CFH (complement factor H) - Rat Genome Database

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Gene: CFH (complement factor H) Chlorocebus sabaeus
Analyze
Symbol: CFH
Name: complement factor H
RGD ID: 18704010
Description: ENCODES a protein that exhibits heparan sulfate proteoglycan binding (ortholog); heparin binding (ortholog); identical protein binding (ortholog); INVOLVED IN activation of membrane attack complex (ortholog); angiogenesis (ortholog); ATP metabolic process (ortholog); ASSOCIATED WITH age related macular degeneration 4 (ortholog); amphetamine abuse (ortholog); anterior uveitis (ortholog); FOUND IN axon (ortholog); external side of plasma membrane (ortholog); extracellular region (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12532,557,697 - 32,744,763 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605533,547,560 - 33,658,543 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
age related macular degeneration 4  (ISO)
amphetamine abuse  (ISO)
anterior uveitis  (ISO)
atypical hemolytic-uremic syndrome  (ISO)
Bacteremia  (ISO)
basal laminar drusen  (ISO)
brain infarction  (ISO)
C3 Glomerulopathy 3  (ISO)
cardiovascular system disease  (ISO)
Cerebral Hemorrhage  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
Choroidal Neovascularization  (ISO)
chronic kidney disease  (ISO)
Complement Factor H Deficiency  (ISO)
COVID-19  (ISO)
diabetic retinopathy  (ISO)
Experimental Arthritis  (ISO)
focal segmental glomerulosclerosis  (ISO)
gastrointestinal stromal tumor  (ISO)
genetic disease  (ISO)
glaucoma  (ISO)
glomerulonephritis  (ISO)
Glomerulonephritis with Isolated C3 Deposits and Factor H Deficiency  (ISO)
hemolytic-uremic syndrome  (ISO)
Hemorrhagic Shock  (ISO)
Intestinal Ischemia  (ISO)
kidney disease  (ISO)
Kidney Reperfusion Injury  (ISO)
Liver Reperfusion Injury  (ISO)
lupus nephritis  (ISO)
macular degeneration  (ISO)
maturity-onset diabetes of the young type 5  (ISO)
membranoproliferative glomerulonephritis  (ISO)
membranous glomerulonephritis  (ISO)
Meningococcal Infections  (ISO)
Multifocal Choroiditis  (ISO)
multiple sclerosis  (ISO)
nephrosis  (ISO)
obstructive jaundice  (ISO)
panuveitis  (ISO)
parathyroid carcinoma  (ISO)
Pneumococcal Infections  (ISO)
Polypoidal Choroidal Vasculopathy  (ISO)
posterior uveitis  (ISO)
primary immunodeficiency disease  (ISO)
proteinuria  (ISO)
psoriasis  (ISO)
Reperfusion Injury  (ISO)
retinal degeneration  (ISO)
retinal detachment  (ISO)
retinal drusen  (ISO)
sarcoidosis  (ISO)
Sepsis  (ISO)
squamous cell carcinoma  (ISO)
Stroke  (ISO)
Systemic Inflammatory Response Syndrome  (ISO)
systemic lupus erythematosus  (ISO)
Thrombotic Microangiopathies  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

