DRG2 (developmentally regulated GTP binding protein 2)

Gene: DRG2 (developmentally regulated GTP binding protein 2) Chlorocebus sabaeus

Analyze

Symbol:

DRG2

Name:

developmentally regulated GTP binding protein 2

RGD ID:

18694747

Description:

ENCODES a protein that exhibits RNA binding (ortholog); INVOLVED IN cytoplasmic translation (inferred); ASSOCIATED WITH autistic disorder (ortholog); Birt-Hogg-Dube syndrome (ortholog); common variable immunodeficiency 2 (ortholog); FOUND IN cytosol (ortholog); intracellular membrane-bounded organelle (ortholog); nucleoplasm (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

developmentally-regulated GTP-binding protein 2

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	16	17,122,529 - 17,147,680 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	16	17,122,561 - 17,147,845 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666059	3,760,231 - 3,780,274 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autistic disorder (ISO)

Birt-Hogg-Dube syndrome (ISO)

common variable immunodeficiency 2 (ISO)

genetic disease (ISO)

Joubert syndrome 1 (ISO)

Potocki-Lupski syndrome (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cytoplasmic translation (IEA)

Cellular Component

cytoplasm (IEA)

cytosol (ISO)

intracellular membrane-bounded organelle (ISO)

nucleoplasm (ISO)

nucleus (ISO)

Molecular Function

GTP binding (IEA)

GTPase activity (IEA)

protein binding (ISO)

RNA binding (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

DRG2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	16	17,122,529 - 17,147,680 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	16	17,122,561 - 17,147,845 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666059	3,760,231 - 3,780,274 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

DRG2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	17	18,087,948 - 18,107,969 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	17	18,087,892 - 18,107,970 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	17	17,991,262 - 18,011,283 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	17	17,932,008 - 17,952,017 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	17	17,932,007 - 17,952,017	NCBI
Celera	17	18,932,430 - 18,952,432 (+)	NCBI		Celera
Cytogenetic Map	17	p11.2	NCBI
HuRef	17	17,744,556 - 17,764,671 (+)	NCBI		HuRef
CHM1_1	17	17,999,959 - 18,020,068 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	17	18,034,778 - 18,054,782 (+)	NCBI		T2T-CHM13v2.0

Drg2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	60,345,442 - 60,359,589 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	60,345,417 - 60,359,580 (+)	Ensembl		GRCm39 Ensembl
GRCm38	11	60,454,587 - 60,468,754 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	60,454,591 - 60,468,754 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	60,268,119 - 60,282,207 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	11	60,270,812 - 60,284,900 (+)	NCBI		MGSCv36	mm8
MGSCv36	11	60,993,116 - 61,007,204 (+)	NCBI		MGSCv36	mm8
Celera	11	66,145,823 - 66,146,916 (-)	NCBI		Celera
Cytogenetic Map	11	B2	NCBI
cM Map	11	37.81	NCBI

Drg2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	45,755,072 - 45,769,493 (+)	NCBI		GRCr8
mRatBN7.2	10	45,255,512 - 45,269,971 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	45,255,507 - 45,269,969 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	49,955,726 - 49,970,234 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	49,446,114 - 49,460,622 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	44,949,718 - 44,964,227 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	46,818,412 - 46,831,308 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	46,818,525 - 46,830,739 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	46,573,612 - 46,587,686 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	46,718,753 - 46,732,841 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	10	44,512,602 - 44,526,767 (+)	NCBI		Celera
Cytogenetic Map	10	q22	NCBI

Drg2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955478	11,193,245 - 11,210,914 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955478	11,193,245 - 11,210,917 (-)	NCBI	ChiLan1.0	ChiLan1.0

LOC100994060
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	19	52,604,577 - 52,624,589 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	17	57,316,816 - 57,336,818 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	17	33,187,571 - 33,206,833 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

