ASB1 (ankyrin repeat and SOCS box containing 1)

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Gene: ASB1 (ankyrin repeat and SOCS box containing 1) Chlorocebus sabaeus

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Symbol:

ASB1

Name:

ankyrin repeat and SOCS box containing 1

RGD ID:

18640702

Description:

ENCODES a protein that exhibits ubiquitin protein ligase activity (ortholog); INVOLVED IN male genitalia development (ortholog); ASSOCIATED WITH Bethlem Myopathy 1A (ortholog); chromosome 2q37 deletion syndrome (ortholog); D-2-hydroxyglutaric aciduria 1 (ortholog); FOUND IN ubiquitin ligase complex (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

ankyrin repeat and SOCS box protein 1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	10	124,456,993 - 124,479,904 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	10	124,456,492 - 124,478,600 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666040	74,937,061 - 74,964,236 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Bethlem Myopathy 1A (ISO)

chromosome 2q37 deletion syndrome (ISO)

D-2-hydroxyglutaric aciduria 1 (ISO)

hereditary spastic paraplegia 30 (ISO)

intellectual disability (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

intracellular signal transduction (IEA)

male genitalia development (IEA,ISO)

protein ubiquitination (IEA)

ubiquitin-dependent protein catabolic process (IEA)

Cellular Component

ubiquitin ligase complex (IEA)

Molecular Function

protein binding (ISO)

ubiquitin protein ligase activity (IEA,ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

ASB1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	10	124,456,993 - 124,479,904 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	10	124,456,492 - 124,478,600 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666040	74,937,061 - 74,964,236 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

ASB1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	238,426,927 - 238,452,250 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	238,426,742 - 238,452,250 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	239,335,568 - 239,360,891 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	239,000,365 - 239,025,630 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	2	239,117,625 - 239,142,890	NCBI
Celera	2	233,048,109 - 233,073,377 (+)	NCBI		Celera
Cytogenetic Map	2	q37.3	NCBI
HuRef	2	231,126,671 - 231,151,945 (+)	NCBI		HuRef
CHM1_1	2	239,341,851 - 239,367,116 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	2	238,917,065 - 238,942,362 (+)	NCBI		T2T-CHM13v2.0

Asb1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	91,467,725 - 91,487,312 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	91,468,266 - 91,487,311 (+)	Ensembl		GRCm39 Ensembl
GRCm38	1	91,540,001 - 91,559,590 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	91,540,544 - 91,559,589 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	1	93,437,142 - 93,456,167 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	1	93,370,971 - 93,390,034 (+)	NCBI		MGSCv36	mm8
Celera	1	94,477,061 - 94,496,069 (+)	NCBI		Celera
Cytogenetic Map	1	D	NCBI
cM Map	1	46.19	NCBI

Asb1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	9	99,566,852 - 99,588,321 (+)	NCBI		GRCr8
mRatBN7.2	9	92,120,332 - 92,140,790 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	92,120,306 - 92,136,376 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	9	100,547,118 - 100,562,967 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	9	105,682,879 - 105,698,728 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	9	104,046,687 - 104,062,664 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	9	98,668,231 - 98,689,471 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	98,668,231 - 98,684,900 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	9	98,344,295 - 98,364,916 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	9	90,758,693 - 90,774,541 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	9	90,963,353 - 90,979,013 (+)	NCBI
Celera	9	89,661,506 - 89,676,975 (+)	NCBI		Celera
Cytogenetic Map	9	q36	NCBI

Asb1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955542	2,243,381 - 2,255,747 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955542	2,243,381 - 2,255,747 (-)	NCBI	ChiLan1.0	ChiLan1.0

ASB1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	13	141,066,796 - 141,093,593 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2B	141,083,318 - 141,108,561 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2B	125,664,934 - 125,690,175 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2B	244,508,295 - 244,533,471 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2B	244,508,295 - 244,527,771 (+)	Ensembl	panpan1.1		panPan2

ASB1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Dog10K_Boxer_Tasha	25	49,349,423 - 49,370,853 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	25	49,239,887 - 49,261,315 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	25	49,217,966 - 49,255,992 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	25	49,114,892 - 49,211,423 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	25	48,903,641 - 48,925,039 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	25	49,135,809 - 49,157,238 (+)	NCBI		UU_Cfam_GSD_1.0

Asb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	190,845,532 - 190,860,128 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936525	84,907 - 97,210 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936525	79,568 - 94,147 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ASB1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	15	137,931,774 - 137,952,046 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	15	137,931,419 - 137,952,050 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	15	152,382,932 - 152,403,282 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Asb1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624847	3,477,516 - 3,491,451 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624847	3,477,499 - 3,489,427 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

ectoderm	endocrine system	hemolymphoid system	mesenchyme	mesoderm	nervous system	reproductive system
76	36	20	36	36	60	20

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_007966854	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038001299	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005241389	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000008	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCSAT00000004054 ⟹ ENSCSAP00000002318

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	10	124,456,492 - 124,478,600 (+)	Ensembl

RefSeq Acc Id:

XM_007966854 ⟹ XP_007965045

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	10	124,456,993 - 124,479,904 (+)	NCBI
Vero_WHO_p1.0	NW_023666040	74,937,063 - 74,964,159 (-)	NCBI

Sequence:

show sequence

CCTCGCTCTCGGCGCCGGAAGTGGTCGGGGGCCGCTTTCCTTCCTGCCCGAGGGGCGCGCGCGG
GCCCGGGGCGGCCGCGGAGGCCGAAGCACCCATGGCGGAGGGCGGCAGCCCAGACGGGCGGGCA
GGGCCGGGCTCCGCAGGTCGTAATCTGAAGGAGTGGCTGAGGGAACAGTTTTGTGATCACCCGC
TGGAGCACTGTGAGGACACGAGGCTCCATGATGCAGCCTACGTCGGGGACCTCCAGACCCTCAG
GAGCCTGTTGCAAGAGGAGAGCTACCGGAGCCGCATCAATGAGAAGTCTGTCTGGTGCTGTGGC
TGGCTGCCCTGCACACCGCTGCGAATCGCGGCCACTGCAGGCCATGGGAACTGTGTGGACTTCC
TCATCCGGAAGGGGGCCGAGGTGGATCTGGTGGACGTAAAAGGACAGACGGCCCTGTATGTGGC
TGTGGTGAACGGGCACCTAGAGAGTACCCAGATCCTTCTTGAAGCTGGCGCAGACCCCAACGGA
AGCCGGCACCATCGCAGCACCCCCGTCTACCACGCCTCTCGCGTGGGCCGGGCCGACATCCTGA
AGGCCCTTATCAGGTATGGGGCTGATGTTGACGTCAACCACCACCTGACTCCTGACATCCAGCC
CCGATTCTCCCGGCGGCTCACTTCCTTGGTGGTCTGCCCCTTGTACATCAGCGCAGCCTACCAC
AACCTCCAGTGCTTCCGGCTGCTCCTCCTGGCAGGAGCGAACCCCGACTTCAACTGCAATGGTC
CTGTCAACACACAGGGATTCTACAGGGGCTCCCCTGGGTGCGTCATGGATGCTGTTCTGCGTCA
CGGCTGTGAGGCAGCCTTCGTGAGCCTGCTGGTGGAGTTTGGAGCCAACCTGAATCTAGTGAAG
TGGGAATCGTTGGGCCCAGAGTCGAGAGGAAGAAGAAAGGTGGACCCTGAGGCCTTGCAGGTCT
TTAAAGAGGCCAGAAGTGTTCCCAGAACCTTGCTGTGTCTGTGCCGTGTGGCTGTGAGAAAAGC
TCTTGGCAAATACCGGCTTCATCTGATTCCTTCGCTGCCTCTGCCAGACCCCATAAAGAAGTTT
CTACTTCATGAGTAGACTTCGAGTGCTGCGGTTGATTCCAGCAAGGGAGAAGGTGATCTGCAGA
GAAGGTGGACACCAAACCCTGAGTGCTGTGCTGCTGGTGGTATCCTGATGGCTGTTGCTACTGA
AGATGTCGTCGTGGACTGTCATTGCTCCTCAGGTGCCTGGGCCGCCGAACAGTCCTTGGGTCAT
TGTCAACTGAGAGGCTCATACAAAAGTTATTATTGTTTTTCCCAAATTCTCTTTTCTGGATTTT
CAGTTGCATATTAATGTAACGGGCCATGGAATGTGTACATGTAGGGACTGAGGTTGGAGGCCTA
CGAATTTCCCTGTAGGGAGGACTCCTAGCACTTCTGGAACTGTGCTTCTCTTTATTTTTCTACT
TCTCAATTTGATTGTTCGATTAAAGCCTTCTAGTATCTCAATGAAAAGGGAGTTTTGTAAGCAA
AGTAGAGGACAGAAATGCAGACATGAACTTGCTGGGTTTTTCCCCGCTCCTGGGGTAACACATG
CTCTTGTCATACATGCCCTTCCTTGCCACTTCAGTATTCTGTCTTTGTGGTGGAGGTCTCATAG
TGATTGTCTTCATTCAAGGGTGGTTTCCTGGCTGCACAGCACCTGTTCCAATACCTTCTGTGCC
TCTCATCAGGTGTCATGATTTTTCTGCCACTTCACCTTAGGGAGCGTCCAGTGATTGATTTTAG
GAGGCCCACACCAAACTCCCCAGGAAATGACTGCCTTCCTTGGGACCAAGGACCGTTCCAACAG
CATTCACTGCCAGTTCTAACAGGCAAGGAAATGCCCGAGGCGCTGTCTTCTATCCCCCACACAT
ACCAGAAAGTGAAAAATGCAGCAAGTCCTCTGGGTGGTTCTGAGCCTCCAGGTGCATGCTGTCC
AGTGGACAAAACATCTGGCGGTTGGTTGATTGCTCTTTTGTCTTGGTAGCTGCTTCTAGAATCT
CTGCAAGGGGATGGCAGTGAGGCCAGAAGTCTTTCCCCGGAGAGACATGGCCTGGGTGATCACT
GCTGATAGCTTTGGCTGCGTGGGTGGGGCTTCCCCTCACCCAGGGCTGCACAGCCAGGTTGAGG
GTCACTGGCAGGTGGGCTGGTGGCTGCAGCCTCAGAGCCCTCCCAGGTTGCTGCTGTTTCCAGT
GAATCACATTTCATCATTTGAAGCCCGTGAGGACCATTGTGTGGGTCCATGGTGATTCTAGACT
TCAGATAGATTTAGGAAGGAGCAGATTTCAAATCTGTGTTTAGATTTTCTGTAATAAGAGAATT
CCAATTTGTAAAAATTGAACAACGATATCATTTTATTTA

