EYA3 (EYA transcriptional coactivator and phosphatase 3) - Rat Genome Database

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Gene: EYA3 (EYA transcriptional coactivator and phosphatase 3) Chlorocebus sabaeus
Analyze
Symbol: EYA3
Name: EYA transcriptional coactivator and phosphatase 3
RGD ID: 18648147
Description: ENCODES a protein that exhibits chromatin binding (ortholog); protein tyrosine/serine/threonine phosphatase activity (ortholog); INVOLVED IN cell differentiation (inferred); chromatin remodeling (inferred); double-strand break repair (inferred); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; ASSOCIATED WITH genetic disease (ortholog); FOUND IN transcription regulator complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: eyes absent homolog 3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120104,720,487 - 104,840,902 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20104,720,482 - 104,840,883 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603311,633,751 - 11,754,343 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
EYA3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120104,720,487 - 104,840,902 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20104,720,482 - 104,840,883 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603311,633,751 - 11,754,343 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
EYA3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38127,970,344 - 28,088,610 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl127,970,344 - 28,088,637 (-)EnsemblGRCh38hg38GRCh38
GRCh37128,296,855 - 28,415,121 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36128,173,406 - 28,287,718 (-)NCBINCBI36Build 36hg18NCBI36
Build 34127,999,126 - 28,099,273NCBI
Celera126,696,435 - 26,810,762 (-)NCBICelera
Cytogenetic Map1p35.3NCBI
HuRef126,552,221 - 26,670,901 (-)NCBIHuRef
CHM1_1128,412,382 - 28,530,637 (-)NCBICHM1_1
T2T-CHM13v2.0127,812,178 - 27,930,443 (-)NCBIT2T-CHM13v2.0
Eya3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394132,366,303 - 132,452,076 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4132,366,298 - 132,452,076 (+)EnsemblGRCm39 Ensembl
GRCm384132,639,025 - 132,724,765 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4132,638,987 - 132,724,765 (+)EnsemblGRCm38mm10GRCm38
MGSCv374132,194,961 - 132,280,678 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364131,911,122 - 131,996,839 (+)NCBIMGSCv36mm8
Celera4130,800,983 - 130,886,901 (+)NCBICelera
Cytogenetic Map4D2.3NCBI
cM Map465.68NCBI
Eya3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85150,090,535 - 150,218,855 (+)NCBIGRCr8
mRatBN7.25144,806,523 - 144,934,522 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5144,806,577 - 144,934,518 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5147,554,161 - 147,632,926 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05149,323,743 - 149,402,508 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05149,311,255 - 149,391,185 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05150,833,754 - 150,915,390 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5150,787,043 - 150,913,757 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05154,501,246 - 154,582,998 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45152,427,552 - 152,507,813 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15152,439,701 - 152,546,295 (-)NCBI
Celera5143,279,068 - 143,358,777 (+)NCBICelera
Cytogenetic Map5q36NCBI
Eya3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554527,150,886 - 7,255,159 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554527,148,762 - 7,273,886 (-)NCBIChiLan1.0ChiLan1.0
EYA3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21198,763,927 - 198,883,142 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11197,880,844 - 198,000,070 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0127,230,623 - 27,349,355 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1128,270,116 - 28,386,878 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl128,270,116 - 28,386,878 (-)Ensemblpanpan1.1panPan2
EYA3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1272,313,412 - 72,417,729 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl272,328,362 - 72,414,058 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha268,891,457 - 68,995,289 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0272,873,523 - 72,977,951 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl272,873,590 - 72,977,551 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1269,700,796 - 69,805,085 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0270,711,314 - 70,815,575 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0271,707,748 - 71,811,729 (+)NCBIUU_Cfam_GSD_1.0
Eya3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505846,367,002 - 46,470,598 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647412,191,389 - 12,295,458 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647412,191,391 - 12,295,380 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EYA3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl685,095,409 - 85,185,799 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1685,095,409 - 85,185,856 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2678,635,980 - 78,683,700 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Eya3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476411,821,609 - 11,898,144 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476411,820,993 - 11,932,183 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 25 33
Low 11 20 27
Below cutoff

Sequence


RefSeq Acc Id: ENSCSAT00000017527   ⟹   ENSCSAP00000017005
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl20104,720,482 - 104,840,883 (+)Ensembl
RefSeq Acc Id: XM_007979795   ⟹   XP_007977986
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.120104,720,487 - 104,837,780 (+)NCBI
Vero_WHO_p1.0NW_02366603311,633,751 - 11,754,333 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007979796   ⟹   XP_007977987
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.120104,741,598 - 104,837,780 (+)NCBI
Vero_WHO_p1.0NW_02366603311,633,751 - 11,728,336 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007979797   ⟹   XP_007977988
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.120104,720,488 - 104,840,902 (+)NCBI
Vero_WHO_p1.0NW_02366603311,633,751 - 11,754,343 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007979798   ⟹   XP_007977989
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.120104,720,489 - 104,837,780 (+)NCBI
Vero_WHO_p1.0NW_02366603311,633,751 - 11,754,332 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007979799   ⟹   XP_007977990
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.120104,720,490 - 104,840,902 (+)NCBI
Vero_WHO_p1.0NW_02366603311,633,751 - 11,754,331 (-)NCBI
Sequence:
RefSeq Acc Id: XM_037986475   ⟹   XP_037842403
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366603311,633,751 - 11,728,337 (-)NCBI
RefSeq Acc Id: XP_007977986   ⟸   XM_007979795
- Peptide Label: isoform X1
RefSeq Acc Id: XP_007977988   ⟸   XM_007979797
- Peptide Label: isoform X2
- UniProtKB: A0A0D9S816 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007977989   ⟸   XM_007979798
- Peptide Label: isoform X3
RefSeq Acc Id: XP_007977990   ⟸   XM_007979799
- Peptide Label: isoform X4
RefSeq Acc Id: XP_007977987   ⟸   XM_007979796
- Peptide Label: isoform X1
RefSeq Acc Id: ENSCSAP00000017005   ⟸   ENSCSAT00000017527
RefSeq Acc Id: XP_037842403   ⟸   XM_037986475
- Peptide Label: isoform X2
- UniProtKB: A0A0D9S816 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000001006 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000017527.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.12350 UniProtKB/TrEMBL
InterPro EYA_dom UniProtKB/TrEMBL
  EYA_dom_metazoan UniProtKB/TrEMBL
  EYA_dom_sf UniProtKB/TrEMBL
  EYA_fam UniProtKB/TrEMBL
NCBI Gene EYA3 ENTREZGENE
PANTHER PTHR10190 UniProtKB/TrEMBL
  PTHR10190:SF5 UniProtKB/TrEMBL
Pfam Hydrolase UniProtKB/TrEMBL
UniProt A0A0D9S816 ENTREZGENE, UniProtKB/TrEMBL