NPRL3 (NPR3 like, GATOR1 complex subunit) - Rat Genome Database

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Gene: NPRL3 (NPR3 like, GATOR1 complex subunit) Chlorocebus sabaeus
Analyze
Symbol: NPRL3
Name: NPR3 like, GATOR1 complex subunit
RGD ID: 18705551
Description: ENCODES a protein that exhibits GTPase activator activity (inferred); INVOLVED IN aorta morphogenesis (ortholog); cardiac muscle tissue development (ortholog); roof of mouth development (ortholog); PARTICIPATES IN mTOR signaling pathway; ASSOCIATED WITH epilepsy (ortholog); familial focal epilepsy with variable foci 1 (ortholog); familial focal epilepsy with variable foci 3 (ortholog); FOUND IN GATOR1 complex (ortholog); lysosomal membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: GATOR complex protein NPRL3; nitrogen permease regulator 3-like protein
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1540,674 - 94,265 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl543,150 - 94,174 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606831,105,807 - 31,182,365 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
GATOR1 complex  (IEA,ISO)
lysosomal membrane  (IEA,ISO)
lysosome  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
NPRL3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1540,674 - 94,265 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl543,150 - 94,174 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606831,105,807 - 31,182,365 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
NPRL3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381685,386 - 138,673 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1684,271 - 138,677 (-)EnsemblGRCh38hg38GRCh38
GRCh3716135,385 - 188,672 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361675,800 - 128,672 (-)NCBINCBI36Build 36hg18NCBI36
Celera16337,330 - 390,318 (-)NCBICelera
Cytogenetic Map16p13.3NCBI
HuRef1654,260 - 106,377 (-)NCBIHuRef
CHM1_116135,746 - 188,665 (-)NCBICHM1_1
T2T-CHM13v2.01678,987 - 132,241 (-)NCBIT2T-CHM13v2.0
Nprl3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391132,181,963 - 32,217,707 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1132,175,628 - 32,217,707 (-)EnsemblGRCm39 Ensembl
GRCm381132,231,963 - 32,267,707 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1132,225,628 - 32,267,707 (-)EnsemblGRCm38mm10GRCm38
MGSCv371132,132,419 - 32,167,614 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361132,132,419 - 32,167,614 (-)NCBIMGSCv36mm8
Celera1134,649,697 - 34,684,772 (-)NCBICelera
Cytogenetic Map11A4NCBI
cM Map1118.83NCBI
Nprl3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81015,859,739 - 15,900,261 (+)NCBIGRCr8
mRatBN7.21015,355,361 - 15,395,812 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1015,355,355 - 15,395,810 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1020,101,453 - 20,141,828 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01019,590,342 - 19,630,715 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01015,083,192 - 15,123,623 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01015,620,824 - 15,661,332 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1015,620,871 - 15,661,331 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01015,515,994 - 15,556,475 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41015,602,474 - 15,642,898 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11015,601,253 - 15,643,813 (+)NCBI
Celera1015,022,975 - 15,063,389 (+)NCBICelera
Cytogenetic Map10q12NCBI
Nprl3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544217,025,194 - 17,070,753 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544217,025,232 - 17,068,399 (+)NCBIChiLan1.0ChiLan1.0
NPRL3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v218299,107 - 369,778 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1164,086,852 - 4,147,637 (-)NCBINHGRI_mPanPan1
PanPan1.11675,187 - 129,220 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1675,187 - 129,220 (-)Ensemblpanpan1.1panPan2
NPRL3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1640,351,757 - 40,394,599 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl640,352,477 - 40,390,489 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha641,614,787 - 41,653,131 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0640,694,293 - 40,733,143 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl640,695,464 - 40,733,139 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1640,382,373 - 40,420,708 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0640,343,316 - 40,381,635 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0640,821,964 - 40,860,811 (+)NCBIUU_Cfam_GSD_1.0
Nprl3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344112,649,923 - 112,685,617 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936501747,736 - 787,244 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936501747,806 - 783,479 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NPRL3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl341,479,193 - 41,540,717 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1341,478,465 - 41,540,719 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2340,897,528 - 40,931,777 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Nprl3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624913968,093 - 1,014,035 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624913968,093 - 1,013,990 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 36 3 26
Low 17 34
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000011225   ⟹   ENSCSAP00000009307
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl543,150 - 94,174 (-)Ensembl
RefSeq Acc Id: XM_037990091   ⟹   XP_037846019
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366606831,105,807 - 31,182,365 (+)NCBI
Protein Sequences
Protein RefSeqs XP_037846019 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000009307.1
Reference Protein Sequences
RefSeq Acc Id: ENSCSAP00000009307   ⟸   ENSCSAT00000011225
RefSeq Acc Id: XP_037846019   ⟸   XM_037990091
- UniProtKB: A0A0D9RL18 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000013134 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000011225.1 UniProtKB/TrEMBL
InterPro Galactose-bd-like_sf UniProtKB/TrEMBL
  Npr3 UniProtKB/TrEMBL
NCBI Gene NPRL3 ENTREZGENE
PANTHER GATOR COMPLEX PROTEIN NPRL3 UniProtKB/TrEMBL
  PTHR13153 UniProtKB/TrEMBL
Pfam NPR3 UniProtKB/TrEMBL
Superfamily-SCOP SSF49785 UniProtKB/TrEMBL
UniProt A0A0D9RL18 ENTREZGENE, UniProtKB/TrEMBL