TLK2 (tousled like kinase 2) - Rat Genome Database

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Gene: TLK2 (tousled like kinase 2) Chlorocebus sabaeus
Analyze
Symbol: TLK2
Name: tousled like kinase 2
RGD ID: 18633768
Description: ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN cellular response to gamma radiation (ortholog); DNA damage response (ortholog); negative regulation of proteasomal ubiquitin-dependent protein catabolic process (ortholog); ASSOCIATED WITH autistic disorder (ortholog); Autosomal Dominant Intellectual Developmental Disorder 57 (ortholog); Developmental Disease (ortholog); FOUND IN intermediate filament (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: serine/threonine-protein kinase tousled-like 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11658,662,284 - 58,800,838 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1658,660,126 - 58,797,786 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607729,296,162 - 29,437,603 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
TLK2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11658,662,284 - 58,800,838 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1658,660,126 - 58,797,786 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607729,296,162 - 29,437,603 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
TLK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381762,470,914 - 62,615,481 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1762,458,658 - 62,615,481 (+)EnsemblGRCh38hg38GRCh38
GRCh371760,555,172 - 60,692,842 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361757,910,136 - 58,044,759 (+)NCBINCBI36Build 36hg18NCBI36
Build 341757,910,135 - 58,044,757NCBI
Celera1754,943,227 - 55,080,744 (+)NCBICelera
Cytogenetic Map17q23.2NCBI
HuRef1755,922,871 - 56,059,913 (+)NCBIHuRef
CHM1_11760,620,742 - 60,757,150 (+)NCBICHM1_1
T2T-CHM13v2.01763,340,853 - 63,485,425 (+)NCBIT2T-CHM13v2.0
Tlk2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911105,066,869 - 105,174,785 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11105,069,633 - 105,174,785 (+)EnsemblGRCm39 Ensembl
GRCm3811105,167,895 - 105,283,959 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11105,178,807 - 105,283,959 (+)EnsemblGRCm38mm10GRCm38
MGSCv3711105,042,844 - 105,145,270 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611104,990,017 - 105,098,266 (+)NCBIMGSCv36mm8
Celera11116,917,176 - 117,016,528 (+)NCBICelera
Cytogenetic Map11E1NCBI
cM Map1168.61NCBI
Tlk2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81090,648,623 - 90,748,427 (+)NCBIGRCr8
mRatBN7.21090,154,449 - 90,248,562 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1090,156,813 - 90,248,561 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1095,206,187 - 95,297,605 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01094,669,374 - 94,760,787 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01090,087,610 - 90,178,997 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01093,410,181 - 93,507,277 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1093,415,399 - 93,507,277 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01093,171,277 - 93,265,759 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41094,583,881 - 94,675,624 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11094,598,540 - 94,690,015 (+)NCBI
Celera1088,840,363 - 88,931,499 (+)NCBICelera
Cytogenetic Map10q32.1NCBI
Tlk2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554789,100,863 - 9,231,281 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554789,100,863 - 9,229,448 (-)NCBIChiLan1.0ChiLan1.0
TLK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21978,625,228 - 78,770,238 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11783,443,071 - 83,589,819 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01756,542,670 - 56,678,294 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11761,685,664 - 61,830,394 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1761,689,998 - 61,830,394 (+)Ensemblpanpan1.1panPan2
TLK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1910,686,424 - 10,804,885 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl910,687,293 - 10,803,963 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha911,714,062 - 11,832,646 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0912,349,863 - 12,468,222 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl912,352,936 - 12,468,395 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1911,296,263 - 11,416,607 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0916,116,584 - 16,234,838 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0916,120,734 - 16,239,324 (-)NCBIUU_Cfam_GSD_1.0
Tlk2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560215,772,329 - 15,890,520 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365413,302,872 - 3,423,058 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365413,303,563 - 3,422,093 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TLK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1216,129,256 - 16,256,359 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11216,129,249 - 16,256,642 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21216,019,893 - 16,122,944 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Tlk2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462484924,867 - 151,002 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462484924,536 - 150,142 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 36 2 46
