CUL1 (cullin 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: CUL1 (cullin 1) Chlorocebus sabaeus
Analyze
Symbol: CUL1
Name: cullin 1
RGD ID: 18705946
Description: ENCODES a protein that exhibits protein-macromolecule adaptor activity (inferred); ubiquitin ligase complex scaffold activity (inferred); ubiquitin protein ligase binding (inferred); INVOLVED IN animal organ morphogenesis (ortholog); apoptotic process (ortholog); cell population proliferation (ortholog); PARTICIPATES IN neddylation pathway; Notch signaling pathway; nuclear factor kappa B signaling pathway; ASSOCIATED WITH cortical dysplasia-focal epilepsy syndrome (ortholog); genetic disease (ortholog); Stevens-Johnson syndrome (ortholog); FOUND IN cullin-RING ubiquitin ligase complex (inferred); Parkin-FBXW7-Cul1 ubiquitin ligase complex (inferred); plasma membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: cullin-1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.121117,271,477 - 117,373,983 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl21117,271,548 - 117,374,379 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607213,218,021 - 13,323,070 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
CUL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.121117,271,477 - 117,373,983 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl21117,271,548 - 117,374,379 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607213,218,021 - 13,323,070 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
CUL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387148,697,756 - 148,801,110 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7148,697,914 - 148,801,110 (+)EnsemblGRCh38hg38GRCh38
GRCh377148,394,848 - 148,498,202 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367148,026,866 - 148,129,135 (+)NCBINCBI36Build 36hg18NCBI36
Build 347147,833,580 - 147,935,849NCBI
Celera7143,066,358 - 143,168,625 (+)NCBICelera
Cytogenetic Map7q36.1NCBI
HuRef7142,474,925 - 142,577,198 (+)NCBIHuRef
CHM1_17148,404,339 - 148,506,599 (+)NCBICHM1_1
T2T-CHM13v2.07149,879,652 - 149,982,884 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27147,733,888 - 147,836,155 (+)NCBI
Cul1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39647,430,516 - 47,503,078 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl647,430,332 - 47,503,073 (+)EnsemblGRCm39 Ensembl
GRCm38647,453,732 - 47,526,144 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl647,453,398 - 47,526,139 (+)EnsemblGRCm38mm10GRCm38
MGSCv37647,404,323 - 47,476,138 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36647,383,910 - 47,455,725 (+)NCBIMGSCv36mm8
Celera647,309,280 - 47,381,243 (+)NCBICelera
Cytogenetic Map6B2.3NCBI
cM Map622.9NCBI
Cul1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8477,551,781 - 77,634,210 (+)NCBIGRCr8
mRatBN7.2476,551,952 - 76,625,830 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl476,551,983 - 76,627,980 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx481,518,199 - 81,586,396 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0477,431,538 - 77,499,741 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0475,811,714 - 75,879,914 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0477,211,814 - 77,283,369 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl477,211,692 - 77,280,250 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04141,883,675 - 141,954,829 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4475,636,914 - 75,705,724 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1475,913,432 - 75,981,935 (+)NCBI
Celera471,356,492 - 71,424,907 (+)NCBICelera
Cytogenetic Map4q24NCBI
Cul1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554914,165,561 - 4,212,054 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554914,165,400 - 4,212,483 (+)NCBIChiLan1.0ChiLan1.0
CUL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26185,284,645 - 185,386,756 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1737,293,911 - 37,397,018 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07140,428,442 - 140,531,136 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17152,907,803 - 153,011,254 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7152,908,303 - 153,011,254 (+)Ensemblpanpan1.1panPan2
CUL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1161,995,637 - 2,086,853 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl161,995,960 - 2,052,864 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha163,094,500 - 3,190,996 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0161,800,318 - 1,893,359 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl161,800,261 - 1,893,706 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1161,786,922 - 1,879,856 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0161,646,255 - 1,739,205 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0161,650,453 - 1,743,455 (-)NCBIUU_Cfam_GSD_1.0
Cul1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244051187,883,967 - 7,967,988 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365274,971,000 - 5,019,562 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365274,971,002 - 5,019,465 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CUL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9109,454,534 - 109,557,649 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19109,454,523 - 109,559,114 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29120,392,339 - 120,495,724 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Cul1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248006,877,986 - 6,978,587 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 36 17 60
Low 3
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000005100   ⟹   ENSCSAP00000003333
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl21117,271,548 - 117,374,379 (+)Ensembl
RefSeq Acc Id: XM_007983344   ⟹   XP_007981535
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.121117,271,477 - 117,373,983 (+)NCBI
Vero_WHO_p1.0NW_02366607213,220,455 - 13,323,065 (+)NCBI
Sequence:
RefSeq Acc Id: XM_037990894   ⟹   XP_037846822
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366607213,220,191 - 13,323,065 (+)NCBI
RefSeq Acc Id: XM_037990895   ⟹   XP_037846823
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366607213,234,180 - 13,323,070 (+)NCBI
RefSeq Acc Id: XM_037990896   ⟹   XP_037846824
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366607213,218,021 - 13,323,070 (+)NCBI
Protein Sequences
Protein RefSeqs XP_007981535 (Get FASTA)   NCBI Sequence Viewer  
  XP_037846822 (Get FASTA)   NCBI Sequence Viewer  
  XP_037846823 (Get FASTA)   NCBI Sequence Viewer  
  XP_037846824 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000003333
  ENSCSAP00000003333.1
Reference Protein Sequences
RefSeq Acc Id: XP_007981535   ⟸   XM_007983344
- UniProtKB: A0A0D9R3Z4 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000003333   ⟸   ENSCSAT00000005100
RefSeq Acc Id: XP_037846824   ⟸   XM_037990896
- UniProtKB: A0A0D9R3Z4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037846822   ⟸   XM_037990894
- UniProtKB: A0A0D9R3Z4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037846823   ⟸   XM_037990895
- UniProtKB: A0A0D9R3Z4 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000007057 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000005100.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.10 UniProtKB/TrEMBL
  Cullin Repeats UniProtKB/TrEMBL
InterPro Cullin UniProtKB/TrEMBL
  Cullin_CS UniProtKB/TrEMBL
  Cullin_homology UniProtKB/TrEMBL
  Cullin_homology_sf UniProtKB/TrEMBL
  Cullin_N UniProtKB/TrEMBL
  Cullin_neddylation_domain UniProtKB/TrEMBL
  Cullin_repeat-like_dom_sf UniProtKB/TrEMBL
  WH-like_DNA-bd_sf UniProtKB/TrEMBL
  WH_DNA-bd_sf UniProtKB/TrEMBL
KEGG Report csab:103227180 UniProtKB/TrEMBL
NCBI Gene CUL1 ENTREZGENE
PANTHER CULLIN-1 UniProtKB/TrEMBL
  PTHR11932 UniProtKB/TrEMBL
Pfam Cullin UniProtKB/TrEMBL
  Cullin_Nedd8 UniProtKB/TrEMBL
PROSITE CULLIN_1 UniProtKB/TrEMBL
  CULLIN_2 UniProtKB/TrEMBL
SMART CULLIN UniProtKB/TrEMBL
  Cullin_Nedd8 UniProtKB/TrEMBL
Superfamily-SCOP SSF46785 UniProtKB/TrEMBL
  SSF74788 UniProtKB/TrEMBL
  SSF75632 UniProtKB/TrEMBL
UniProt A0A0D9R3Z4 ENTREZGENE, UniProtKB/TrEMBL