DRG2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	5	41,428,233 - 41,445,706 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	5	41,428,802 - 41,445,649 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	5	41,567,726 - 41,585,202 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	5	41,534,978 - 41,552,500 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	5	41,534,997 - 41,552,492 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	5	41,502,795 - 41,520,271 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	5	41,450,216 - 41,467,679 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	5	41,642,082 - 41,659,563 (-)	NCBI		UU_Cfam_GSD_1.0

Drg2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	61,204,103 - 61,220,415 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936741	1,646,638 - 1,663,150 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936741	1,646,840 - 1,663,128 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

DRG2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	12	60,586,215 - 60,598,283 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	12	60,586,222 - 60,598,290 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

Drg2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624849	3,351,963 - 3,370,229 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624849	3,352,124 - 3,370,288 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	endocrine system	hemolymphoid system	nervous system
High
Medium	36	11	34
Low		9	26
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_008010546	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000027	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCSAT00000006379 ⟹ ENSCSAP00000004584

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	16	17,122,561 - 17,147,845 (+)	Ensembl

RefSeq Acc Id:

XM_008010546 ⟹ XP_008008737

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	16	17,122,529 - 17,147,680 (+)	NCBI
Vero_WHO_p1.0	NW_023666059	3,760,231 - 3,780,274 (-)	NCBI

Sequence:

show sequence

GCTCGCTCGGACTCTGAATCCCGGAGCACCAGGCGCCCACGAGAACGCTGTTCTCCTCGACTTC
CGGGCGCACGCTCCTCTGTCGCCGCCGTCAGAGCGGAATTCCCGGTGCCACCGCAGCCGCTGTC
TGTGCGCCCAGCTCAGCTGCCGCCATGGGGATCTTAGAGAAGATTTCGGAGATCGAGAAGGAGA
TCGCTCGGACGCAGAAGAACAAGGCCACTGAGTATCATCTGGGCCTGCTGAAAGCTAAGCTCGC
CAAGTATCGGGCCCAGCTCCTGGAACCGTCCAAATCAGCCTCGTCCAAAGGAGAGGGCTTCGAT
GTCATGAAGTCGGGCGATGCCCGTGTGGCGCTGATTGGATTTCCCTCTGTGGGTAAGTCCACAT
TCTTGAGTCTGATGACCTCCACGGCCAGCGAGGCAGCGTCCTATGAGTTCACCACTCTGACGTG
TATTCCTGGGGTCATTGAATACAAAGGCGCCAACATCCAGCTCCTGGACCTTCCTGGAATCATT
GAAGGCGCAGCCCAAGGAAAAGGCCGTGGCCGGCAGGTGATCGCTGTGGCACGCACCGCTGATG
TCGTCATCATGATGCTGGATGCCACCAAGGGAGAGGTGCAGAGGTCTCTGCTAGAGAAGGAGCT
GGAGTCTGTGGGCATCCGTCTCAACAAGCACAAGCCTAACATCTACTTCAAGCCCAAGAAAGGT
GGTGGCATCTCCTTTAATTCAACAGTCACGCTGACCCAGTGCTCGGAAAAGCTGGTGCAGCTCA
TCCTGCACGAATACAAGATCTTCAACGCAGAAGTGCTCTTCCGAGAAGACTGCTCCCCAGACGA
GTTCATCGATGTGATCGTGGGCAACCGGGTGTACATGCCCTGCCTGTATGTTTATAACAAAATC
GACCAGATCTCCATGGAAGAGGTGGACCGCTTGGCCCGAAAACCCAACAGTGTGGTCATCAGCT
GCGGCATGAAGCTGAACCTGGACTATCTGCTGGAGATGCTTTGGGAGTACTTGGCCCTGACCTG
CATCTACACCAAGAAGAGAGGACAGAGGCCGGACTTCACAGATGCCATCATTCTCCGGAAAGGG
GCCTCGGTGGAGCATGTGTGCCACCGCATCCACCGGTCACTCGCCAGCCAGTTCAAGTACGCCC
TGGTGTGGGGCACCAGCACCAAGTACAGTCCGCAGCGGGTGGGGCTGACCCACACCATGGAGCA
CGAGGACGTCATCCAGATCGTGAAGAAGTAACGGCGCCCACCAGGCCTCCCGCCCACCTGCCTC
CTCTCCCTGGGGAGCTGGTCCCACTGGGACACACAAACACCCAAACAGAAAAATACAAATACAC
GTACCCCAGGAAGGGGTCCCTCAAGTCTCTGCTATTTACAGAGGTTTCTTCAGTAGGCAGATGA
AGAGGGTGTCGGGGCAGAGGGGCTCGGCTGGAGGCATTTCCCATAAGACTGAGCCCTCGCATGG
GGGTTTTGAGTTTGTAGTGCTGAGCGTGCATCTGTGCCTCCAGCCCCCTGCACTGAGGGAGCAA
GTTGCCCACCTGCCCGCCAGCCGGGGCCTAAAGCAGATGGCATGCTCAGTGCCAGGCTGGTAGC
TGGGCCTGCCTGGGTCTCCGGGTGCTGTGGCTGCTGTCACGGCACCTCACTCCCTCAGTTCGTG
CCAGCTTCTCTGACACTTGGGGTGGGGGCCCTTCCAGGAGGAAGCCCCCTTGGGTCCCCCACAC
AGGGCTCTCCATGATGGGAACCAGAGGTTAGTGGCTTCAGAGGCCCAGCTGACACCCTTCACAG
CCTAAGGGCTGTCTTAAAGTGCCTCCCCCAATATCCCTCTCCCAGGGCAGCCCCTGCCCAGCAC
AAAACCCCAGGACCCTGGCTCTGCACGCCTGGGGCAGGGACTTCTGAGTTTAGGATCTGTATTT
TCTAAGTCCCCAGTTCTCCTGACTCTCCTTTCTGAAATAAAGGATTGAAAACGGTT

