GLUD1 (glutamate dehydrogenase 1) - Rat Genome Database

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Gene: GLUD1 (glutamate dehydrogenase 1) Chlorocebus sabaeus
Analyze
Symbol: GLUD1
Name: glutamate dehydrogenase 1
RGD ID: 18663616
Description: ENCODES a protein that exhibits enzyme binding (ortholog); glutamate dehydrogenase (NAD+) activity (ortholog); INVOLVED IN cerebellum development (ortholog); long-term memory (ortholog); positive regulation of insulin secretion (ortholog); PARTICIPATES IN 2-hydroxyglutaric aciduria pathway; AGAT deficiency pathway; arginine and proline metabolic pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); brain ischemia (ortholog); Canavan disease (ortholog); FOUND IN cytoplasm (inferred); endoplasmic reticulum (inferred); mitochondrial matrix (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: glutamate dehydrogenase 1, mitochondrial
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1944,653,044 - 44,690,142 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl944,653,289 - 44,688,954 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660484,464,625 - 4,502,426 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:15378063   PMID:30032202  


Genomics

Comparative Map Data
GLUD1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1944,653,044 - 44,690,142 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl944,653,289 - 44,688,954 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660484,464,625 - 4,502,426 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
GLUD1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381087,050,202 - 87,094,843 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1087,050,202 - 87,094,843 (-)EnsemblGRCh38hg38GRCh38
GRCh371088,809,959 - 88,854,600 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361088,800,223 - 88,844,603 (-)NCBINCBI36Build 36hg18NCBI36
Build 341088,800,224 - 88,844,603NCBI
Celera1082,812,987 - 82,857,799 (-)NCBICelera
Cytogenetic Map10q23.2NCBI
HuRef1082,663,600 - 82,708,547 (-)NCBIHuRef
CHM1_11089,091,700 - 89,136,514 (-)NCBICHM1_1
T2T-CHM13v2.01087,933,838 - 87,978,476 (-)NCBIT2T-CHM13v2.0
Glud1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391434,032,684 - 34,066,990 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1434,032,684 - 34,067,222 (+)EnsemblGRCm39 Ensembl
GRCm381434,310,727 - 34,345,033 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1434,310,727 - 34,345,265 (+)EnsemblGRCm38mm10GRCm38
MGSCv371435,123,913 - 35,158,219 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361433,139,843 - 33,173,999 (+)NCBIMGSCv36mm8
Celera1430,576,519 - 30,610,613 (+)NCBICelera
Cytogenetic Map14BNCBI
cM Map1420.8NCBI
Glud1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8169,646,569 - 9,680,215 (+)NCBIGRCr8
mRatBN7.2169,640,312 - 9,673,961 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl169,640,312 - 9,673,957 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx169,661,045 - 9,694,118 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01610,805,759 - 10,838,834 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0169,656,127 - 9,689,198 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01610,661,486 - 10,695,557 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1610,662,021 - 10,695,557 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0168,980,352 - 9,014,005 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4169,965,718 - 9,999,254 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1169,965,715 - 9,999,248 (+)NCBI
Celera165,542,860 - 5,576,454 (-)NCBICelera
Cytogenetic Map16p15NCBI
Glud1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555105,987,811 - 6,021,001 (-)NCBIChiLan1.0ChiLan1.0
GLUD1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2899,065,241 - 99,107,679 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11099,070,556 - 99,112,996 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01083,498,338 - 83,540,730 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
GLUD1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1434,629,046 - 34,662,711 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha434,620,536 - 34,654,550 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0434,989,453 - 35,023,479 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1434,834,668 - 34,868,716 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0435,003,687 - 35,037,703 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0435,510,039 - 35,544,117 (-)NCBIUU_Cfam_GSD_1.0
Glud1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721343,783,257 - 43,803,587 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049366015,415,857 - 5,435,964 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GLUD1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1487,968,850 - 88,005,520 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11487,968,850 - 88,005,375 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21495,361,081 - 95,397,604 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Glud1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624841133,267 - 171,324 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 36 20 60
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000007811   ⟹   ENSCSAP00000005979
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl944,653,289 - 44,688,954 (+)Ensembl
RefSeq Acc Id: XM_007962672   ⟹   XP_007960863
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1944,653,044 - 44,690,142 (+)NCBI
Vero_WHO_p1.0NW_0236660484,464,625 - 4,502,426 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_007960863 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAU11837 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000005979
  ENSCSAP00000005979.1
Reference Protein Sequences
RefSeq Acc Id: XP_007960863   ⟸   XM_007962672
- UniProtKB: A0A0D9RBJ0 (UniProtKB/TrEMBL),   Q64H33 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000005979   ⟸   ENSCSAT00000007811


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000009827 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000007811.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.140 UniProtKB/TrEMBL
  Leucine Dehydrogenase, chain A, domain 1 UniProtKB/TrEMBL
  NAD(P)-binding Rossmann-like Domain UniProtKB/TrEMBL
InterPro Aminiacid_DH-like_N_sf UniProtKB/TrEMBL
  Glu/Leu/Phe/Val_DH UniProtKB/TrEMBL
  Glu/Leu/Phe/Val_DH_AS UniProtKB/TrEMBL
  Glu/Leu/Phe/Val_DH_C UniProtKB/TrEMBL
  Glu/Leu/Phe/Val_DH_dimer_dom UniProtKB/TrEMBL
  Glu_DH UniProtKB/TrEMBL
  NAD(P)-bd_dom_sf UniProtKB/TrEMBL
  NAD_bind_Glu_DH UniProtKB/TrEMBL
KEGG Report csab:103215860 UniProtKB/TrEMBL
NCBI Gene GLUD1 ENTREZGENE
PANTHER GLUTAMATE DEHYDROGENASE UniProtKB/TrEMBL
  GLUTAMATE DEHYDROGENASE 1, MITOCHONDRIAL UniProtKB/TrEMBL
Pfam ELFV_dehydrog UniProtKB/TrEMBL
  ELFV_dehydrog_N UniProtKB/TrEMBL
PIRSF Glu_DH UniProtKB/TrEMBL
PRINTS GLFDHDRGNASE UniProtKB/TrEMBL
PROSITE GLFV_DEHYDROGENASE UniProtKB/TrEMBL
SMART ELFV_dehydrog UniProtKB/TrEMBL
Superfamily-SCOP SSF51735 UniProtKB/TrEMBL
  SSF53223 UniProtKB/TrEMBL
UniProt A0A0D9RBJ0 ENTREZGENE, UniProtKB/TrEMBL
  Q64H33 ENTREZGENE, UniProtKB/TrEMBL