KCNK18 (potassium two pore domain channel subfamily K member 18) - Rat Genome Database

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Gene: KCNK18 (potassium two pore domain channel subfamily K member 18) Chlorocebus sabaeus
Analyze
Symbol: KCNK18
Name: potassium two pore domain channel subfamily K member 18
RGD ID: 18666606
Description: ENCODES a protein that exhibits calcium-activated potassium channel activity (ortholog); INVOLVED IN cellular response to pH (ortholog); potassium ion export across plasma membrane (ortholog); potassium ion transmembrane transport (ortholog); ASSOCIATED WITH genetic disease (ortholog); migraine (ortholog); FOUND IN plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: potassium channel subfamily K member 18
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.19109,994,379 - 110,009,295 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl9109,995,843 - 110,008,739 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604871,252,146 - 71,266,091 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
KCNK18
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.19109,994,379 - 110,009,295 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl9109,995,843 - 110,008,739 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604871,252,146 - 71,266,091 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
KCNK18
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810117,197,489 - 117,210,299 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl10117,197,489 - 117,210,299 (+)EnsemblGRCh38hg38GRCh38
GRCh3710118,957,000 - 118,969,810 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610118,946,990 - 118,959,800 (+)NCBINCBI36Build 36hg18NCBI36
Build 3410118,946,989 - 118,959,800NCBI
Celera10112,687,102 - 112,699,920 (+)NCBICelera
Cytogenetic Map10q25.3NCBI
HuRef10112,584,507 - 112,597,305 (+)NCBIHuRef
CHM1_110119,241,229 - 119,254,016 (+)NCBICHM1_1
T2T-CHM13v2.010118,091,991 - 118,104,789 (+)NCBIT2T-CHM13v2.0
Kcnk18
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391959,208,080 - 59,225,802 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1959,207,646 - 59,225,806 (+)EnsemblGRCm39 Ensembl
GRCm381959,219,648 - 59,237,370 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1959,219,214 - 59,237,374 (+)EnsemblGRCm38mm10GRCm38
MGSCv371959,294,138 - 59,311,860 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361959,272,898 - 59,290,620 (+)NCBIMGSCv36mm8
Celera1961,420,573 - 61,435,885 (+)NCBICelera
Cytogenetic Map19D3NCBI
cM Map1954.63NCBI
Kcnk18
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81268,360,738 - 268,375,012 (+)NCBIGRCr8
mRatBN7.21258,374,671 - 258,388,945 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1258,374,671 - 258,388,945 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1266,580,176 - 266,594,492 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01273,286,195 - 273,300,505 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01265,927,693 - 265,941,666 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01280,383,579 - 280,397,784 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1280,383,579 - 280,397,784 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01287,744,272 - 287,758,268 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41265,749,192 - 265,764,641 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11265,960,270 - 265,975,609 (+)NCBI
Celera1254,028,695 - 254,042,550 (+)NCBICelera
Cytogenetic Map1q55NCBI
Kcnk18
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495543121,916,587 - 21,927,346 (+)NCBIChiLan1.0ChiLan1.0
KCNK18
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28129,063,298 - 129,082,154 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110129,068,636 - 129,086,687 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v010113,775,944 - 113,792,520 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.110117,206,815 - 117,219,701 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10117,206,815 - 117,219,701 (+)Ensemblpanpan1.1panPan2
KCNK18
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12827,694,532 - 27,707,607 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2827,694,532 - 27,706,453 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2827,838,011 - 27,851,088 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02828,224,259 - 28,237,339 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2828,224,259 - 28,236,185 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12827,785,267 - 27,798,331 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02827,798,855 - 27,810,744 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02827,993,454 - 28,006,542 (+)NCBIUU_Cfam_GSD_1.0
Kcnk18
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721318,508,340 - 18,519,675 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049364867,041,623 - 7,075,224 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNK18
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.114127,323,291 - 127,335,320 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214138,724,648 - 138,736,336 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Kcnk18
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473729,414,733 - 29,425,855 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium
Low 8 12 11
Below cutoff 12 5 43

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_007964221 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JACDXN010000016 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSCSAT00000002837   ⟹   ENSCSAP00000001131
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl9109,995,843 - 110,008,739 (+)Ensembl
RefSeq Acc Id: XM_007964221   ⟹   XP_007962412
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.19109,994,379 - 110,009,295 (+)NCBI
Vero_WHO_p1.0NW_02366604871,252,146 - 71,266,091 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_007962412 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000001131.1
RefSeq Acc Id: XP_007962412   ⟸   XM_007964221
- UniProtKB: A0A0D9QXP2 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000001131   ⟸   ENSCSAT00000002837


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000004806 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000002837.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.70 UniProtKB/TrEMBL
InterPro 2pore_dom_K_chnl UniProtKB/TrEMBL
  K_chnl_dom UniProtKB/TrEMBL
NCBI Gene KCNK18 ENTREZGENE
PANTHER POTASSIUM CHANNEL SUBFAMILY K MEMBER 18 UniProtKB/TrEMBL
  PTHR11003 UniProtKB/TrEMBL
Pfam Ion_trans_2 UniProtKB/TrEMBL
PRINTS 2POREKCHANEL UniProtKB/TrEMBL
Superfamily-SCOP Voltage-gated potassium channels UniProtKB/TrEMBL
UniProt A0A0D9QXP2 ENTREZGENE, UniProtKB/TrEMBL