CBFA2T2 (CBFA2/RUNX1 partner transcriptional co-repressor 2) - Rat Genome Database

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Gene: CBFA2T2 (CBFA2/RUNX1 partner transcriptional co-repressor 2) Chlorocebus sabaeus
Analyze
Symbol: CBFA2T2
Name: CBFA2/RUNX1 partner transcriptional co-repressor 2
RGD ID: 18696747
Description: ENCODES a protein that exhibits metal ion binding (inferred); transcription corepressor activity (inferred); INVOLVED IN epithelial cell differentiation (ortholog); intestinal epithelial cell differentiation (ortholog); negative regulation of DNA-templated transcription (ortholog); ASSOCIATED WITH genetic disease (ortholog); long QT syndrome (ortholog); FOUND IN nucleus (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: CBFA2/RUNX1 translocation partner 2; protein CBFA2T2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1237,781,107 - 37,938,150 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl237,781,273 - 37,937,253 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605088,939,201 - 89,101,091 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nucleus  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
CBFA2T2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1237,781,107 - 37,938,150 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl237,781,273 - 37,937,253 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605088,939,201 - 89,101,091 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
CBFA2T2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382033,490,096 - 33,650,030 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2033,490,075 - 33,650,036 (+)EnsemblGRCh38hg38GRCh38
GRCh372032,077,902 - 32,237,836 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362031,541,589 - 31,701,498 (+)NCBINCBI36Build 36hg18NCBI36
Build 342031,613,846 - 31,701,498NCBI
Celera2028,831,000 - 28,990,870 (+)NCBICelera
Cytogenetic Map20q11.21-q11.22NCBI
HuRef2028,864,904 - 29,023,937 (+)NCBIHuRef
CHM1_12031,979,005 - 32,138,929 (+)NCBICHM1_1
T2T-CHM13v2.02035,216,640 - 35,376,563 (+)NCBIT2T-CHM13v2.0
Cbfa2t2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392154,278,018 - 154,381,276 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2154,278,401 - 154,381,276 (+)EnsemblGRCm39 Ensembl
GRCm382154,436,098 - 154,539,356 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2154,436,481 - 154,539,356 (+)EnsemblGRCm38mm10GRCm38
MGSCv372154,262,220 - 154,365,092 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362154,127,959 - 154,230,797 (+)NCBIMGSCv36mm8
Celera2160,348,902 - 160,453,695 (+)NCBICelera
Cytogenetic Map2H1NCBI
cM Map276.62NCBI
Cbfa2t2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83163,397,160 - 163,503,409 (+)NCBIGRCr8
mRatBN7.23142,936,945 - 143,043,205 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3142,936,985 - 143,043,197 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3146,804,093 - 146,906,504 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03155,422,259 - 155,524,668 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03153,161,618 - 153,264,036 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03149,935,731 - 150,041,545 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3149,935,731 - 150,038,257 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03156,308,253 - 156,414,187 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43144,904,533 - 145,007,851 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13144,810,169 - 144,913,400 (+)NCBI
Celera3141,671,889 - 141,774,386 (+)NCBICelera
Cytogenetic Map3q41NCBI
Cbfa2t2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542227,671,215 - 27,809,381 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542227,671,215 - 27,809,384 (-)NCBIChiLan1.0ChiLan1.0
CBFA2T2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22139,184,385 - 39,340,964 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12039,177,507 - 39,334,065 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02029,780,902 - 29,937,398 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12031,002,486 - 31,078,304 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2031,002,486 - 31,072,929 (+)Ensemblpanpan1.1panPan2
