IRF2 (interferon regulatory factor 2) - Rat Genome Database

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Gene: IRF2 (interferon regulatory factor 2) Chlorocebus sabaeus
Analyze
Symbol: IRF2
Name: interferon regulatory factor 2
RGD ID: 18595423
Description: ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); DNA-binding transcription factor activity (inferred); INVOLVED IN defense response to virus (inferred); immune system process (inferred); positive regulation of transcription by RNA polymerase II (inferred); ASSOCIATED WITH COVID-19 (ortholog); genetic disease (ortholog); hepatocellular carcinoma (ortholog); FOUND IN cytosol (inferred); focal adhesion (inferred); nucleoplasm (inferred)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.17130,352,809 - 130,440,485 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl7130,350,262 - 130,440,600 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037110,607,609 - 110,696,393 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
IRF2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.17130,352,809 - 130,440,485 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl7130,350,262 - 130,440,600 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037110,607,609 - 110,696,393 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
IRF2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384184,387,729 - 184,474,550 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4184,385,702 - 184,474,558 (-)EnsemblGRCh38hg38GRCh38
GRCh374185,308,883 - 185,395,704 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364185,545,870 - 185,632,720 (-)NCBINCBI36Build 36hg18NCBI36
Build 344185,684,063 - 185,770,852NCBI
Celera4182,637,543 - 182,724,388 (-)NCBICelera
Cytogenetic Map4q35.1NCBI
HuRef4181,063,134 - 181,150,003 (-)NCBIHuRef
CHM1_14185,285,381 - 185,372,245 (-)NCBICHM1_1
T2T-CHM13v2.04187,731,563 - 187,818,372 (-)NCBIT2T-CHM13v2.0
Irf2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39847,192,751 - 47,300,493 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl847,192,767 - 47,300,493 (+)EnsemblGRCm39 Ensembl
GRCm38846,739,745 - 46,847,458 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl846,739,732 - 46,847,458 (+)EnsemblGRCm38mm10GRCm38
MGSCv37847,825,099 - 47,932,812 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36848,238,592 - 48,346,275 (+)NCBIMGSCv36mm8
Celera849,422,414 - 49,530,424 (+)NCBICelera
Cytogenetic Map8B1.1NCBI
cM Map826.42NCBI
Irf2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81652,171,855 - 52,283,620 (-)NCBIGRCr8
mRatBN7.21645,439,215 - 45,550,054 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1645,439,225 - 45,550,024 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1650,839,474 - 50,949,404 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01654,206,552 - 54,316,157 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01649,478,876 - 49,588,780 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01648,582,354 - 48,732,129 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1648,582,026 - 48,732,932 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01648,294,559 - 48,446,482 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41648,672,930 - 48,725,511 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11648,672,601 - 48,725,589 (-)NCBI
Celera1643,443,543 - 43,496,401 (-)NCBICelera
Cytogenetic Map16q11NCBI
Irf2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540324,433,258 - 24,517,618 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540324,433,334 - 24,517,618 (+)NCBIChiLan1.0ChiLan1.0
IRF2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23182,111,693 - 182,198,550 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14182,475,293 - 182,562,154 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04176,554,979 - 176,641,827 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14188,779,134 - 188,865,764 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4188,779,134 - 188,865,764 (-)Ensemblpanpan1.1panPan2
IRF2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11646,053,148 - 46,131,677 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1646,053,206 - 46,130,781 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1646,545,906 - 46,625,442 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01648,268,829 - 48,348,786 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1648,268,843 - 48,348,784 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11646,233,717 - 46,313,550 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01646,848,118 - 46,927,755 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01646,981,845 - 47,061,671 (+)NCBIUU_Cfam_GSD_1.0
Irf2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494333,316,727 - 33,403,291 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365544,706,650 - 4,793,701 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365544,706,688 - 4,793,236 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IRF2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1545,546,783 - 45,634,704 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11545,546,779 - 45,693,241 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21552,135,048 - 52,232,993 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Irf2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476915,164,744 - 15,251,745 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476915,167,228 - 15,251,689 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 36 19 22
Low 1 38
Below cutoff

Sequence


RefSeq Acc Id: ENSCSAT00000001034   ⟹   ENSCSAP00000015031
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl7130,350,262 - 130,440,600 (-)Ensembl
RefSeq Acc Id: XM_008000386   ⟹   XP_007998577
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.17130,352,809 - 130,440,485 (-)NCBI
Vero_WHO_p1.0NW_023666037110,607,610 - 110,696,393 (-)NCBI
Sequence:
RefSeq Acc Id: XM_037994125   ⟹   XP_037850053
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_023666037110,607,610 - 110,696,075 (-)NCBI
RefSeq Acc Id: XM_037994132   ⟹   XP_037850060
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_023666037110,607,609 - 110,695,882 (-)NCBI
RefSeq Acc Id: XM_037994139   ⟹   XP_037850067
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_023666037110,607,610 - 110,696,371 (-)NCBI
RefSeq Acc Id: XM_037994145   ⟹   XP_037850073
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_023666037110,612,690 - 110,696,380 (-)NCBI
RefSeq Acc Id: XP_007998577   ⟸   XM_008000386
- Peptide Label: isoform X1
- UniProtKB: A0A0D9S2E2 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000015031   ⟸   ENSCSAT00000001034
RefSeq Acc Id: XP_037850060   ⟸   XM_037994132
- Peptide Label: isoform X1
- UniProtKB: A0A0D9S2E2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037850067   ⟸   XM_037994139
- Peptide Label: isoform X2
RefSeq Acc Id: XP_037850053   ⟸   XM_037994125
- Peptide Label: isoform X1
- UniProtKB: A0A0D9S2E2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037850073   ⟸   XM_037994145
- Peptide Label: isoform X3


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000003010 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000001034.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.10 UniProtKB/TrEMBL
InterPro Interferon_reg_fac_CS UniProtKB/TrEMBL
  Interferon_reg_fact_DNA-bd_dom UniProtKB/TrEMBL
  IRF1/IRF2 UniProtKB/TrEMBL
  WH-like_DNA-bd_sf UniProtKB/TrEMBL
  WH_DNA-bd_sf UniProtKB/TrEMBL
NCBI Gene IRF2 ENTREZGENE
PANTHER INTERFERON REGULATORY FACTOR UniProtKB/TrEMBL
  PTHR11949:SF22 UniProtKB/TrEMBL
Pfam IRF UniProtKB/TrEMBL
PIRSF IFN_RF1/2 UniProtKB/TrEMBL
PRINTS INTFRNREGFCT UniProtKB/TrEMBL
PROSITE IRF_1 UniProtKB/TrEMBL
  IRF_2 UniProtKB/TrEMBL
SMART IRF UniProtKB/TrEMBL
Superfamily-SCOP SSF46785 UniProtKB/TrEMBL
UniProt A0A0D9S2E2 ENTREZGENE, UniProtKB/TrEMBL