SH2B1 (SH2B adaptor protein 1) - Rat Genome Database

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Gene: SH2B1 (SH2B adaptor protein 1) Chlorocebus sabaeus
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Symbol: SH2B1
Name: SH2B adaptor protein 1
RGD ID: 18673155
Description: ENCODES a protein that exhibits signaling adaptor activity (inferred); transmembrane receptor protein tyrosine kinase adaptor activity (inferred); INVOLVED IN cell motility (ortholog); lamellipodium assembly (ortholog); positive regulation of SMAD protein signal transduction (ortholog); PARTICIPATES IN leptin system pathway; ASSOCIATED WITH Brody myopathy (ortholog); chromosome 16p11.2 deletion syndrome, 220-kb (ortholog); chromosome 16p11.2 deletion syndrome, 593-kb (ortholog); FOUND IN plasma membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: SH2B adapter protein 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1526,197,483 - 26,208,332 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl526,196,778 - 26,207,398 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660683,406,643 - 3,417,685 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
SH2B1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1526,197,483 - 26,208,332 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl526,196,778 - 26,207,398 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660683,406,643 - 3,417,685 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
SH2B1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381628,846,606 - 28,874,205 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1628,846,600 - 28,874,212 (+)EnsemblGRCh38hg38GRCh38
GRCh371628,857,927 - 28,885,526 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361628,782,815 - 28,793,027 (+)NCBINCBI36Build 36hg18NCBI36
Celera1627,829,836 - 27,840,291 (+)NCBICelera
Cytogenetic Map16p11.2NCBI
HuRef1626,742,418 - 26,752,871 (+)NCBIHuRef
CHM1_11629,886,916 - 29,897,372 (+)NCBICHM1_1
T2T-CHM13v2.01629,127,175 - 29,154,707 (+)NCBIT2T-CHM13v2.0
Sh2b1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397126,066,165 - 126,075,882 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7126,066,166 - 126,074,596 (-)EnsemblGRCm39 Ensembl
GRCm387126,466,993 - 126,476,650 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7126,466,994 - 126,475,424 (-)EnsemblGRCm38mm10GRCm38
MGSCv377133,610,508 - 133,618,644 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367126,258,144 - 126,264,159 (-)NCBIMGSCv36mm8
Celera7126,319,559 - 126,327,690 (-)NCBICelera
Cytogenetic Map7F3NCBI
cM Map769.06NCBI
Sh2b1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81190,479,211 - 190,492,030 (-)NCBIGRCr8
mRatBN7.21181,048,622 - 181,057,036 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1181,048,623 - 181,056,579 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1189,379,202 - 189,387,169 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01196,565,281 - 196,573,248 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01189,253,186 - 189,261,106 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01197,878,839 - 197,888,223 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1197,878,840 - 197,886,759 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01204,857,973 - 204,867,302 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1178,707,989 - 178,715,895 (-)NCBICelera
Cytogenetic Map1q36NCBI
Sh2b1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554936,583,415 - 6,592,452 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554936,583,415 - 6,592,690 (-)NCBIChiLan1.0ChiLan1.0
SH2B1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21831,886,951 - 31,913,957 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11636,704,473 - 36,731,390 (-)NCBINHGRI_mPanPan1
PanPan1.11629,233,705 - 29,261,072 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1629,249,597 - 29,263,334 (+)Ensemblpanpan1.1panPan2
SH2B1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1618,370,881 - 18,380,965 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl618,371,832 - 18,380,962 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha619,950,137 - 19,959,175 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0618,507,858 - 18,516,906 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl618,507,815 - 18,516,904 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1618,307,240 - 18,316,447 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0618,222,112 - 18,231,023 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0618,538,095 - 18,547,144 (+)NCBIUU_Cfam_GSD_1.0
Sh2b1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344123,742,367 - 123,750,916 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650111,840,190 - 11,848,780 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493650111,840,227 - 11,849,742 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SH2B1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl318,524,820 - 18,543,135 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1318,533,282 - 18,543,133 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2318,718,536 - 18,728,408 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Sh2b1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478212,888,817 - 12,897,707 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478212,888,818 - 12,897,773 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 36 44
Low 20 16
Below cutoff

