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Gene: LBH (LBH regulator of WNT signaling pathway) Chlorocebus sabaeus

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Symbol:

LBH

Name:

LBH regulator of WNT signaling pathway

RGD ID:

18633893

Description:

INVOLVED IN positive regulation of DNA-templated transcription (ortholog); ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); FOUND IN cytoplasm (inferred); nucleus (inferred); protein-containing complex (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

limb bud and heart development; protein LBH

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	14	77,278,080 - 77,306,721 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	14	77,280,510 - 77,306,518 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666045	34,778,813 - 34,807,286 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Experimental Liver Cirrhosis (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

mammary gland development (IEA)

mammary gland epithelial cell differentiation (IEA)

negative regulation of DNA-templated transcription (IEA)

negative regulation of intracellular estrogen receptor signaling pathway (IEA)

negative regulation of stem cell differentiation (IEA)

positive regulation of DNA-templated transcription (IEA,ISO)

positive regulation of mammary stem cell proliferation (IEA)

positive regulation of somatic stem cell division (IEA)

positive regulation of somatic stem cell population maintenance (IEA)

regulation of DNA-templated transcription (IEA)

regulation of gene expression (IEA)

regulation of MAPK cascade (IEA)

Cellular Component

cytoplasm (IEA)

nucleus (IEA)

protein-containing complex (IEA)

Molecular Function

protein binding (ISO)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

LBH
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	14	77,278,080 - 77,306,721 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	14	77,280,510 - 77,306,518 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666045	34,778,813 - 34,807,286 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

LBH
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	30,231,534 - 30,260,028 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	30,231,534 - 30,323,730 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	30,454,400 - 30,482,894 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	30,307,901 - 30,336,403 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	2	30,288,761 - 30,325,820 (+)	NCBI		Celera
Cytogenetic Map	2	p23.1	NCBI
HuRef	2	30,192,937 - 30,221,438 (+)	NCBI		HuRef
CHM1_1	2	30,384,624 - 30,413,128 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	2	30,275,785 - 30,304,277 (+)	NCBI		T2T-CHM13v2.0

Lbh
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	73,225,300 - 73,248,941 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	17	73,225,300 - 73,248,942 (+)	Ensembl		GRCm39 Ensembl
GRCm38	17	72,918,305 - 72,941,946 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	72,918,305 - 72,941,947 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	17	73,267,645 - 73,291,286 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	17	72,823,326 - 72,846,942 (+)	NCBI		MGSCv36	mm8
Celera	17	77,201,369 - 77,224,975 (+)	NCBI		Celera
Cytogenetic Map	17	E1.3	NCBI
cM Map	17	44.73	NCBI

Lbh
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	28,321,040 - 28,344,855 (-)	NCBI		GRCr8
mRatBN7.2	6	22,569,238 - 22,593,056 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	22,568,834 - 22,593,079 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	6	22,900,702 - 22,924,517 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	23,216,535 - 23,240,350 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	22,699,234 - 22,723,154 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	24,154,207 - 24,184,217 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	24,160,226 - 24,181,866 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	6	34,010,473 - 34,031,267 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	6	22,662,376 - 22,664,667 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	6	22,105,340 - 22,129,287 (-)	NCBI		Celera
Cytogenetic Map	6	q14	NCBI

Lbh
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955469	12,054,727 - 12,078,796 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955469	12,054,727 - 12,078,796 (+)	NCBI	ChiLan1.0	ChiLan1.0

LBH
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	12	96,240,784 - 96,269,439 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2A	96,244,758 - 96,273,413 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2A	30,244,474 - 30,273,048 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2A	30,320,247 - 30,348,139 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2A	30,320,249 - 30,411,779 (+)	Ensembl	panpan1.1		panPan2

LBH
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	17	23,939,135 - 23,969,611 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	17	23,938,772 - 24,022,140 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	17	23,736,913 - 23,762,365 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	17	24,505,537 - 24,531,139 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	17	24,500,181 - 24,583,683 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	17	23,811,250 - 23,836,515 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	17	23,874,403 - 23,899,677 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	17	23,973,706 - 23,999,175 (+)	NCBI		UU_Cfam_GSD_1.0

Lbh
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024406292	68,040,234 - 68,088,820 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936493	2,750,745 - 2,776,141 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936493	2,750,745 - 2,776,145 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