CBFA2T2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12422,722,902 - 22,871,098 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2422,723,018 - 22,866,484 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2422,370,388 - 22,516,320 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02423,410,951 - 23,557,814 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2423,410,965 - 23,557,811 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12422,838,145 - 22,850,315 (+)NCBIUMICH_Zoey_3.1
UMICH_Zoey_3.12422,685,509 - 22,827,996 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02422,796,861 - 22,943,864 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02423,228,013 - 23,374,942 (+)NCBIUU_Cfam_GSD_1.0
Cbfa2t2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640171,739,052 - 171,822,371 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365616,924,897 - 6,971,793 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365616,926,856 - 6,971,062 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CBFA2T2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1736,990,070 - 37,150,387 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11736,990,075 - 37,150,390 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21741,988,696 - 42,071,393 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Cbfa2t2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248425,641,589 - 5,772,323 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248425,637,266 - 5,772,263 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 17 46
Low 19 20 14
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000010384   ⟹   ENSCSAP00000008478
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl237,781,273 - 37,937,253 (+)Ensembl
RefSeq Acc Id: XM_008021011   ⟹   XP_008019202
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1237,781,107 - 37,938,150 (+)NCBI
Vero_WHO_p1.0NW_02366605088,939,201 - 89,101,091 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008021020   ⟹   XP_008019211
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1237,781,107 - 37,938,150 (+)NCBI
Vero_WHO_p1.0NW_02366605088,939,201 - 89,101,091 (-)NCBI
Sequence:
RefSeq Acc Id: XM_037982871   ⟹   XP_037838799
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366605088,939,201 - 89,101,091 (-)NCBI
RefSeq Acc Id: XM_037982872   ⟹   XP_037838800
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366605088,939,201 - 89,101,091 (-)NCBI
RefSeq Acc Id: XM_037982873   ⟹   XP_037838801
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366605088,939,201 - 89,032,127 (-)NCBI
RefSeq Acc Id: XM_037982874   ⟹   XP_037838802
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366605088,939,201 - 89,101,091 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_008019202   ⟸   XM_008021011
- Peptide Label: isoform X3
- UniProtKB: A0A0D9RIN9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_008019211   ⟸   XM_008021020
- Peptide Label: isoform X4
RefSeq Acc Id: ENSCSAP00000008478   ⟸   ENSCSAT00000010384
RefSeq Acc Id: XP_037838802   ⟸   XM_037982874
- Peptide Label: isoform X6
RefSeq Acc Id: XP_037838800   ⟸   XM_037982872
- Peptide Label: isoform X2
RefSeq Acc Id: XP_037838799   ⟸   XM_037982871
- Peptide Label: isoform X1
RefSeq Acc Id: XP_037838801   ⟸   XM_037982873
- Peptide Label: isoform X5


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000012281 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000010384.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.120.1110 UniProtKB/TrEMBL
  6.10.140.2220 UniProtKB/TrEMBL
  6.10.250.230 UniProtKB/TrEMBL
InterPro CBFA2T1/2/3 UniProtKB/TrEMBL
  MTGR1 UniProtKB/TrEMBL
  NHR2 UniProtKB/TrEMBL
  TAFH/NHR1_dom_sf UniProtKB/TrEMBL
  TAFH_NHR1 UniProtKB/TrEMBL
  Znf_MYND UniProtKB/TrEMBL
KEGG Report csab:103248557 UniProtKB/TrEMBL
NCBI Gene CBFA2T2 ENTREZGENE
PANTHER PROTEIN CBFA2T2 UniProtKB/TrEMBL
  PTHR10379 UniProtKB/TrEMBL
Pfam NHR2 UniProtKB/TrEMBL
  TAFH UniProtKB/TrEMBL
  zf-MYND UniProtKB/TrEMBL
PRINTS ETOFAMILY UniProtKB/TrEMBL
  MTGR1PROTEIN UniProtKB/TrEMBL
PROSITE TAFH UniProtKB/TrEMBL
  ZF_MYND_1 UniProtKB/TrEMBL
  ZF_MYND_2 UniProtKB/TrEMBL
SMART TAFH UniProtKB/TrEMBL
Superfamily-SCOP HIT/MYND zinc finger-like UniProtKB/TrEMBL
  SSF158553 UniProtKB/TrEMBL
UniProt A0A0D9RIN9 ENTREZGENE, UniProtKB/TrEMBL