E2F8 (E2F transcription factor 8) - Rat Genome Database

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Gene: E2F8 (E2F transcription factor 8) Chlorocebus sabaeus
Analyze
Symbol: E2F8
Name: E2F transcription factor 8
RGD ID: 18612831
Description: ENCODES a protein that exhibits cis-regulatory region sequence-specific DNA binding (inferred); DNA binding (inferred); DNA-binding transcription factor activity (inferred); INVOLVED IN fibroblast proliferation (ortholog); ASSOCIATED WITH Disease Progression (ortholog); genetic disease (ortholog); hepatocellular carcinoma (ortholog); FOUND IN cytosol (inferred); nucleolus (inferred); nucleoplasm (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: transcription factor E2F8
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1145,751,937 - 45,772,698 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl145,756,301 - 45,772,632 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038143,089,850 - 143,107,152 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
E2F8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1145,751,937 - 45,772,698 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl145,756,301 - 45,772,632 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038143,089,850 - 143,107,152 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
E2F8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381119,224,063 - 19,241,655 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1119,224,063 - 19,241,620 (-)EnsemblGRCh38hg38GRCh38
GRCh371119,245,610 - 19,263,202 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361119,202,186 - 19,219,083 (-)NCBINCBI36Build 36hg18NCBI36
Celera1119,378,036 - 19,394,995 (-)NCBICelera
Cytogenetic Map11p15.1NCBI
HuRef1118,929,541 - 18,947,128 (-)NCBIHuRef
CHM1_11119,244,897 - 19,262,487 (-)NCBICHM1_1
T2T-CHM13v2.01119,344,150 - 19,361,742 (-)NCBIT2T-CHM13v2.0
E2f8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39748,516,177 - 48,531,821 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl748,516,177 - 48,531,344 (-)EnsemblGRCm39 Ensembl
GRCm38748,866,429 - 48,882,073 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl748,866,429 - 48,881,596 (-)EnsemblGRCm38mm10GRCm38
MGSCv37756,121,799 - 56,136,411 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36748,734,481 - 48,749,617 (-)NCBIMGSCv36mm8
Celera744,310,478 - 44,325,086 (-)NCBICelera
Cytogenetic Map7B4NCBI
cM Map731.11NCBI
E2f8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81107,701,985 - 107,720,538 (-)NCBIGRCr8
mRatBN7.2198,565,717 - 98,584,265 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl198,565,717 - 98,584,098 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1103,919,427 - 103,937,428 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01112,391,351 - 112,409,352 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01105,713,994 - 105,732,016 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01104,185,436 - 104,203,683 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1104,187,100 - 104,202,591 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01105,245,743 - 105,261,113 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4198,640,381 - 98,694,764 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1198,718,495 - 98,763,993 (-)NCBI
Celera192,773,529 - 92,791,422 (-)NCBICelera
Cytogenetic Map1q22NCBI
E2f8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955476197,630 - 213,441 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955476197,699 - 215,227 (-)NCBIChiLan1.0ChiLan1.0
E2F8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2921,529,385 - 21,546,998 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11121,489,669 - 21,507,289 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01119,250,045 - 19,267,629 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11119,162,837 - 19,180,280 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1119,162,837 - 19,179,744 (-)Ensemblpanpan1.1panPan2
E2F8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12141,340,410 - 41,358,261 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2141,340,969 - 41,357,206 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2140,818,978 - 40,836,517 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02142,463,746 - 42,481,520 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2142,463,758 - 42,479,509 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12141,466,050 - 41,483,600 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02141,643,476 - 41,661,038 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02142,020,665 - 42,038,222 (-)NCBIUU_Cfam_GSD_1.0
E2f8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494743,587,159 - 43,603,726 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936654322,863 - 338,699 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936654322,863 - 339,365 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
E2F8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl240,178,177 - 40,194,935 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1240,178,182 - 40,194,932 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2243,156,985 - 43,173,717 (+)NCBISscrofa10.2Sscrofa10.2susScr3
E2f8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476610,652,745 - 10,669,909 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476610,652,749 - 10,670,886 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium
Low 3 16 3
Below cutoff 32 4 24

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000003124   ⟹   ENSCSAP00000001414
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl145,756,301 - 45,772,632 (+)Ensembl
RefSeq Acc Id: XM_008004455   ⟹   XP_008002646
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1145,751,937 - 45,772,698 (+)NCBI
Vero_WHO_p1.0NW_023666038143,089,850 - 143,107,152 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008004465   ⟹   XP_008002656
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1145,751,937 - 45,772,698 (+)NCBI
Vero_WHO_p1.0NW_023666038143,089,921 - 143,107,152 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008004474   ⟹   XP_008002665
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1145,751,937 - 45,772,698 (+)NCBI
Vero_WHO_p1.0NW_023666038143,089,870 - 143,107,152 (+)NCBI
Sequence:
RefSeq Acc Id: XM_037999576   ⟹   XP_037855504
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_023666038143,090,524 - 143,107,152 (+)NCBI
RefSeq Acc Id: XR_005240653
Type: NON-CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_023666038143,090,525 - 143,106,665 (+)NCBI
Protein Sequences
Protein RefSeqs XP_008002646 (Get FASTA)   NCBI Sequence Viewer  
  XP_008002656 (Get FASTA)   NCBI Sequence Viewer  
  XP_008002665 (Get FASTA)   NCBI Sequence Viewer  
  XP_037855504 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000001414.1
Reference Protein Sequences
RefSeq Acc Id: XP_008002665   ⟸   XM_008004474
- Peptide Label: isoform X1
- UniProtKB: A0A0D9QYH5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_008002656   ⟸   XM_008004465
- Peptide Label: isoform X1
- UniProtKB: A0A0D9QYH5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_008002646   ⟸   XM_008004455
- Peptide Label: isoform X1
- UniProtKB: A0A0D9QYH5 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000001414   ⟸   ENSCSAT00000003124
RefSeq Acc Id: XP_037855504   ⟸   XM_037999576
- Peptide Label: isoform X2


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000005093 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000003124.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.10 UniProtKB/TrEMBL
InterPro E2F UniProtKB/TrEMBL
  E2F_WHTH_DNA-bd_dom UniProtKB/TrEMBL
  WH-like_DNA-bd_sf UniProtKB/TrEMBL
  WH_DNA-bd_sf UniProtKB/TrEMBL
KEGG Report csab:103238969 UniProtKB/TrEMBL
NCBI Gene E2F8 ENTREZGENE
PANTHER PTHR12081 UniProtKB/TrEMBL
  TRANSCRIPTION FACTOR E2F8 UniProtKB/TrEMBL
Pfam E2F_TDP UniProtKB/TrEMBL
SMART E2F_TDP UniProtKB/TrEMBL
Superfamily-SCOP SSF46785 UniProtKB/TrEMBL
UniProt A0A0D9QYH5 ENTREZGENE, UniProtKB/TrEMBL