NLE1 (notchless homolog 1) - Rat Genome Database

Name: NLE1
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: NLE1 (notchless homolog 1) Chlorocebus sabaeus

Analyze

Symbol:

NLE1

Name:

notchless homolog 1

RGD ID:

18650037

Description:

INVOLVED IN hematopoietic stem cell homeostasis (ortholog); inner cell mass cell differentiation (ortholog); kidney development (ortholog); ASSOCIATED WITH genetic disease (ortholog); Neurodevelopmental Disorders (ortholog); FOUND IN nucleolus (inferred); nucleoplasm (inferred); nucleus (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

notchless protein homolog 1

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	NLE1 (notchless homolog 1)	NCBI	Ortholog
Mus musculus (house mouse):	Nle1 (notchless homolog 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Nle1 (notchless homolog 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Nle1 (notchless homolog 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	NLE1 (notchless homolog 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	NLE1 (notchless homolog 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Nle1 (notchless homolog 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	NLE1 (notchless homolog 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Nle1 (notchless homolog 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	16	28,635,054 - 28,645,527 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	16	28,634,318 - 28,645,355 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666075	1,341,768 - 1,352,943 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

Neurodevelopmental Disorders (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

hematopoietic stem cell homeostasis (IEA,ISO)

inner cell mass cell differentiation (IEA,ISO)

kidney development (IEA,ISO)

mitotic cell cycle (IEA,ISO)

negative regulation of mitotic cell cycle (IEA,ISO)

Notch signaling pathway (IEA,ISO)

positive regulation of canonical Wnt signaling pathway (IEA,ISO)

ribosomal large subunit biogenesis (IEA,ISO)

skeletal system morphogenesis (IEA,ISO)

somitogenesis (IEA,ISO)

Cellular Component

nucleolus (IEA)

nucleoplasm (IEA)

nucleus (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

NLE1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	16	28,635,054 - 28,645,527 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	16	28,634,318 - 28,645,355 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666075	1,341,768 - 1,352,943 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

NLE1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	17	35,128,730 - 35,142,303 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	17	35,128,730 - 35,142,304 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	17	33,455,749 - 33,469,322 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	17	30,482,481 - 30,493,435 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	17	30,368,560 - 30,379,514 (-)	NCBI		Celera
Cytogenetic Map	17	q12	NCBI
HuRef	17	29,643,049 - 29,654,013 (-)	NCBI		HuRef
CHM1_1	17	33,522,727 - 33,533,680 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	17	36,076,643 - 36,090,215 (-)	NCBI		T2T-CHM13v2.0

Nle1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	82,791,594 - 82,799,272 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	82,791,594 - 82,799,237 (-)	Ensembl		GRCm39 Ensembl
GRCm38	11	82,900,768 - 82,908,446 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	82,900,768 - 82,908,411 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	82,714,270 - 82,721,897 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	11	82,716,966 - 82,724,566 (-)	NCBI		MGSCv36	mm8
Celera	11	92,519,883 - 92,532,416 (-)	NCBI		Celera
Cytogenetic Map	11	C	NCBI
cM Map	11	50.3	NCBI

Nle1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	68,331,609 - 68,342,562 (-)	NCBI		GRCr8
mRatBN7.2	10	67,834,059 - 67,844,771 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	67,834,062 - 67,842,658 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	72,454,101 - 72,462,678 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	71,959,482 - 71,968,055 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	67,423,574 - 67,432,130 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	70,250,959 - 70,261,880 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	70,250,959 - 70,259,553 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	69,882,122 - 69,893,084 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	71,117,125 - 71,125,696 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	10	71,130,748 - 71,139,322 (-)	NCBI
Celera	10	66,778,297 - 66,786,868 (-)	NCBI		Celera
Cytogenetic Map	10	q26	NCBI

Nle1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955481	9,821,329 - 9,830,555 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955481	9,821,329 - 9,830,350 (-)	NCBI	ChiLan1.0	ChiLan1.0

NLE1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	19	29,323,620 - 29,334,140 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	17	31,204,592 - 31,215,112 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	17	21,643,865 - 21,654,169 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	17	21,935,800 - 21,946,049 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	17	21,935,800 - 21,946,049 (+)	Ensembl	panpan1.1		panPan2

NLE1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	9	38,222,083 - 38,230,819 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	9	38,222,051 - 38,365,621 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	9	37,445,639 - 37,454,795 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	9	39,033,586 - 39,042,748 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	9	39,033,539 - 39,042,397 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	9	37,817,157 - 37,826,312 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	9	38,102,689 - 38,111,830 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	9	38,190,191 - 38,199,364 (+)	NCBI		UU_Cfam_GSD_1.0

Nle1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	37,223,243 - 37,231,849 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936538	101,047 - 109,873 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936538	101,245 - 109,796 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

NLE1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	12	40,035,547 - 40,044,397 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	12	40,035,518 - 40,044,395 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	12	41,546,660 - 41,555,535 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Nle1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624875	2,998,006 - 3,006,303 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624875	2,997,648 - 3,006,345 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	endocrine system	hemolymphoid system	nervous system
High
Medium			7
Low	36	20	53
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_008011047	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_037992521	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000043	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCSAT00000004346 ⟹ ENSCSAP00000002600

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	16	28,634,318 - 28,645,355 (-)	Ensembl

RefSeq Acc Id:

XM_008011047 ⟹ XP_008009238

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	16	28,635,054 - 28,645,527 (-)	NCBI
Vero_WHO_p1.0	NW_023666075	1,341,769 - 1,352,943 (+)	NCBI

Sequence:

show sequence

CAGAGGGCGATGTGGCCGGCGGCTACCCCGCCCGACCACGGAGATGGCGCTCTGTCTGCCGGGC
TCTTTCTCCTCCACGTGGGTACGCAGGATGGCGGCGGCAGTGGCGGACGAGTCGGTGGCGCGCG
ATGTGCAGCGGTTGCTAGTGCAGTTCCAGGATGAGGGCGGGCAGCTGCTGGGCTCCCCGTTCGA
CGTGCCCGTGGACATCACCCCGGACAGGCTGCAGCTCGTGTGCAACGCGCTACTGGCCCAGGAG
GATCCCCTGCCACTGGCTTTCTTTGTCCACGATGCTGAGATCGTCTCCTCACTGGGGAAGACGT
TGGAGTCCCAGGCAGTGGAGACTGAGAAGGTCCTAGACATCATCTACCAGCCACAGGCTGTCTT
CAGAGTCCGGGCCGTGACTCGCTGCACCAGCTCCTTGGATGGTCACAGTGAGGCAGTCATTTCT
GTGGCCTTCAGCCCCACGGGAAAGTACCTGGCCAGTGGCTCTGGTGACACCACCGTGCGCTTCT
GGGATCTCAGCACAGAGACACCACATTTCATATGCAAGGGACATAGACACTGGGTCCTTAGTAT
ATCGTGGTCTCCAGATGGCAAGAAGCTGGCCTCAGGCTGCAAGAATGGCCAGATTCTCCTCTGG
GACCCAAGCACAGGGAAGCAGGTGGGCAGGACCCTCGCTGGCCACAGCAAGTGGATCACAGGCC
TGAGCTGGGAGCCCCTCCATGCGAACCCGGAGTGCCGCTATGTGGCCAGCAGCTCCAAGGATGG
CAGTGTGCGGATCTGGGACACAACTGCAGGCCGCTGTGAGCGCATCCTCACCGGGCACACCCAG
TCGGTCACCTGTCTCCGGTGGGGAGGGGACGGGCTTCTCTACTCTGCCTCCCAGGACCGCACCA
TCAAAGTCTGGAGGGCTCATGACGGTGTGCTGTGCCGGACTCTGCAAGGCCATGGCCACTGGGT
GAACACCATGGCGCTCAGCACTGATTATGCCCTGCGCACTGGGGCCTTTGAACCTGCTGAGGCC
TCAGTTAATGCCCAAGACCTCCAAGGATCCTTGCAGGAGTTGAAGGAGAGGGCTCTGAGCCGAT
ACAACCTCGTGCGGGGCCAGGGTCCAGAGAGGCTGGTGTCTGGCTCAGATGACTTCACCTTATT
CCTGTGGTCCCCAGCAGAGGACAAAAAGCCTCTCACTCGGATGACAGGACACCAAGCTCTCATC
AACCAGGTGCTCTTCTCTCCTGACTCCCGCATCGTGGCTAGTGCCTCCTTCGACAAGTCCATCA
AGCTGTGGGATGGCAGGACGGGCAAGTACCTGGCTTCCCTACGCGGCCACGTGGCTGCCGTGTA
CCAGATTGCATGGTCAGCTGACAGCCGGCTCCTGGTCAGCGGCAGCAGTGACAGCACACTGAAG
GTGTGGGATGTGAAGGCCCAGAAGCTGGCCATGGACCTGCCTGGCCACGCAGATGAGGTATATG
CTGTTGACTGGAGTCCAGATGGCCAGAGAGTGGCAAGTGGTGGGAAGGACAAATGCCTCCGGAT
ATGGAGGAGATGAGAAGGCCTGCAGTTCTCTCTGACCCCCACCTGGACTGGGCCTCTGCCAGCC
CCCTTTCCTGCCGGAGAACAAAGACTCGGTGGCAGCGCACACACCCTTCCCACCAGTGGGGACC
TGAGAATGCGCATGGCCTGCTGTCCTCGACAGACCCGAGTGGGGTCTTCCCACAGATCTCCTGC
TTGTGGCATACCCCAGAGCCAGAAATCAAAGGTCACAGGAAGTTGTCACCGAACTTGGCCTGTG
TCTGCTACTCTATACCTTACTGGTACAGACGGGGGTGGTGGGCGGCCAGGCTCTGTGAGTGGGC
CGGTAGTGTCAACTCTGTACAGGGTCAGACCCCAGGTTCTATGACCACATAAATAACTTATGTT
TTGTGT

