TINF2 (TERF1 interacting nuclear factor 2)

Gene: TINF2 (TERF1 interacting nuclear factor 2) Chlorocebus sabaeus

Analyze

Symbol:

TINF2

Name:

TERF1 interacting nuclear factor 2

RGD ID:

18686959

Description:

ENCODES a protein that exhibits DNA binding (ortholog); INVOLVED IN negative regulation of telomere maintenance (ortholog); ASSOCIATED WITH aplastic anemia (ortholog); Autosomal Dominant Dyskeratosis Congenita (ortholog); autosomal dominant dyskeratosis congenita 1 (ortholog); FOUND IN shelterin complex (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

TERF1-interacting nuclear factor 2

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	24	1,222,617 - 1,225,981 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	24	1,222,999 - 1,225,716 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666036	12,907,032 - 12,910,478 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

aplastic anemia (ISO)

Autosomal Dominant Dyskeratosis Congenita (ISO)

autosomal dominant dyskeratosis congenita 1 (ISO)

autosomal dominant dyskeratosis congenita 3 (ISO)

autosomal recessive congenital ichthyosis 1 (ISO)

bone marrow disease (ISO)

Brain-Lung-Thyroid Syndrome (ISO)

breast cancer (ISO)

cerebellar disease (ISO)

dyskeratosis congenita (ISO)

Growth Disorders (ISO)

Hoyeraal Hreidarsson Syndrome (ISO)

lysinuric protein intolerance (ISO)

nail disease (ISO)

primary immunodeficiency disease (ISO)

pulmonary fibrosis (ISO)

Revesz syndrome (ISO)

Specific Granule Deficiency (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

negative regulation of epithelial cell proliferation (IEA)

negative regulation of telomere maintenance (ISO)

negative regulation of telomere maintenance via telomerase (IEA)

protein localization to chromosome, telomeric region (IEA)

regulation of telomere maintenance via telomere lengthening (IEA)

telomere assembly (IEA)

telomere capping (IEA)

Cellular Component

chromosome, telomeric region (IEA)

nuclear body (IEA)

nuclear telomere cap complex (IEA)

perinucleolar chromocenter (IEA)

shelterin complex (IEA,ISO)

Molecular Function

DNA binding (ISO)

protein binding (ISO)

telomeric DNA binding (IEA)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

TINF2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	24	1,222,617 - 1,225,981 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	24	1,222,999 - 1,225,716 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666036	12,907,032 - 12,910,478 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

TINF2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	14	24,239,640 - 24,242,674 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	14	24,238,286 - 24,242,663 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	14	24,708,846 - 24,711,880 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	14	23,778,689 - 23,781,720 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	14	23,778,692 - 23,781,640	NCBI
Celera	14	4,573,487 - 4,576,518 (-)	NCBI		Celera
Cytogenetic Map	14	q12	NCBI
HuRef	14	4,823,619 - 4,826,650 (-)	NCBI		HuRef
CHM1_1	14	24,707,472 - 24,710,503 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	14	18,438,013 - 18,441,046 (-)	NCBI		T2T-CHM13v2.0

Tinf2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	14	55,912,120 - 55,919,265 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	14	55,912,146 - 55,919,277 (-)	Ensembl		GRCm39 Ensembl
GRCm38	14	55,676,208 - 55,682,159 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	14	55,674,689 - 55,681,820 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	14	56,297,917 - 56,300,654 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	14	54,633,173 - 54,635,799 (-)	NCBI		MGSCv36	mm8
Celera	14	53,484,153 - 53,486,890 (-)	NCBI		Celera
Cytogenetic Map	14	C3	NCBI
cM Map	14	28.19	NCBI

