MTFMT (mitochondrial methionyl-tRNA formyltransferase)

Gene: MTFMT (mitochondrial methionyl-tRNA formyltransferase) Chlorocebus sabaeus

Analyze

Symbol:

MTFMT

Name:

mitochondrial methionyl-tRNA formyltransferase

RGD ID:

18640813

Description:

ENCODES a protein that exhibits catalytic activity (inferred); methionyl-tRNA formyltransferase activity (inferred); transferase activity (inferred); INVOLVED IN biosynthetic process (inferred); conversion of methionyl-tRNA to N-formyl-methionyl-tRNA (inferred); translation (inferred); PARTICIPATES IN folate metabolic pathway; glycine N-methyltransferase deficiency pathway; hereditary folate malabsorption pathway; ASSOCIATED WITH Bloom syndrome (ortholog); colorectal cancer (ortholog); combined oxidative phosphorylation deficiency 15 (ortholog); FOUND IN cytosol (inferred); mitochondrion (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

methionyl-tRNA formyltransferase, mitochondrial

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	26	18,556,747 - 18,583,528 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	26	18,556,791 - 18,583,446 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666048	122,849,535 - 122,876,821 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Bloom syndrome (ISO)

colorectal cancer (ISO)

combined oxidative phosphorylation deficiency 15 (ISO)

Dwarfism (ISO)

genetic disease (ISO)

Leigh disease (ISO)

microcephaly (ISO)

mitochondrial complex I deficiency (ISO)

nemaline myopathy 6 (ISO)

nuclear type mitochondrial complex I deficiency 27 (ISO)

Subacute Necrotizing Encephalopathy of Leigh, Infantile (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

biosynthetic process (IEA)

conversion of methionyl-tRNA to N-formyl-methionyl-tRNA (IEA)

translation (IEA)

translational initiation (IEA)

Cellular Component

cytosol (IEA)

mitochondrion (IEA)

Molecular Function

catalytic activity (IEA)

methionyl-tRNA formyltransferase activity (IEA)

transferase activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

folate metabolic pathway (ISO)

glycine N-methyltransferase deficiency pathway (ISO)

hereditary folate malabsorption pathway (ISO)

homocystinuria pathway (ISO)

hypermethioninemia pathway (ISO)

methionine cycle/metabolic pathway (ISO)

methotrexate pharmacodynamics pathway (ISO)

methylenetetrahydrofolate reductase deficiency pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

MTFMT
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	26	18,556,747 - 18,583,528 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	26	18,556,791 - 18,583,446 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666048	122,849,535 - 122,876,821 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

MTFMT
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	15	65,001,512 - 65,029,639 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	15	65,001,512 - 65,029,639 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	15	65,293,850 - 65,321,977 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	15	63,081,901 - 63,109,018 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	15	42,172,045 - 42,200,175 (-)	NCBI		Celera
Cytogenetic Map	15	q22.31	NCBI
HuRef	15	42,118,760 - 42,146,953 (-)	NCBI		HuRef
CHM1_1	15	65,413,707 - 65,441,816 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	15	62,810,917 - 62,839,061 (-)	NCBI		T2T-CHM13v2.0

Mtfmt
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	65,343,064 - 65,360,336 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	65,343,064 - 65,360,336 (+)	Ensembl		GRCm39 Ensembl
GRCm38	9	65,435,782 - 65,453,054 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	65,435,782 - 65,453,054 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	9	65,283,589 - 65,300,861 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	9	65,233,788 - 65,250,408 (+)	NCBI		MGSCv36	mm8
Celera	9	62,665,176 - 62,682,547 (+)	NCBI		Celera
Cytogenetic Map	9	C	NCBI
cM Map	9	35.31	NCBI

Mtfmt
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	74,848,936 - 74,866,987 (+)	NCBI		GRCr8
mRatBN7.2	8	65,953,787 - 65,971,841 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	65,953,767 - 65,971,841 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	8	71,466,158 - 71,484,219 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	69,739,169 - 69,757,231 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	67,608,805 - 67,626,822 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	70,952,209 - 70,986,393 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	70,952,203 - 70,986,408 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	70,644,131 - 70,674,636 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	69,683,737 - 69,701,721 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	8	69,702,790 - 69,720,775 (+)	NCBI
Celera	8	65,351,577 - 65,369,621 (+)	NCBI		Celera
Cytogenetic Map	8	q24	NCBI

Mtfmt
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955450	10,399,470 - 10,415,872 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955450	10,399,472 - 10,415,813 (+)	NCBI	ChiLan1.0	ChiLan1.0

MTFMT
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	16	54,248,598 - 54,275,521 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	15	58,419,167 - 58,447,109 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	15	43,942,227 - 43,969,182 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	15	62,225,620 - 62,253,612 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	15	62,225,620 - 62,253,612 (-)	Ensembl	panpan1.1		panPan2

MTFMT
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	30	29,388,600 - 29,415,578 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	30	29,388,649 - 29,450,430 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	30	29,316,102 - 29,343,074 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	30	29,575,346 - 29,602,377 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	30	29,575,395 - 29,638,967 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	30	29,508,217 - 29,535,124 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	30	29,569,540 - 29,596,594 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	30	29,810,600 - 29,837,619 (-)	NCBI		UU_Cfam_GSD_1.0

Mtfmt
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	107,486,806 - 107,504,465 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936471	25,335,068 - 25,352,480 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936471	25,334,544 - 25,352,520 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MTFMT
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	106,970,640 - 107,001,564 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	106,970,620 - 107,001,563 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	117,634,592 - 117,665,105 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Mtfmt
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624781	7,494,892 - 7,514,604 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624781	7,494,958 - 7,510,527 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	endocrine system	hemolymphoid system	nervous system
High
Medium	21		33
Low	15	20	27
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_008016265	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_501955	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000016	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCSAT00000010749 ⟹ ENSCSAP00000008837

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	26	18,556,791 - 18,583,446 (+)	Ensembl

RefSeq Acc Id:

XM_008016265 ⟹ XP_008014456

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	26	18,556,749 - 18,583,528 (+)	NCBI
Vero_WHO_p1.0	NW_023666048	122,849,535 - 122,876,821 (-)	NCBI

Sequence:

show sequence

CCCGACGCGCCTGCGCAGAGCGGGCCGCCGGCAGCCTAGGCGATGAGGGTGTTGGTGCGGTGCT
GTTGGGGTCCTCCGCTGGCTCATGGCGCTGGGCGTGGGAGGCCGAGTCCCCAGTGGCGAGGCCT
GGCCCAGCTCGGCTGGGAGGACTCCAGAGTCCGCAAGAAGCCTCCCTGGCGGGTGCTCTTCTTC
GGCACGGACCAGTTCGCCCGCGAGGCGCTGCGGGCGCTGCACGCCGCCAGGGAAAACAAACAGG
AAGAGTTAATCGACAAACTGGAGGTGGTCACAATGCCTTCCCTATCACCAAGAGGACTGCCAGT
GAAGCAATATGCTGTGCAGTCTCAGCTTCCAATATACGAGTGGCCGGACGTGGGATCTGGAGAA
TATGATGTTGGAGTAGTGGCTTCGTTTGGCCGACTTTTGAGTGAGGCTCTTATTCTTAAATTTC
CCTATGGCATATTGAATGTCCATCCCAGTTGCCTCCCGAGATGGCGTGGCCCAGCCCCTGTAAT
CCATACAGTGCTTCACGGAGACACAGTTACTGGAGTAACAATTATGCAAATTAGACCTAAAAGG
TTTGATGTAGGTCCAATTCTCAAACAAGAAACTATTCCTGTGCCACCCAAGAGCACTGCGAAGG
AATTGGAAGCAGTGTTGTCACGACTGGGTGCCAACATGCTCATTTCAGTTTTGAAAAATTTGCC
TGAAAGTCTGAGCAATGGAAGGCAGCAGCCAACAGAGGGGGCGACTTATGCCCCTAAGATTTCT
GCTGGTACCAGTTGTGTAAAATGGGAGGAACAAACTTCAGAACAAGTATTCAGACTTTACCGTG
CCATTGGAAATATAATTCCATTGCAGACGCTCTGGATGGGGAATACCATTAAACTTCTGGATTT
GGTAGAAGTTAACAGTTCAGTCTTTGCTGACCCAAAATTAACGGGACAGGCTCTTATTCCAGGA
TCAGTAATATACCACAAACAGTCACAAATACTGTTGGTTTATTGCAAGGATAGTTGGATTGGTG
TTCGATCAGTGATGCTCAAGAAAACATTAACGGCTACTGACTTCTACAATGGATATTTGCACCC
CTGGTACCAAAAAAATTCCCAGGCTCAACCAAGCCAATGCAGATTTCAGACTCTCAAACTTCCA
ACAAAGAAGAAGCAGAATAAAACTGTTGCTATGTAACAATGCATTGAGTAGTTAGGAAGAAGAT
GGATAAAAACCTATTACGTATTTGTAATTTATTAAAAACCTCATTTACAAGGAA

hide sequence

RefSeq Acc Id:

XR_501955

Type:

NON-CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	26	18,556,747 - 18,583,353 (+)	NCBI
Vero_WHO_p1.0	NW_023666048	122,850,143 - 122,876,821 (-)	NCBI

Sequence:

show sequence

GCCCCGACGCGCCTGCGCAGAGCGGGCCGCCGGCAGCCTAGGCGATGAGGGTGTTGGTGCGGTG
CTGTTGGGGTCCTCCGCTGGCTCATGGCGCTGGGCGTGGGAGGCCGAGTCCCCAGTGGCGAGGC
CTGGCCCAGCTCGGCTGGGAGGACTCCAGAGTCCGCAAGAAGCCTCCCTGGCGGGTGCTCTTCT
TCGGCACGGACCAGTTCGCCCGCGAGGCGCTGCGGGCGCTGCACGCCGCCAGGGAAAACAAACA
GGAAGAGTTAATCGACAAACTGGAGGTGGTCACAATGCCTTCCCTATCACCAAGAGGACTGCCA
GTGAAGCAATATGCTGTGCAGTCTCAGCTTCCAATATACGAGTGGCCGGACGTGGGATCTGGAG
AATATGATGTTGGAGTAGTGGCTTCGTTTGGCCGACTTTTGAGTGAGGCTCTTATTCTTAAATT
TCCCTATGGCATATTGAATGTCCATCCCAGTTGCCTCCCGAGATGGCGTGGCCCAGCCCCTGTA
ATCCATACAGTGCTTCACGGAGACACAGTTACTGGAGTAACAATTATGCAAATTAGACCTAAAA
GGTTTGATGTAGGTCCAATTCTCAAACAAGAAACTATTCCTGTGCCACCCAAGAGCACTGCGAA
GGAATTGGAAGCAGTGTTGTCACGACTGGGTGCCAACATGCTCATTTCAGTTTTGAAAAATTTG
CCTGAAAGTCTGAGCAATGGAAGGCAGCAGCCAACAGAGGGGGCGACTTATGCCCCTAAGATTT
CTGCTGGTACCAGTTGTGTAAAATGGGAGGAACAAACTTCAGAACAAGTATTCAGACTTTACCG
TGCCATTGGAAATATAATTCCATTGCAGACGCTCTGGATGGGGAATACCATTAAACTTCTGGAT
TTGGTAGAAGTTAACAGTTCAGTCTTTGCTGACCCAAAATTAACGGGACAGGCTCTTATTCCAG
GATCAGTAATATACCACAAACAGTCACAAATACTGTTGGTTTATTGCAAGGTATTTTGCATCAT
ATGGTGTTCATGTGAGATATTTCATACTTAAGAAGAGGTTTAGCTGGGCGCAGTGGCTCACACC
AGAAATCCAGCACTTTGAGAGGCTGAGGATAGTTGGATTGGTGTTCGATCAGTGATGCTCAAGA
AAACATTAACGGCTACTGACTTCTACAATGGATATTTGCACCCCTGGTAC

hide sequence

Protein Sequences


Protein RefSeqs	XP_008014456	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000008837.1

RefSeq Acc Id:	XP_008014456 ⟸ XM_008016265
- UniProtKB:	A0A0D9RJP8 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSCSAP00000008837 ⟸ ENSCSAT00000010749

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000012690	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000010749.1	UniProtKB/TrEMBL
Gene3D-CATH	3.40.50.12230	UniProtKB/TrEMBL
InterPro	Fmt	UniProtKB/TrEMBL
	Formyl_trans_C	UniProtKB/TrEMBL
	Formyl_transf_N	UniProtKB/TrEMBL
	Formyl_transf_N_sf	UniProtKB/TrEMBL
	Formyl_transferase-like_C_sf	UniProtKB/TrEMBL
	Met-tRNA-FMT_N	UniProtKB/TrEMBL
KEGG Report	csab:103245481	UniProtKB/TrEMBL
NCBI Gene	MTFMT	ENTREZGENE
PANTHER	METHIONYL-TRNA FORMYLTRANSFERASE	UniProtKB/TrEMBL
	METHIONYL-TRNA FORMYLTRANSFERASE, MITOCHONDRIAL	UniProtKB/TrEMBL
Pfam	Formyl_trans_C	UniProtKB/TrEMBL
	Formyl_trans_N	UniProtKB/TrEMBL
Superfamily-SCOP	SSF50486	UniProtKB/TrEMBL
	SSF53328	UniProtKB/TrEMBL
UniProt	A0A0D9RJP8	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

Imported Annotations - SMPDB

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

Imported Annotations - SMPDB