hide sequence

RefSeq Acc Id:

XM_038001299 ⟹ XP_037857227

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
Vero_WHO_p1.0	NW_023666040	74,937,064 - 74,964,236 (-)	NCBI

RefSeq Acc Id:

XR_005241389

Type:

NON-CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
Vero_WHO_p1.0	NW_023666040	74,937,061 - 74,964,236 (-)	NCBI

Protein Sequences


Protein RefSeqs	XP_007965045	(Get FASTA)	NCBI Sequence Viewer
	XP_037857227	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000002318
	ENSCSAP00000002318.1

RefSeq Acc Id:	XP_007965045 ⟸ XM_007966854
- Peptide Label:	isoform X2
- UniProtKB:	A0A0D9R129 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSCSAP00000002318 ⟸ ENSCSAT00000004054

RefSeq Acc Id:	XP_037857227 ⟸ XM_038001299
- Peptide Label:	isoform X1

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000006016	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000004054.1	UniProtKB/TrEMBL
Gene3D-CATH	1.25.40.20	UniProtKB/TrEMBL
	SOCS box	UniProtKB/TrEMBL
InterPro	Ankyrin_rpt	UniProtKB/TrEMBL
	Ankyrin_rpt-contain_sf	UniProtKB/TrEMBL
	ASB1_SOCS	UniProtKB/TrEMBL
	CRL2_E3_Ligase_Fem-1	UniProtKB/TrEMBL
	SOCS_box	UniProtKB/TrEMBL
	SOCS_box-like_dom_sf	UniProtKB/TrEMBL
KEGG Report	csab:103218187	UniProtKB/TrEMBL
NCBI Gene	ASB1	ENTREZGENE
PANTHER	ANKYRIN REPEAT AND SOCS BOX PROTEIN 1	UniProtKB/TrEMBL
	ANKYRIN REPEAT CONTAINING	UniProtKB/TrEMBL
Pfam	Ank	UniProtKB/TrEMBL
	Ank_2	UniProtKB/TrEMBL
	SOCS_box	UniProtKB/TrEMBL
PRINTS	ANKYRIN	UniProtKB/TrEMBL
PROSITE	ANK_REP_REGION	UniProtKB/TrEMBL
	ANK_REPEAT	UniProtKB/TrEMBL
	SOCS	UniProtKB/TrEMBL
SMART	ANK	UniProtKB/TrEMBL
	SOCS_box	UniProtKB/TrEMBL
Superfamily-SCOP	SSF158235	UniProtKB/TrEMBL
	SSF48403	UniProtKB/TrEMBL
UniProt	A0A0D9R129	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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