TP63 (tumor protein p63) - Rat Genome Database

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Gene: TP63 (tumor protein p63) Chlorocebus sabaeus
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Symbol: TP63
Name: tumor protein p63
RGD ID: 18627842
Description: ENCODES a protein that exhibits chromatin binding (ortholog); damaged DNA binding (ortholog); DNA binding (ortholog); INVOLVED IN anatomical structure formation involved in morphogenesis (ortholog); animal organ morphogenesis (ortholog); cellular senescence (ortholog); PARTICIPATES IN altered p53 signaling pathway; ASSOCIATED WITH adenocarcinoma (ortholog); ADULT syndrome (ortholog); amenorrhea (ortholog); FOUND IN chromatin (ortholog); cytoplasm (ortholog); dendrite (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: tumor protein 63
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11583,861,489 - 84,126,675 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604157,444,595 - 57,708,553 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
adenocarcinoma  (ISO)
ADULT syndrome  (ISO)
amenorrhea  (ISO)
Ankyloblepharon Filiforme Adnatum  (ISO)
ankyloblepharon-ectodermal defects-cleft lip/palate syndrome  (ISO)
Auditory Neuropathy  (ISO)
bladder exstrophy  (ISO)
bladder exstrophy-epispadias-cloacal exstrophy complex  (ISO)
breast disease  (ISO)
Breast Neoplasms  (ISO)
carcinoma  (ISO)
cervix uteri carcinoma in situ  (ISO)
cleft lip  (ISO)
Cleft Lip with or without Cleft Palate, Nonsyndromic, 8  (ISO)
cleft palate  (ISO)
Colorectal Neoplasms  (ISO)
Congenital Foot Deformities  (ISO)
Congenital Hand Deformities  (ISO)
Congenital Limb Deformities  (ISO)
Corneal Injuries  (ISO)
Craniofacial Abnormalities  (ISO)
ectodermal dysplasia  (ISO)
ectrodactyly, ectodermal dysplasia, and cleft lip-palate syndrome 3  (ISO)
EEC syndrome  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Neoplasms  (ISO)
Female Urogenital Diseases  (ISO)
fissured tongue  (ISO)
gastroesophageal reflux disease  (ISO)
genetic disease  (ISO)
Limb-Mammary Syndrome  (ISO)
lung adenocarcinoma  (ISO)
lung cancer  (ISO)
Lung Neoplasms  (ISO)
Multiple Abnormalities  (ISO)
muscular dystrophy  (ISO)
Neoplasm Metastasis  (ISO)
Neoplastic Cell Transformation  (ISO)
orofacial cleft 8  (ISO)
osteochondrodysplasia  (ISO)
Ovarian Neoplasms  (ISO)
pancreatic cancer  (ISO)
primary ovarian insufficiency  (ISO)
Primary Ovarian Insufficiency 21  (ISO)
prostate cancer  (ISO)
prostate carcinoma in situ  (ISO)
Prostatic Neoplasms  (ISO)
Rapp-Hodgkin syndrome  (ISO)
schizophrenia  (ISO)
Skin Abnormalities  (ISO)
spermatogenic failure 5  (ISO)
split hand-foot malformation  (ISO)
split hand-foot malformation 4  (ISO)
squamous cell carcinoma  (ISO)
squamous cell neoplasm  (ISO)
Sweat Gland Neoplasms  (ISO)
transitional cell carcinoma  (ISO)
urinary bladder cancer  (ISO)
Urologic Neoplasms  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
anatomical structure formation involved in morphogenesis  (ISO)
animal organ morphogenesis  (ISO)
cellular senescence  (ISO)
chromatin remodeling  (ISO)
cloacal septation  (ISO)
cranial skeletal system development  (ISO)
determination of adult lifespan  (ISO)
DNA damage response  (ISO)
ectoderm and mesoderm interaction  (ISO)
embryonic forelimb morphogenesis  (ISO)
embryonic hindlimb morphogenesis  (ISO)
embryonic limb morphogenesis  (ISO)
epidermal cell differentiation  (ISO)
epidermal cell division  (ISO)
epidermis development  (ISO)
epithelial cell development  (ISO)
epithelial cell differentiation  (ISO)
establishment of planar polarity  (ISO)
establishment of skin barrier  (ISO)
female genitalia morphogenesis  (ISO)
hair follicle development  (ISO)
hair follicle morphogenesis  (ISO)
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator  (ISO)
keratinocyte differentiation  (ISO)
keratinocyte proliferation  (ISO)
morphogenesis of a polarized epithelium  (ISO)
negative regulation of cellular senescence  (ISO)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of intracellular estrogen receptor signaling pathway  (ISO)
negative regulation of keratinocyte differentiation  (ISO)
negative regulation of mesoderm development  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
neuron apoptotic process  (ISO)
Notch signaling pathway  (ISO)
odontogenesis of dentin-containing tooth  (ISO)
pattern specification process  (ISO)
polarized epithelial cell differentiation  (ISO)
positive regulation of apoptotic signaling pathway  (ISO)
positive regulation of cell cycle G1/S phase transition  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of fibroblast apoptotic process  (ISO)
positive regulation of keratinocyte proliferation  (ISO)
positive regulation of Notch signaling pathway  (ISO)
positive regulation of osteoblast differentiation  (ISO)
positive regulation of somatic stem cell population maintenance  (ISO)
positive regulation of stem cell proliferation  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
post-anal tail morphogenesis  (ISO)
prostate gland development  (ISO)
prostatic bud formation  (ISO)
proximal/distal pattern formation  (ISO)
regulation of cysteine-type endopeptidase activity involved in apoptotic process  (ISO)
regulation of epidermal cell division  (ISO)
skeletal system development  (ISO)
skin epidermis development  (ISO)
skin morphogenesis  (ISO)
spermatogenesis  (ISO)
