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Gene: IL27 (interleukin 27) Chlorocebus sabaeus

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Symbol:

IL27

Name:

interleukin 27

RGD ID:

18603130

Description:

ENCODES a protein that exhibits interleukin-27 receptor binding (inferred); signaling receptor binding (inferred); INVOLVED IN positive regulation of defense response to virus by host (ortholog); regulation of T cell proliferation (ortholog); response to bacterium (ortholog); PARTICIPATES IN interleukin-27 signaling pathway; ASSOCIATED WITH Acute-On-Chronic Liver Failure (ortholog); Arenaviridae infectious disease (ortholog); asthma (ortholog); FOUND IN cell surface (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

interleukin-27 subunit alpha

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	IL27 (interleukin 27)	NCBI	Ortholog
Mus musculus (house mouse):	Il27 (interleukin 27)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Il27 (interleukin 27)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Il27 (interleukin 27)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	IL27 (interleukin 27)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	IL27 (interleukin 27)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Il27 (interleukin 27)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	IL27 (interleukin 27)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Il27 (interleukin 27)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	5	26,348,559 - 26,358,028 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	5	26,348,848 - 26,356,360 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666068	3,217,584 - 3,222,518 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Acute-On-Chronic Liver Failure (ISO)

Arenaviridae infectious disease (ISO)

asthma (ISO)

atherosclerosis (ISO)

Bacteremia (ISO)

Brody myopathy (ISO)

Chronic Hepatitis C (ISO)

chronic obstructive pulmonary disease (ISO)

Clostridium Infections (ISO)

Cor pulmonale (ISO)

Cytomegalovirus Infections (ISO)

duodenal ulcer (ISO)

Experimental Autoimmune Encephalomyelitis (ISO)

Henoch-Schoenlein purpura (ISO)

hepatitis B (ISO)

human immunodeficiency virus infectious disease (ISO)

infectious mononucleosis (ISO)

influenza A (ISO)

leishmaniasis (ISO)

lepromatous leprosy (ISO)

liver cirrhosis (ISO)

malaria (ISO)

Neonatal Sepsis (ISO)

neuronal ceroid lipofuscinosis (ISO)

Ocular Toxoplasmosis (ISO)

peptic ulcer disease (ISO)

pleural tuberculosis (ISO)

Pneumococcal Infections (ISO)

pneumonia (ISO)

Prostatic Neoplasms (ISO)

Pseudomonas Infections (ISO)

pulmonary tuberculosis (ISO)

respiratory allergy (ISO)

respiratory syncytial virus infectious disease (ISO)

schizophrenia (ISO)

Sepsis (ISO)

Septic Peritonitis (ISO)

sialadenitis (ISO)

spondyloarthropathy (ISO)

systemic scleroderma (ISO)

toxic shock syndrome (ISO)

toxoplasmosis (ISO)

tropical spastic paraparesis (ISO)

tuberculosis (ISO)

type 1 diabetes mellitus (ISO)

Viral Myocarditis (ISO)

visceral leishmaniasis (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

positive regulation of defense response to virus by host (IEA,ISO)

positive regulation of type II interferon production (IEA)

regulation of T cell proliferation (IEA,ISO)

regulation of T-helper 1 cell differentiation (IEA)

response to bacterium (ISO)

response to Gram-positive bacterium (ISO)

Cellular Component

cell surface (ISO)

extracellular space (IEA)

Molecular Function

interleukin-27 receptor binding (IEA)

protein binding (ISO)

signaling receptor binding (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

interleukin-27 signaling pathway (ISO)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

IL27
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	5	26,348,559 - 26,358,028 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	5	26,348,848 - 26,356,360 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666068	3,217,584 - 3,222,518 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

IL27
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	16	28,499,362 - 28,506,834 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	16	28,499,362 - 28,512,051 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	16	28,510,683 - 28,518,155 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	16	28,418,184 - 28,425,656 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	16	28,418,472 - 28,425,633	NCBI
Celera	16	27,685,614 - 27,693,084 (+)	NCBI		Celera
Cytogenetic Map	16	p12.1-p11.2	NCBI
HuRef	16	26,536,601 - 26,544,073 (-)	NCBI		HuRef
CHM1_1	16	29,522,293 - 29,529,765 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	16	28,869,090 - 28,896,415 (+)	NCBI		T2T-CHM13v2.0

Il27
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	126,188,181 - 126,194,197 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	126,188,182 - 126,194,113 (-)	Ensembl		GRCm39 Ensembl
GRCm38	7	126,589,009 - 126,595,035 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	126,589,010 - 126,594,941 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	7	133,732,809 - 133,738,424 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	7	126,380,443 - 126,386,058 (-)	NCBI		MGSCv36	mm8
Celera	7	126,438,423 - 126,444,039 (-)	NCBI		Celera
Cytogenetic Map	7	F3	NCBI
cM Map	7	69.18	NCBI

Il27
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	190,603,684 - 190,609,292 (-)	NCBI		GRCr8
mRatBN7.2	1	181,173,108 - 181,178,720 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	181,173,372 - 181,178,582 (-)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	1	198,003,615 - 198,010,112 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	198,003,683 - 198,008,893 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	204,981,789 - 204,987,782 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	185,730,394 - 185,735,604 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	1	178,831,320 - 178,837,817 (-)	NCBI		Celera
Cytogenetic Map	1	q36	NCBI

Il27
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955493	6,712,005 - 6,717,417 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955493	6,712,005 - 6,717,417 (-)	NCBI	ChiLan1.0	ChiLan1.0

IL27
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	18	31,104,366 - 31,111,861 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	16	34,982,084 - 34,989,328 (+)	NCBI		NHGRI_mPanPan1
PanPan1.1	16	28,979,717 - 28,984,655 (-)	NCBI	panpan1.1	PanPan1.1	panPan2

IL27
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	6	18,243,988 - 18,248,369 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	6	18,244,040 - 18,247,635 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	6	19,822,685 - 19,827,046 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	6	18,380,027 - 18,384,391 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	6	18,380,086 - 18,384,093 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	6	18,179,035 - 18,183,396 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	6	18,094,139 - 18,098,496 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	6	18,410,212 - 18,414,571 (+)	NCBI		UU_Cfam_GSD_1.0

Il27
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	123,875,494 - 123,879,941 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936501	11,973,385 - 11,976,583 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936501	11,972,715 - 11,978,152 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

IL27
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	18,421,981 - 18,427,915 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	18,421,962 - 18,427,916 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

Il27
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624782	13,009,564 - 13,015,440 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624782	13,009,450 - 13,015,548 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

ectoderm	endocrine system	hemolymphoid system	mesenchyme	mesoderm	nervous system	reproductive system
22	17	20	27	27	15	10

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_007989098	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_007989104	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_007989114	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_007989119	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000036	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCSAT00000004313 ⟹ ENSCSAP00000002571

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	5	26,348,848 - 26,356,360 (-)	Ensembl

RefSeq Acc Id:

XM_007989098 ⟹ XP_007987289

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	5	26,348,559 - 26,353,776 (-)	NCBI
Vero_WHO_p1.0	NW_023666068	3,217,584 - 3,222,518 (+)	NCBI

Sequence:

show sequence

TCAGGTGATCCTCCCGCCTCGGTCTCCCAAATTGTTGGGATTACAGGCGTGAGTCACCGCACCT
GGCCTCCACTGTGGTTTTGAGGAGGCAGAGGAATGATGATGGTGAAAGTGGCTGCATTATGCTC
ACAGCTAGCACAGGCTCAGATAAGGCATGTTCCTTTCCTTCTCCCGAGTTCTCAAGCTCTCTCC
CTGTCTCGCCCACCCTCTCCCCACCTCTCCAGGGCTCAGCCTGTTGCTGCTTCCCTTGCTCCTG
GTTCAAGCTGGTGTCTGGGGATTCCCAAGGCCCCCAGGGAGGCCCCAGCTGAGCGTGCAGAAGC
TGCAGAGGGAGTTCACGGTCAGCCTGCATCTCGCCAGGAAGCTGCTCTCCGAGGTTCGGGGCCA
GGCCCACCGCTTTGTAAGTCCCCAAAATGCAGCTGGTGCTGGGGAAGGGCAGACCCCCAATCCC
TTCTGGCCCCCACTAACAGACCTTGTCCCCCAGGCGGAATCTCACCTGCCAGGAGTGAACCTGG
ACCTTCTGCCCCTGGGAGAGCAGCTCCCCGATGTTTCCCTGACCTTCCAGGCCTGGCCCCGCCT
CTCTGACCTGGAGCGTCTCTGCTTCCTCTCCACCACGCTTCAGCCCTTCCGTGCCCTGCTGGGA
GGGCTGGGGACCCAGGGCCGCTGGACCAACACGGAGAGGATGCAGCTGTGGGCCATGAGGCTGG
ACCTCCGTGATCTGCAGCGGCACCTGCGCTTCCAGGTGCTGGCTTCGGGATTCCACCTCCCGGA
GGAGGAGGAGGAAGAGGAGGAGGAGGAGGAAGAGAGGAAGGGGCTGCTCCCAGGGGCACTGGGC
AATGCCTCACAGGGGCCGGCCCAGGTGTCCTGGCCCCAACTCCTCTCCACCTACCGCCTGCTGC
ACTCCTTGGAGCTCGTCTTATCTCGGGCCGTGCGGGACTTGCTGCTGCTGTCCAAGGCCGGGCA
CTCAGTCTGGCCCTTGGGGTTCCCAACATTGGGCCCCCAGCCCTGATTGGGTGGCTTCTTAGCC
CCCTGCCCCTCACCCTTTAGTACTTTAGGACTGGAGTCTTGGCATCAGGGCAGCCTCCGCATCA
TCAGCGTTGGACAAGGGAGGGCTCTTCCAGCCCCCTGCCCCCGGCCCTACCCAGTAACTGAAAG
CCCCTCTGGTCCTTGCCAGCTATTTATTTCTTGGATATTTATTTATTGTTAGAGAGATGATGGT
TTATTTATTGTCTCAGAACCTGCTGGTCCTCCTTGGGCCGAGCCCCCATGCTGGGTGCCCAATA
AAGCACTCTCATCCA

hide sequence

Protein Sequences


Protein RefSeqs	XP_007987289	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000002571.1

RefSeq Acc Id:	XP_007987289 ⟸ XM_007989098
- UniProtKB:	A0A0D9R1T2 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSCSAP00000002571 ⟸ ENSCSAT00000004313

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000006276	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000004313.1	UniProtKB/TrEMBL
Gene3D-CATH	1.20.1250.10	UniProtKB/TrEMBL
InterPro	4_helix_cytokine-like_core	UniProtKB/TrEMBL
	IL-27_alpha	UniProtKB/TrEMBL
NCBI Gene	IL27	ENTREZGENE
PANTHER	INTERLEUKIN-27 SUBUNIT ALPHA	UniProtKB/TrEMBL
	PTHR20879	UniProtKB/TrEMBL
UniProt	A0A0D9R1T2	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - PID (archival)