PAX8 (paired box 8) - Rat Genome Database

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Gene: PAX8 (paired box 8) Chlorocebus sabaeus
Analyze
Symbol: PAX8
Name: paired box 8
RGD ID: 18684793
Description: ENCODES a protein that exhibits DNA binding (ortholog); DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); sequence-specific DNA binding (ortholog); INVOLVED IN epithelial cell differentiation (ortholog); metanephros development (ortholog); positive regulation of transcription by RNA polymerase II (ortholog); ASSOCIATED WITH Colorectal Neoplasms (ortholog); congenital hypothyroidism (ortholog); congenital nongoitrous hypothyroidism 2 (ortholog); FOUND IN nucleoplasm (inferred); nucleus (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: paired box protein Pax-8
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11416,236,074 - 16,299,650 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1416,233,378 - 16,297,365 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660803,382,976 - 3,450,250 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
branching involved in ureteric bud morphogenesis  (IEA)
cellular response to gonadotropin stimulus  (IEA)
central nervous system development  (IEA)
DNA-templated transcription  (IEA)
epithelial cell differentiation  (IEA,ISO)
inner ear morphogenesis  (IEA)
kidney development  (IEA)
kidney epithelium development  (IEA)
mesenchymal to epithelial transition involved in metanephros morphogenesis  (IEA)
mesonephric tubule development  (IEA)
mesonephros development  (IEA)
metanephric comma-shaped body morphogenesis  (IEA)
metanephric distal convoluted tubule development  (IEA)
metanephric epithelium development  (IEA)
metanephric nephron tubule formation  (IEA)
metanephric S-shaped body morphogenesis  (IEA)
metanephros development  (IEA,ISO)
negative regulation of apoptotic process involved in metanephric collecting duct development  (IEA)
negative regulation of apoptotic process involved in metanephric nephron tubule development  (IEA)
negative regulation of cardiac muscle cell apoptotic process  (IEA)
negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis  (IEA)
negative regulation of mesenchymal cell apoptotic process involved in metanephros development  (IEA)
otic vesicle development  (IEA)
positive regulation of branching involved in ureteric bud morphogenesis  (IEA)
positive regulation of DNA-templated transcription  (IEA)
positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis  (IEA)
positive regulation of metanephric DCT cell differentiation  (IEA)
positive regulation of thyroid hormone generation  (IEA)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
pronephric field specification  (IEA)
pronephros development  (IEA)
regulation of apoptotic process  (IEA)
regulation of DNA-templated transcription  (IEA,ISO)
regulation of metanephric nephron tubule epithelial cell differentiation  (IEA)
regulation of thyroid-stimulating hormone secretion  (IEA)
regulation of transcription by RNA polymerase II  (IEA)
S-shaped body morphogenesis  (IEA)
sulfur compound metabolic process  (ISO)
thyroid gland development  (IEA,ISO)
urogenital system development  (IEA)
ventricular septum development  (IEA)

Cellular Component
nucleoplasm  (IEA)
nucleus  (IEA)

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
PAX8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11416,236,074 - 16,299,650 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1416,233,378 - 16,297,365 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660803,382,976 - 3,450,250 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
PAX8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382113,215,997 - 113,278,921 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2113,215,997 - 113,278,921 (-)EnsemblGRCh38hg38GRCh38
GRCh372113,973,574 - 114,036,498 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362113,690,045 - 113,752,968 (-)NCBINCBI36Build 36hg18NCBI36
Build 342113,691,170 - 113,752,728NCBI
Celera2107,358,161 - 107,421,066 (-)NCBICelera
Cytogenetic Map2q14.1NCBI
HuRef2106,427,614 - 106,522,962 (-)NCBIHuRef
CHM1_12113,977,965 - 114,040,915 (-)NCBICHM1_1
T2T-CHM13v2.02113,642,573 - 113,705,473 (-)NCBIT2T-CHM13v2.0
Pax8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39224,310,563 - 24,365,611 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl224,310,572 - 24,365,611 (-)EnsemblGRCm39 Ensembl
GRCm38224,420,551 - 24,475,599 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl224,420,560 - 24,475,599 (-)EnsemblGRCm38mm10GRCm38
MGSCv37224,276,080 - 24,331,086 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36224,242,569 - 24,297,575 (-)NCBIMGSCv36mm8
Celera224,140,049 - 24,195,191 (-)NCBICelera
Cytogenetic Map2A3NCBI
cM Map216.43NCBI
Pax8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8327,584,000 - 27,641,094 (-)NCBIGRCr8
mRatBN7.237,185,721 - 7,242,363 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl37,185,723 - 7,242,363 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx310,289,591 - 10,345,823 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0318,875,838 - 18,932,068 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0317,065,649 - 17,121,886 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.031,527,316 - 1,586,019 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl31,527,279 - 1,584,946 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.031,520,144 - 1,576,052 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.432,671,478 - 2,726,801 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.132,672,153 - 2,726,345 (-)NCBI
Celera32,022,899 - 2,078,650 (-)NCBICelera
Cytogenetic Map3p13NCBI
Pax8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554701,016,289 - 1,073,796 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554701,016,226 - 1,072,643 (+)NCBIChiLan1.0ChiLan1.0
PAX8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21214,933,395 - 14,971,937 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A14,936,160 - 14,974,705 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A88,845,877 - 88,905,266 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A114,162,110 - 114,222,865 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A114,162,110 - 114,222,865 (-)Ensemblpanpan1.1panPan2
PAX8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11737,307,130 - 37,331,729 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1737,306,033 - 37,363,178 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1737,077,650 - 37,133,660 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01738,084,443 - 38,141,710 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1738,085,541 - 38,141,710 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11737,220,866 - 37,276,852 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01737,277,373 - 37,333,166 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01737,490,112 - 37,546,218 (-)NCBIUU_Cfam_GSD_1.0
Pax8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629282,629,178 - 82,682,663 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367831,523,661 - 1,576,568 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367831,523,658 - 1,553,464 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
Pax8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474913,300,606 - 13,357,903 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474913,291,880 - 13,358,066 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PAX8
1882 total Variants

