GARS1 (glycyl-tRNA synthetase 1) - Rat Genome Database

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Gene: GARS1 (glycyl-tRNA synthetase 1) Chlorocebus sabaeus
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Symbol: GARS1
Name: glycyl-tRNA synthetase 1
RGD ID: 18690874
Description: ENCODES a protein that exhibits bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity (ortholog); identical protein binding (ortholog); protein dimerization activity (ortholog); INVOLVED IN diadenosine tetraphosphate biosynthetic process (ortholog); glycyl-tRNA aminoacylation (ortholog); PARTICIPATES IN dihydropyrimidine dehydrogenase deficiency pathway; dimethylglycine dehydrogenase deficiency pathway; nonketotic hyperglycinemia pathway; ASSOCIATED WITH autosomal dominant distal hereditary motor neuronopathy (ortholog); autosomal dominant distal hereditary motor neuronopathy 14 (ortholog); autosomal dominant distal hereditary motor neuronopathy 5 (ortholog); FOUND IN axon (ortholog); cytosol (ortholog); extracellular exosome (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: GARS; glycine--tRNA ligase
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12127,750,532 - 27,791,143 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2127,749,514 - 27,790,881 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604276,909,963 - 76,953,465 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
GARS1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12127,750,532 - 27,791,143 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2127,749,514 - 27,790,881 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604276,909,963 - 76,953,465 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
GARS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38730,594,735 - 30,634,033 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl730,580,533 - 30,634,033 (+)EnsemblGRCh38hg38GRCh38
GRCh37730,634,351 - 30,673,649 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36730,600,706 - 30,640,174 (+)NCBINCBI36Build 36hg18NCBI36
Build 34730,407,420 - 30,446,884NCBI
Celera730,623,360 - 30,662,827 (+)NCBICelera
Cytogenetic Map7p14.3NCBI
HuRef730,516,030 - 30,555,489 (+)NCBIHuRef
CHM1_1730,634,438 - 30,673,905 (+)NCBICHM1_1
T2T-CHM13v2.0730,732,340 - 30,771,637 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2730,683,834 - 30,723,301 (+)NCBI
Gars1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39655,014,986 - 55,056,489 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl655,014,992 - 55,056,485 (+)EnsemblGRCm39 Ensembl
GRCm38655,038,001 - 55,079,504 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl655,038,007 - 55,079,500 (+)EnsemblGRCm38mm10GRCm38
MGSCv37654,987,995 - 55,029,498 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36654,967,598 - 55,009,078 (+)NCBIMGSCv36mm8
Celera655,573,683 - 55,614,743 (+)NCBICelera
Cytogenetic Map6B3NCBI
cM Map627.29NCBI
Gars1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8485,484,939 - 85,542,876 (+)NCBIGRCr8
mRatBN7.2484,171,596 - 84,212,609 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl484,171,596 - 84,212,609 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx489,394,653 - 89,435,634 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0485,170,068 - 85,211,053 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0483,582,545 - 83,623,437 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0485,235,122 - 85,276,085 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl485,235,172 - 85,276,044 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04149,884,600 - 149,933,329 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4483,718,584 - 83,759,591 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1484,123,817 - 84,165,539 (-)NCBI
Celera479,038,903 - 79,079,749 (+)NCBICelera
Cytogenetic Map4q24NCBI
Gars1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541031,779,543 - 31,819,113 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541031,778,654 - 31,819,287 (+)NCBIChiLan1.0ChiLan1.0
GARS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2635,406,501 - 35,445,814 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1783,731,131 - 83,770,542 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0731,208,351 - 31,247,841 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1731,329,572 - 31,368,719 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl731,329,456 - 31,368,582 (+)Ensemblpanpan1.1panPan2
GARS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11443,308,274 - 43,351,999 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1443,308,152 - 43,396,487 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1442,741,012 - 42,784,674 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01443,249,452 - 43,293,125 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1443,249,308 - 43,295,729 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11443,365,329 - 43,408,974 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01443,041,322 - 43,084,982 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01443,402,683 - 43,446,352 (+)NCBIUU_Cfam_GSD_1.0
Gars1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511887,636,717 - 87,677,496 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364786,848,322 - 6,889,045 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364786,848,448 - 6,889,103 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GARS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1842,311,576 - 42,352,162 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11842,311,711 - 42,352,201 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21846,675,442 - 46,768,505 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Gars1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624739171,777 - 211,164 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624739172,111 - 211,229 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 36 4 60
Low 16
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_007981718 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JACDXN010000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSCSAT00000012677   ⟹   ENSCSAP00000010708
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl2127,749,514 - 27,790,881 (-)Ensembl
RefSeq Acc Id: XM_007981718   ⟹   XP_007979909
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12127,750,532 - 27,791,143 (-)NCBI
Vero_WHO_p1.0NW_02366604276,909,963 - 76,953,465 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_007979909 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000010708
  ENSCSAP00000010708.1
RefSeq Acc Id: XP_007979909   ⟸   XM_007981718
- UniProtKB: A0A0D9RQ19 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000010708   ⟸   ENSCSAT00000012677


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000014588 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000012677.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.40.230 UniProtKB/TrEMBL
  3.30.720.200 UniProtKB/TrEMBL
  3.40.50.800 UniProtKB/TrEMBL
  S15/NS1, RNA-binding UniProtKB/TrEMBL
InterPro aa-tRNA-synt_IIb UniProtKB/TrEMBL
  aa-tRNA-synth_II UniProtKB/TrEMBL
  aa-tRNA-synth_II/BPL/LPL UniProtKB/TrEMBL
  Anticodon-bd UniProtKB/TrEMBL
  Anticodon-bd_dom_sf UniProtKB/TrEMBL
  Gly-tRNA_synthase/POLG2 UniProtKB/TrEMBL
  GlyRS-like_core UniProtKB/TrEMBL
  S15_NS1_RNA-bd UniProtKB/TrEMBL
  tRNA-synt_gly UniProtKB/TrEMBL
  WHEP-TRS_dom UniProtKB/TrEMBL
KEGG Report csab:103226274 UniProtKB/TrEMBL
NCBI Gene GARS1 ENTREZGENE
PANTHER GLYCINE--TRNA LIGASE UniProtKB/TrEMBL
  PTHR10745 UniProtKB/TrEMBL
Pfam HGTP_anticodon UniProtKB/TrEMBL
  tRNA-synt_2b UniProtKB/TrEMBL
  WHEP-TRS UniProtKB/TrEMBL
PRINTS TRNASYNTHGLY UniProtKB/TrEMBL
PROSITE AA_TRNA_LIGASE_II UniProtKB/TrEMBL
  WHEP_TRS_1 UniProtKB/TrEMBL
  WHEP_TRS_2 UniProtKB/TrEMBL
SMART WHEP-TRS UniProtKB/TrEMBL
Superfamily-SCOP Class II aaRS ABD-related UniProtKB/TrEMBL
  SSF47060 UniProtKB/TrEMBL
  SSF55681 UniProtKB/TrEMBL
UniProt A0A0D9RQ19 ENTREZGENE, UniProtKB/TrEMBL