hide sequence

Protein Sequences


Protein RefSeqs	XP_008008737	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000004584.1

RefSeq Acc Id:

XP_008008737 ⟸ XM_008010546

RefSeq Acc Id:

ENSCSAP00000004584 ⟸ ENSCSAT00000006379

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000008328	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000006379.1	UniProtKB/TrEMBL
Gene3D-CATH	3.10.20.30	UniProtKB/TrEMBL
	6.10.140.1070	UniProtKB/TrEMBL
InterPro	Beta-grasp_dom_sf	UniProtKB/TrEMBL
	DRG	UniProtKB/TrEMBL
	G_OBG	UniProtKB/TrEMBL
	GTP-binding_2	UniProtKB/TrEMBL
	GTP1-OBG_CS	UniProtKB/TrEMBL
	GTP_binding_domain	UniProtKB/TrEMBL
	P-loop_NTPase	UniProtKB/TrEMBL
	Small_GTP-bd_dom	UniProtKB/TrEMBL
	TGS	UniProtKB/TrEMBL
	TGS-like	UniProtKB/TrEMBL
KEGG Report	csab:103242481	UniProtKB/TrEMBL
NCBI Gene	DRG2	ENTREZGENE
PANTHER	DEVELOPMENTALLY-REGULATED GTP-BINDING PROTEIN 2	UniProtKB/TrEMBL
	PTHR43127	UniProtKB/TrEMBL
Pfam	MMR_HSR1	UniProtKB/TrEMBL
	MMR_HSR1_Xtn	UniProtKB/TrEMBL
	TGS	UniProtKB/TrEMBL
PRINTS	GTP1OBG	UniProtKB/TrEMBL
PROSITE	G_OBG	UniProtKB/TrEMBL
	GTP1_OBG	UniProtKB/TrEMBL
	TGS	UniProtKB/TrEMBL
Superfamily-SCOP	SSF52540	UniProtKB/TrEMBL
	SSF81271	UniProtKB/TrEMBL
UniProt	A0A0D9R7J5_CHLSB	UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar