RPA1 (replication protein A1) - Rat Genome Database

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Gene: RPA1 (replication protein A1) Chlorocebus sabaeus
Analyze
Symbol: RPA1
Name: replication protein A1
RGD ID: 18641004
Description: ENCODES a protein that exhibits chromatin binding (ortholog); single-stranded DNA binding (ortholog); INVOLVED IN chromosome organization (ortholog); double-strand break repair via homologous recombination (ortholog); hemopoiesis (ortholog); PARTICIPATES IN mismatch repair pathway; nucleotide excision repair pathway; ASSOCIATED WITH Chloracne (ortholog); genetic disease (ortholog); Pulmonary Fibrosis and/or Bone Marrow Failure Syndrome, Telomere-Related, 6 (ortholog); FOUND IN condensed chromosome (ortholog); condensed nuclear chromosome (ortholog); DNA replication factor A complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: replication protein A 70 kDa DNA-binding subunit
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1161,470,375 - 1,537,603 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl161,470,474 - 1,539,246 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605920,435,051 - 20,500,960 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
RPA1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1161,470,375 - 1,537,603 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl161,470,474 - 1,539,246 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605920,435,051 - 20,500,960 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
RPA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38171,830,005 - 1,900,082 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl171,829,702 - 1,900,082 (+)EnsemblGRCh38hg38GRCh38
GRCh37171,733,299 - 1,803,376 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36171,680,095 - 1,748,120 (+)NCBINCBI36Build 36hg18NCBI36
Build 34171,680,094 - 1,748,119NCBI
Celera171,749,843 - 1,819,455 (+)NCBICelera
Cytogenetic Map17p13.3NCBI
HuRef171,629,684 - 1,699,337 (+)NCBIHuRef
CHM1_1171,742,032 - 1,811,637 (+)NCBICHM1_1
T2T-CHM13v2.0171,718,730 - 1,788,877 (+)NCBIT2T-CHM13v2.0
Rpa1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391175,191,085 - 75,239,478 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1175,188,992 - 75,239,150 (-)EnsemblGRCm39 Ensembl
GRCm381175,300,259 - 75,348,454 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1175,298,166 - 75,348,324 (-)EnsemblGRCm38mm10GRCm38
MGSCv371175,113,761 - 75,161,885 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361175,116,543 - 75,164,498 (-)NCBIMGSCv36mm8
Celera1182,808,378 - 82,856,486 (-)NCBICelera
Cytogenetic Map11B5NCBI
cM Map1145.79NCBI
Rpa1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81060,647,185 - 60,698,279 (-)NCBIGRCr8
mRatBN7.21060,148,869 - 60,199,970 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1060,148,793 - 60,199,949 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1064,795,256 - 64,846,359 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01064,300,846 - 64,351,950 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01059,763,249 - 59,814,350 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01062,140,419 - 62,191,518 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1062,140,419 - 62,191,512 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01061,854,541 - 61,904,617 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41062,613,169 - 62,656,565 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11062,626,791 - 62,670,188 (-)NCBI
Celera1059,179,824 - 59,222,962 (-)NCBICelera
Cytogenetic Map10q24NCBI
Rpa1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554811,304,035 - 1,361,806 (-)NCBIChiLan1.0ChiLan1.0
RPA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2199,401,164 - 9,475,584 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11711,367,763 - 11,442,603 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0171,813,610 - 1,886,093 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1171,705,373 - 1,775,596 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl171,705,380 - 1,775,596 (+)Ensemblpanpan1.1panPan2
RPA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1945,958,566 - 46,034,850 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl945,958,619 - 46,034,328 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha945,109,298 - 45,184,734 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0946,786,119 - 46,864,304 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl946,786,117 - 46,864,301 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1945,555,674 - 45,631,679 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0945,850,448 - 45,928,573 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0945,904,608 - 45,980,898 (+)NCBIUU_Cfam_GSD_1.0
Rpa1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560245,063,116 - 45,117,773 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365387,946,403 - 7,994,864 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365387,941,074 - 7,997,062 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RPA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1248,009,719 - 48,048,741 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11248,009,652 - 48,048,744 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21249,862,650 - 49,901,712 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Rpa1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247864,547,962 - 4,604,290 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247864,547,889 - 4,604,605 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 36 15 54
Low 5 6
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000011920   ⟹   ENSCSAP00000009979
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl161,470,474 - 1,539,246 (+)Ensembl
RefSeq Acc Id: XM_037987504   ⟹   XP_037843432
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366605920,435,051 - 20,500,960 (-)NCBI
Protein Sequences
Protein RefSeqs XP_037843432 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000009979.1
Reference Protein Sequences
RefSeq Acc Id: ENSCSAP00000009979   ⟸   ENSCSAT00000011920
RefSeq Acc Id: XP_037843432   ⟸   XM_037987504
- UniProtKB: A0A0D9RMZ0 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000013833 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000011920.1 UniProtKB/TrEMBL
Gene3D-CATH 2.40.50.140 UniProtKB/TrEMBL
InterPro Euk_RPA1_DBD_C UniProtKB/TrEMBL
  NA-bd_OB-fold UniProtKB/TrEMBL
  NA-bd_OB_tRNA UniProtKB/TrEMBL
  Rep_factor-A_C UniProtKB/TrEMBL
  Rep_factor-A_N UniProtKB/TrEMBL
  REPA_OB_2 UniProtKB/TrEMBL
  Rfa1 UniProtKB/TrEMBL
NCBI Gene RPA1 ENTREZGENE
PANTHER PTHR23273 UniProtKB/TrEMBL
  REPLICATION PROTEIN A 70 KDA DNA-BINDING SUBUNIT UniProtKB/TrEMBL
Pfam Rep-A_N UniProtKB/TrEMBL
  Rep_fac-A_C UniProtKB/TrEMBL
  REPA_OB_2 UniProtKB/TrEMBL
  tRNA_anti-codon UniProtKB/TrEMBL
Superfamily-SCOP SSF50249 UniProtKB/TrEMBL
UniProt A0A0D9RMZ0 ENTREZGENE, UniProtKB/TrEMBL