adult walking behavior (ortholog); eating behavior (ortholog); histamine metabolic process (ortholog); ASSOCIATED WITH acute myeloid leukemia (ortholog); alkaptonuria (ortholog); amnestic disorder (ortholog); FOUND IN secretory granule (ortholog)

Type:

protein-coding

RefSeq Status:

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	22	51,075,814 - 51,079,852 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	22	51,076,157 - 51,078,236 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666041	115,412,012 - 115,415,595 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

acute myeloid leukemia (ISO)

alkaptonuria (ISO)

amnestic disorder (ISO)

Bradycardia (ISO)

Cardiac Arrhythmias (ISO)

Catalepsy (ISO)

Developmental Disabilities (ISO)

endometriosis (ISO)

hypertension (ISO)

Hypothermia (ISO)

hypothyroidism (ISO)

immunodeficiency 21 (ISO)

learning disability (ISO)

narcolepsy (ISO)

Pain (ISO)

Post-Head Injury Coma (ISO)

Primary Lymphedema with Myelodysplasia (ISO)

respiratory failure (ISO)

stereotypic movement disorder (ISO)

Stupor (ISO)

Tachycardia (ISO)

Thyrotropin-Releasing Hormone Deficiency (ISO)

Tremor (ISO)

Unconsciousness (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

adult walking behavior (ISO)

eating behavior (IEA,ISO)

histamine metabolic process (IEA,ISO)

hormone-mediated signaling pathway (IEA)

negative regulation of feeding behavior (ISO)

negative regulation of glutamate secretion (IEA,ISO)

positive regulation of gamma-aminobutyric acid secretion (IEA,ISO)

positive regulation of insulin secretion (IEA,ISO)

response to corticosterone (ISO)

response to ethanol (ISO)

response to glucose (ISO)

response to hypoxia (ISO)

Cellular Component

extracellular region (IEA)

secretory granule (IEA,ISO)

Molecular Function

hormone activity (IEA)

protein binding (ISO)

thyrotropin-releasing hormone activity (IEA,ISO)

References

Additional References at PubMed

PMID:22301074

Genomics

Comparative Map Data

TRH
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	22	51,075,814 - 51,079,852 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	22	51,076,157 - 51,078,236 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666041	115,412,012 - 115,415,595 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

TRH
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	3	129,974,720 - 129,977,935 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	3	129,974,688 - 129,977,935 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	3	129,693,563 - 129,696,778 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	131,176,253 - 131,179,470 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	3	131,176,260 - 131,179,478	NCBI
Celera	3	128,120,232 - 128,123,896 (+)	NCBI		Celera
Cytogenetic Map	3	q22.1	NCBI
HuRef	3	127,076,564 - 127,080,109 (+)	NCBI		HuRef
CHM1_1	3	129,656,247 - 129,659,792 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	3	132,718,521 - 132,721,736 (+)	NCBI		T2T-CHM13v2.0

Trh
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	6	92,219,042 - 92,221,631 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	6	92,219,042 - 92,221,631 (-)	Ensembl		GRCm39 Ensembl
GRCm38	6	92,242,061 - 92,244,650 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	6	92,242,061 - 92,244,650 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	6	92,192,056 - 92,194,642 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	6	92,207,565 - 92,209,391 (-)	NCBI		MGSCv36	mm8
Celera	6	94,137,673 - 94,140,256 (-)	NCBI		Celera
Cytogenetic Map	6	D1	NCBI
cM Map	6	41.03	NCBI

Trh
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	126,299,236 - 126,301,762 (-)	NCBI		GRCr8
mRatBN7.2	4	124,742,111 - 124,777,094 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	124,742,111 - 124,744,637 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	4	130,209,920 - 130,212,447 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	125,984,348 - 125,986,875 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	124,608,890 - 124,611,417 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	124,110,716 - 124,113,242 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	124,110,716 - 124,113,242 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	4	189,116,103 - 189,151,296 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	4	126,425,212 - 126,427,670 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	4	126,670,058 - 126,672,508 (-)	NCBI
Celera	4	113,659,987 - 113,662,513 (-)	NCBI		Celera
RH 3.4 Map	4	736.33	RGD
Cytogenetic Map	4	q34	NCBI

