ARHGEF18 (Rho/Rac guanine nucleotide exchange factor 18) - Rat Genome Database

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Gene: ARHGEF18 (Rho/Rac guanine nucleotide exchange factor 18) Chlorocebus sabaeus
Analyze
Symbol: ARHGEF18
Name: Rho/Rac guanine nucleotide exchange factor 18
RGD ID: 18617901
Description: ENCODES a protein that exhibits guanyl-nucleotide exchange factor activity (inferred); INVOLVED IN actin cytoskeleton organization (ortholog); negative regulation of stress fiber assembly (ortholog); protein localization to cell-cell junction (ortholog); ASSOCIATED WITH fundus dystrophy (ortholog); genetic disease (ortholog); hereditary spastic paraplegia 39 (ortholog); FOUND IN apical part of cell (ortholog); cytosol (ortholog); plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: rho guanine nucleotide exchange factor 18
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.166,846,595 - 6,972,701 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl66,869,318 - 6,973,989 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666081898,649 - 1,027,439 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
ARHGEF18
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.166,846,595 - 6,972,701 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl66,869,318 - 6,973,989 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666081898,649 - 1,027,439 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
ARHGEF18
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38197,348,937 - 7,479,989 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl197,348,937 - 7,472,485 (+)EnsemblGRCh38hg38GRCh38
GRCh37197,413,842 - 7,537,364 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36197,351,866 - 7,443,371 (+)NCBINCBI36Build 36hg18NCBI36
Build 34197,351,865 - 7,443,370NCBI
Celera197,331,115 - 7,409,876 (+)NCBICelera
Cytogenetic Map19p13.2NCBI
HuRef197,128,031 - 7,179,714 (+)NCBIHuRef
HuRef197,186,895 - 7,208,106 (+)NCBIHuRef
CHM1_1197,459,437 - 7,537,381 (+)NCBICHM1_1
T2T-CHM13v2.0197,341,415 - 7,480,103 (+)NCBIT2T-CHM13v2.0
Arhgef18
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3983,403,339 - 3,506,601 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl83,403,415 - 3,506,601 (+)EnsemblGRCm39 Ensembl
GRCm3883,353,338 - 3,456,601 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl83,353,415 - 3,456,601 (+)EnsemblGRCm38mm10GRCm38
MGSCv3783,393,008 - 3,456,600 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3683,393,008 - 3,456,600 (+)NCBIMGSCv36mm8
Celera83,618,863 - 3,682,398 (+)NCBICelera
Cytogenetic Map8A1.1NCBI
cM Map81.92NCBI
Arhgef18
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8126,192,958 - 6,300,997 (+)NCBIGRCr8
mRatBN7.2121,395,035 - 1,503,082 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl121,395,088 - 1,503,081 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx122,058,113 - 2,167,374 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0122,681,667 - 2,790,942 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0121,453,728 - 1,562,982 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0121,889,252 - 1,998,128 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl121,889,331 - 1,998,127 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0124,056,145 - 4,161,174 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4122,712,198 - 2,855,137 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1122,713,997 - 2,740,671 (-)NCBI
Celera123,250,654 - 3,359,236 (+)NCBICelera
Cytogenetic Map12p12NCBI
Arhgef18
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555631,746,838 - 1,772,772 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555631,745,202 - 1,823,411 (-)NCBIChiLan1.0ChiLan1.0
ARHGEF18
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22012,057,368 - 12,143,966 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11911,175,668 - 11,262,115 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0196,677,468 - 6,763,286 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1197,580,173 - 7,622,096 (+)NCBIpanpan1.1PanPan1.1panPan2
ARHGEF18
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12052,196,670 - 52,281,491 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2052,201,007 - 52,283,000 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2052,001,555 - 52,087,194 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02052,726,796 - 52,812,572 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2052,726,780 - 52,812,567 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12051,930,590 - 52,016,159 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02052,374,118 - 52,459,723 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02052,604,731 - 52,690,664 (+)NCBIUU_Cfam_GSD_1.0
Arhgef18
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118213,262,232 - 213,334,821 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365884,514,691 - 4,572,518 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365884,522,517 - 4,572,551 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ARHGEF18
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl271,651,100 - 71,747,409 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1271,651,096 - 71,747,513 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2272,176,541 - 72,198,429 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Arhgef18
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624828536,926 - 605,119 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624828529,529 - 604,996 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 36 17 32
Low 3 28
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000006886   ⟹   ENSCSAP00000005077
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl66,869,318 - 6,973,989 (+)Ensembl
RefSeq Acc Id: XM_007995025   ⟹   XP_007993216
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.166,846,596 - 6,972,701 (+)NCBI
Vero_WHO_p1.0NW_023666081898,649 - 1,027,439 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007995026   ⟹   XP_007993217
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.166,846,596 - 6,972,701 (+)NCBI
Vero_WHO_p1.0NW_023666081898,649 - 1,027,439 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007995027   ⟹   XP_007993218
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.166,851,974 - 6,970,994 (+)NCBI
Vero_WHO_p1.0NW_023666081898,649 - 1,021,454 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007995030   ⟹   XP_007993221
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.166,888,535 - 6,970,994 (+)NCBI
Vero_WHO_p1.0NW_023666081898,649 - 980,091 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007995031   ⟹   XP_007993222
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.166,888,535 - 6,972,701 (+)NCBI
Vero_WHO_p1.0NW_023666081898,649 - 980,091 (-)NCBI
Sequence:
RefSeq Acc Id: XM_037994350   ⟹   XP_037850278
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_023666081898,649 - 1,027,439 (-)NCBI
RefSeq Acc Id: XM_037994352   ⟹   XP_037850280
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_023666081898,649 - 1,003,790 (-)NCBI
RefSeq Acc Id: XM_037994353   ⟹   XP_037850281
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_023666081898,649 - 980,090 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_007993216   ⟸   XM_007995025
- Peptide Label: isoform X1
RefSeq Acc Id: XP_007993217   ⟸   XM_007995026
- Peptide Label: isoform X1
RefSeq Acc Id: XP_007993218   ⟸   XM_007995027
- Peptide Label: isoform X2
- UniProtKB: A0A0D9R8Y8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007993222   ⟸   XM_007995031
- Peptide Label: isoform X4
- UniProtKB: A0A0D9R8Y8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007993221   ⟸   XM_007995030
- Peptide Label: isoform X4
- UniProtKB: A0A0D9R8Y8 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000005077   ⟸   ENSCSAT00000006886
RefSeq Acc Id: XP_037850278   ⟸   XM_037994350
- Peptide Label: isoform X1
RefSeq Acc Id: XP_037850280   ⟸   XM_037994352
- Peptide Label: isoform X3
- UniProtKB: A0A0D9R8Y8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037850281   ⟸   XM_037994353
- Peptide Label: isoform X4
- UniProtKB: A0A0D9R8Y8 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000008824 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000006886.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.900.10 UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/TrEMBL
InterPro ARHGEF18_PH UniProtKB/TrEMBL
  DBL_dom_sf UniProtKB/TrEMBL
  DH-domain UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
  PH_16 UniProtKB/TrEMBL
  PH_domain UniProtKB/TrEMBL
NCBI Gene ARHGEF18 ENTREZGENE
PANTHER RHO/RAC GUANINE NUCLEOTIDE EXCHANGE FACTOR 18 UniProtKB/TrEMBL
  RIKEN CDNA A430078G23 GENE UniProtKB/TrEMBL
Pfam PH_16 UniProtKB/TrEMBL
  RhoGEF UniProtKB/TrEMBL
PROSITE DH_2 UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/TrEMBL
SMART RhoGEF UniProtKB/TrEMBL
  SM00233 UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
  SSF48065 UniProtKB/TrEMBL
UniProt A0A0D9R8Y8 ENTREZGENE, UniProtKB/TrEMBL