SGSM1 (small G protein signaling modulator 1) - Rat Genome Database

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Gene: SGSM1 (small G protein signaling modulator 1) Chlorocebus sabaeus
Analyze
Symbol: SGSM1
Name: small G protein signaling modulator 1
RGD ID: 18643258
Description: ENCODES a protein that exhibits small GTPase binding (ortholog); INVOLVED IN positive regulation of transcription by RNA polymerase II (ortholog); ASSOCIATED WITH genetic disease (ortholog); FOUND IN cytoplasm (ortholog); cytoplasmic vesicle membrane (ortholog); cytosol (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1197,906,444 - 8,024,484 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl197,906,657 - 8,024,488 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666045118,097,305 - 118,215,335 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
SGSM1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1197,906,444 - 8,024,484 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl197,906,657 - 8,024,488 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666045118,097,305 - 118,215,335 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
SGSM1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382224,806,211 - 24,927,578 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2224,806,169 - 24,927,578 (+)EnsemblGRCh38hg38GRCh38
GRCh372225,202,178 - 25,323,545 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362223,532,136 - 23,652,813 (+)NCBINCBI36Build 36hg18NCBI36
Celera229,006,548 - 9,127,191 (+)NCBICelera
Cytogenetic Map22q11.23NCBI
HuRef228,151,216 - 8,271,579 (+)NCBIHuRef
CHM1_12225,161,077 - 25,281,547 (+)NCBICHM1_1
T2T-CHM13v2.02225,267,600 - 25,389,136 (+)NCBIT2T-CHM13v2.0
Sgsm1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395113,391,086 - 113,458,654 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5113,391,086 - 113,458,652 (-)EnsemblGRCm39 Ensembl
GRCm385113,243,220 - 113,310,788 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5113,243,220 - 113,310,786 (-)EnsemblGRCm38mm10GRCm38
MGSCv375113,672,240 - 113,739,806 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365113,483,532 - 113,551,022 (-)NCBIMGSCv36mm8
Celera5110,363,560 - 110,432,092 (-)NCBICelera
Cytogenetic Map5FNCBI
cM Map555.45NCBI
Sgsm1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81248,969,578 - 49,049,110 (+)NCBIGRCr8
mRatBN7.21243,320,500 - 43,386,469 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1243,321,256 - 43,386,457 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1244,487,875 - 44,552,684 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01245,100,490 - 45,165,694 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01244,161,013 - 44,226,220 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01249,329,093 - 49,395,078 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1249,328,977 - 49,395,125 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01251,102,730 - 51,169,362 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41244,329,807 - 44,395,211 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11244,211,959 - 44,256,802 (+)NCBI
Celera1244,917,920 - 44,983,077 (+)NCBICelera
Cytogenetic Map12q16NCBI
Sgsm1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955455260,410 - 343,253 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955455258,472 - 343,079 (-)NCBIChiLan1.0ChiLan1.0
SGSM1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22334,705,565 - 34,826,547 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12237,403,798 - 37,525,340 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0225,761,495 - 5,882,410 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12223,429,802 - 23,549,021 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2223,429,702 - 23,546,446 (+)Ensemblpanpan1.1panPan2
SGSM1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12618,977,100 - 19,057,190 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2618,976,361 - 19,075,458 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2618,843,281 - 18,923,350 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02619,342,265 - 19,422,695 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2619,342,236 - 19,422,695 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12619,048,218 - 19,126,544 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02619,312,628 - 19,393,906 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02619,381,741 - 19,463,028 (+)NCBIUU_Cfam_GSD_1.0
Sgsm1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118115,728,506 - 115,807,723 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493665765,586 - 142,206 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936657109,232 - 142,195 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SGSM1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1442,882,154 - 42,974,741 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11442,882,101 - 42,974,755 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21445,613,319 - 45,705,958 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Sgsm1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247472,114,562 - 2,206,060 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247472,113,259 - 2,205,718 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 34 47
Low 2 16 13
Below cutoff 4

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000008343   ⟹   ENSCSAP00000006490
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl197,906,657 - 8,024,488 (+)Ensembl
RefSeq Acc Id: XM_007975204   ⟹   XP_007973395
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1197,906,444 - 8,024,484 (+)NCBI
Vero_WHO_p1.0NW_023666045118,097,305 - 118,215,335 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007975205   ⟹   XP_007973396
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1197,906,455 - 8,024,484 (+)NCBI
Vero_WHO_p1.0NW_023666045118,097,310 - 118,215,335 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_007973395 (Get FASTA)   NCBI Sequence Viewer  
  XP_007973396 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000006490.1
Reference Protein Sequences
RefSeq Acc Id: XP_007973395   ⟸   XM_007975204
- Peptide Label: isoform X1
- UniProtKB: A0A0D9RD01 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007973396   ⟸   XM_007975205
- Peptide Label: isoform X2
- UniProtKB: A0A0D9RD01 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000006490   ⟸   ENSCSAT00000008343


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000010256 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000008343.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.58.900 UniProtKB/TrEMBL
  2.30.29.230 UniProtKB/TrEMBL
  putative rabgap domain of human tbc1 domain family member 14 like domains UniProtKB/TrEMBL
  Ypt/Rab-GAP domain of gyp1p, domain 3 UniProtKB/TrEMBL
InterPro Rab-GTPase-TBC_dom UniProtKB/TrEMBL
  Rab-GTPase_TBC_sf UniProtKB/TrEMBL
  Run_dom UniProtKB/TrEMBL
  Run_dom_sf UniProtKB/TrEMBL
  RUN_SGSM1 UniProtKB/TrEMBL
  SGSM1/2 UniProtKB/TrEMBL
  SGSM1/2_RBD UniProtKB/TrEMBL
KEGG Report csab:103223072 UniProtKB/TrEMBL
NCBI Gene SGSM1 ENTREZGENE
PANTHER SMALL G PROTEIN SIGNALING MODULATOR 1 UniProtKB/TrEMBL
  TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN UniProtKB/TrEMBL
Pfam PH_RBD UniProtKB/TrEMBL
  RabGAP-TBC UniProtKB/TrEMBL
  RUN UniProtKB/TrEMBL
PROSITE RUN UniProtKB/TrEMBL
  TBC_RABGAP UniProtKB/TrEMBL
SMART RUN UniProtKB/TrEMBL
  TBC UniProtKB/TrEMBL
Superfamily-SCOP SSF140741 UniProtKB/TrEMBL
  SSF47923 UniProtKB/TrEMBL
UniProt A0A0D9RD01 ENTREZGENE, UniProtKB/TrEMBL