PUS7 (pseudouridine synthase 7) - Rat Genome Database

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Gene: PUS7 (pseudouridine synthase 7) Chlorocebus sabaeus
Analyze
Symbol: PUS7
Name: pseudouridine synthase 7
RGD ID: 18615084
Description: ENCODES a protein that exhibits enzyme binding (ortholog); INVOLVED IN mRNA pseudouridine synthesis (ortholog); negative regulation of translation (ortholog); regulation of hematopoietic stem cell differentiation (ortholog); ASSOCIATED WITH genetic disease (ortholog); intellectual developmental disorder with abnormal behavior, microcephaly, and short stature (ortholog); pleomorphic xanthoastrocytoma (ortholog); FOUND IN nucleus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: pseudouridylate synthase 7 (putative); pseudouridylate synthase 7 homolog
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12174,381,482 - 74,447,531 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2174,381,054 - 74,447,444 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604229,469,976 - 29,536,355 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nucleus  (IEA,ISO)

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
PUS7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12174,381,482 - 74,447,531 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2174,381,054 - 74,447,444 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604229,469,976 - 29,536,355 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
PUS7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387105,456,501 - 105,522,271 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7105,439,661 - 105,522,271 (-)EnsemblGRCh38hg38GRCh38
GRCh377105,096,948 - 105,162,718 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367104,884,194 - 104,949,921 (-)NCBINCBI36Build 36hg18NCBI36
Celera799,902,490 - 99,967,797 (-)NCBICelera
Cytogenetic Map7q22.3NCBI
HuRef799,455,087 - 99,520,939 (-)NCBIHuRef
CHM1_17105,030,270 - 105,095,994 (-)NCBICHM1_1
T2T-CHM13v2.07106,770,730 - 106,836,467 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27104,457,538 - 104,523,236 (-)NCBI
Pus7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39523,945,163 - 23,988,709 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl523,945,646 - 23,988,709 (-)EnsemblGRCm39 Ensembl
GRCm38523,740,165 - 23,783,711 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl523,740,648 - 23,783,711 (-)EnsemblGRCm38mm10GRCm38
MGSCv37523,246,514 - 23,289,479 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36523,252,472 - 23,295,114 (-)NCBIMGSCv36mm8
Celera520,688,329 - 20,732,827 (-)NCBICelera
Cytogenetic Map5A3NCBI
cM Map510.42NCBI
Pus7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8412,252,553 - 12,293,547 (+)NCBIGRCr8
mRatBN7.2411,360,169 - 11,401,139 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl411,360,188 - 11,401,172 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx416,511,124 - 16,552,309 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0412,336,284 - 12,377,447 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0410,683,104 - 10,724,292 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.047,889,727 - 7,931,357 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl47,889,869 - 7,930,706 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.047,897,599 - 7,939,219 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.446,734,140 - 6,774,552 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.146,738,084 - 6,774,291 (+)NCBI
Celera46,972,955 - 7,013,111 (+)NCBICelera
Cytogenetic Map4q11NCBI
Pus7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541010,060,071 - 10,119,757 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541010,062,768 - 10,119,751 (-)NCBIChiLan1.0ChiLan1.0
PUS7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26142,307,982 - 142,373,387 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17190,577,898 - 190,643,355 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0797,447,332 - 97,512,812 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17110,177,282 - 110,243,923 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7110,177,284 - 110,243,923 (-)Ensemblpanpan1.1panPan2
PUS7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11814,882,276 - 14,939,070 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1814,878,034 - 14,938,537 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1814,533,040 - 14,590,271 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01815,184,462 - 15,241,869 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1815,184,227 - 15,241,333 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11814,970,648 - 15,027,753 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01814,893,426 - 14,950,646 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01815,173,826 - 15,230,859 (+)NCBIUU_Cfam_GSD_1.0
Pus7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511857,230,240 - 57,271,201 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647918,354,022 - 18,395,765 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647918,354,009 - 18,395,765 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PUS7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9105,325,763 - 105,388,928 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19105,325,762 - 105,388,972 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29116,095,213 - 116,145,316 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pus7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473924,043,483 - 24,100,359 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473924,043,553 - 24,097,857 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 10 19
Low 26 20 41
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000009617   ⟹   ENSCSAP00000007729
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl2174,381,054 - 74,447,444 (-)Ensembl
RefSeq Acc Id: XM_007982501   ⟹   XP_007980692
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12174,382,572 - 74,447,531 (-)NCBI
Vero_WHO_p1.0NW_02366604229,469,977 - 29,536,355 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007982502   ⟹   XP_007980693
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12174,381,482 - 74,447,531 (-)NCBI
Vero_WHO_p1.0NW_02366604229,469,992 - 29,536,312 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007982503   ⟹   XP_007980694
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12174,382,572 - 74,447,531 (-)NCBI
Vero_WHO_p1.0NW_02366604229,469,976 - 29,536,315 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_007980692 (Get FASTA)   NCBI Sequence Viewer  
  XP_007980693 (Get FASTA)   NCBI Sequence Viewer  
  XP_007980694 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000007729.1
Reference Protein Sequences
RefSeq Acc Id: XP_007980693   ⟸   XM_007982502
- Peptide Label: isoform X2
- UniProtKB: A0A0D9RGJ0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007980694   ⟸   XM_007982503
- Peptide Label: isoform X3
- UniProtKB: A0A0D9RGJ0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007980692   ⟸   XM_007982501
- Peptide Label: isoform X1
- UniProtKB: A0A0D9RGJ0 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000007729   ⟸   ENSCSAT00000009617


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000011530 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000009617.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.2350.20 UniProtKB/TrEMBL
InterPro PsdUridine_synth_cat_dom_sf UniProtKB/TrEMBL
  PsdUridine_synth_TruD UniProtKB/TrEMBL
  PsdUridine_synth_TruD_CS UniProtKB/TrEMBL
  PsdUridine_synth_TruD_insert UniProtKB/TrEMBL
  TruD_catalytic UniProtKB/TrEMBL
NCBI Gene PUS7 ENTREZGENE
PANTHER PSEUDOURIDYLATE SYNTHASE 7 HOMOLOG UniProtKB/TrEMBL
  PTHR13326 UniProtKB/TrEMBL
Pfam TruD UniProtKB/TrEMBL
PIRSF Pseudouridin_synth_euk_prd UniProtKB/TrEMBL
PROSITE TRUD UniProtKB/TrEMBL
  UPF0024 UniProtKB/TrEMBL
Superfamily-SCOP SSF55120 UniProtKB/TrEMBL
UniProt A0A0D9RGJ0 ENTREZGENE, UniProtKB/TrEMBL