DMGDH (dimethylglycine dehydrogenase) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: DMGDH (dimethylglycine dehydrogenase) Chlorocebus sabaeus
Analyze
Symbol: DMGDH
Name: dimethylglycine dehydrogenase
RGD ID: 18590683
Description: ENCODES a protein that exhibits dimethylglycine dehydrogenase activity (ortholog); flavin adenine dinucleotide binding (ortholog); folic acid binding (ortholog); INVOLVED IN tetrahydrofolate interconversion (ortholog); PARTICIPATES IN dihydropyrimidine dehydrogenase deficiency pathway; dimethylglycine dehydrogenase deficiency pathway; folate cycle metabolic pathway; ASSOCIATED WITH Dimethylglycine Dehydrogenase Deficiency (ortholog); genetic disease (ortholog); hepatocellular carcinoma (ortholog); FOUND IN cytosol (inferred); mitochondrion (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: dimethylglycine dehydrogenase, mitochondrial
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1473,217,523 - 73,339,646 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl473,216,579 - 73,290,268 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604922,063,950 - 22,136,314 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (IEA)
mitochondrion  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
DMGDH
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1473,217,523 - 73,339,646 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl473,216,579 - 73,290,268 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604922,063,950 - 22,136,314 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
DMGDH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38578,997,564 - 79,069,674 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl578,997,564 - 79,236,038 (-)EnsemblGRCh38hg38GRCh38
GRCh37578,293,387 - 78,365,497 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36578,329,185 - 78,401,205 (-)NCBINCBI36Build 36hg18NCBI36
Build 34578,329,185 - 78,401,205NCBI
Celera574,186,336 - 74,258,332 (-)NCBICelera
Cytogenetic Map5q14.1NCBI
HuRef573,499,350 - 73,571,433 (-)NCBIHuRef
CHM1_1577,725,882 - 77,797,969 (-)NCBICHM1_1
T2T-CHM13v2.0579,478,676 - 79,550,778 (-)NCBIT2T-CHM13v2.0
Dmgdh
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391393,810,944 - 93,889,331 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1393,810,941 - 93,889,341 (+)EnsemblGRCm39 Ensembl
GRCm381393,674,436 - 93,752,823 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1393,674,433 - 93,752,833 (+)EnsemblGRCm38mm10GRCm38
MGSCv371394,444,391 - 94,522,778 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361394,775,189 - 94,853,576 (+)NCBIMGSCv36mm8
Celera1397,280,488 - 97,360,770 (+)NCBICelera
Cytogenetic Map13C3NCBI
cM Map1347.88NCBI
Dmgdh
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8226,647,540 - 26,722,496 (+)NCBIGRCr8
mRatBN7.2224,912,600 - 24,987,533 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl224,912,578 - 24,987,528 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx231,939,901 - 32,014,960 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0230,040,160 - 30,115,220 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0224,865,886 - 24,940,204 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0223,289,376 - 23,370,360 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl223,289,374 - 23,370,477 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0242,469,950 - 42,545,633 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4223,976,563 - 24,052,766 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1223,896,931 - 23,973,132 (+)NCBI
Celera220,986,895 - 21,062,849 (+)NCBICelera
Cytogenetic Map2q12NCBI
Dmgdh
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542522,045,993 - 22,102,852 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542522,045,977 - 22,103,381 (+)NCBIChiLan1.0ChiLan1.0
DMGDH
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2436,235,936 - 36,308,377 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1534,389,544 - 34,461,365 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0536,241,341 - 36,313,995 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1536,732,011 - 36,803,202 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl536,732,005 - 36,805,883 (+)Ensemblpanpan1.1panPan2
DMGDH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1327,789,089 - 27,857,348 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl327,790,324 - 27,856,601 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha329,028,288 - 29,094,786 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0327,707,912 - 27,777,243 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl327,708,388 - 27,777,248 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1327,648,089 - 27,713,749 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0327,625,520 - 27,692,247 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0327,906,242 - 27,972,124 (+)NCBIUU_Cfam_GSD_1.0
Dmgdh
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213183,959,062 - 184,020,082 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365496,839,295 - 6,899,911 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365496,838,773 - 6,899,961 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DMGDH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl287,791,943 - 87,866,679 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1287,791,827 - 87,867,189 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2289,475,706 - 89,593,728 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Dmgdh
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248693,500,293 - 3,576,245 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248693,498,851 - 3,576,341 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium
Low 35 10 19
Below cutoff 1 7 41

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000013350   ⟹   ENSCSAP00000011351
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl473,216,579 - 73,290,268 (-)Ensembl
RefSeq Acc Id: XM_007976310   ⟹   XP_007974501
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1473,217,523 - 73,289,857 (-)NCBI
Vero_WHO_p1.0NW_02366604922,063,950 - 22,136,314 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_007974501 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000011351
  ENSCSAP00000011351.1
Reference Protein Sequences
RefSeq Acc Id: XP_007974501   ⟸   XM_007976310
- UniProtKB: A0A0D9RRW2 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000011351   ⟸   ENSCSAT00000013350


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000015255 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000013350.1 UniProtKB/TrEMBL
Gene3D-CATH 3.50.50.60 UniProtKB/TrEMBL
  Aminomethyltransferase beta-barrel domains UniProtKB/TrEMBL
  Aminomethyltransferase beta-barrel domains UniProtKB/TrEMBL
  D-Amino Acid Oxidase, subunit A, domain 2 UniProtKB/TrEMBL
InterPro FAD-dep_OxRdtase UniProtKB/TrEMBL
  FAD/NAD-bd_sf UniProtKB/TrEMBL
  FAO_M UniProtKB/TrEMBL
  GCST/YgfZ/DmdA UniProtKB/TrEMBL
  GCV_T_C UniProtKB/TrEMBL
  GCV_T_N UniProtKB/TrEMBL
  GcvT/YgfZ_C UniProtKB/TrEMBL
  TrmE/GcvT_dom1 UniProtKB/TrEMBL
KEGG Report csab:103223602 UniProtKB/TrEMBL
NCBI Gene DMGDH ENTREZGENE
PANTHER AMINOMETHYLTRANSFERASE UniProtKB/TrEMBL
  AMINOMETHYLTRANSFERASE, MITOCHONDRIAL UniProtKB/TrEMBL
Pfam DAO UniProtKB/TrEMBL
  FAO_M UniProtKB/TrEMBL
  GCV_T UniProtKB/TrEMBL
  GCV_T_C UniProtKB/TrEMBL
Superfamily-SCOP FAD-linked reductases, C-terminal domain UniProtKB/TrEMBL
  Folate-binding domain UniProtKB/TrEMBL
  SSF101790 UniProtKB/TrEMBL
  SSF51905 UniProtKB/TrEMBL
UniProt A0A0D9RRW2 ENTREZGENE, UniProtKB/TrEMBL