ATP1A1 (ATPase Na+/K+ transporting subunit alpha 1) - Rat Genome Database

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Gene: ATP1A1 (ATPase Na+/K+ transporting subunit alpha 1) Chlorocebus sabaeus
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Symbol: ATP1A1
Name: ATPase Na+/K+ transporting subunit alpha 1
RGD ID: 18615446
Description: ENCODES a protein that exhibits ADP binding (ortholog); ankyrin binding (ortholog); ATP binding (ortholog); INVOLVED IN cellular response to mechanical stimulus (ortholog); heart contraction (ortholog); membrane hyperpolarization (ortholog); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; alfentanil pharmacodynamics pathway; ASSOCIATED WITH adenoma (ortholog); adrenal cortical adenoma (ortholog); catecholaminergic polymorphic ventricular tachycardia 1 (ortholog); FOUND IN caveola (ortholog); endoplasmic reticulum (ortholog); endosome (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: sodium/potassium-transporting ATPase subunit alpha-1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12017,319,440 - 17,351,054 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2017,315,117 - 17,351,054 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603820,010,534 - 20,042,335 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway   (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
alfentanil pharmacodynamics pathway  (ISO)
amiloride pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
bendroflumethiazide pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bumetanide pharmacodynamics pathway  (ISO)
bupivacaine pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway  (ISO)
buprenorphine pharmacodynamics pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
chloroprocaine pharmacodynamics pathway  (ISO)
chlorothiazide pharmacodynamics pathway  (ISO)
chlorthalidone pharmacodynamics pathway  (ISO)
citalopram pharmacodynamics pathway  (ISO)
cocaine pharmacodynamics pathway  (ISO)
codeine and morphine pharmacodynamics pathway  (ISO)
cystinuria pathway  (ISO)
desipramine pharmacodynamics pathway  (ISO)
diltiazem pharmacodynamics pathway  (ISO)
diphenoxylate pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
eplerenone pharmacodynamics pathway  (ISO)
escitalopram pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
etacrynic acid pharmacodynamics pathway  (ISO)
ethylmorphine pharmacodynamics pathway  (ISO)
fentanyl pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fluoxetine pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
furosemide pharmacodynamics pathway  (ISO)
Hartnup disease pathway  (ISO)
heroin pharmacodynamics pathway  (ISO)
hydrochlorothiazide pharmacodynamics pathway  (ISO)
hydrocodone pharmacodynamics pathway  (ISO)
hydroflumethiazide pharmacodynamics pathway  (ISO)
hydromorphone pharmacodynamics pathway  (ISO)
ibutilide pharmacodynamics pathway  (ISO)
iminoglycinuria pathway  (ISO)
imipramine pharmacodynamics pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
lactose degradation pathway  (ISO)
levacetylmethadol pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
levobupivacaine phgarmacodynamics pathway  (ISO)
levorphanol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
lysinuric protein intolerance pathway  (ISO)
mepivacaine pharmacodynamics pathway  (ISO)
methadone pharmacodynamics pathway  (ISO)
metolazone pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nalbuphine pharmacodynamics pathway  (ISO)
naloxone pharmacodynamics pathway  (ISO)
naltrexone pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nicotine pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
oxybuprocaine pharmacodynamics pathway  (ISO)
oxycodone pharmacodynamics pathway  (ISO)
oxymorphone pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
pentazocine pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
prilocaine pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
procaine pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
remifentanil pharmacodynamics pathway  (ISO)
ropivacaine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
spironolactone pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
torasemide pharmacodynamics pathway  (ISO)
tramadol pharmacodynamics pathway  (ISO)
trehalose degradation pathway  (ISO)
triamterene pharmacodynamics pathway  (ISO)
trichlormethiazide pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

References
Additional References at PubMed
PMID:22301074   PMID:30032202   PMID:31199885  


Genomics

Comparative Map Data
ATP1A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12017,319,440 - 17,351,054 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2017,315,117 - 17,351,054 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603820,010,534 - 20,042,335 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
ATP1A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381116,373,244 - 116,404,774 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1116,372,668 - 116,410,261 (+)EnsemblGRCh38hg38GRCh38
GRCh371116,915,866 - 116,947,396 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361116,717,359 - 116,748,919 (+)NCBINCBI36Build 36hg18NCBI36
Build 341116,627,877 - 116,659,436NCBI
Celera1115,144,421 - 115,176,022 (+)NCBICelera
Cytogenetic Map1p13.1NCBI
HuRef1114,773,961 - 114,805,562 (+)NCBIHuRef
CHM1_11117,030,620 - 117,062,221 (+)NCBICHM1_1
T2T-CHM13v2.01116,381,314 - 116,412,844 (+)NCBIT2T-CHM13v2.0
Atp1a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393101,483,535 - 101,512,023 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3101,483,535 - 101,512,000 (-)EnsemblGRCm39 Ensembl
GRCm383101,576,219 - 101,604,707 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3101,576,219 - 101,604,684 (-)EnsemblGRCm38mm10GRCm38
MGSCv373101,380,146 - 101,408,580 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363101,705,284 - 101,733,721 (-)NCBIMGSCv36mm8
Celera3103,788,093 - 103,816,528 (-)NCBICelera
Cytogenetic Map3F2.2NCBI
cM Map344.3NCBI
Atp1a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82191,709,311 - 191,737,414 (-)NCBIGRCr8
mRatBN7.22189,020,722 - 189,048,826 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2189,020,722 - 189,048,837 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2196,653,579 - 196,681,622 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02194,505,708 - 194,533,839 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02189,331,424 - 189,359,536 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02204,003,742 - 204,032,023 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2204,003,742 - 204,032,023 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02223,440,514 - 223,469,880 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42196,657,749 - 196,687,242 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12196,620,502 - 196,649,996 (-)NCBI
Celera2181,455,492 - 181,483,650 (-)NCBICelera
Cytogenetic Map2q34NCBI
Atp1a1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543519,536,634 - 19,564,580 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543519,537,224 - 19,563,631 (+)NCBIChiLan1.0ChiLan1.0
ATP1A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21109,022,509 - 109,054,043 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11108,622,152 - 108,653,661 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0186,162,401 - 86,193,883 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11121,212,161 - 121,232,876 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1121,212,488 - 121,243,099 (-)Ensemblpanpan1.1panPan2
ATP1A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11753,828,482 - 53,847,043 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1753,813,976 - 53,847,167 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1753,476,043 - 53,494,904 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01754,699,283 - 54,728,846 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1754,699,543 - 54,728,855 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11753,747,272 - 53,766,129 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01753,783,159 - 53,802,012 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01754,356,732 - 54,375,594 (+)NCBIUU_Cfam_GSD_1.0
Atp1a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505812,904,636 - 12,933,790 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366271,554,873 - 1,584,638 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366271,555,151 - 1,584,370 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ATP1A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4104,353,506 - 104,384,680 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14104,353,506 - 104,384,321 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24114,431,993 - 114,451,892 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap4q1.6-q2.3NCBI
Atp1a1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477212,099,435 - 12,127,737 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477212,099,523 - 12,127,437 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression

ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
reproductive system
76 36 20 36 36 60 20

Sequence


Ensembl Acc Id: ENSCSAT00000016838   ⟹   ENSCSAP00000016336
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl2017,315,117 - 17,351,054 (-)Ensembl
RefSeq Acc Id: XM_007977438   ⟹   XP_007975629
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12017,319,440 - 17,351,054 (-)NCBI
Vero_WHO_p1.0NW_02366603820,010,534 - 20,042,335 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_007975629 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000016336
  ENSCSAP00000016336.1
RefSeq Acc Id: XP_007975629   ⟸   XM_007977438
- UniProtKB: A0A0D9S647 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCSAP00000016336   ⟸   ENSCSAT00000016838


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000001691 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000016838.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.1110.10 UniProtKB/TrEMBL
  3.40.50.1000 UniProtKB/TrEMBL
  Calcium-transporting ATPase, cytoplasmic transduction domain A UniProtKB/TrEMBL
  Calcium-transporting ATPase, transmembrane domain UniProtKB/TrEMBL
InterPro ATPase_P-typ_cation-transptr_C UniProtKB/TrEMBL
  ATPase_P-typ_cation-transptr_N UniProtKB/TrEMBL
  ATPase_P-typ_cyto_dom_N UniProtKB/TrEMBL
  ATPase_P-typ_P_site UniProtKB/TrEMBL
  ATPase_P-typ_TM_dom_sf UniProtKB/TrEMBL
  ATPase_P-typ_transduc_dom_A_sf UniProtKB/TrEMBL
  Cation_transp_ATPase_P-type UniProtKB/TrEMBL
  HAD-like_sf UniProtKB/TrEMBL
  HAD_sf UniProtKB/TrEMBL
  P-type_ATPase_IIC UniProtKB/TrEMBL
  P_typ_ATPase UniProtKB/TrEMBL
  P_typ_ATPase_HD_dom UniProtKB/TrEMBL
KEGG Report csab:103224143 UniProtKB/TrEMBL
NCBI Gene ATP1A1 ENTREZGENE
PANTHER SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA UniProtKB/TrEMBL
  SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA-1 UniProtKB/TrEMBL
Pfam Cation_ATPase UniProtKB/TrEMBL
  Cation_ATPase_C UniProtKB/TrEMBL
  Cation_ATPase_N UniProtKB/TrEMBL
  E1-E2_ATPase UniProtKB/TrEMBL
PRINTS CATATPASE UniProtKB/TrEMBL
  NAKATPASE UniProtKB/TrEMBL
PROSITE ATPASE_E1_E2 UniProtKB/TrEMBL
SMART Cation_ATPase_N UniProtKB/TrEMBL
Superfamily-SCOP SSF56784 UniProtKB/TrEMBL
  SSF81653 UniProtKB/TrEMBL
  SSF81660 UniProtKB/TrEMBL
  SSF81665 UniProtKB/TrEMBL
UniProt A0A0D9S647 ENTREZGENE, UniProtKB/TrEMBL