Tinf2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	15	33,140,611 - 33,146,930 (-)	NCBI		GRCr8
mRatBN7.2	15	29,170,663 - 29,178,015 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	15	29,170,652 - 29,176,984 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	15	31,019,560 - 31,022,668 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	15	32,166,781 - 32,169,889 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	15	30,409,120 - 30,412,228 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	15	34,358,697 - 34,365,085 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	15	34,360,974 - 34,364,081 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	15	38,248,720 - 38,255,059 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	15	33,828,924 - 33,832,032 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	15	33,844,624 - 33,847,732 (-)	NCBI
Celera	15	28,750,266 - 28,753,374 (-)	NCBI		Celera
Cytogenetic Map	15	p13	NCBI

TINF2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	15	25,594,634 - 25,597,748 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	14	24,811,126 - 24,814,494 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	14	5,015,862 - 5,019,228 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	14	23,139,445 - 23,142,825 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	14	23,139,445 - 23,142,825 (-)	Ensembl	panpan1.1		panPan2

TINF2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	8	4,221,183 - 4,223,863 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	8	4,221,269 - 4,223,512 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	8	4,139,863 - 4,145,505 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	8	4,328,953 - 4,334,598 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	8	4,328,964 - 4,334,585 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	8	4,019,338 - 4,024,981 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	8	4,081,135 - 4,086,784 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	8	4,343,466 - 4,349,114 (-)	NCBI		UU_Cfam_GSD_1.0

Tinf2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	36,065,276 - 36,068,387 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936722	320,917 - 324,492 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936722	320,171 - 323,703 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TINF2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	75,056,798 - 75,063,979 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	7	75,056,790 - 75,067,895 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	80,327,728 - 80,332,937 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Tinf2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624820	8,262,595 - 8,311,872 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624820	8,262,171 - 8,265,275 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	hemolymphoid system
High
Medium
Low	2
Below cutoff	5

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_007986318	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000004	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCSAT00000014048 ⟹ ENSCSAP00000012029

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	24	1,222,999 - 1,225,716 (-)	Ensembl

RefSeq Acc Id:

XM_007986318 ⟹ XP_007984509

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	24	1,222,617 - 1,225,981 (-)	NCBI
Vero_WHO_p1.0	NW_023666036	12,907,032 - 12,910,478 (-)	NCBI

Sequence:

show sequence

GCAGGGGAAGGCTTTGTAGACGCCGGCTCGGGTCTGGGATTTAAGGAACTGAATTTCGACGGGT
GAAGACAGTGGGAAGAGGCGGTGGCACGATCCTCGTTTCACACACTAGGAAGTCGAGGGGAGTG
ACGGGGCTTCTCCGCAGAAGAAATCGAGGATAGGAGGACCCAGACGAGCGGCCACAACAGCCTC
GGCGGCCAATTCAAGTCAGCCAGCAGAGGGCGCAGGGCGCAGCGAGCAGGCAGCGCCAGATCCG
CTGGGGCGTGGCCTTCTGACGCACCGTCACAGTTCCCTCTGTGGCCACCCATTGGCTCCCTCTT
ACCGCCCTTTTCCGGGGCAAGGGAAGCTAGTAGCGGAGCCGGAAGTGAGGCACCCTCGGGCTCG
AGACAGAGGCGGCGTTTAAAGCTGAGCGACCCAGTACCACTGGGACGGCCAGCTTTTCCACTCA
GACTCCTCCAGCCTGAGCCAGAAGACCCCCTCCCCCAGAATTCTGGGGGCCTATGGAAGGGAGC
CGAGTCGGATCGCGAGGTACCCAGAGCCGACAAACCCGAGCCACAGAGTGTTGCCAGAAGCCCC
GCCCCTAGGAGTGATCGGAAAGCCTCACCCATCCGGGTGAGGAACCTGGAGGGACCGCCTCAGG
GCGGAGCCCGCCGACCATGGCTACGCCCCCGGGGGCCGGTCCTGCAGCTCTACGCTTTGCCGCC
GCAGCTAGCTGGCAGGTTGTTCGCGGACGCTGTGTGGAACATTTTCCCCAAGTACTGGAGTTTC
TGCGATCTCTGCGCTCTGTTGCCCCTGGCTTGGTTCGCTACCGGCACCACGAACGCCTTTGTAT
GGGCCTAAAGGCCAAGGTGGTGGTGGAGCTGATCCTGCAGGGCCGGCCTTGGGCCCAAGTCCTG
AAAACCCTGAATCACCACTTTCCAGAATCTGGACCTATAGTGCGGGATCCCAAGGCTACAAAGC
AGGATCTGAGGAAGATTTTGGAGGCACAGGAGACTTTCTACCAACAGGTGAAGCAGCTGTCAGA
GGCTCCTGTGGATTTGGCCTCGAAGCTGCAGGAACTTGAACAAGAATATGGGGAACCCTTTCTG
GCTGCCATGGAAAAGCTGCTTTTTGAGTACTTGTGTCAGCTGGAGAAAGCACTGCCTACACCGC
AGGCACAGCAGCTTCAGGATGTGCTGAGTTGGATGCAGCCTGGAGTCTCTATCACCTCTTCTCT
TGCCTGGAGACAATATGGTGTGGACATGGGGTGGCCACTTCCAGAGTGCTCTGTTACTGACTCA
GTGAACCTGGCTGAGCCCATGGAACAGAATCCTCCTCAGCAACAAAGACTAGCACTCCACAATC
CTCTGCCAAAAACCAAGCCTGGCCCATGTCTTCCTCAGGGACCATCTTCAAGGACGCACCCAGA
ACCTCTAGCTGGCCGCCACTTCAATCTGGCCCCTTTAGGCCGACGAAGAGTCCAGTCCCAATGG
GCGTCCACTAGGGGAGGCCATAAGGAGCGCCCCACAGTCATGCTGTTTCCCTTTAGGAATCTGG
GCTCACCAACCCAGGTCATATCTAAGCCTGAGAGCAAGGAAGAACATGTGATATACACAGCAGA
CCTAGCCGTGGGCACAAGAGCAGCCTCTACTGGGAAGTCTAAGAGTCCATGCCAGACCCTGGGG
GGAAGGGCTCTGAAGGAGAACCCAGTTGACTTGCCTGCCACAGAGCAAAAGGAGAATTGCTTGG
ATTGCTACATGGACCCCCTGAGACTATCATTATTACCTCCTAGGGCCAAGAAGCCAGTGTGTCC
TCCATCTCTGTGCAGCTCCATCATTACCATAGGGGACTTGGTTTTAGACTCTGATGAGGAAGAA
AATGGCCAGGGGGAAGGAAAGGAATCTCTGGAAAACTATCAGAAGACAAAGTTTGACACCTTGA
TCCCCACTTTCTGTGAATACCTACCCTCTTCTGGCCATGGTGCCATGCCTGTTCCTTCCTATGA
CTGTAGAGACAGCTCTAGACCCCTGTGATAGAACTAAAATGCCCTTTGTACTCTGCCTGTCTCC
TGCCTTCAGCTAAACTTCAGCTCTGCAAGTAGTTTAGTAGGAATGGAGTAGAAGTCCAGGCTTG
GACTGCCTGACTACACTGCTAAAAGTATTTGTAATGCTTAATAATTAAACTTTGGATTTGTTAA
AATA

hide sequence

Protein Sequences


Protein RefSeqs	XP_007984509	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000012029.1

RefSeq Acc Id:	XP_007984509 ⟸ XM_007986318
- UniProtKB:	A0A0D9RTU0 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSCSAP00000012029 ⟸ ENSCSAT00000014048

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000015955	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000014048.1	UniProtKB/TrEMBL
InterPro	TINF2	UniProtKB/TrEMBL
	TINF2_N	UniProtKB/TrEMBL
NCBI Gene	TINF2	ENTREZGENE
PANTHER	PTHR15512	UniProtKB/TrEMBL
	TERF1-INTERACTING NUCLEAR FACTOR 2	UniProtKB/TrEMBL
Pfam	TINF2_N	UniProtKB/TrEMBL
UniProt	A0A0D9RTU0	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

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