GATM (glycine amidinotransferase)

Gene: GATM (glycine amidinotransferase) Chlorocebus sabaeus

Analyze

Symbol:

GATM

Name:

glycine amidinotransferase

RGD ID:

18660988

Description:

ENCODES a protein that exhibits amidinotransferase activity (ortholog); glycine amidinotransferase activity (ortholog); INVOLVED IN creatine biosynthetic process (ortholog); embryonic liver development (ortholog); kidney development (ortholog); PARTICIPATES IN AGAT deficiency pathway; arginine and proline metabolic pathway; creatine metabolic pathway; ASSOCIATED WITH abdominal aortic aneurysm (ortholog); acute kidney failure (ortholog); AGAT deficiency (ortholog); FOUND IN cytosol (ortholog); mitochondrial inner membrane (ortholog); mitochondrion (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

glycine amidinotransferase, mitochondrial

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	26	37,836,207 - 37,853,811 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	26	37,836,335 - 37,852,822 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666048	103,208,357 - 103,226,225 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

abdominal aortic aneurysm (ISO)

acute kidney failure (ISO)

AGAT deficiency (ISO)

Animal Mammary Neoplasms (ISO)

Bloom syndrome (ISO)

carcinoma (ISO)

cerebral creatine deficiency syndrome (ISO)

colorectal cancer (ISO)

congestive heart failure (ISO)

Diabetic Nephropathies (ISO)

epilepsy (ISO)

Experimental Mammary Neoplasms (ISO)

Fanconi renotubular syndrome 1 (ISO)

Fanconi syndrome (ISO)

genetic disease (ISO)

intellectual disability (ISO)

kidney disease (ISO)

Lennox-Gastaut syndrome (ISO)

myocardial infarction (ISO)

Myocardial Ischemia (ISO)

Necrosis (ISO)

nephrotoxicity (ISO)

pre-eclampsia (ISO)

transient cerebral ischemia (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

creatine biosynthetic process (IEA,ISO)

creatine metabolic process (IEA)

embryonic liver development (ISO)

kidney development (ISO)

learning or memory (IEA)

muscle atrophy (IEA)

positive regulation of cold-induced thermogenesis (IEA)

response to mercury ion (ISO)

response to nutrient (ISO)

response to organic substance (ISO)

response to oxidative stress (ISO)

response to peptide hormone (ISO)

tissue regeneration (ISO)

Cellular Component

cytosol (ISO)

mitochondrial inner membrane (IEA,ISO)

mitochondrial intermembrane space (IEA)

mitochondrion (IEA,ISO)

Molecular Function

amidinotransferase activity (IEA,ISO)

glycine amidinotransferase activity (IEA,ISO)

protein binding (ISO)

transferase activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

AGAT deficiency pathway (ISO)

arginine and proline metabolic pathway (ISO)

creatine metabolic pathway (ISO)

dihydropyrimidine dehydrogenase deficiency pathway (ISO)

dimethylglycine dehydrogenase deficiency pathway (ISO)

guanidinoacetate methyltransferase deficiency pathway (ISO)

gyrate atrophy pathway (ISO)

hyperprolinemia type I pathway (ISO)

hyperprolinemia type II pathway (ISO)

nonketotic hyperglycinemia pathway (ISO)

ornithine translocase deficiency pathway (ISO)

prolidase deficiency pathway (ISO)

sarcosinemia pathway (ISO)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

GATM
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	26	37,836,207 - 37,853,811 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	26	37,836,335 - 37,852,822 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666048	103,208,357 - 103,226,225 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

GATM
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	15	45,361,124 - 45,402,227 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	15	45,361,124 - 45,402,327 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	15	45,653,322 - 45,694,425 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	15	43,440,614 - 43,458,272 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	15	43,440,613 - 43,457,998	NCBI
Celera	15	22,544,733 - 22,562,401 (-)	NCBI		Celera
Cytogenetic Map	15	q21.1	NCBI
HuRef	15	22,477,507 - 22,495,086 (-)	NCBI		HuRef
CHM1_1	15	45,771,808 - 45,789,455 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	15	43,169,297 - 43,210,402 (-)	NCBI		T2T-CHM13v2.0

Gatm
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	122,424,954 - 122,441,758 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	122,424,948 - 122,441,784 (-)	Ensembl		GRCm39 Ensembl
GRCm38	2	122,594,473 - 122,611,277 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	122,594,467 - 122,611,303 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	122,420,209 - 122,437,013 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	122,285,913 - 122,302,703 (-)	NCBI		MGSCv36	mm8
Celera	2	123,756,992 - 123,773,746 (-)	NCBI		Celera
Cytogenetic Map	2	E5	NCBI
cM Map	2	60.63	NCBI

Gatm
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	130,112,508 - 130,137,664 (-)	NCBI		GRCr8
mRatBN7.2	3	109,658,919 - 109,675,508 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	109,658,951 - 109,684,129 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	113,555,275 - 113,571,827 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	122,150,802 - 122,167,354 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	119,811,184 - 119,827,736 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	114,711,570 - 114,728,155 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	114,711,562 - 114,728,410 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	121,249,707 - 121,266,292 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	109,558,043 - 109,565,432 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	109,463,621 - 109,470,996 (-)	NCBI
Celera	3	108,536,141 - 108,553,426 (-)	NCBI		Celera
RH 3.4 Map	3	965.7	RGD
Cytogenetic Map	3	q35	NCBI

Gatm
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955409	8,068,476 - 8,084,603 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955409	8,068,524 - 8,084,603 (+)	NCBI	ChiLan1.0	ChiLan1.0

GATM
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	16	34,601,733 - 34,619,192 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	15	38,778,402 - 38,795,861 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	15	24,309,045 - 24,326,673 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	15	42,639,597 - 42,657,209 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	15	42,639,597 - 42,657,209 (-)	Ensembl	panpan1.1		panPan2

GATM
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	30	11,724,446 - 11,742,214 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	30	11,723,519 - 11,742,214 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
ROS_Cfam_1.0	30	11,861,543 - 11,879,299 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	30	11,859,577 - 11,879,307 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	30	11,782,971 - 11,800,732 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	30	11,889,472 - 11,907,009 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	30	12,009,534 - 12,027,312 (-)	NCBI		UU_Cfam_GSD_1.0

Gatm
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	90,169,547 - 90,184,640 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936471	8,017,603 - 8,032,703 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936471	8,017,611 - 8,032,703 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GATM
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	126,361,945 - 126,380,871 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	126,361,968 - 126,378,705 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	140,845,025 - 140,861,764 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Gatm
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624731	13,941,049 - 13,955,461 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624731	13,941,084 - 13,954,910 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	endocrine system	hemolymphoid system	nervous system
High
Medium	20	2	60
Low	16	18
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_008016757	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000016	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCSAT00000008356 ⟹ ENSCSAP00000006505

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	26	37,836,335 - 37,852,822 (+)	Ensembl

RefSeq Acc Id:

XM_008016757 ⟹ XP_008014948

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	26	37,836,207 - 37,853,811 (+)	NCBI
Vero_WHO_p1.0	NW_023666048	103,208,357 - 103,226,225 (-)	NCBI

Sequence:

show sequence

GGGGCGCTCTGCCGGCCCCACCACCTGTTCCCGGCAGCCAATGGGGCCGCGGGGGGCGGCCGGG
GCGGAGCGCGGCTACAAAAGGCCGCGGGCCCAGCGCACCCGCCCATCACGCTCCGGGCGCGCTT
TCGGGGAGGCTTGGACCGACGCGGCCCAGNGGCCAGGAACATTCCGTGCGTGGACCAGCCGGGC
CGGGGCGATGCTGCGGGTGCGGTGTCTGCGCGGCGGGAGCCGCGGCGCCGACGCGGTGCACTAC
ATCGGGTCTCGGCTTGGACGAACCTTGACGGGATGGGTGCAGCGAACTTTCCAGAGCACCCAGG
CAGCTACGGCTTCCTCCCGGAACTCCTTTGCAGCTGACGACAAGGCCACTGAACCTCTGCCCAA
GGACTGCCCTGTCTCTTCTTACAACGAATGGGACCCCTTAGAGGAAGTGATAGTGGGCAGAGCA
GAAAACGCCTGTGTTCCGCCGTTCACCATCGAGGTGAAGGCCAACACATATGAAAAGTACTGGC
CATTTTACCAGAAGCATGGAGGGCATTATTTTCCCAAAGATCATTTGAAAAAGGCTGTTACTGA
AATTGAAGAAATGTGCAATATTTTAAAAATGGAAGGAGTGACAGTGAGGAGGCCTGACCCCATT
GACTGGTCATTGAAGTATAAAACTCCTGATTTTGAGTCTACGGGTTTATACAGTGCAATGCCTC
GAGACATCCTGATAGTTGTGGGCAATGAGATTATCGAGGCTCCCATGGCATGGCGTTCACGCTT
CTTTGAGTACCGAGCGTACAGGTCAATTATCAAAGACTACTTCCACCGTGGCGCCAAGTGGACA
ACAGCTCCTAAGCCCACAATGGCTGATGAGCTTTATGACCGGGATTATCCCATCCACTCTGTAG
AAGACAGACACAAATTGGCTGCTCAGGGAAAATTTGTGACAACTGAGTTTGAGCCATGCTTTGA
TGCTGCTGACTTCATTCGAGCTGGAAAAGATATTTTTGCACAGAGAAGCCAGGTTACAAACTAC
CTAGGCATTGAATGGATGCGTAGGCATCTTGCTCCAGATTACAGAGTACATATCATCTCCTTTA
AAGATCCCAATCCCATGCATATTGATGCTACTTTCAACATCATTGGACCTGGTACTGTGCTTTC
CAACCCTGACCGACCATGTCACCAGATTGATCTTTTCAAGAAAGCAGGATGGACTATCATTACT
CCTCCAACACCAATTATCCCAGACGATCATCCACTCTGGATGTCATCCAAATGGCTTTCCATGA
ATGTCTTAATGCTAGATGAAAAACGTGTTATGGTGGATGCCAATGAAGTTCCAACTCAAAAGAT
GTTTGAAAAGCTGGGTATCACTACCATTAAAGTTAACATTCGTAATGCCAATTCCCTGGGAGGA
GGCTTCCACTGCTGGACCTGCGATGTCCGGCGCCGAGGCACCCTACAGTCCTACTTGGACTGAA
CAGGCCTGATGGAGCTTGTGGCTGGCCTCAGATACACCTAAGAAGCTTAGGGGCAAGGTTCATT
ATCCTGCTTTGAAAAGTGCATGAACTGTAGTGCTTTAAACAATCATCTCCTTAACAGGGGTAGT
AAGCCTGGTTTGCTTCTATTACTTTTCTTTGACATAAAGAAAATAACTTCTGCTAGGTATTACT
CTCTACTCCTAAAGTTATTTACTATTTGGCTTCAAGTATAAAATTTTGGCGAATGTGTACCAAG
ACAAAAGTTAGTCACCTGAGTAACTTGGCCACTAATAATTAACCATCTACCTCTGTTTTTAATT
TTCTTTCCAAAAGGCAGCTTGAAATGTTGGTCCTAATCTTAATTTTTTTTTCCTTTTCTATAGA
CTTGAGAATGTTTTTCTCTAAATGAGAGAAAGACTTAGAATGTACACAGATCCTAAATAGAATC
AGATAATCTCTTTTTTTATAAAGGAGAGAAAGACTTAGAACATACACGGATCCTAAGTAGAACC
AGGTAATTGCCTCTTTTCCTAATAAGGAATTTGGGTAATTTTTAATTTTTTGTTTTTTAAAAAG
TAACCTAGACTATGCAAAACATCAAAGTGAATTTTCCATGAATGTTTTTAATATTCTCATCTCA
ACATTGTGATATATGCTACTAAAAACCTTTTCATATACATCTTACCTCATTTCAAGTGAATTAT
TTTAATCTTTTCCTTTCTTTCCAAAAATTTACAGGAATGTTGAGTGTAATTGGATTTCGCTATC
AGTTCCCATCCTTAAGTTTTGATATTCAATATCTGATAGATATACTGCATCTTTGGTAATCTAA
GATTTGTTTACAAATGTGCAAATTATTTAGAGCATAGACTTTATAAGCATTAAAAAAAACTAAT
GGAGGTAAAACCTATATGCGTTGTGAAATAATTTTAGTGTTGATACTGTATGTGTATTTTTATT
CTAATAAACTTTTGTGTTCCAGACTGAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_008014948	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000006505.1

RefSeq Acc Id:	XP_008014948 ⟸ XM_008016757
- UniProtKB:	A0A0D9RD16 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSCSAP00000006505 ⟸ ENSCSAT00000008356

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000010274	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000008356.1	UniProtKB/TrEMBL
InterPro	AmidinoTrfase	UniProtKB/TrEMBL
NCBI Gene	GATM	ENTREZGENE
PANTHER	GLYCINE AMIDINOTRANSFERASE, MITOCHONDRIAL	UniProtKB/TrEMBL
	PTHR10488	UniProtKB/TrEMBL
Superfamily-SCOP	Pentein	UniProtKB/TrEMBL
UniProt	A0A0D9RD16	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB