PKNOX2 (PBX/knotted 1 homeobox 2) - Rat Genome Database

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Gene: PKNOX2 (PBX/knotted 1 homeobox 2) Chlorocebus sabaeus
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Symbol: PKNOX2
Name: PBX/knotted 1 homeobox 2
RGD ID: 18593319
Description: ENCODES a protein that exhibits actin filament binding (inferred); actin monomer binding (inferred); DNA binding (inferred); INVOLVED IN regulation of transcription by RNA polymerase II (ortholog); ASSOCIATED WITH Chromosome 11, Partial Trisomy 11q (ortholog); Dwarfism (ortholog); Familial Prostate Cancer (ortholog); FOUND IN actin cytoskeleton (inferred); cytoplasm (inferred); intercellular bridge (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: homeobox protein PKNOX2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11116,332,851 - 116,604,758 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1116,523,593 - 116,605,161 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660439,519,677 - 9,788,985 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
PKNOX2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11116,332,851 - 116,604,758 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1116,523,593 - 116,605,161 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660439,519,677 - 9,788,985 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
PKNOX2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811125,164,751 - 125,433,389 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11125,164,687 - 125,433,389 (+)EnsemblGRCh38hg38GRCh38
GRCh3711125,034,647 - 125,303,285 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611124,539,769 - 124,808,495 (+)NCBINCBI36Build 36hg18NCBI36
Build 3411124,726,419 - 124,808,264NCBI
Celera11122,194,601 - 122,463,611 (+)NCBICelera
Cytogenetic Map11q24.2NCBI
HuRef11120,976,463 - 121,244,840 (+)NCBIHuRef
CHM1_111124,920,619 - 125,189,521 (+)NCBICHM1_1
T2T-CHM13v2.011125,193,419 - 125,462,086 (+)NCBIT2T-CHM13v2.0
Pknox2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39936,802,278 - 37,058,637 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl936,802,278 - 37,058,703 (-)EnsemblGRCm39 Ensembl
GRCm38936,890,979 - 37,147,342 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl936,890,982 - 37,147,407 (-)EnsemblGRCm38mm10GRCm38
MGSCv37936,698,567 - 36,954,899 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36936,640,653 - 36,896,985 (-)NCBIMGSCv36mm8
Celera934,095,372 - 34,359,379 (-)NCBICelera
Cytogenetic Map9A4NCBI
cM Map920.7NCBI
Pknox2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8844,789,464 - 45,051,933 (-)NCBIGRCr8
mRatBN7.2836,600,633 - 36,863,131 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl836,600,636 - 36,790,940 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx840,610,916 - 40,800,359 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0838,893,988 - 39,083,446 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0836,756,879 - 36,946,335 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0839,361,698 - 39,551,700 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl839,361,218 - 39,551,700 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0839,364,740 - 39,554,742 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4838,136,835 - 38,325,406 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera837,651,569 - 37,840,535 (+)NCBICelera
Cytogenetic Map8q22NCBI
Pknox2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541226,372,846 - 26,468,926 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541226,214,671 - 26,468,737 (+)NCBIChiLan1.0ChiLan1.0
PKNOX2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29125,807,624 - 126,128,241 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111126,912,553 - 127,240,365 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011119,991,916 - 120,259,800 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111123,906,012 - 124,173,865 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11124,072,715 - 124,173,865 (+)Ensemblpanpan1.1panPan2
PKNOX2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.159,054,138 - 9,363,750 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl59,056,134 - 9,178,159 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha59,098,622 - 9,408,616 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.058,994,772 - 9,302,925 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl58,994,772 - 9,251,650 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.159,065,978 - 9,375,742 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.059,036,663 - 9,346,271 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.059,072,792 - 9,382,834 (-)NCBIUU_Cfam_GSD_1.0
Pknox2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947107,342,759 - 107,612,737 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367431,661,791 - 1,858,278 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367431,661,783 - 1,860,299 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PKNOX2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl952,349,714 - 52,610,680 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1952,303,022 - 52,608,505 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2958,127,081 - 58,195,478 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pknox2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249271,275,956 - 1,460,170 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249271,197,610 - 1,459,777 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 15 15
Low 21 11 45
Below cutoff 6

Sequence


RefSeq Acc Id: ENSCSAT00000000327   ⟹   ENSCSAP00000015727
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl1116,523,593 - 116,605,161 (+)Ensembl
RefSeq Acc Id: XM_008021384   ⟹   XP_008019575
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11116,332,851 - 116,604,758 (+)NCBI
Vero_WHO_p1.0NW_0236660439,519,677 - 9,788,985 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008021385   ⟹   XP_008019576
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11116,332,889 - 116,604,758 (+)NCBI
Vero_WHO_p1.0NW_0236660439,519,897 - 9,788,949 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008021386   ⟹   XP_008019577
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11116,332,875 - 116,604,758 (+)NCBI
Vero_WHO_p1.0NW_0236660439,519,897 - 9,788,961 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038005015   ⟹   XP_037860943
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_0236660439,519,897 - 9,723,432 (-)NCBI
RefSeq Acc Id: XM_038005016   ⟹   XP_037860944
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_0236660439,519,897 - 9,723,433 (-)NCBI
RefSeq Acc Id: XM_038005017   ⟹   XP_037860945
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_0236660439,519,897 - 9,723,432 (-)NCBI
RefSeq Acc Id: XP_008019575   ⟸   XM_008021384
- Peptide Label: isoform X1
- UniProtKB: A0A0D9S4D8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_008019577   ⟸   XM_008021386
- Peptide Label: isoform X2
RefSeq Acc Id: XP_008019576   ⟸   XM_008021385
- Peptide Label: isoform X1
- UniProtKB: A0A0D9S4D8 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000015727   ⟸   ENSCSAT00000000327
RefSeq Acc Id: XP_037860944   ⟸   XM_038005016
- Peptide Label: isoform X1
- UniProtKB: A0A0D9S4D8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037860945   ⟸   XM_038005017
- Peptide Label: isoform X2
RefSeq Acc Id: XP_037860943   ⟸   XM_038005015
- Peptide Label: isoform X1
- UniProtKB: A0A0D9S4D8 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000002312 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000000327.1 UniProtKB/TrEMBL
Gene3D-CATH Homeodomain-like UniProtKB/TrEMBL
InterPro Homeobox-like_sf UniProtKB/TrEMBL
  Homeobox_dom UniProtKB/TrEMBL
  Homeobox_KN_domain UniProtKB/TrEMBL
  PKNOX/Meis_N UniProtKB/TrEMBL
KEGG Report csab:103248764 UniProtKB/TrEMBL
NCBI Gene PKNOX2 ENTREZGENE
PANTHER HOMEOBOX PROTEIN PKNOX2 UniProtKB/TrEMBL
  HOMEOBOX PROTEIN TRANSCRIPTION FACTORS UniProtKB/TrEMBL
Pfam Homeobox_KN UniProtKB/TrEMBL
  Meis_PKNOX_N UniProtKB/TrEMBL
PROSITE HOMEOBOX_2 UniProtKB/TrEMBL
SMART HOX UniProtKB/TrEMBL
Superfamily-SCOP SSF46689 UniProtKB/TrEMBL
UniProt A0A0D9S4D8 ENTREZGENE, UniProtKB/TrEMBL