ADISSP (adipose secreted signaling protein)

Gene: ADISSP (adipose secreted signaling protein) Chlorocebus sabaeus

Analyze

Symbol:

ADISSP

Name:

adipose secreted signaling protein

RGD ID:

18642934

Description:

ENCODES a protein that exhibits protein phosphatase 1 binding (inferred); INVOLVED IN adaptive thermogenesis (ortholog); glucose homeostasis (ortholog); positive regulation of protein kinase A signaling (ortholog); ASSOCIATED WITH Huntington's disease-like 1 (ortholog); Inosine Triphosphatase Deficiency (ortholog); pantothenate kinase-associated neurodegeneration (ortholog); FOUND IN extracellular space (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

C2H20orf27; chromosome 2 open reading frame, human C20orf27; chromosome unknown C20orf27 homolog; CUNH20orf27; UPF0687 protein C20orf27 homolog

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	2	34,434,077 - 34,449,254 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	2	34,430,912 - 34,440,681 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666071	10,001,060 - 10,016,237 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Huntington's disease-like 1 (ISO)

Inosine Triphosphatase Deficiency (ISO)

pantothenate kinase-associated neurodegeneration (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

adaptive thermogenesis (ISO)

glucose homeostasis (ISO)

positive regulation of non-canonical NF-kappaB signal transduction (IEA)

positive regulation of protein kinase A signaling (ISO)

positive regulation of transforming growth factor beta receptor signaling pathway (IEA)

Cellular Component

extracellular space (ISO)

Molecular Function

protein phosphatase 1 binding (IEA)

References

Genomics

Comparative Map Data

ADISSP
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	2	34,434,077 - 34,449,254 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	2	34,430,912 - 34,440,681 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666071	10,001,060 - 10,016,237 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

ADISSP
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	20	3,753,508 - 3,768,388 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	20	3,753,508 - 3,767,781 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	20	3,734,155 - 3,749,035 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	20	3,682,158 - 3,696,452 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	20	3,682,155 - 3,696,382	NCBI
Celera	20	3,796,043 - 3,810,314 (-)	NCBI		Celera
Cytogenetic Map	20	p13	NCBI
HuRef	20	3,682,651 - 3,697,556 (-)	NCBI		HuRef
CHM1_1	20	3,734,463 - 3,749,355 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	20	3,784,462 - 3,799,327 (-)	NCBI		T2T-CHM13v2.0

Adissp
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	130,988,235 - 131,002,001 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	130,988,244 - 131,002,001 (-)	Ensembl		GRCm39 Ensembl
GRCm38	2	131,146,315 - 131,160,085 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	131,146,324 - 131,160,081 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	130,972,061 - 130,985,756 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	130,837,766 - 130,851,461 (-)	NCBI		MGSCv36	mm8
Celera	2	132,370,655 - 132,384,355 (-)	NCBI		Celera
Cytogenetic Map	2	F1	NCBI
cM Map	2	63.28	NCBI

Adissp
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	138,817,752 - 138,832,208 (-)	NCBI		GRCr8
mRatBN7.2	3	118,364,730 - 118,378,881 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	118,362,363 - 118,378,838 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	122,259,065 - 122,273,184 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	130,858,352 - 130,872,496 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	128,515,173 - 128,529,292 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	123,688,633 - 123,702,762 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	123,688,634 - 123,702,732 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	130,187,019 - 130,201,142 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	118,851,409 - 118,865,511 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	118,756,981 - 118,771,084 (-)	NCBI
Celera	3	117,172,894 - 117,186,989 (-)	NCBI		Celera
Cytogenetic Map	3	q36	NCBI

Adissp
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955415	14,596,522 - 14,610,181 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955415	14,596,522 - 14,610,181 (-)	NCBI	ChiLan1.0	ChiLan1.0