Expression

RNA-SEQ Expression

ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
reproductive system
35 35 17 33 33 19 19

Sequence


Ensembl Acc Id: ENSCSAT00000014776   ⟹   ENSCSAP00000012737
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl1416,233,378 - 16,297,365 (-)Ensembl
RefSeq Acc Id: XM_008008445   ⟹   XP_008006636
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11416,236,074 - 16,265,988 (-)NCBI
Vero_WHO_p1.0NW_0236660803,383,494 - 3,444,668 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008008447   ⟹   XP_008006638
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11416,236,074 - 16,297,291 (-)NCBI
Vero_WHO_p1.0NW_0236660803,382,976 - 3,444,668 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008008450   ⟹   XP_008006641
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11416,236,074 - 16,265,988 (-)NCBI
Vero_WHO_p1.0NW_0236660803,383,494 - 3,444,668 (+)NCBI
Sequence:
RefSeq Acc Id: XM_037994288   ⟹   XP_037850216
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_0236660803,383,494 - 3,444,668 (+)NCBI
RefSeq Acc Id: XM_037994289   ⟹   XP_037850217
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_0236660803,382,976 - 3,444,668 (+)NCBI
RefSeq Acc Id: XM_037994290   ⟹   XP_037850218
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_0236660803,383,494 - 3,450,250 (+)NCBI
RefSeq Acc Id: XM_037994291   ⟹   XP_037850219
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_0236660803,383,494 - 3,444,668 (+)NCBI
RefSeq Acc Id: XM_037994292   ⟹   XP_037850220
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_0236660803,383,494 - 3,450,250 (+)NCBI
RefSeq Acc Id: XM_037994293   ⟹   XP_037850221
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_0236660803,382,976 - 3,444,668 (+)NCBI
RefSeq Acc Id: XP_008006638   ⟸   XM_008008447
- Peptide Label: isoform X4
- UniProtKB: A0A0D9RVU8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_008006641   ⟸   XM_008008450
- Peptide Label: isoform X8
RefSeq Acc Id: XP_008006636   ⟸   XM_008008445
- Peptide Label: isoform X2
Ensembl Acc Id: ENSCSAP00000012737   ⟸   ENSCSAT00000014776
RefSeq Acc Id: XP_037850217   ⟸   XM_037994289
- Peptide Label: isoform X3
RefSeq Acc Id: XP_037850221   ⟸   XM_037994293
- Peptide Label: isoform X9
RefSeq Acc Id: XP_037850218   ⟸   XM_037994290
- Peptide Label: isoform X5
RefSeq Acc Id: XP_037850220   ⟸   XM_037994292
- Peptide Label: isoform X7
RefSeq Acc Id: XP_037850216   ⟸   XM_037994288
- Peptide Label: isoform X1
RefSeq Acc Id: XP_037850219   ⟸   XM_037994291
- Peptide Label: isoform X6


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000016682 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000014776.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.10 UniProtKB/TrEMBL
InterPro Homeobox-like_sf UniProtKB/TrEMBL
  PAIRED_DNA_bd_dom UniProtKB/TrEMBL
  Paired_dom UniProtKB/TrEMBL
  Pax2_C UniProtKB/TrEMBL
  PAX_fam UniProtKB/TrEMBL
  WH-like_DNA-bd_sf UniProtKB/TrEMBL
NCBI Gene PAX8 ENTREZGENE
PANTHER PAIRED BOX PROTEIN PAX-8 UniProtKB/TrEMBL
  PTHR45636 UniProtKB/TrEMBL
Pfam PAX UniProtKB/TrEMBL
  Pax2_C UniProtKB/TrEMBL
PRINTS PAIREDBOX UniProtKB/TrEMBL
PROSITE PAIRED_1 UniProtKB/TrEMBL
  PAIRED_2 UniProtKB/TrEMBL
SMART PAX UniProtKB/TrEMBL
Superfamily-SCOP SSF46689 UniProtKB/TrEMBL
UniProt A0A0D9RVU8 ENTREZGENE, UniProtKB/TrEMBL