Sequence


RefSeq Acc Id: ENSCSAT00000004356   ⟹   ENSCSAP00000002610
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl526,196,778 - 26,207,398 (-)Ensembl
RefSeq Acc Id: XM_007988915   ⟹   XP_007987106
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1526,197,483 - 26,207,785 (-)NCBI
Vero_WHO_p1.0NW_0236660683,407,374 - 3,417,685 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007988922   ⟹   XP_007987113
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1526,197,483 - 26,208,332 (-)NCBI
Vero_WHO_p1.0NW_0236660683,406,643 - 3,417,685 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007988928   ⟹   XP_007987119
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1526,197,483 - 26,206,537 (-)NCBI
Vero_WHO_p1.0NW_0236660683,407,520 - 3,417,685 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007988950   ⟹   XP_007987141
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1526,197,483 - 26,207,785 (-)NCBI
Vero_WHO_p1.0NW_0236660683,407,374 - 3,417,685 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007988957   ⟹   XP_007987148
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1526,197,483 - 26,207,785 (-)NCBI
Vero_WHO_p1.0NW_0236660683,407,374 - 3,417,685 (+)NCBI
Sequence:
RefSeq Acc Id: XM_037989706   ⟹   XP_037845634
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_0236660683,407,392 - 3,417,685 (+)NCBI
RefSeq Acc Id: XM_037989707   ⟹   XP_037845635
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_0236660683,407,520 - 3,417,685 (+)NCBI
RefSeq Acc Id: XM_037989708   ⟹   XP_037845636
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_0236660683,407,520 - 3,417,685 (+)NCBI
RefSeq Acc Id: XP_007987113   ⟸   XM_007988922
- Peptide Label: isoform X1
- UniProtKB: A0A0D9R1X1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007987106   ⟸   XM_007988915
- Peptide Label: isoform X1
- UniProtKB: A0A0D9R1X1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007987148   ⟸   XM_007988957
- Peptide Label: isoform X4
- UniProtKB: A0A0D9R1X1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007987141   ⟸   XM_007988950
- Peptide Label: isoform X3
- UniProtKB: A0A0D9R1X1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007987119   ⟸   XM_007988928
- Peptide Label: isoform X1
- UniProtKB: A0A0D9R1X1 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000002610   ⟸   ENSCSAT00000004356
RefSeq Acc Id: XP_037845634   ⟸   XM_037989706
- Peptide Label: isoform X1
- UniProtKB: A0A0D9R1X1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037845636   ⟸   XM_037989708
- Peptide Label: isoform X3
- UniProtKB: A0A0D9R1X1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037845635   ⟸   XM_037989707
- Peptide Label: isoform X2
- UniProtKB: A0A0D9R1X1 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000006319 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000004356.1 UniProtKB/TrEMBL
Gene3D-CATH 2.30.29.30 UniProtKB/TrEMBL
  3.30.505.10 UniProtKB/TrEMBL
  6.10.140.110 UniProtKB/TrEMBL
InterPro PH-like_dom_sf UniProtKB/TrEMBL
  PH_domain UniProtKB/TrEMBL
  Phe_ZIP UniProtKB/TrEMBL
  Phe_ZIP_sf UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/TrEMBL
  SH2B UniProtKB/TrEMBL
  SH2B1_SH2 UniProtKB/TrEMBL
NCBI Gene SH2B1 ENTREZGENE
PANTHER PTHR10872 UniProtKB/TrEMBL
  PTHR10872:SF3 UniProtKB/TrEMBL
Pfam PF00169 UniProtKB/TrEMBL
  Phe_ZIP UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
PRINTS SH2DOMAIN UniProtKB/TrEMBL
PROSITE SH2 UniProtKB/TrEMBL
SMART SH2 UniProtKB/TrEMBL
  SM00233 UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
  SSF109805 UniProtKB/TrEMBL
  SSF55550 UniProtKB/TrEMBL
UniProt A0A0D9R1X1 ENTREZGENE, UniProtKB/TrEMBL