PLCB2 (phospholipase C beta 2) - Rat Genome Database

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Gene: PLCB2 (phospholipase C beta 2) Chlorocebus sabaeus
Analyze
Symbol: PLCB2
Name: phospholipase C beta 2
RGD ID: 18693710
Description: ENCODES a protein that exhibits G-protein beta/gamma-subunit complex binding (ortholog); phospholipase C activity (ortholog); phospholipid binding (ortholog); INVOLVED IN detection of chemical stimulus involved in sensory perception of bitter taste (ortholog); phospholipase C-activating G protein-coupled receptor signaling pathway (ortholog); sensory perception of bitter taste (ortholog); PARTICIPATES IN eicosanoid signaling pathway; endothelin signaling pathway; G protein mediated signaling pathway via Galphaq family; ASSOCIATED WITH Bloom syndrome (ortholog); colorectal cancer (ortholog); genetic disease (ortholog); FOUND IN G-protein beta/gamma-subunit complex (ortholog); neuronal dense core vesicle (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12642,706,462 - 42,727,516 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2642,707,625 - 42,727,145 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604898,236,858 - 98,257,092 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
PLCB2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12642,706,462 - 42,727,516 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2642,707,625 - 42,727,145 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604898,236,858 - 98,257,092 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
PLCB2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381540,284,256 - 40,307,935 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1540,278,176 - 40,307,935 (-)EnsemblGRCh38hg38GRCh38
GRCh371540,580,110 - 40,600,136 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361538,367,390 - 38,387,466 (-)NCBINCBI36Build 36hg18NCBI36
Build 341538,367,401 - 38,387,330NCBI
Celera1517,346,090 - 17,366,157 (-)NCBICelera
Cytogenetic Map15q15.1NCBI
HuRef1517,423,058 - 17,443,532 (-)NCBIHuRef
CHM1_11540,700,041 - 40,720,115 (-)NCBICHM1_1
T2T-CHM13v2.01538,091,173 - 38,114,815 (-)NCBIT2T-CHM13v2.0
Plcb2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392118,535,484 - 118,559,140 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2118,537,998 - 118,558,919 (-)EnsemblGRCm39 Ensembl
GRCm382118,705,003 - 118,728,661 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2118,707,517 - 118,728,438 (-)EnsemblGRCm38mm10GRCm38
MGSCv372118,533,253 - 118,554,174 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362118,398,958 - 118,419,879 (-)NCBIMGSCv36mm8
Celera2119,861,823 - 119,882,734 (-)NCBICelera
Cytogenetic Map2E5NCBI
cM Map259.43NCBI
Plcb2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83126,134,925 - 126,158,303 (-)NCBIGRCr8
mRatBN7.23105,683,676 - 105,704,384 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3105,684,815 - 105,704,302 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3109,357,684 - 109,377,152 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03117,953,248 - 117,972,712 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03115,613,610 - 115,633,075 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03110,497,760 - 110,517,563 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3110,498,114 - 110,517,163 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03117,038,677 - 117,058,132 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43105,203,524 - 105,223,342 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13105,099,951 - 105,119,770 (-)NCBI
Celera3104,599,222 - 104,618,601 (-)NCBICelera
Cytogenetic Map3q35NCBI
Plcb2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554167,218,417 - 7,240,739 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554167,221,326 - 7,240,743 (-)NCBIChiLan1.0ChiLan1.0
PLCB2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21629,518,245 - 29,541,893 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11533,669,673 - 33,693,337 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01519,218,329 - 19,241,977 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11537,476,699 - 37,496,813 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1537,476,699 - 37,496,813 (-)Ensemblpanpan1.1panPan2
PLCB2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1307,472,208 - 7,493,106 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl307,472,413 - 7,492,801 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha307,526,161 - 7,547,075 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0307,598,044 - 7,618,970 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl307,594,683 - 7,619,120 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1307,522,589 - 7,543,490 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0307,628,543 - 7,649,438 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0307,757,123 - 7,778,226 (-)NCBIUU_Cfam_GSD_1.0
Plcb2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864085,908,907 - 85,928,377 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364713,756,970 - 3,776,392 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364713,756,978 - 3,776,452 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLCB2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1131,005,408 - 131,028,689 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11131,005,408 - 131,031,864 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21146,286,447 - 146,302,118 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Plcb2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248047,591,844 - 7,612,645 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248047,593,956 - 7,612,860 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 5 17 12
Low 31 3 48
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_008017043 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008017044 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008017045 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008017046 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008017048 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008017049 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008017050 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008017051 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008017052 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008017053 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008017054 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008017055 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008017056 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008017057 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008017058 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005244286 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005244287 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005244288 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JACDXN010000016 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSCSAT00000005420   ⟹   ENSCSAP00000003642
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl2642,707,625 - 42,727,145 (+)Ensembl
RefSeq Acc Id: XM_008017043   ⟹   XP_008015234
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12642,707,308 - 42,727,516 (+)NCBI
Vero_WHO_p1.0NW_02366604898,236,858 - 98,257,092 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008017045   ⟹   XP_008015236
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12642,707,307 - 42,727,516 (+)NCBI
Vero_WHO_p1.0NW_02366604898,236,858 - 98,257,092 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008017046   ⟹   XP_008015237
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12642,707,309 - 42,727,516 (+)NCBI
Vero_WHO_p1.0NW_02366604898,236,858 - 98,257,092 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008017048   ⟹   XP_008015239
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12642,707,620 - 42,727,516 (+)NCBI
Vero_WHO_p1.0NW_02366604898,236,858 - 98,256,818 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008017054   ⟹   XP_008015245
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12642,707,305 - 42,724,001 (+)NCBI
Vero_WHO_p1.0NW_02366604898,240,248 - 98,257,092 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008017055   ⟹   XP_008015246
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12642,707,305 - 42,723,998 (+)NCBI
Vero_WHO_p1.0NW_02366604898,240,364 - 98,257,092 (-)NCBI
Sequence:
RefSeq Acc Id: XR_005244286
Type: NON-CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366604898,237,579 - 98,257,092 (-)NCBI
RefSeq Acc Id: XR_005244287
Type: NON-CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366604898,239,722 - 98,257,092 (-)NCBI
RefSeq Acc Id: XR_005244288
Type: NON-CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366604898,240,895 - 98,257,092 (-)NCBI
RefSeq Acc Id: XP_008015245   ⟸   XM_008017054
- Peptide Label: isoform X5
RefSeq Acc Id: XP_008015246   ⟸   XM_008017055
- Peptide Label: isoform X5
RefSeq Acc Id: XP_008015236   ⟸   XM_008017045
- Peptide Label: isoform X2
RefSeq Acc Id: XP_008015234   ⟸   XM_008017043
- Peptide Label: isoform X1
- UniProtKB: A0A0D9R4V3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_008015237   ⟸   XM_008017046
- Peptide Label: isoform X3
RefSeq Acc Id: XP_008015239   ⟸   XM_008017048
- Peptide Label: isoform X4
RefSeq Acc Id: ENSCSAP00000003642   ⟸   ENSCSAT00000005420


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000007432 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000005420.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1230.10 UniProtKB/TrEMBL
  2.30.29.240 UniProtKB/TrEMBL
  2.60.40.150 UniProtKB/TrEMBL
  3.20.20.190 UniProtKB/TrEMBL
  EF-hand UniProtKB/TrEMBL
InterPro C2_dom UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/TrEMBL
  EF-hand-dom_pair UniProtKB/TrEMBL
  PI-PLC_fam UniProtKB/TrEMBL
  PLC-beta UniProtKB/TrEMBL
  PLC-beta2 UniProtKB/TrEMBL
  PLC-beta_C UniProtKB/TrEMBL
  PLC-beta_C_sf UniProtKB/TrEMBL
  PLC-beta_PH UniProtKB/TrEMBL
  PLC-like_Pdiesterase_TIM-brl UniProtKB/TrEMBL
  PLC_EF-hand-like UniProtKB/TrEMBL
  PLCbeta2_EF UniProtKB/TrEMBL
  PLipase_C_PInositol-sp_X_dom UniProtKB/TrEMBL
  PLipase_C_Pinositol-sp_Y UniProtKB/TrEMBL
KEGG Report csab:103245842 UniProtKB/TrEMBL
NCBI Gene PLCB2 ENTREZGENE
PANTHER PTHR10336 UniProtKB/TrEMBL
  PTHR10336:SF10 UniProtKB/TrEMBL
Pfam EF-hand_like UniProtKB/TrEMBL
  PF00168 UniProtKB/TrEMBL
  PH_14 UniProtKB/TrEMBL
  PI-PLC-X UniProtKB/TrEMBL
  PI-PLC-Y UniProtKB/TrEMBL
  PLC-beta_C UniProtKB/TrEMBL
PIRSF PLC-beta UniProtKB/TrEMBL
PRINTS PHPHLIPASEC UniProtKB/TrEMBL
PROSITE PIPLC_X_DOMAIN UniProtKB/TrEMBL
  PIPLC_Y_DOMAIN UniProtKB/TrEMBL
  PS50004 UniProtKB/TrEMBL
SMART PLCXc UniProtKB/TrEMBL
  PLCYc UniProtKB/TrEMBL
  SM00239 UniProtKB/TrEMBL
Superfamily-SCOP C-terminal domain of PLC-beta UniProtKB/TrEMBL
  PH domain-like UniProtKB/TrEMBL
  SSF47473 UniProtKB/TrEMBL
  SSF49562 UniProtKB/TrEMBL
  SSF51695 UniProtKB/TrEMBL
UniProt A0A0D9R4V3 ENTREZGENE, UniProtKB/TrEMBL