TTLL6 (tubulin tyrosine ligase like 6) - Rat Genome Database

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Gene: TTLL6 (tubulin tyrosine ligase like 6) Chlorocebus sabaeus
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Symbol: TTLL6
Name: tubulin tyrosine ligase like 6
RGD ID: 18644271
Description: ENCODES a protein that exhibits protein-glutamic acid ligase activity (inferred); tubulin binding (inferred); tubulin-glutamic acid ligase activity (inferred); INVOLVED IN microtubule bundle formation (ortholog); microtubule severing (ortholog); positive regulation of cilium movement (ortholog); ASSOCIATED WITH hereditary breast ovarian cancer syndrome (ortholog); trichodontoosseous syndrome (ortholog); FOUND IN 9+0 non-motile cilium (inferred); ciliary basal body (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: tubulin polyglutamylase TTLL6
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11669,179,314 - 69,232,038 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1669,179,323 - 69,215,928 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607740,272,854 - 40,317,830 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
TTLL6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11669,179,314 - 69,232,038 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1669,179,323 - 69,215,928 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607740,272,854 - 40,317,830 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
TTLL6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381748,762,234 - 48,817,229 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1748,762,234 - 48,817,229 (-)EnsemblGRCh38hg38GRCh38
GRCh371746,839,596 - 46,894,591 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361744,194,601 - 44,226,685 (-)NCBINCBI36Build 36hg18NCBI36
Celera1743,293,738 - 43,348,592 (-)NCBICelera
Cytogenetic Map17q21.32NCBI
HuRef1742,208,488 - 42,262,957 (-)NCBIHuRef
CHM1_11746,905,571 - 46,960,457 (-)NCBICHM1_1
T2T-CHM13v2.01749,625,842 - 49,680,794 (-)NCBIT2T-CHM13v2.0
Ttll6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391196,015,283 - 96,057,008 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1196,024,612 - 96,056,277 (+)EnsemblGRCm39 Ensembl
GRCm381196,124,457 - 96,166,182 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1196,133,786 - 96,165,451 (+)EnsemblGRCm38mm10GRCm38
MGSCv371195,995,100 - 96,026,766 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361195,937,264 - 95,981,541 (+)NCBIMGSCv36mm8
Celera11105,784,568 - 105,816,141 (+)NCBICelera
Cytogenetic Map11DNCBI
cM Map1159.48NCBI
Ttll6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81081,579,110 - 81,623,917 (+)NCBIGRCr8
mRatBN7.21081,081,985 - 81,118,009 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1081,091,975 - 81,127,234 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01083,954,221 - 83,999,542 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1083,954,279 - 83,999,710 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01083,757,515 - 83,803,135 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41084,857,020 - 84,887,025 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11084,871,346 - 84,901,178 (+)NCBI
Celera1079,849,287 - 79,894,629 (+)NCBICelera
Cytogenetic Map10q26NCBI
Ttll6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545112,473,935 - 12,509,192 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545112,474,035 - 12,509,104 (+)NCBIChiLan1.0ChiLan1.0
TTLL6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21916,267,625 - 16,340,115 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11718,236,186 - 18,305,648 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0178,719,010 - 8,774,299 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1178,904,856 - 8,960,176 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl178,905,029 - 8,953,080 (+)Ensemblpanpan1.1panPan2
TTLL6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1924,993,135 - 25,039,616 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl924,999,126 - 25,033,525 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha924,454,570 - 24,503,375 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0925,785,259 - 25,834,760 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl925,794,110 - 25,831,126 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1924,553,225 - 24,602,666 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0924,813,825 - 24,862,844 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0924,942,407 - 24,991,880 (-)NCBIUU_Cfam_GSD_1.0
Ttll6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560224,422,673 - 24,456,391 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649012,626,007 - 12,652,286 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649012,625,977 - 12,652,318 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TTLL6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1224,987,347 - 25,022,530 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11224,980,421 - 25,033,509 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21224,935,799 - 24,989,080 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Ttll6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247955,222,844 - 5,250,688 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247955,226,094 - 5,249,956 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression

ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
reproductive system
73 33 20 33 33 60 20

Sequence


Ensembl Acc Id: ENSCSAT00000000525   ⟹   ENSCSAP00000015535
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl1669,179,323 - 69,215,928 (-)Ensembl
RefSeq Acc Id: XM_037993050   ⟹   XP_037848978
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366607740,272,854 - 40,317,310 (-)NCBI
RefSeq Acc Id: XM_037993051   ⟹   XP_037848979
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366607740,279,038 - 40,317,830 (-)NCBI
RefSeq Acc Id: XM_037993052   ⟹   XP_037848980
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366607740,279,038 - 40,314,020 (-)NCBI
Protein Sequences
Protein RefSeqs XP_037848978 (Get FASTA)   NCBI Sequence Viewer  
  XP_037848979 (Get FASTA)   NCBI Sequence Viewer  
  XP_037848980 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000015535.1
Ensembl Acc Id: ENSCSAP00000015535   ⟸   ENSCSAT00000000525
RefSeq Acc Id: XP_037848978   ⟸   XM_037993050
- Peptide Label: isoform X1
- UniProtKB: A0A0D9S3U6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037848979   ⟸   XM_037993051
- Peptide Label: isoform X2
- UniProtKB: A0A0D9S3U6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037848980   ⟸   XM_037993052
- Peptide Label: isoform X3


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000002511 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000000525.1 UniProtKB/TrEMBL
Gene3D-CATH ATP-grasp fold, B domain UniProtKB/TrEMBL
InterPro TTL/TTLL_fam UniProtKB/TrEMBL
NCBI Gene TTLL6 ENTREZGENE
PANTHER PTHR12241:SF96 UniProtKB/TrEMBL
  TUBULIN POLYGLUTAMYLASE UniProtKB/TrEMBL
Pfam TTL UniProtKB/TrEMBL
PROSITE TTL UniProtKB/TrEMBL
Superfamily-SCOP Glutathione synthetase ATP-binding domain-like UniProtKB/TrEMBL
UniProt A0A0D9S3U6 ENTREZGENE, UniProtKB/TrEMBL