WARS2 (tryptophanyl tRNA synthetase 2, mitochondrial) - Rat Genome Database

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Gene: WARS2 (tryptophanyl tRNA synthetase 2, mitochondrial) Chlorocebus sabaeus
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Symbol: WARS2
Name: tryptophanyl tRNA synthetase 2, mitochondrial
RGD ID: 18681978
Description: ENCODES a protein that exhibits aminoacyl-tRNA ligase activity (inferred); ATP binding (inferred); tryptophan-tRNA ligase activity (inferred); INVOLVED IN positive regulation of angiogenesis (ortholog); vasculogenesis (ortholog); PARTICIPATES IN tryptophan metabolic pathway; ASSOCIATED WITH genetic disease (ortholog); Hajdu-Cheney syndrome (ortholog); Mitochondrial Neurodevelopmental Disorder, with Abnormal Movements and Lactic Acidosis, with or without Seizures (ortholog); FOUND IN mitochondrial matrix (inferred); mitochondrion (inferred); nucleoplasm (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: tryptophan--tRNA ligase, mitochondrial
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12014,614,902 - 14,726,630 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2014,615,349 - 14,726,780 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603817,270,507 - 17,393,968 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
WARS2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12014,614,902 - 14,726,630 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2014,615,349 - 14,726,780 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603817,270,507 - 17,393,968 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
WARS2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381119,031,216 - 119,140,672 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1119,031,216 - 119,140,654 (-)EnsemblGRCh38hg38GRCh38
GRCh371119,573,839 - 119,683,295 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361119,375,362 - 119,484,818 (-)NCBINCBI36Build 36hg18NCBI36
Build 341119,285,882 - 119,395,329NCBI
Celera1117,804,670 - 117,914,139 (-)NCBICelera
Cytogenetic Map1p12NCBI
HuRef1117,432,899 - 117,542,355 (-)NCBIHuRef
CHM1_11119,689,114 - 119,798,567 (-)NCBICHM1_1
T2T-CHM13v2.01119,044,400 - 119,154,015 (-)NCBIT2T-CHM13v2.0
Wars2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39399,047,423 - 99,128,546 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl399,048,384 - 99,146,502 (+)EnsemblGRCm39 Ensembl
GRCm38399,140,107 - 99,221,230 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl399,141,068 - 99,239,186 (+)EnsemblGRCm38mm10GRCm38
MGSCv37398,945,013 - 99,024,126 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36399,270,151 - 99,349,264 (+)NCBIMGSCv36mm8
MGSCv36399,350,466 - 99,429,579 (+)NCBIMGSCv36mm8
Cytogenetic Map3F2.2NCBI
cM Map343.03NCBI
Wars2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82189,150,322 - 189,233,606 (+)NCBIGRCr8
mRatBN7.22186,459,744 - 186,543,581 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2186,459,444 - 186,543,571 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2194,125,237 - 194,209,552 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02191,938,946 - 192,023,252 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02186,757,892 - 186,841,864 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02201,170,363 - 201,256,115 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2201,172,312 - 201,255,703 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02220,638,872 - 220,721,873 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42193,819,862 - 193,902,421 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2178,941,140 - 179,020,771 (+)NCBICelera
Cytogenetic Map2q34NCBI
Wars2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543522,032,230 - 22,115,138 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543522,032,230 - 22,115,138 (-)NCBIChiLan1.0ChiLan1.0
WARS2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21111,654,951 - 111,765,149 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11111,257,544 - 111,369,015 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0183,405,595 - 83,515,718 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11118,402,385 - 118,511,699 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1118,402,385 - 118,516,099 (+)Ensemblpanpan1.1panPan2
WARS2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11756,229,175 - 56,322,688 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1756,229,769 - 56,322,638 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1755,877,127 - 55,971,652 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01757,100,900 - 57,195,725 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1757,100,941 - 57,195,693 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11756,136,854 - 56,231,602 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01756,169,008 - 56,263,812 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01756,758,810 - 56,853,584 (-)NCBIUU_Cfam_GSD_1.0
Wars2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505810,526,304 - 10,598,363 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366273,890,629 - 3,962,899 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366273,890,629 - 3,963,169 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
WARS2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4101,787,583 - 101,883,070 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14101,787,585 - 101,881,231 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24111,920,791 - 111,924,709 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Wars2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477214,654,403 - 14,735,315 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477214,652,874 - 14,735,732 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression

ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
reproductive system
76 36 20 36 36 60 20

Sequence


Ensembl Acc Id: ENSCSAT00000016816   ⟹   ENSCSAP00000016315
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl2014,615,349 - 14,726,780 (+)Ensembl
RefSeq Acc Id: XM_037997309   ⟹   XP_037853237
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366603817,270,507 - 17,393,968 (+)NCBI
Protein Sequences
Protein RefSeqs XP_037853237 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000016315.1
Ensembl Acc Id: ENSCSAP00000016315   ⟸   ENSCSAT00000016816
RefSeq Acc Id: XP_037853237   ⟸   XM_037997309
- UniProtKB: A0A0D9S626 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000001713 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000016816.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.620 UniProtKB/TrEMBL
  Tyrosyl-Transfer RNA Synthetase UniProtKB/TrEMBL
InterPro aa-tRNA-synth_I_CS UniProtKB/TrEMBL
  aa-tRNA-synth_Ic UniProtKB/TrEMBL
  Rossmann-like_a/b/a_fold UniProtKB/TrEMBL
  Trp-tRNA-ligase UniProtKB/TrEMBL
  Trp-tRNA-ligase_bac-type UniProtKB/TrEMBL
  Trp-tRNA_synthetase UniProtKB/TrEMBL
KEGG Report csab:103224110 UniProtKB/TrEMBL
NCBI Gene WARS2 ENTREZGENE
PANTHER TRYPTOPHAN--TRNA LIGASE, MITOCHONDRIAL UniProtKB/TrEMBL
  TRYPTOPHAN--TRNA LIGASE, MITOCHONDRIAL UniProtKB/TrEMBL
Pfam tRNA-synt_1b UniProtKB/TrEMBL
PRINTS TRNASYNTHTRP UniProtKB/TrEMBL
PROSITE AA_TRNA_LIGASE_I UniProtKB/TrEMBL
Superfamily-SCOP Nucleotidylyl transferase UniProtKB/TrEMBL
UniProt A0A0D9S626 ENTREZGENE, UniProtKB/TrEMBL