DMBX1 (diencephalon/mesencephalon homeobox 1)

Gene: DMBX1 (diencephalon/mesencephalon homeobox 1) Chlorocebus sabaeus

Analyze

Symbol:

DMBX1

Name:

diencephalon/mesencephalon homeobox 1

RGD ID:

18696620

Description:

ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription factor activity (inferred); DNA-binding transcription factor activity, RNA polymerase II-specific (inferred); INVOLVED IN adult feeding behavior (ortholog); adult locomotory behavior (ortholog); negative regulation of transcription by RNA polymerase II (ortholog); ASSOCIATED WITH Developmental Disabilities (ortholog); genetic disease (ortholog); FOUND IN nucleus (inferred); transcription regulator complex (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

diencephalon/mesencephalon homeobox protein 1

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	86,294,309 - 86,315,688 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	86,295,354 - 86,300,816 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666033	30,676,140 - 30,700,662 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Developmental Disabilities (ISO)

genetic disease (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

adult feeding behavior (IEA,ISO)

adult locomotory behavior (IEA,ISO)

brain development (IEA)

central nervous system development (IEA)

developmental growth (IEA)

negative regulation of DNA-templated transcription (IEA)

negative regulation of transcription by RNA polymerase II (IEA,ISO)

regulation of DNA-templated transcription (IEA)

regulation of transcription by RNA polymerase II (IEA)

Cellular Component

nucleus (IEA)

transcription regulator complex (IEA)

Molecular Function

DNA binding (IEA)

DNA-binding transcription factor activity (IEA)

DNA-binding transcription factor activity, RNA polymerase II-specific (IEA)

DNA-binding transcription repressor activity, RNA polymerase II-specific (IEA)

identical protein binding (IEA)

protein binding (ISO)

RNA polymerase II transcription regulatory region sequence-specific DNA binding (IEA)

sequence-specific DNA binding (IEA)

sequence-specific double-stranded DNA binding (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

DMBX1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	86,294,309 - 86,315,688 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	86,295,354 - 86,300,816 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666033	30,676,140 - 30,700,662 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

DMBX1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	46,489,836 - 46,516,216 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	46,489,836 - 46,516,216 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	46,955,508 - 46,981,888 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	46,745,255 - 46,752,485 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	46,684,687 - 46,691,904	NCBI
Celera	1	45,260,058 - 45,267,288 (+)	NCBI		Celera
Cytogenetic Map	1	p33	NCBI
HuRef	1	45,088,209 - 45,095,438 (+)	NCBI		HuRef
CHM1_1	1	47,089,685 - 47,096,914 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	1	46,367,063 - 46,393,431 (+)	NCBI		T2T-CHM13v2.0

Dmbx1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	115,772,316 - 115,797,794 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	115,772,316 - 115,797,123 (-)	Ensembl		GRCm39 Ensembl
GRCm38	4	115,915,119 - 115,940,597 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	115,915,119 - 115,939,926 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	4	115,587,724 - 115,612,531 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	4	115,413,051 - 115,437,858 (-)	NCBI		MGSCv36	mm8
Celera	4	114,654,783 - 114,679,268 (-)	NCBI		Celera
Cytogenetic Map	4	D1	NCBI
cM Map	4	53.07	NCBI

Dmbx1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	134,630,968 - 134,639,781 (-)	NCBI		GRCr8
mRatBN7.2	5	129,394,221 - 129,403,040 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	129,394,221 - 129,403,040 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	132,011,271 - 132,020,068 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	133,766,141 - 133,774,934 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	133,788,299 - 133,797,094 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	134,767,436 - 134,792,840 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	134,767,436 - 134,776,247 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	138,550,553 - 138,559,364 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	136,177,328 - 136,188,212 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	136,185,495 - 136,192,157 (-)	NCBI
Celera	5	127,925,079 - 127,933,890 (-)	NCBI		Celera
Cytogenetic Map	5	q35	NCBI

Dmbx1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955464	11,788,494 - 11,811,890 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955464	11,788,526 - 11,811,885 (-)	NCBI	ChiLan1.0	ChiLan1.0

DMBX1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	180,292,577 - 180,318,939 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	179,434,209 - 179,460,556 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	45,792,574 - 45,818,915 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	47,165,658 - 47,172,872 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	47,165,667 - 47,171,140 (+)	Ensembl	panpan1.1		panPan2

DMBX1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	15	13,931,272 - 13,939,650 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	15	13,934,530 - 13,953,408 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	15	14,055,028 - 14,060,291 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	15	14,085,095 - 14,090,351 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	15	14,085,230 - 14,103,868 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	15	13,886,362 - 13,891,626 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	15	13,954,914 - 13,960,179 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	15	14,024,288 - 14,029,544 (-)	NCBI		UU_Cfam_GSD_1.0

Dmbx1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	61,679,542 - 61,704,422 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936474	27,500,669 - 27,529,205 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936474	27,504,419 - 27,529,196 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

DMBX1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	164,970,176 - 164,991,968 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	164,967,890 - 164,978,541 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	152,487,419 - 152,494,450 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Dmbx1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624906	2,396,435 - 2,401,379 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624906	2,396,426 - 2,402,705 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	endocrine system	hemolymphoid system	nervous system
High
Medium
Low		11
Below cutoff	19	6	10

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_007978897	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_037999261	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCSAT00000017298 ⟹ ENSCSAP00000016779

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	20	86,295,354 - 86,300,816 (-)	Ensembl

RefSeq Acc Id:

XM_007978897 ⟹ XP_007977088

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	20	86,294,309 - 86,315,688 (-)	NCBI
Vero_WHO_p1.0	NW_023666033	30,676,245 - 30,700,662 (+)	NCBI

Sequence:

show sequence

GAGAGAGAAACAGAACAGAACTCGAAATTCCGAGGCAGTGAGAGCGGAGGGCGAGCGGTGGGTA
GAAACACGCCAAGGCGAAGACGGAGGCCTTGGCCCGCGGAGACGCAGGCACCCGCGGAGGACGC
TTCGGATCCGTCACGGTTTTGCCTCATTTGGAAGATATTACTTCGCCCCTGAAAAAAAAAATTC
AAAAAAGGCGAATGCCGCCATGCAGCACTACGGGGTGAACGGCTACTCGCTGCATGCCATGAAC
TCACTCAGCGCCATGTACAACCTGCACCAGCAGGCAGCCCAGCAGGCCCAGCACGCCCCTGACT
ACCGGCCTTCGGTGCATGCGCTTACATTGGCTGAGCGCCTGGCTGACATCATCTTGGAGGCCCG
TTATGGTTCCCAGCACCGCAAACAACGTCGCAGCCGCACAGCGTTCACAGCTCAGCAGCTCGAG
GCCCTGGAAAAGACCTTCCAGAAGACTCACTACCCAGATGTGGTGATGCGTGAGAGGCTGGCCA
TGTGTACCAACCTGCCTGAGGCCCGGGTGCAGGTGTGGTTCAAGAACCGCCGGGCCAAGTTCCG
GAAGAAGCAGCGTAGCCTGCAGAAAGAACAGCTCCAGAAGCAGAAGGAGGCTGAGGGCTCCCAT
GGGGAAGACAAGGCAGAGGCCCCCACTCCAGATACCCAGCTGGACACTGACCAGCCCCCACGCC
TGCCTGGCAGCGACCCCCCTGCTGAGCTTCACCTGAGTCTGTCTGAGCAGTCAGCCAGTGAGTC
AGCCCCCGAGGATCAGCTGGAACGTGAGGAGGACCCCCGGGCAGGGGCTGAGGACCCCAAAACT
GAGAAGAGCCCTGGGGCTGAGAGCAAAGGGCTGGGCTGCAAGAGGGGCAGCCCCAAGGCAGATT
CCCCAGGCAGCCTGACCATCACTCCTGCGGCCCCAGGGGGTGGCCTCCTGGGCCCCTCCCACTC
CTATTCCTCGTCCCCGCTGAGCCTCTTCCGTCTGCAGGAGCAATTCCGCCAGCACATGGCGGCC
ACCAACAACCTGGTGCACTACTCATCCTTCGAAGTAGGGGGTCCGGCCCCTGCTGCTGCCGCGG
CGGCTGCTGCTGTGCCCTACCTGGGCGTCAACATGGCCCCGCTGGGCTCACTGCACTGCCAGTC
CTACTACCAGTCCCTGTCAGCAGCCGCTGCTGCCCACCAGGGTGTGTGGGGGTCCCCTCTGCTG
CCTGCACCCCCAGCAGGCCTGGCTCCTGCATCAGCTACCCTGAACAGTAAAACCACAAGCATCG
AGAACCTGCGGCTCCGGGCCAAGCAGCATGCGGCCTCCCTGGGACTCGATACACTGCCCAACTG
ACTGTTTGGCCTCCAACCCAGCCAGGGGTCTTAGGTGTCCCCTCCTAGCCCTGTGGTTATCCCT
AGGTGGCTCTTGAGGAGTTAACTCCATGAGCACAGGGATCCTAGGGCCCGGCATCCTGTTCCCT
GCTCCACTTCCCCATACCCCAGCCTGAGGCGAAGCCCACACCTACACACCCTCTGCATGGCCCT
GCCTGGACCCCATGAAGGCCGAATAGGGAGGAGGTCAGGGGCTGGGGTGCCCCAAGCTTCCCTC
AGGGAAGTGAGAGGCTCTTCCTGGCTAGACCCCCATCTCAATACCACCTCCTCCCTTTTCTCCC
TCCCCTTCTGCCCCTTAGTAAGTCTATGTGTGGAATGTGAGATATAAATATAAATATATAAAGC
TATATTTTCAGGCACCTGCCTGCCCCAAGCCCCCTGCCCCACTCCCATCTCTTCTTCCCTGCCA
CCCCTCCCTGCAGCCTCCGAGGCTTACTCCAGCCATACCTTCTCTTTCTCCTCTCTCCTTCCTT
CTTCCCTTGATCTCCCTCTTCCTGTCTCTGTCCTGGTCCCTGCCCCCGTCTCAGCCCAGCCTCT
GTATTCTCCACCCTTGATCTTTCTCCCTGTCTCTCCTGCTGCCCCTGGTTTCTTCCTTTGGTGC
TGGCTGTGTTGGTATCGTCAGTTCTTGAGCTATATTTTGTTTGGGGTTGTGGCTGGTTTTGGTT
TTAGTAATTTTGCTGCTTCCCGTTGCTCTCCTTCTATTCCCTCCCTTCTGCCCTGCCTGCCTGT
CTCCTCCCTGCACCTGCGGCCTCTCTGGGAAGCTGTTCCTTTCCATGCCAAATAGAAGCAACAA
GGCCCTAGCTGGAGACCCTGGGGATCTGGAACTGCAGGCAGGAGGTAGCACTGGCTCCCACTCC
CACCCTTGCCCAGCCTGGCATCTAGAAGGTGTCACGAATTACTTTCTCTTCTGTCTTCTCAGTT
TTGATGTCCTCATCCCCAAGATTAAGGAGGCAGTAGTCAGGCTGGGAAGGCAGTAGAATGGCCA
GCATTCCTGCCTGTAAGCCCTC

