ANO5 (anoctamin 5) - Rat Genome Database

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Gene: ANO5 (anoctamin 5) Chlorocebus sabaeus
Analyze
Symbol: ANO5
Name: anoctamin 5
RGD ID: 18668492
Description: ENCODES a protein that exhibits intracellularly calcium-gated chloride channel activity (ortholog); phospholipid scramblase activity (ortholog); INVOLVED IN chloride transport (ortholog); plasma membrane repair (ortholog); ASSOCIATED WITH autosomal recessive limb-girdle muscular dystrophy (ortholog); autosomal recessive limb-girdle muscular dystrophy type 2L (ortholog); COVID-19 (ortholog); FOUND IN vesicle (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: anoctamin-5
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1142,722,072 - 42,823,340 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl142,722,015 - 42,822,374 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038140,032,681 - 140,132,071 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
ANO5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1142,722,072 - 42,823,340 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl142,722,015 - 42,822,374 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038140,032,681 - 140,132,071 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
ANO5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381122,192,473 - 22,283,357 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1121,782,659 - 22,283,567 (+)EnsemblGRCh38hg38GRCh38
GRCh371122,214,631 - 22,304,903 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361122,171,298 - 22,257,975 (+)NCBINCBI36Build 36hg18NCBI36
Build 341122,171,297 - 22,257,975NCBI
Celera1122,346,769 - 22,437,966 (+)NCBICelera
Cytogenetic Map11p14.3NCBI
HuRef1121,897,150 - 21,988,511 (+)NCBIHuRef
CHM1_11122,214,324 - 22,304,648 (+)NCBICHM1_1
T2T-CHM13v2.01122,313,008 - 22,403,882 (+)NCBIT2T-CHM13v2.0
Ano5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39751,160,668 - 51,248,459 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl751,160,777 - 51,248,457 (+)EnsemblGRCm39 Ensembl
GRCm38751,510,007 - 51,598,707 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl751,511,029 - 51,598,709 (+)EnsemblGRCm38mm10GRCm38
MGSCv37758,766,399 - 58,854,079 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36751,379,048 - 51,466,728 (+)NCBIMGSCv36mm8
Celera748,889,506 - 48,979,118 (+)NCBICelera
Cytogenetic Map7B4NCBI
cM Map732.76NCBI
Ano5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81110,222,411 - 110,323,505 (+)NCBIGRCr8
mRatBN7.21101,086,490 - 101,187,547 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1101,087,341 - 101,187,555 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01106,873,580 - 106,971,769 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1106,896,790 - 106,968,885 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01107,915,458 - 108,013,421 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41101,298,300 - 101,341,709 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera195,261,635 - 95,360,097 (+)NCBICelera
Cytogenetic Map1q22NCBI
Ano5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554762,694,258 - 2,779,304 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554762,705,596 - 2,777,848 (+)NCBIChiLan1.0ChiLan1.0
ANO5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2924,478,884 - 24,572,951 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11124,438,258 - 24,532,291 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01122,201,694 - 22,295,781 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11122,112,466 - 22,203,925 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1122,112,482 - 22,206,637 (+)Ensemblpanpan1.1panPan2
ANO5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12143,903,422 - 43,986,778 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2143,903,537 - 43,984,822 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2143,389,226 - 43,459,917 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02145,009,529 - 45,104,081 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2145,009,540 - 45,102,880 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12144,030,402 - 44,101,274 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02144,203,022 - 44,273,728 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02144,595,596 - 44,666,444 (+)NCBIUU_Cfam_GSD_1.0
Ano5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494740,949,492 - 41,035,567 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366542,891,013 - 2,977,551 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366542,891,019 - 2,976,465 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ANO5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl237,171,412 - 37,255,489 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1237,171,402 - 37,256,204 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2240,382,286 - 40,466,462 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Ano5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476613,224,295 - 13,294,968 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476613,220,250 - 13,301,447 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 1 38
Low 32 10 22
Below cutoff 3 8

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000003210   ⟹   ENSCSAP00000001488
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl142,722,015 - 42,822,374 (-)Ensembl
RefSeq Acc Id: XM_008004181   ⟹   XP_008002372
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1142,722,072 - 42,822,436 (-)NCBI
Vero_WHO_p1.0NW_023666038140,032,681 - 140,132,031 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008004186   ⟹   XP_008002377
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1142,725,406 - 42,822,436 (-)NCBI
Vero_WHO_p1.0NW_023666038140,035,485 - 140,132,031 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008004206   ⟹   XP_008002397
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1142,725,406 - 42,823,340 (-)NCBI
Vero_WHO_p1.0NW_023666038140,035,485 - 140,132,071 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008004212   ⟹   XP_008002403
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1142,725,406 - 42,823,340 (-)NCBI
Vero_WHO_p1.0NW_023666038140,035,485 - 140,132,060 (-)NCBI
Sequence:
RefSeq Acc Id: XM_037999570   ⟹   XP_037855498
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_023666038140,035,485 - 140,132,031 (-)NCBI
RefSeq Acc Id: XM_037999571   ⟹   XP_037855499
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_023666038140,035,485 - 140,132,031 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_008002372   ⟸   XM_008004181
- Peptide Label: isoform X1
RefSeq Acc Id: XP_008002403   ⟸   XM_008004212
- Peptide Label: isoform X6
- UniProtKB: A0A0D9QYP9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_008002397   ⟸   XM_008004206
- Peptide Label: isoform X5
- UniProtKB: A0A0D9QYP9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_008002377   ⟸   XM_008004186
- Peptide Label: isoform X2
RefSeq Acc Id: ENSCSAP00000001488   ⟸   ENSCSAT00000003210
RefSeq Acc Id: XP_037855499   ⟸   XM_037999571
- Peptide Label: isoform X4
RefSeq Acc Id: XP_037855498   ⟸   XM_037999570
- Peptide Label: isoform X3


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000005168 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000003210.1 UniProtKB/TrEMBL
InterPro Anoct_dimer UniProtKB/TrEMBL
  Anoctamin UniProtKB/TrEMBL
  Anoctamin_TM UniProtKB/TrEMBL
NCBI Gene ANO5 ENTREZGENE
PANTHER PTHR12308 UniProtKB/TrEMBL
  PTHR12308:SF23 UniProtKB/TrEMBL
Pfam Anoct_dimer UniProtKB/TrEMBL
  Anoctamin UniProtKB/TrEMBL
UniProt A0A0D9QYP9 ENTREZGENE, UniProtKB/TrEMBL