squamous basal epithelial stem cell differentiation involved in prostate gland acinus development  (ISO)
stem cell differentiation  (ISO)
stem cell proliferation  (ISO)
sympathetic nervous system development  (ISO)
transcription by RNA polymerase II  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
TP63
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11583,861,489 - 84,126,675 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604157,444,595 - 57,708,553 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
TP63
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383189,596,746 - 189,897,276 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3189,631,389 - 189,897,276 (+)EnsemblGRCh38hg38GRCh38
GRCh373189,314,535 - 189,615,065 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363190,831,910 - 191,097,759 (+)NCBINCBI36Build 36hg18NCBI36
Celera3187,783,803 - 188,042,610 (+)NCBICelera
Cytogenetic Map3q28NCBI
HuRef3186,752,882 - 187,012,887 (+)NCBIHuRef
CHM1_13189,312,090 - 189,577,623 (+)NCBICHM1_1
T2T-CHM13v2.03192,413,470 - 192,713,713 (+)NCBIT2T-CHM13v2.0
Trp63
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391625,502,513 - 25,710,842 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1625,502,513 - 25,710,852 (+)EnsemblGRCm39 Ensembl
GRCm381625,683,763 - 25,892,088 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1625,683,763 - 25,892,102 (+)EnsemblGRCm38mm10GRCm38
MGSCv371625,683,851 - 25,892,174 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361625,717,291 - 25,807,429 (+)NCBIMGSCv36mm8
Celera1626,227,614 - 26,435,704 (+)NCBICelera
Cytogenetic Map16B1NCBI
cM Map1617.37NCBI
Tp63
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81188,343,647 - 88,554,543 (-)NCBIGRCr8
mRatBN7.21174,838,858 - 75,049,764 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1174,838,859 - 75,049,398 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1183,648,386 - 83,858,432 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01176,283,447 - 76,493,481 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01175,342,697 - 75,553,279 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01178,234,853 - 78,456,559 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1178,234,800 - 78,456,501 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01182,262,234 - 82,484,354 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41176,900,622 - 77,200,251 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11176,958,211 - 77,257,840 (-)NCBI
Celera1173,744,494 - 73,953,104 (-)NCBICelera
Cytogenetic Map11q22NCBI
Tp63
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542018,176,155 - 18,384,786 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542018,178,639 - 18,384,786 (-)NCBIChiLan1.0ChiLan1.0
TP63
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22187,462,332 - 187,762,966 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13187,467,050 - 187,767,682 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03186,651,879 - 186,918,300 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13195,172,810 - 195,473,085 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3195,199,167 - 195,474,104 (+)Ensemblpanpan1.1panPan2
TP63
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13421,766,861 - 21,985,095 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3421,766,496 - 21,983,046 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3425,860,495 - 26,078,655 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03421,700,749 - 21,919,495 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3421,700,663 - 21,918,660 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13421,716,204 - 21,934,749 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03421,710,660 - 21,927,985 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03421,951,749 - 22,170,136 (+)NCBIUU_Cfam_GSD_1.0
Tp63
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602114,397,903 - 114,613,831 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936578491,507 - 705,729 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936578492,267 - 705,282 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TP63
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13127,116,105 - 127,347,068 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113127,115,990 - 127,347,082 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213136,309,804 - 136,515,766 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Tp63
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473067,286,160 - 67,489,670 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473067,283,444 - 67,489,808 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Sequence


RefSeq Acc Id: XM_038003061   ⟹   XP_037858989
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366604157,444,595 - 57,693,004 (+)NCBI
RefSeq Acc Id: XM_038003062   ⟹   XP_037858990
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366604157,549,512 - 57,708,553 (+)NCBI
Protein Sequences
Protein RefSeqs XP_037858989 (Get FASTA)   NCBI Sequence Viewer  
  XP_037858990 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_037858989   ⟸   XM_038003061
- Peptide Label: isoform X1
RefSeq Acc Id: XP_037858990   ⟸   XM_038003062
- Peptide Label: isoform X2


Additional Information

Database Acc Id Source(s)
NCBI Gene TP63 ENTREZGENE