HERC3 (HECT and RLD domain containing E3 ubiquitin protein ligase 3) - Rat Genome Database

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Gene: HERC3 (HECT and RLD domain containing E3 ubiquitin protein ligase 3) Chlorocebus sabaeus
Analyze
Symbol: HERC3
Name: HECT and RLD domain containing E3 ubiquitin protein ligase 3
RGD ID: 18596309
Description: ENCODES a protein that exhibits ubiquitin protein ligase activity (inferred); ubiquitin-protein transferase activity (inferred); INVOLVED IN protein ubiquitination (inferred); ubiquitin-dependent protein catabolic process (inferred); ASSOCIATED WITH autosomal dominant polycystic kidney disease (ortholog); genetic disease (ortholog); Liver Neoplasms (ortholog); FOUND IN cytoplasm (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: probable E3 ubiquitin-protein ligase HERC3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1736,945,452 - 37,068,574 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl736,958,239 - 37,066,994 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603715,696,537 - 15,821,009 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
HERC3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1736,945,452 - 37,068,574 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl736,958,239 - 37,066,994 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603715,696,537 - 15,821,009 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
HERC3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38488,523,843 - 88,708,539 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl488,592,434 - 88,708,541 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p14 Ensembl488,523,810 - 88,708,450 (+)EnsemblGRCh38hg38GRCh38
GRCh37489,444,994 - 89,629,690 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36489,732,670 - 89,848,709 (+)NCBINCBI36Build 36hg18NCBI36
Build 34489,870,824 - 89,986,864NCBI
Celera486,810,333 - 86,926,068 (+)NCBICelera
Cytogenetic Map4q22.1NCBI
HuRef485,265,488 - 85,382,068 (+)NCBIHuRef
CHM1_1489,490,048 - 89,606,164 (+)NCBICHM1_1
T2T-CHM13v2.0491,855,488 - 92,040,225 (+)NCBIT2T-CHM13v2.0
Herc3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39658,808,440 - 58,897,383 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl658,808,450 - 58,897,383 (+)EnsemblGRCm39 Ensembl
GRCm38658,831,455 - 58,920,398 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl658,831,465 - 58,920,398 (+)EnsemblGRCm38mm10GRCm38
MGSCv37658,783,694 - 58,870,392 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36658,763,267 - 58,849,976 (+)NCBIMGSCv36mm8
Celera660,987,933 - 61,074,874 (+)NCBICelera
Cytogenetic Map6B3NCBI
cM Map627.82NCBI
Herc3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8489,282,374 - 89,372,656 (+)NCBIGRCr8
mRatBN7.2487,952,202 - 88,042,492 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl487,952,274 - 88,042,488 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx493,167,703 - 93,257,629 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0488,943,019 - 89,032,951 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0487,312,095 - 87,402,026 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0489,078,670 - 89,169,150 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl489,078,711 - 89,169,146 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04153,899,767 - 153,990,206 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4487,725,194 - 87,816,242 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1487,971,772 - 88,060,671 (+)NCBI
Celera482,712,679 - 82,802,650 (+)NCBICelera
Cytogenetic Map4q24NCBI
Herc3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547411,725,259 - 11,871,104 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495547411,725,323 - 11,871,132 (-)NCBIChiLan1.0ChiLan1.0
HERC3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2386,596,267 - 86,732,150 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1486,858,780 - 86,975,420 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0480,882,236 - 80,998,111 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1491,604,802 - 91,720,136 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl491,617,672 - 91,720,136 (+)Ensemblpanpan1.1panPan2
HERC3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13211,863,987 - 11,977,764 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3211,866,405 - 11,976,442 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3229,977,035 - 30,090,529 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03211,917,640 - 12,031,184 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3211,917,666 - 12,031,189 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13212,004,955 - 12,118,402 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03211,825,450 - 11,938,900 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03227,977,966 - 28,091,715 (-)NCBIUU_Cfam_GSD_1.0
Herc3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530129,392,364 - 29,514,554 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366851,054,302 - 1,163,704 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366851,041,176 - 1,163,290 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HERC3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8130,346,214 - 130,470,247 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18130,346,207 - 130,467,311 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28139,756,471 - 139,879,865 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Herc3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475716,232,982 - 16,404,902 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475716,232,912 - 16,402,489 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 36 18 60
Low 2
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000002267   ⟹   ENSCSAP00000000592
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl736,958,239 - 37,066,994 (+)Ensembl
RefSeq Acc Id: XM_007999232   ⟹   XP_007997423
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1736,945,452 - 37,068,574 (+)NCBI
Vero_WHO_p1.0NW_02366603715,696,537 - 15,821,009 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007999237   ⟹   XP_007997428
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1736,945,504 - 37,062,949 (+)NCBI
Vero_WHO_p1.0NW_02366603715,696,537 - 15,816,524 (+)NCBI
Sequence:
RefSeq Acc Id: XM_037986617   ⟹   XP_037842545
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366603715,696,537 - 15,819,623 (+)NCBI
Protein Sequences
Protein RefSeqs XP_007997423 (Get FASTA)   NCBI Sequence Viewer  
  XP_007997428 (Get FASTA)   NCBI Sequence Viewer  
  XP_037842545 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000000592.1
Reference Protein Sequences
RefSeq Acc Id: XP_007997423   ⟸   XM_007999232
- Peptide Label: isoform X1
- UniProtKB: A0A0D9QW53 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007997428   ⟸   XM_007999237
- Peptide Label: isoform X2
RefSeq Acc Id: XP_037842545   ⟸   XM_037986617
- Peptide Label: isoform X1
- UniProtKB: A0A0D9QW53 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000000592   ⟸   ENSCSAT00000002267


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000004279 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000002267.1 UniProtKB/TrEMBL
Gene3D-CATH 2.130.10.30 UniProtKB/TrEMBL
  Hect, E3 ligase catalytic domain UniProtKB/TrEMBL
  Hect, E3 ligase catalytic domain UniProtKB/TrEMBL
  Hect, E3 ligase catalytic domains UniProtKB/TrEMBL
InterPro HECT_dom UniProtKB/TrEMBL
  Hect_E3_ubiquitin_ligase UniProtKB/TrEMBL
  RCC1/BLIP-II UniProtKB/TrEMBL
  Reg_chr_condens UniProtKB/TrEMBL
KEGG Report csab:103235960 UniProtKB/TrEMBL
NCBI Gene HERC3 ENTREZGENE
PANTHER UBIQUITIN-PROTEIN LIGASE E3A-RELATED UniProtKB/TrEMBL
  X-LINKED RETINITIS PIGMENTOSA GTPASE REGULATOR UniProtKB/TrEMBL
Pfam HECT UniProtKB/TrEMBL
  RCC1 UniProtKB/TrEMBL
PRINTS RCCNDNSATION UniProtKB/TrEMBL
PROSITE HECT UniProtKB/TrEMBL
  RCC1_2 UniProtKB/TrEMBL
  RCC1_3 UniProtKB/TrEMBL
SMART HECTc UniProtKB/TrEMBL
Superfamily-SCOP SSF50985 UniProtKB/TrEMBL
  SSF56204 UniProtKB/TrEMBL
UniProt A0A0D9QW53 ENTREZGENE, UniProtKB/TrEMBL