hide sequence

RefSeq Acc Id:

XM_037999261 ⟹ XP_037855189

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
Vero_WHO_p1.0	NW_023666033	30,676,140 - 30,700,662 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_007977088	(Get FASTA)	NCBI Sequence Viewer
	XP_037855189	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000016779
	ENSCSAP00000016779.1

RefSeq Acc Id:	XP_007977088 ⟸ XM_007978897
- UniProtKB:	A0A0D9S7E0 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSCSAP00000016779 ⟸ ENSCSAT00000017298

RefSeq Acc Id:	XP_037855189 ⟸ XM_037999261
- UniProtKB:	A0A0D9S7E0 (UniProtKB/TrEMBL)

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000001235	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000017298.1	UniProtKB/TrEMBL
Gene3D-CATH	Homeodomain-like	UniProtKB/TrEMBL
InterPro	Homeobox-like_sf	UniProtKB/TrEMBL
	Homeobox_CS	UniProtKB/TrEMBL
	Homeobox_dom	UniProtKB/TrEMBL
	OAR_dom	UniProtKB/TrEMBL
NCBI Gene	DMBX1	ENTREZGENE
PANTHER	DIENCEPHALON/MESENCEPHALON HOMEOBOX PROTEIN 1	UniProtKB/TrEMBL
	DIENCEPHALON/MESENCEPHALON HOMEOBOX PROTEIN 1	UniProtKB/TrEMBL
Pfam	Homeodomain	UniProtKB/TrEMBL
	OAR	UniProtKB/TrEMBL
PROSITE	HOMEOBOX_1	UniProtKB/TrEMBL
	HOMEOBOX_2	UniProtKB/TrEMBL
	OAR	UniProtKB/TrEMBL
SMART	HOX	UniProtKB/TrEMBL
Superfamily-SCOP	SSF46689	UniProtKB/TrEMBL
UniProt	A0A0D9S7E0	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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