Genomics

Comparative Map Data
CFH
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12532,557,697 - 32,744,763 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605533,547,560 - 33,658,543 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
CFH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381196,652,043 - 196,747,504 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1196,651,754 - 196,752,476 (+)EnsemblGRCh38hg38GRCh38
GRCh371196,621,173 - 196,716,634 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361194,887,764 - 194,983,257 (+)NCBINCBI36Build 36hg18NCBI36
Build 341193,352,831 - 193,448,257NCBI
Celera1169,729,995 - 169,825,611 (+)NCBICelera
Cytogenetic Map1q31.3NCBI
HuRef1167,862,965 - 167,958,566 (+)NCBIHuRef
CHM1_11198,042,727 - 198,138,292 (+)NCBICHM1_1
T2T-CHM13v2.01195,998,386 - 196,093,925 (+)NCBIT2T-CHM13v2.0
Cfh
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391140,013,593 - 140,111,149 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1140,012,446 - 140,111,502 (-)EnsemblGRCm39 Ensembl
GRCm381140,085,855 - 140,183,411 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1140,084,708 - 140,183,764 (-)EnsemblGRCm38mm10GRCm38
MGSCv371141,982,432 - 142,079,988 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361141,902,290 - 141,999,733 (-)NCBIMGSCv36mm8
Celera1142,720,865 - 142,812,024 (-)NCBICelera
Cytogenetic Map1FNCBI
cM Map161.62NCBI
Cfh
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81354,063,079 - 54,164,523 (-)NCBIGRCr8
mRatBN7.21351,512,376 - 51,613,829 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1351,511,828 - 51,613,838 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1354,104,450 - 54,199,522 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01355,392,371 - 55,487,454 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01352,655,305 - 52,757,017 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01356,979,155 - 57,080,540 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1356,978,607 - 57,080,622 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01361,997,444 - 62,094,826 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41353,252,249 - 53,355,987 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11353,266,346 - 53,370,041 (-)NCBI
Celera1351,770,541 - 51,871,522 (-)NCBICelera
Cytogenetic Map13q13NCBI
CFH
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2153,056,725 - 53,152,308 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1152,576,787 - 52,757,831 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01172,155,882 - 172,251,632 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11176,434,107 - 176,507,049 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1176,455,247 - 176,525,521 (+)Ensemblpanpan1.1panPan2
CFH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1382,878,677 - 2,956,226 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha382,970,756 - 3,047,389 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0382,876,209 - 2,953,077 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl382,875,485 - 2,953,035 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1382,869,120 - 2,945,692 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0383,262,568 - 3,340,656 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0383,463,162 - 3,540,549 (-)NCBIUU_Cfam_GSD_1.0
CFH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa10.21024,337,539 - 24,406,888 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Cfh
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247983,332,549 - 3,414,435 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: XM_007989082   ⟹   XP_007987273
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12532,633,417 - 32,744,763 (-)NCBI
Vero_WHO_p1.0NW_02366605533,547,560 - 33,658,543 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007989083   ⟹   XP_007987274
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12532,633,417 - 32,744,669 (-)NCBI
Vero_WHO_p1.0NW_02366605533,547,560 - 33,658,543 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007989085   ⟹   XP_007987276
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12532,693,683 - 32,744,763 (-)NCBI
Vero_WHO_p1.0NW_02366605533,607,641 - 33,658,543 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_007987273 (Get FASTA)   NCBI Sequence Viewer  
  XP_007987274 (Get FASTA)   NCBI Sequence Viewer  
  XP_007987276 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000009714.1
Reference Protein Sequences
RefSeq Acc Id: XP_007987273   ⟸   XM_007989082
- Peptide Label: isoform X1
- UniProtKB: A0A0D9RM75 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007987274   ⟸   XM_007989083
- Peptide Label: isoform X2
- UniProtKB: A0A0D9RM75 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007987276   ⟸   XM_007989085
- Peptide Label: isoform X3


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000013551 UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000011648.1 UniProtKB/TrEMBL
Gene3D-CATH Complement Module, domain 1 UniProtKB/TrEMBL
InterPro Sushi/SCR/CCP_sf UniProtKB/TrEMBL
  Sushi_SCR_CCP_dom UniProtKB/TrEMBL
NCBI Gene CFH ENTREZGENE
PANTHER COMPLEMENT FACTOR H UniProtKB/TrEMBL
  COMPLEMENT FACTOR H-RELATED UniProtKB/TrEMBL
Pfam Sushi UniProtKB/TrEMBL
PROSITE SUSHI UniProtKB/TrEMBL
SMART CCP UniProtKB/TrEMBL
Superfamily-SCOP Complement control module/SCR domain UniProtKB/TrEMBL
UniProt A0A0D9RM75 ENTREZGENE, UniProtKB/TrEMBL