KPNA2 (karyopherin subunit alpha 2)

Gene: KPNA2 (karyopherin subunit alpha 2) Chlorocebus sabaeus

Analyze

Symbol:

KPNA2

Name:

karyopherin subunit alpha 2

RGD ID:

18643750

Description:

ENCODES a protein that exhibits DNA-binding transcription factor binding (ortholog); INVOLVED IN entry of viral genome into host nucleus through nuclear pore complex via importin (ortholog); positive regulation of viral life cycle (ortholog); postsynapse to nucleus signaling pathway (ortholog); ASSOCIATED WITH Animal Disease Models (ortholog); genetic disease (ortholog); lung adenocarcinoma (ortholog); FOUND IN cytoplasm (ortholog); cytoplasmic stress granule (ortholog); glutamatergic synapse (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

importin subunit alpha-1

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	16	53,422,792 - 53,434,693 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	16	53,423,040 - 53,433,290 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666077	24,363,548 - 24,375,627 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Animal Disease Models (ISO)

genetic disease (ISO)

lung adenocarcinoma (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

entry of viral genome into host nucleus through nuclear pore complex via importin (IEA,ISO)

NLS-bearing protein import into nucleus (IEA)

positive regulation of type I interferon production (IEA)

positive regulation of viral life cycle (IEA,ISO)

postsynapse to nucleus signaling pathway (ISO)

protein import into nucleus (IEA,ISO)

protein transport (IEA)

regulation of transcription by glucose (ISO)

Cellular Component

cytoplasm (IEA,ISO)

cytoplasmic stress granule (ISO)

cytosol (IEA)

glutamatergic synapse (ISO)

host cell (IEA)

NLS-dependent protein nuclear import complex (IEA,ISO)

nuclear membrane (IEA,ISO)

nucleoplasm (IEA)

nucleus (IEA)

postsynaptic density (ISO)

Molecular Function

DNA-binding transcription factor binding (ISO)

histone deacetylase binding (IEA)

nuclear import signal receptor activity (IEA)

nuclear localization sequence binding (IEA)

protein binding (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202	PMID:38038431

Genomics

Comparative Map Data

KPNA2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	16	53,422,792 - 53,434,693 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	16	53,423,040 - 53,433,290 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666077	24,363,548 - 24,375,627 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

KPNA2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	17	68,035,735 - 68,046,854 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	17	68,035,636 - 68,047,364 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	17	66,031,851 - 66,042,970 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	17	63,462,310 - 63,473,432 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	17	62,601,848 - 62,612,972 (+)	NCBI		Celera
Cytogenetic Map	17	q24.2	NCBI
HuRef	17	61,416,714 - 61,427,908 (+)	NCBI		HuRef
CHM1_1	17	66,096,665 - 66,107,785 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	17	68,911,511 - 68,922,628 (+)	NCBI		T2T-CHM13v2.0

Kpna2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	106,879,455 - 106,890,351 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	106,879,455 - 106,890,367 (-)	Ensembl		GRCm39 Ensembl
GRCm38	11	106,988,629 - 106,999,525 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	106,988,629 - 106,999,541 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	106,849,943 - 106,860,839 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	11	106,804,719 - 106,815,615 (-)	NCBI		MGSCv36	mm8
Celera	11	118,719,792 - 118,733,297 (-)	NCBI		Celera
Cytogenetic Map	11	E1	NCBI
cM Map	11	70.08	NCBI

Kpna2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	92,433,678 - 92,445,841 (-)	NCBI		GRCr8
mRatBN7.2	10	91,933,951 - 91,946,115 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	91,933,951 - 91,946,150 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	96,991,813 - 97,004,201 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	96,454,982 - 96,467,370 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	91,856,366 - 91,868,402 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	95,200,029 - 95,212,111 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	95,200,030 - 95,212,111 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	94,940,856 - 94,952,938 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	96,342,214 - 96,352,613 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	10	96,356,583 - 96,366,983 (-)	NCBI
Celera	10	90,599,417 - 90,611,576 (-)	NCBI		Celera
Cytogenetic Map	10	q32.1	NCBI