Trh
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955429	17,487,275 - 17,489,385 (-)	NCBI	ChiLan1.0	ChiLan1.0

TRH
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	2	127,905,957 - 127,911,897 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	3	127,910,679 - 127,916,625 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	3	127,037,069 - 127,041,299 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	3	134,383,016 - 134,386,541 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	134,383,016 - 134,387,736 (+)	Ensembl	panpan1.1		panPan2

TRH
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	5,219,495 - 5,222,914 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	20	5,219,594 - 5,222,866 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	5,256,400 - 5,324,009 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	5,240,648 - 5,307,811 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	20	5,240,655 - 5,244,046 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	20	4,958,873 - 5,026,447 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	20	5,309,588 - 5,376,738 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	5,293,272 - 5,360,877 (-)	NCBI		UU_Cfam_GSD_1.0

Trh
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404942	18,283,064 - 18,286,124 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936602	623,535 - 626,445 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936602	623,542 - 626,337 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TRH
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	69,364,093 - 69,365,493 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	13	69,362,892 - 69,366,183 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	76,784,937 - 76,833,534 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Trh
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624872	866,365 - 868,739 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624872	866,370 - 868,624 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in TRH
115 total Variants

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

ectoderm	endocrine system	hemolymphoid system	mesenchyme	mesoderm	nervous system	reproductive system
76	36	17	33	33	60	20

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_007985353	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_007985354	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_007985355	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000009	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCSAT00000007232 ⟹ ENSCSAP00000005418

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	22	51,076,157 - 51,078,236 (-)	Ensembl

RefSeq Acc Id:

XM_007985355 ⟹ XP_007983546

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	22	51,075,814 - 51,079,852 (-)	NCBI
Vero_WHO_p1.0	NW_023666041	115,412,012 - 115,415,595 (+)	NCBI

Sequence:

show sequence

ACTCCAGTCTGGGGGACAAAGCGAGATCCCATCTCTCTCTCTCTCTCTTTTTTTTTAAAGTAGA
GCTCCACTCCCACTTGTCCCCCATTCTCTCTCTCTCTCTCTGGCCCTTCTCTCGCCCATCTGTG
TTCTGCATTGGTGTCCCTTTTGTGTGTGTCTGCCCTGTGTTTCTCCGTCGTCTCCGTGTGGATC
TCGATTTTCGTCTCGCCCTCTCGCTCTCTGGTGCGTCTGGGTTTAATCGTGTGCTTCTCTCAAT
CTCTCTGTCCCTCCCTTTGCCCCCTACACGAGTGTTCTCGTCAACAGATCTCCGGAGGTGATGC
AGAAACGACCCCGCGCCGGCGCCCCATCCTGCGGCCAGTGTCTCCGCGCCCTGGCTCGCGTCCC
CACCGTTCCCGCCCCAGATTTCCGGAGGAGCAGTCGGGCGGGGTCCCGCGGGGCCAGCTGCCGT
CAGCGCCCCTTCCCGGCGGCCGCGACCCCTCCCCGCTGACCTCACCGGAGCCGCCGCCTCGCGC
AGATAAAAGCGGCGGCCCGGCTGAAGAGCGCTCGGCAGGCGCCCGGGGTCCTCAGCGCTACGGA
CTCCTGACCTGCCGACTGCGGACCCCAAGTCCCCGGATCCTGGACCCATCCTGTGGAGCCCACG
CCCGGCAGACGCCGCGATGCCCGGCCCTTGGTTGCTGCTCGCCCTGGCTTTGACCCTGAACCTG
ACCGGTGTCCCTGGCGGCCGTGCTCAGCCAGAGGCGGCCCAGCAGGAGGCAGTGACAGCCGCGG
AGCGTCCGGGCCTGGATGACCTCCTGCGCCAGGTGGAGCGCGTCCTCTTCCTCCGGGAAAACAT
CCAGCGGCTGCAAGGGGACCAGGGTGAGCACTCCGCGTCCCAGATCCTTCAATCTGACTGGCTC
TCCAAACGTCAGCATCCAGGCAAAAGAGAGGAGGAGGAGGAAGAGGGAGTTGAAGAAGAGGAAG
AGGAAGAAGCCGGGGCTGTGGGACCCCACAAACGGCAGCACCCTGGCCGACGGGAAGATGAGGC
TTCATGGTCAGTTGATGTAACCCAGCACAAGCGGCAGCATCCTGGCCGGCGCTCCCCCTGGCTT
GGGTATGCTGTCACGAAGCGGCAGCACCCAGGCAGAAGGCTGGCAGGTCCCAAGGCTCAAAGGA
GCTGGGAAGAAGAGGAGGAGGAGGAAGAGAGAGAGGAAGAGCTGATGCCTGAGAAACGCCAGCA
TCCGGGCAAGAGGGCCCTGGGAGGACCCTGTGGGCCCCAGGGAGCCTGTGGTCAGGCGGGCCTC
CTGCTGGGGCTCCTGGATGACCTGAGTAGGAACCAGGGAGCTGAGGAAAAGCGGCAGCACCCTG
GCCGGCGGGCTGCCTAGGTCAGGGAGCCCCTGGAGGAGTGAAGTCAAGTTTGTAGTCTAAGGAT
GTCTTGAGCCCTGTGTGCCCCACCATTCATGTCCTCTGCATTCTCTCATTAGATCCCTGACCAT
AAGCCTGAGCCCCTCCCTCCCCGCCCCATATTCACACACATCCTAGCCCCTGGCCTTGCCCTCT
TCCTTTCAGCACGTCAGAAAATCAGCCTAGAAGTTTAAACCCCACTTTCCCCCACTTAGCACCA
CAGACAAAGGGGCAGATCCCAGAACCCCTGTCACCCCCACCTCCACAGGTCTGCTCCTTCCTTA
GCCCTGGCTAAGAGGGTCCTTCTGTGTCTTGCAAAGGCTCCCCAAGTGGTACAGGGAGCCCCTG
GGATGGCAGCCAGTGAGGGTGGGCTGAGACTGAGGCATTGATGTGCAAATCCAGCTTCCATCCC
CTCCCCCATCTGGCAGGATTCTCCGTGTGTAAACTTCACCCCCAGGACCCAGGCTCTTCTCCTT
TCTGGGCATCCCTTTGTGGGTGGGCAGAGCCCTGACCCACAGCTGTGTTTCTGCTTGGAGAAGC
ATATGTAGGGGAATACCCTATGGTGTTGCGCTGTGTGTGGCTGTGGGATAAATGTGTGTGGGAA
TATTGAAACATCGCCCAATAATTGTGGTTTGTATATAACCCTCTAAGCCCCTTTCCCTTGTCAA
TGACAGTCATCCTAATGATAATAAAACCTGCATCCAGATAATCACGGAGCTCTGTGGTTGCTGT
TCTGTCGCAGCTGGCATGGGATTCTTCTTTTGCATTGAGAGGGATATTTAAAAGGGGATGGGAC
TAGAGTTCTCAGCTCTGCTGCAGAGGGAATCAGGGACCCTGGGGGGGGATGACAAGTCCTCTCT
ACTGTCCCCATTTCAGAACACACTTGGGAGGTAGATGGGGTTCTGGAGCCCAGTTGACTCCTGG
GGAGACTAAGGCTTGGAGAGAAGGAAGGTCTTGCCCAGAGACACACAGCTGGCTGAGGTGGAGC
CATGGGTCTGAGAGGTCAGCTCAGGGATTTGCCTTGAGTTTGCCGGATTTGGGAG

hide sequence

Protein Sequences


Protein RefSeqs	XP_007983546	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000005418.1

RefSeq Acc Id:	XP_007983546 ⟸ XM_007985355
- UniProtKB:	A0A0D9R9X9 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSCSAP00000005418 ⟸ ENSCSAT00000007232

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000009163	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000007232.1	UniProtKB/TrEMBL
InterPro	TRH	UniProtKB/TrEMBL
NCBI Gene	TRH	ENTREZGENE
PANTHER	PRO-THYROTROPIN-RELEASING HORMONE	UniProtKB/TrEMBL
	PRO-THYROTROPIN-RELEASING HORMONE	UniProtKB/TrEMBL
Pfam	TRH	UniProtKB/TrEMBL
PIRSF	TRH	UniProtKB/TrEMBL
UniProt	A0A0D9R9X9	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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