hide sequence

RefSeq Acc Id:

XM_037992521 ⟹ XP_037848449

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
Vero_WHO_p1.0	NW_023666075	1,341,768 - 1,352,943 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_008009238	(Get FASTA)	NCBI Sequence Viewer
	XP_037848449	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000002600
	ENSCSAP00000002600.1

RefSeq Acc Id:	XP_008009238 ⟸ XM_008011047
- Peptide Label:	isoform X1
- UniProtKB:	A0A0D9R1W1 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSCSAP00000002600 ⟸ ENSCSAT00000004346

RefSeq Acc Id:	XP_037848449 ⟸ XM_037992521
- Peptide Label:	isoform X2

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000006308	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000004346.1	UniProtKB/TrEMBL
Gene3D-CATH	2.130.10.10	UniProtKB/TrEMBL
InterPro	G-protein_beta_WD-40_rep	UniProtKB/TrEMBL
	Gprotein_B	UniProtKB/TrEMBL
	NLE	UniProtKB/TrEMBL
	WD40/YVTN_repeat-like_dom_sf	UniProtKB/TrEMBL
	WD40_repeat	UniProtKB/TrEMBL
	WD40_repeat_CS	UniProtKB/TrEMBL
	WD40_repeat_dom_sf	UniProtKB/TrEMBL
NCBI Gene	NLE1	ENTREZGENE
PANTHER	NOTCHLESS PROTEIN HOMOLOG 1	UniProtKB/TrEMBL
	WD40 REPEAT PROTEIN	UniProtKB/TrEMBL
Pfam	NLE	UniProtKB/TrEMBL
	WD40	UniProtKB/TrEMBL
PRINTS	GPROTEINB	UniProtKB/TrEMBL
	GPROTEINBRPT	UniProtKB/TrEMBL
PROSITE	WD_REPEATS_1	UniProtKB/TrEMBL
	WD_REPEATS_2	UniProtKB/TrEMBL
	WD_REPEATS_REGION	UniProtKB/TrEMBL
SMART	WD40	UniProtKB/TrEMBL
Superfamily-SCOP	SSF50978	UniProtKB/TrEMBL
UniProt	A0A0D9R1W1	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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