ISYNA1 (inositol-3-phosphate synthase 1)

Gene: ISYNA1 (inositol-3-phosphate synthase 1) Chlorocebus sabaeus

Analyze

Symbol:

ISYNA1

Name:

inositol-3-phosphate synthase 1

RGD ID:

18650640

Description:

ENCODES a protein that exhibits inositol-3-phosphate synthase activity (ortholog); INVOLVED IN negative regulation of inositol biosynthetic process (ortholog); PARTICIPATES IN inositol metabolic pathway; inositol phosphate metabolic pathway; ASSOCIATED WITH adenoid cystic carcinoma (ortholog); Experimental Liver Cirrhosis (ortholog); genetic disease (ortholog); FOUND IN cytoplasm (inferred)

Type:

protein-coding

RefSeq Status:

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	16,906,724 - 16,910,194 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	6	16,905,472 - 16,910,030 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666074	2,431,203 - 2,435,020 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

adenoid cystic carcinoma (ISO)

Experimental Liver Cirrhosis (ISO)

genetic disease (ISO)

Megalencephaly-Polymicrogyria-Polydactyly-Hydrocephalus Syndrome 1 (ISO)

polycystic ovary syndrome (ISO)

Salivary Gland Neoplasms (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

inositol biosynthetic process (IEA)

lipid metabolic process (IEA)

negative regulation of inositol biosynthetic process (ISO)

phospholipid biosynthetic process (IEA)

Cellular Component

cytoplasm (IEA)

Molecular Function

inositol-3-phosphate synthase activity (IEA,ISO)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

inositol metabolic pathway (ISO)

inositol phosphate metabolic pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

ISYNA1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	16,906,724 - 16,910,194 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	6	16,905,472 - 16,910,030 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666074	2,431,203 - 2,435,020 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

ISYNA1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	18,434,388 - 18,438,133 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	18,434,388 - 18,438,167 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	19	18,545,198 - 18,548,943 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	18,406,625 - 18,409,943 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	19	18,447,020 - 18,450,933 (-)	NCBI		Celera
Cytogenetic Map	19	p13.11	NCBI
HuRef	19	18,108,499 - 18,112,412 (-)	NCBI		HuRef
CHM1_1	19	18,545,346 - 18,549,259 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	19	18,568,567 - 18,572,312 (-)	NCBI		T2T-CHM13v2.0

Isyna1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	71,047,131 - 71,049,940 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	8	71,047,023 - 71,049,940 (+)	Ensembl		GRCm39 Ensembl
GRCm38	8	70,594,481 - 70,597,290 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	70,594,373 - 70,597,290 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	8	73,118,380 - 73,121,189 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	8	73,523,470 - 73,526,279 (+)	NCBI		MGSCv36	mm8
Celera	8	73,150,596 - 73,153,405 (+)	NCBI		Celera
Cytogenetic Map	8	B3.3	NCBI
cM Map	8	34.15	NCBI

Isyna1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	16	18,873,119 - 18,876,116 (-)	NCBI		GRCr8
mRatBN7.2	16	18,839,143 - 18,841,979 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	16	18,839,145 - 18,841,979 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	16	18,880,839 - 18,883,671 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	16	20,013,623 - 20,016,455 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	16	18,933,801 - 18,936,633 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	16	20,589,497 - 20,592,333 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	16	20,589,481 - 20,592,449 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	16	20,445,206 - 20,448,042 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	16	19,345,305 - 19,348,141 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	16	19,345,311 - 19,348,054 (-)	NCBI
Celera	16	19,030,610 - 19,033,446 (-)	NCBI		Celera
Cytogenetic Map	16	p14	NCBI

Isyna1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955524	3,098,995 - 3,100,454 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955524	3,099,017 - 3,100,454 (+)	NCBI	ChiLan1.0	ChiLan1.0

ISYNA1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	20	23,295,288 - 23,299,230 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	19	22,303,623 - 22,307,529 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	17,913,400 - 17,916,789 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	19	18,884,406 - 18,887,931 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	19	18,884,412 - 18,887,931 (-)	Ensembl	panpan1.1		panPan2

ISYNA1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	44,594,816 - 44,598,495 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	20	44,489,219 - 44,598,497 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	44,509,230 - 44,512,910 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	45,080,806 - 45,084,487 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	20	44,999,052 - 45,085,082 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	20	44,318,111 - 44,321,783 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	20	44,728,243 - 44,731,923 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	45,003,669 - 45,007,342 (+)	NCBI		UU_Cfam_GSD_1.0

Isyna1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	203,266,570 - 203,269,890 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936596	2,815,821 - 2,819,020 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936596	2,815,782 - 2,819,100 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ISYNA1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	59,363,716 - 59,367,002 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	59,363,672 - 59,367,003 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

Isyna1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624908	1,658,512 - 1,661,640 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624908	1,658,512 - 1,661,507 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	endocrine system	hemolymphoid system	nervous system
High
Medium
Low	36	10	60
Below cutoff		10

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_007995805	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_037992436	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000042	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCSAT00000003382 ⟹ ENSCSAP00000001660

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	6	16,905,472 - 16,910,030 (-)	Ensembl

RefSeq Acc Id:

XM_007995805 ⟹ XP_007993996

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	6	16,906,724 - 16,910,194 (-)	NCBI
Vero_WHO_p1.0	NW_023666074	2,431,203 - 2,435,020 (+)	NCBI

Sequence:

show sequence

TGCCAGACGAGGACCCGATGGCCACGATGGCTCTGAGTTGTCGGGCCTCGAACCGGGTCTCCAG
ACATTGGGCCCCTCCCCCCCAACGCGGGAGAGGCGGGGAAGGGGGCGGGGCGGGGGCGGGGCCG
CAGCGCTTTTCTCCGGAGGTCGCGCGCCCGAGAGCCCGCGCTGTTAGCCACCGCTGCCTGAGTC
GACTCTGCGCCGCCCGCCACGATGGAGGCCGCCGCCCAGTTCTTCGTCGAGAGCCCGGACGTGG
TCTACGGCCCCGAGGCCATCGAGGCGCAATACGAGTACCGGACGACGCGCGTCAGCCGGGAGGG
CGGCGTCCTCAAGGTGCACCCCACGTCCACGCGCTTCACCTTCCGGACCGCCCGGCAGGTGCCC
CGGCTTGGGGTCATGCTTGTCGGCTGGGGCGGGAACAACGGCTCCACACTCACTGCTGCGGTGC
TGGCCAACCGGCTGCGTCTGTCCTGGCCCACGCGCAGCGGCCGCAAGGAGGCCAACTACTACGG
CTCGCTGACTCAGGCAGGCACCGTGAGCCTGGGCCTGGACGCCGAGGGCCAGGAGGTGTTCGTG
CCCTTCAGCGCGCTGCTGCCCATGGTGGCGCCCAACGACCTCGTGTTCGATGGCTGGGACATCT
CGTCGCTGAACCTGGCTGAGGCGATGCGGCGCGCGAAGGTGCTGGATTGGGGGCTGCAGGAGCA
ACTGTGGCCGCACATGGAGGCCCTGCGGCCCCGGCCTTCTGTTTACATACCCGAGTTCATCGCG
GCCAACCAGAGCGCGCGCGCGGACAACCTCATCCCGGGCTCGCGCGCGCAGCAGTTGGAGCAGA
TCCGCAGGGACATCCGAGACTTCCGGTCTAGCGCGGGGCTGGACAAAATCATCGTGCTGTGGAC
GGCGAACACGGAGCGCTTCTGTGAGGTGATTCCAGGCCTCAACGACACAGCCGAGAACCTACTA
CACACCATTGAGCTTGGTCTGGAGGTGTCGCCCTCCACACTCTTCGCCGTGGCCAGCATCCTAG
AGGGCTGTGCCTTCCTCAATGGGTCCCCGCAGAACACCCTGGTGCCCGGAGCCCTTGAGCTCGC
ATGGCAGCGCCGGGTTTTTGTGGGCGGAGATGACTTCAAGTCAGGCCAGACCAAAGTCAAGTCC
GTGCTCGTGGACTTCCTCATTGGCTCCGGCCTCAAGACCATGTCCATCGTGAGTTACAACCACC
TGGGCAACAACGATGGGGAGAACCTGTCGGCGCCATTGCAGTTCCGCTCTAAGGAGGTGTCCAA
AAGCAACGTGGTGGACGACATGGTGCAGAGCAACCCAGTGCTCTATGCGCCCGGCGAGGAGCCT
GACCACTGCGTGGTCATCAAGTATGTGCCATACGTGGGTGACAGCAAGCGCGCGCTGGATGAGT
ATACCTCGGAGCTGATGCTGGGCGGAACCAACACACTGGTGTTGCACAACACATGCGAGGACTC
GCTGCTGGCCGCACCCATCATGCTGGACCTCGCACTGCTGACCGAACTGTGCCAGCGTGTGAGT
TTCTGCACTGACGCCGACCCCGAGCCGCAGACCTTCCACCCCGTGCTATCCCTGCTCAGCTTCC
TCTTCAAGGCGCCACTGGTGCCACCGGGCAGCCCGGTGGTCAATGCGCTTTTCCGCCAGCGCAG
CTGCATCGAGAACATCCTCAGGGCCTGCGTGGGGCTCCCGCCACAGAACCACATGCTACTGGAG
CATAAGATGGAGCGCCCAGGGCCCGTCCTCAAGCGAGTCGGACCCGTGGCTGCTGCCTGCCCTG
TGTTGAACAAGAAAGGACCGGTACCCGCTGCCACCAACGGCTGCACTGGTGATGCCAATGGGCA
TCCGCAAGTGGAGGAACCCCAGATGCCCACCACCTGAGGCCCTGGTCACACAGCTTCCCAGCTG
TTCCTCCCTGCTGCCCCCCAAGACCCCACCTTGCTAGGCCCCCACAAAGACAATAAAGGCGCTG
CCACTCTTAGCCCTCCTTCCACCCAGGGTTCTTGGGGCCTGTGA

hide sequence

RefSeq Acc Id:

XM_037992436 ⟹ XP_037848364

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
Vero_WHO_p1.0	NW_023666074	2,431,203 - 2,435,020 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_007993996	(Get FASTA)	NCBI Sequence Viewer
	XP_037848364	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000001660
	ENSCSAP00000001660.1

RefSeq Acc Id:	XP_007993996 ⟸ XM_007995805
- Peptide Label:	isoform X2
- UniProtKB:	A0A0D9QZ71 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSCSAP00000001660 ⟸ ENSCSAT00000003382

RefSeq Acc Id:	XP_037848364 ⟸ XM_037992436
- Peptide Label:	isoform X1

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000005350	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000003382.1	UniProtKB/TrEMBL
Gene3D-CATH	NAD(P)-binding Rossmann-like Domain	UniProtKB/TrEMBL
InterPro	Myo-inos-1-P_Synthase	UniProtKB/TrEMBL
	Myo-inos-1-P_Synthase_GAPDH	UniProtKB/TrEMBL
	NAD(P)-bd_dom_sf	UniProtKB/TrEMBL
KEGG Report	csab:103234182	UniProtKB/TrEMBL
NCBI Gene	ISYNA1	ENTREZGENE
PANTHER	INOSITOL-3-PHOSPHATE SYNTHASE 1	UniProtKB/TrEMBL
	PTHR11510	UniProtKB/TrEMBL
Pfam	Inos-1-P_synth	UniProtKB/TrEMBL
	NAD_binding_5	UniProtKB/TrEMBL
PIRSF	Myoinos-ppht_syn	UniProtKB/TrEMBL
Superfamily-SCOP	Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain	UniProtKB/TrEMBL
	SSF51735	UniProtKB/TrEMBL
UniProt	A0A0D9QZ71	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

Imported Annotations - SMPDB

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Imported Disease Annotations - CTD

Imported Annotations - SMPDB