LBH
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	109,078,286 - 109,105,529 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	109,078,285 - 109,113,536 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	115,765,351 - 115,795,411 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Lbh
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624738	12,106,236 - 12,130,052 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624738	12,098,227 - 12,129,968 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in LBH
616 total Variants

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

ectoderm	endocrine system	hemolymphoid system	mesenchyme	mesoderm	nervous system	reproductive system
76	36	20	36	36	60	20

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_007971051	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000013	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCSAT00000009198 ⟹ ENSCSAP00000007325

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	14	77,280,510 - 77,306,518 (-)	Ensembl

RefSeq Acc Id:

XM_007971051 ⟹ XP_007969242

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	14	77,278,080 - 77,306,721 (-)	NCBI
Vero_WHO_p1.0	NW_023666045	34,778,813 - 34,807,286 (+)	NCBI

Sequence:

show sequence

TGAGAGCTCAGTGGAGAGCGGGGAGTTGTGTCCGCCTCGCAAACGCTGCTGGCCGTGGGGCTGT
CCTGGGAAGGCGGACGGCGAGCGCCAGGTGCCCGCACTAGGCCGCCTGCCGTGCCTGTCTGCGC
CCGTGTCATCCTCACTCGGGACGCAGGGACCGTTTTTAAATCACAGGGGCGTGTGTCAGCCTGC
CCTAGGACTTCATGTCTATATATTTCCCCATTCACTGCCCTGACTATCTGAGATCGGCCGAGAT
GACTGAGGTGATGATGAACACCCAGCCCATGGAGGAAATCGGCCTCAGCCCCCGCAAGGATGGA
CTTTCCTACCAGATCTTCCCAGACCCGTCAGACTTTGACCGCTGCTGCAAACTGAAGGACCGCC
TCCCCTCCATAGTGGTGGAACCCACAGAAGGGGAGGTGGAGAGCGGGGAGCTCCGGTGGCCCCC
TGAGGAGTTCCTGGTCCAGGAGGATGAGCAAGACAACTGCGAAGAGACAGCGAAAGAAAATAAA
GAGCAGTAGAGTCCCTGTGGACTCCCATGGGTCATACCAGCCAGCATCTGTTCCTGAACTGTGT
TTTTCCCATCGTGACGGAAGAAGAGAGTGAGCCACAATCGTTCTGAAAATGTCAAACGAGGCTT
CTGTTTTGCAGCTGCAGATCACCGAGTTGGTTTTCTTTTCTTTTCTTGTCCTTTTTTTTTTTTT
TTTTTTTTTTTTTTGAAACTTGCCGAGCAGTGGAGCCCTCTGACAATTTGCAAGGCCCTCTGAG
AAAGGAAGCTGCTTAGAGCCAGGGGGTTAGGGGGTGGGGGGAGCGAGGGCTGTTTTTGAGATCA
TTATCTGAACTAAGGCAGCCTAGTAGAGGCAGTGGTGGGATTCCAATGGGTCTTGGTGGGTGGG
AGGTGGGGCATGTGCAAAGCAAGCAAGGAACATTTGGGGTAAGAAAACAAACACAAGGCAAAAG
AAAAAAATACATGTTTTTAAGAAAACATTGAGCAGAGAACTGCAGCCAGGATGCACTCAGCAGA
CATTCACTGTGGCTGCTGGTGCATCAGAAAACAAGGTCTTCATCTCTCCAGTTTCACCCACCCC
ACCCTTTGCTTTCATTTCAGGTGTGTTGGTCTATGACAGGGAGGAGAGGAAAGGAGAGCAGGAG
CAATTGGCTGCCTGCAAAGCCAGCTGGAGGTGATGTGCAGGAAAGGCAAGGTCACCCCATTCTT
CTCCATGGCCTGTCTGCTCCCAGCTGTGGTAGACTCACATAGCCAAGGTGATCGGTTTTTAAGA