Low 18 14
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_008012193 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008012194 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008012195 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008012196 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008012197 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008012198 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008012199 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008012200 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008012201 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008012202 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008012203 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008012204 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_037993189 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_037993190 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_037993191 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_037993192 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_037993193 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_037993194 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JACDXN010000045 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCSAT00000001879   ⟹   ENSCSAP00000000214
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl1658,660,126 - 58,797,786 (-)Ensembl
RefSeq Acc Id: XM_008012193   ⟹   XP_008010384
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11658,662,287 - 58,799,594 (-)NCBI
Vero_WHO_p1.0NW_02366607729,296,163 - 29,436,927 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008012194   ⟹   XP_008010385
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11658,662,287 - 58,799,594 (-)NCBI
Vero_WHO_p1.0NW_02366607729,296,163 - 29,436,927 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008012197   ⟹   XP_008010388
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11658,662,287 - 58,799,714 (-)NCBI
Vero_WHO_p1.0NW_02366607729,296,163 - 29,437,603 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008012200   ⟹   XP_008010391
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11658,662,284 - 58,800,149 (-)NCBI
Vero_WHO_p1.0NW_02366607729,296,163 - 29,437,603 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008012201   ⟹   XP_008010392
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11658,662,287 - 58,799,763 (-)NCBI
Vero_WHO_p1.0NW_02366607729,296,163 - 29,437,603 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008012203   ⟹   XP_008010394
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11658,662,287 - 58,797,784 (-)NCBI
Vero_WHO_p1.0NW_02366607729,296,163 - 29,404,247 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008012204   ⟹   XP_008010395
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11658,662,287 - 58,770,681 (-)NCBI
Vero_WHO_p1.0NW_02366607729,296,163 - 29,406,507 (-)NCBI
Sequence:
RefSeq Acc Id: XM_037993189   ⟹   XP_037849117
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366607729,296,163 - 29,437,603 (-)NCBI
RefSeq Acc Id: XM_037993190   ⟹   XP_037849118
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366607729,296,162 - 29,437,603 (-)NCBI
RefSeq Acc Id: XM_037993191   ⟹   XP_037849119
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366607729,296,163 - 29,436,923 (-)NCBI
RefSeq Acc Id: XM_037993192   ⟹   XP_037849120
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366607729,296,163 - 29,436,989 (-)NCBI
RefSeq Acc Id: XM_037993193   ⟹   XP_037849121
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366607729,296,163 - 29,404,246 (-)NCBI
RefSeq Acc Id: XM_037993194   ⟹   XP_037849122
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366607729,296,163 - 29,404,240 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_008010391   ⟸   XM_008012200
- Peptide Label: isoform X1
RefSeq Acc Id: XP_008010392   ⟸   XM_008012201
- Peptide Label: isoform X2
- UniProtKB: A0A0D9QV25 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_008010388   ⟸   XM_008012197
- Peptide Label: isoform X1
RefSeq Acc Id: XP_008010385   ⟸   XM_008012194
- Peptide Label: isoform X4
RefSeq Acc Id: XP_008010384   ⟸   XM_008012193
- Peptide Label: isoform X3
RefSeq Acc Id: XP_008010394   ⟸   XM_008012203
- Peptide Label: isoform X8
RefSeq Acc Id: XP_008010395   ⟸   XM_008012204
- Peptide Label: isoform X8
RefSeq Acc Id: ENSCSAP00000000214   ⟸   ENSCSAT00000001879
RefSeq Acc Id: XP_037849118   ⟸   XM_037993190
- Peptide Label: isoform X6
RefSeq Acc Id: XP_037849117   ⟸   XM_037993189
- Peptide Label: isoform X5
RefSeq Acc Id: XP_037849120   ⟸   XM_037993192
- Peptide Label: isoform X8
RefSeq Acc Id: XP_037849119   ⟸   XM_037993191
- Peptide Label: isoform X7
RefSeq Acc Id: XP_037849121   ⟸   XM_037993193
- Peptide Label: isoform X9
RefSeq Acc Id: XP_037849122   ⟸   XM_037993194
- Peptide Label: isoform X10


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000003847 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000001879.1 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
NCBI Gene TLK2 ENTREZGENE
PANTHER MIXED LINEAGE PROTEIN KINASE UniProtKB/TrEMBL
  PTHR22974:SF20 UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt A0A0D9QV25 ENTREZGENE, UniProtKB/TrEMBL