ADISSP
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	21	4,717,165 - 4,732,806 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	20	4,713,990 - 4,728,293 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	20	3,836,066 - 3,850,936 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	20	3,593,404 - 3,608,267 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	20	3,593,404 - 3,608,267 (-)	Ensembl	panpan1.1		panPan2

ADISSP
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	24	17,586,111 - 17,600,147 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	24	17,586,782 - 17,599,696 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	24	17,415,814 - 17,429,751 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	24	18,004,929 - 18,018,863 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	24	18,005,451 - 18,018,860 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	24	17,599,767 - 17,613,691 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	24	17,710,872 - 17,725,019 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	24	18,038,526 - 18,052,452 (+)	NCBI		UU_Cfam_GSD_1.0

Adissp
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	166,505,093 - 166,511,587 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936485	14,930,517 - 14,942,951 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936485	14,930,525 - 14,942,951 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ADISSP
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	17	31,950,169 - 31,956,750 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	17	31,943,018 - 31,956,754 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	17	36,275,259 - 36,284,324 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Adissp
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624741	4,838,261 - 4,852,233 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624741	4,838,261 - 4,852,217 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	endocrine system	hemolymphoid system	nervous system
High
Medium	17		37
Low	19	20	23
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_008019545	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008019552	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_037990833	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000039	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCSAT00000011068 ⟹ ENSCSAP00000009151

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	2	34,430,912 - 34,440,681 (-)	Ensembl

RefSeq Acc Id:

XM_008019545 ⟹ XP_008017736

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	2	34,434,077 - 34,449,254 (-)	NCBI
Vero_WHO_p1.0	NW_023666071	10,001,060 - 10,016,237 (+)	NCBI

Sequence:

show sequence

GATGCTTCTCCAGGCCGGGCCGGGCTCCCGGGACGTGTCTCGGGCCTGCACGGGGGCGCTTCTT
CCGACACAGGGGATGGGGTGGAAGGGGAAGAGGTCCAAACCCTGGGGTCGAAATAGGAGTGATG
GAGGGTTCCTCAGCTCCTGAACGAGACTAGCACGGCCCGTATCGATGGCCGAAGCCAGCGTGGA
AGCCCTGGGAGAAAGGCCACCTTCAGGAGCTCCACCCAGCCCCGAGACGCGCCCGACAGCCCTC
CCGACAACGCAGGGCCCAAGGGAGGCGCGTCCTTAGGAAACGTCAAGGCTGGAGGCGCTATCCC
CTAGGCGGAAGCGGCGGGGGCGGGGCCAATCCGCGGCCCTCCTTCCCCCTCTTCCCGTGCCGGG
TTCTGGCCCCTGGCCCAGTTGGGCCGGCTGCCCACCTTCCTCGCGAGAGCTCGCCCGGCAGGCG
CGGACTCGCAGGGCGCAGCCTCATCGACCCTTGCACGTGACGTAGGCGGCCCTCGCCAGTTGGC
CGTTCTTTGGAGCCCGCTTATTGGTCCGAAGCATCCCTTGCCCCACCCCCAGATCAACCAATGG
GCGGAGGCGGGGGCGTGCCGACGGGCGGGCGGCAGCCGCGCGGGGCTCCCTTCCTCGTGTTCGG
CGTTGAGCCCCTGCAGCCGCCCGCAGCGGTCGTCCCTGCCCTCCCCGGCCCTGGGGTGCACCCC
GCAAGGCTCCTGCTGGTGTCCCTGGAGCATGGGAGGCCGCTGAGTGTGAGTGGCGGTGTCCGGC
AGGAGCTGCGTGGCAGGGAGGGCGTCCATGGCTGCGGCTAACAAGGGCAACAAGCCCAGAGTCC
GGAGTATCCGCTTTGCGGCAGGCCACGATGCGGAAGGATCCCACAGCCACGTCCACTTTGATGA
GAAGCTGCATGACTCAGTGGTCATGGTCACCCAGGAGAGTGACAGCAGCTTTCTGGTCAAGGTT
GGCTTCCTGAAGATCCTGCACAGGTATGAGATTACCTTCACTCTGCCCCCAGTGCACAAGCTGA
GCAAGGACGTCCGTGAGGCACCTGTCCCCAGCCTGCACCTCAAGCTCCTCAGCGTGGTGCCCGT
CCCTGAAGGTTATAGTGTCAAGTGTGAATACTCGGCACACAAAGAGGGCGTCCTCAAAGAGGAG
ATACTGCTAGCCTGTGAAGGTGGCACCGGCACCTGTGTGCGTGTGACGGTGCAGGCCCGCGTCA
TGGACCGACACCACGGCACGCCCATGCTGCTGGACGGTGTCAAGTGTGTGGGCGCCGAGCTGGA
ATATGACTCAGAGCACAGCGACTGGCATGGCTTTGACTGAGGCCTGAGGCCCCGCCTGCCCCAG
GCCCCTCAGCCTTAAACCCCGCCTTGTCCCCCCGACATGCTGCGTGATGGTGTGGCTTCCTCGC
CCCTCTCTGGGGTGGGCGTGGGGGTGGAGTGGCCTTGCCCACACCTCTCACCTCTGCCTTCATT
TGTGCCCCCACCCTGCCCCTCCCACGTCCTCCTCTCCCACTTCCTCCTCTCCGTGTGCCTCAGT
CTCCTGCCGGAAGAAATGGGTTGAGCCCGAAAGGAGGCTGTCTGAGGAAGGGAGAGGGAGGGCC
TGGGGTGGGTTTCCCATTCCCCACCCCAAGCCATAGGGGCTCCAACCAGGGTCTGGGAGAGGAT
GGAGCTGGCTCTGTGGTGTCGTGGCCCCATTACTGCTGCTGCTGCCTTGCTTCAGCCACCTCTC
CTGCCCCTCCCTCGTCCCCACTGCTGTCCACCATGAGTAGGAGGGAGGTGCAGTCCCCAGCCCC
CCCCCGCCCTCAGGTCTGTGTTACTTGGTTTTTAAGCGACTGGTTGGGATAGAACCCTAAAGAA
ATAAAACTTCCAGTGAATACCGGAA

hide sequence

RefSeq Acc Id:

XM_037990833 ⟹ XP_037846761

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
Vero_WHO_p1.0	NW_023666071	10,001,618 - 10,015,339 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_008017736	(Get FASTA)	NCBI Sequence Viewer
	XP_037846761	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000009151
	ENSCSAP00000009151.1

RefSeq Acc Id:	XP_008017736 ⟸ XM_008019545
- Peptide Label:	isoform X1
- UniProtKB:	A0A0D9RKL2 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSCSAP00000009151 ⟸ ENSCSAT00000011068

RefSeq Acc Id:	XP_037846761 ⟸ XM_037990833
- Peptide Label:	isoform X2

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000012973	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000011068.1	UniProtKB/TrEMBL
InterPro	UPF0687	UniProtKB/TrEMBL
KEGG Report	csab:103247419	UniProtKB/TrEMBL
NCBI Gene	C2H20orf27	ENTREZGENE
PANTHER	PTHR13287	UniProtKB/TrEMBL
	UPF0687 PROTEIN C20ORF27 HOMOLOG	UniProtKB/TrEMBL
Pfam	DUF4517	UniProtKB/TrEMBL
UniProt	A0A0D9RKL2	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2023-03-29	ADISSP	adipose secreted signaling protein	CUNH20orf27	adipose secreted signaling protein	Symbol and/or name change	5135510	APPROVED
2022-12-20	CUNH20orf27	adipose secreted signaling protein	CUNH20orf27	chromosome unknown C20orf27 homolog	Symbol and/or name change	5135510	APPROVED
2020-12-08	CUNH20orf27	chromosome unknown C20orf27 homolog	C2H20orf27	chromosome 2 open reading frame, human C20orf27	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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