GGCAGTGCTTTTCAGCTTTTCTCCCTGATATATCCATTTTGCTTCCCAGCACTTTTTAGGAGTA
GTGAGAGCACTTCCTGCCCTTGTTGGAAGCCCCAGGGTGGACACTTGGCATGAAGGTCTCTCCC
TCAACTGCTGCCCTCCCAAGACTTGCTCCCAAGGTGGAATGGGTGTGCTCTCCCAGGCCGGCCC
TTCCTCCTCCTCACCGCCACCTTCCCTGCCCCAGCCACAGCAGCCATGGGTACATGGGTCCCCA
GCTCAGCTGCGGATTCCCGCCAGTCTGCCCAGCTGCAATACTCACACCCATGGGGGCTCTCGGT
CTGTTTTTCTTGTGGTTGCCAAGTGGAGAGCAGACGTGGCTTTTTCTGTGTCTCGTTGGGGAGG
TGACTTGCATGGTGGGGACAAGGGATCGTGGCAGCCTTGGGATCGAGTTTGAAACTAAAGGATG
CCATGAGGTCCCTGGCTTCTCCCCATGTTGTTCCCGGACAAGGGCAGAAGGGAGGCATGGCAAG
GGACCTACACTGTCCTTACTCAACAGTGGTCCTCATCCCTCCCCACCTCCCACTGCTTCCTGCA
AGGGCACCAGTTGTATGAGAAAGTTGGCCTTTGGACTTAGCATTTCTTGTCGTAGCTAAGAGCC
ATCTGAAGCAGCAGGTTGCAGGACAAACGCTTCAGTCCACCCGGGAGCAGTACCATGTGACCAA
GAGGTGGACTCAGAGCCTTCCTTGAGCTAAACTCGGCCAACCAAGGCACGCAGCTTGTCCCCTC
AGGTCTCCAGTCAGTCCAGGTTGACCCTCAGTTCTGGACACGTGTATATAGCTGTATTTAATAC
CTCAAGGTCATTGTGGCTCTGGGGATGCCGGGGCAGGAGGACGAGGGTGTGCTGTGGACACAGC
AGTCCGTGGGATTCCGTTCTGGGAAGCCGATGGTCCCGGCACCCCCTGCTTCCTCCCTCTGTTG
TCTGCCTGTGTGACACACATCAATGGCAATAACTTCTTCCAACTCCTCGCAGAAGTGGGAGAGG
CCTGCAGCCTGCACCGAGAGGGGCTTTCCTCTCTCTTGCTCCCCGCTTCGTTCTGTTTTGGCTG
CAGAGAGTGGTTCATCCATACTCTCATTCCCTCGCCTCCCCTAGTGGACGGAGGCGGGGGTCTT
GCCTTTTCAATTCCTGTGTTTTGGTGTCTTCCCTTATCTGCTCCCCTGAATCACCTGTCCCGGT
CTTGCTGTGTGATGGGAACGTGCTTGTAAACTGCGTAACAAATCTACTTTGTGTATGTGTCTGT
TTATGGGGGTGGTTTATTCTTTTTGCTGGTCCCTAGACCACTTTGTATGACCGTTTGCAGTCTG
AGCAGGCCAGGGGCTGACAGCTAATGTCAGGACCCTCAGCGGTGGAGCCTGCTGGGGGGACCCA
GCTGCTCTTGGACAAGTGGCTGAGCTCCTATCTGGCCTCCTCTTTTTTTTTTTCCCCCCCAAGT
AATTTGTGTGTATTTCTAACTGATTGTATTGAAAAAATTCTTAGTATTTCAGTAAAAATGCCTG
TTGTGAGATGAACCTCCTGTAACTTCTATCTGTTCTTTTTTGAGGCTCAGGGAGAAACTAGCAT
TTTTTTTTTTTTCCAAACTACTTTTTGTCACTGTGACAGTTGTAAATAAAGTTTGAAAATGCTT
TCCA

hide sequence

Protein Sequences


Protein RefSeqs	XP_007969242	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000007325
	ENSCSAP00000007325.1

RefSeq Acc Id:	XP_007969242 ⟸ XM_007971051
- UniProtKB:	A0A0D9RFD6 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSCSAP00000007325 ⟸ ENSCSAT00000009198

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000011112	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000009198.1	UniProtKB/TrEMBL
InterPro	LBH	UniProtKB/TrEMBL
	LBH_dom	UniProtKB/TrEMBL
	LBH_dom_prot	UniProtKB/TrEMBL
KEGG Report	csab:103220553	UniProtKB/TrEMBL
NCBI Gene	LBH	ENTREZGENE
PANTHER	PROTEIN LBH	UniProtKB/TrEMBL
	PTHR14987	UniProtKB/TrEMBL
Pfam	Lbh	UniProtKB/TrEMBL
PIRSF	LBH	UniProtKB/TrEMBL
PRINTS	LBHPROTEIN	UniProtKB/TrEMBL
UniProt	A0A0D9RFD6	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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