Kpna2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955478	7,121,432 - 7,134,327 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955478	7,121,432 - 7,134,327 (+)	NCBI	ChiLan1.0	ChiLan1.0

KPNA2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	19	84,035,576 - 84,071,181 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	17	88,856,717 - 88,892,339 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	17	61,968,807 - 61,979,954 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	17	67,161,908 - 67,173,410 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	17	67,161,908 - 67,173,410 (+)	Ensembl	panpan1.1		panPan2

KPNA2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	9	12,546,912 - 12,556,163 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	9	13,442,712 - 13,451,963 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	9	14,205,539 - 14,214,799 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	9	14,205,541 - 14,214,742 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	9	13,154,710 - 13,163,965 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	9	14,370,477 - 14,379,722 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	9	14,369,408 - 14,378,660 (+)	NCBI		UU_Cfam_GSD_1.0

Kpna2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	13,965,860 - 13,977,209 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936541	5,217,362 - 5,228,846 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936541	5,217,389 - 5,228,816 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

KPNA2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	12	14,283,087 - 14,296,746 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	12	14,283,092 - 14,296,749 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

Kpna2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624870	444,558 - 457,872 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624870	444,551 - 457,986 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	endocrine system	hemolymphoid system	nervous system
High
Medium	36	13	60
Low		7
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_008012007	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000045	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCSAT00000002226 ⟹ ENSCSAP00000000554

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	16	53,423,040 - 53,433,290 (-)	Ensembl

RefSeq Acc Id:

XM_008012007 ⟹ XP_008010198

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	16	53,422,792 - 53,434,693 (-)	NCBI
Vero_WHO_p1.0	NW_023666077	24,363,548 - 24,375,627 (-)	NCBI

Sequence:

show sequence

CACACGGTCTTTGAGCTGAGTCGAGGTGGACGCTTTGAGTGCATCCGTCCCACAGCCGCTGATT
CCCCGCATCGCCTCCCGTGGAAGCCCGGGCCCGCTTCGCAGCTTTCTCCCTTTGTCTCATAACC
ATGTCCACCAACGAGAATGCTAATACACCAGCTGCCCGTCTTCACAGATTCAAGAACAAGGGAA
AAGACAGTACAGAAATGAGGCGTCGCAGAATAGAGGTCAATGTGGAGCTGAGGAAAGCTAAGAA
GGATGACCAGATGCTGAAGAGGAGAAACGTAAGCTCATTTCCTGATGATGCTACTTCTCCGCTG
CAGGAAAACCGCAACAACCAGGGTACTGTAAATTGGTCTGTTGATGACATTGTCAAAGGCATAA
ATAGCAGCAATGTGGAAAATCAGCTCCAAGCTACTCAAGCTGCCAGGAAACTACTTTCTAGAGA
AAAACAGCCCCCCATAGACAACATAATCCGGGCTGGTTTGATTCCAAAATTTGTGTACTTCTTG
GGCAGAACTGATTGTAGTCCCATTCAGTTTGAGTCTGCTTGGGCACTTACTAACATTGCTTCTG
GGACATCAGAACAGACCAAGGCTGTGGTAGATGGAGGTGCCATCCCAGCATTCATCTCTCTGTT
GGCATCTCCCCATGCTCACATCAGTGAACAAGCCGTCTGGGCTCTAGGAAACATTGCAGGTGAC
GGCTCAGTGTTCCGAGACTTGGTTATTAAGTATGGTGCAGTTGACCCACTGTTGGCTCTCCTTG
CGGTTCCTGATATGTCATCTTTAGCATGTGGCTACTTACGTAATCTTACCTGGACACTTTCAAA
TCTTTGCCGCAACAAGAATCCTGCACCCCCGATAGATGCTGTTGAGCAGATTCTTCCTACCTTA
GTTCGGCTCCTGCATCATGATGATCCAGAAGTATTAGCAGATACCTGCTGGGCTATTTCCTACC
TTACTGATGGTCCAAATGAACGAATTGACATGGTTGTGAAAACAGGAGTTGTGCCCCAACTTGT
GAAGCTTCTCGGAGCTTCTGAATTGCCAATTGTGACTCCTGCCCTAAGAGCCATAGGGAATATT
GTCACTGGTACAGATGAACAGACTCAGGTTGTAATTGATGCAGGAGCACTCGCTGTCTTTCCCA
GCCTGCTCACCAACCCCAAAACTAACATTCAGAAGGAAGCTACATGGACAATGTCAAACATCAC
AGCTGGCCGTCAGGACCAGATACAGCAAGTTGTGAATCATGGATTAGTCCCATTCCTTGTCAGT
GTTCTCTCTAAGGCAGATTTTAAGACACAAAAGGAAGCTGTATGGGCTGTGACCAACTACACTA
GTGGTGGAACAGTTGAGCAGATTGTGTACCTTGTTCACTGTGGCATAATAGAACCATTGATGAA
CCTCTTAACTGCAAAAGATACCAAGATTATTCTGGTTATCCTGGATGCCATTTCAAATATCTTT
CAGGCTGCTGAAAAACTAGGTGAAACTGAGAAACTTAGTATAATGATTGAAGAATGTGGTGGCT
TAGACAAAATTGAAGCTCTACAAAACCATGAAAATGAGTCTGTGTATAAGGCTTCGTTAAGCTT
AATTGAGAAGTATTTCTCTGTAGAGGAAGAGGAAGATCAAAACGTTGTGCCGGAAACTACCTCT
GAAGGCTACACCTTCCAAGTTCAGGATGGGGCTCCTGGGACCTTTACCTTTTAGATCACATAGC
TGAGGCATACATTTGTTGTGTACCATGTTTGGTATTTTGTCTTATTGTTTCTCTACTAAGAACT
CTTTTTAAATGTGGTTTGTTATTGTAGCACTTTTTACACTGAAACTATACTTGAACAGTTCCAA
CTGTACATACTGTATGAAGCTTGTCCTCTGACTAGGTTTCTTATTTCTATGTGGAATTTCATAT
CTTGCAGCATCCTGTAAATAAACATTAAAGTCCACCCTTTACTTCA

hide sequence

Protein Sequences


Protein RefSeqs	XP_008010198	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000000554
	ENSCSAP00000000554.1

RefSeq Acc Id:	XP_008010198 ⟸ XM_008012007
- UniProtKB:	A0A0D9QW15 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSCSAP00000000554 ⟸ ENSCSAT00000002226

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000004208	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000002226.1	UniProtKB/TrEMBL
Gene3D-CATH	1.20.5.690	UniProtKB/TrEMBL
	1.25.10.10	UniProtKB/TrEMBL
InterPro	ARM-like	UniProtKB/TrEMBL
	ARM-type_fold	UniProtKB/TrEMBL
	Arm_3	UniProtKB/TrEMBL
	Armadillo	UniProtKB/TrEMBL
	Importin-a_IBB	UniProtKB/TrEMBL
	Importin-a_IBB_sf	UniProtKB/TrEMBL
	Importing_su_alpha	UniProtKB/TrEMBL
KEGG Report	csab:103243153	UniProtKB/TrEMBL
NCBI Gene	KPNA2	ENTREZGENE
PANTHER	IMPORTIN ALPHA	UniProtKB/TrEMBL
	IMPORTIN SUBUNIT ALPHA-1	UniProtKB/TrEMBL
Pfam	Arm	UniProtKB/TrEMBL
	Arm_3	UniProtKB/TrEMBL
	IBB	UniProtKB/TrEMBL
PIRSF	Importin_alpha	UniProtKB/TrEMBL
PROSITE	ARM_REPEAT	UniProtKB/TrEMBL
	IBB	UniProtKB/TrEMBL
SMART	ARM	UniProtKB/TrEMBL
Superfamily-SCOP	SSF48371	UniProtKB/TrEMBL
UniProt	A0A0D9QW15	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD