DYRK2 (dual specificity tyrosine phosphorylation regulated kinase 2) - Rat Genome Database

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Gene: DYRK2 (dual specificity tyrosine phosphorylation regulated kinase 2) Chlorocebus sabaeus
Analyze
Symbol: DYRK2
Name: dual specificity tyrosine phosphorylation regulated kinase 2
RGD ID: 18588706
Description: ENCODES a protein that exhibits magnesium ion binding (ortholog); manganese ion binding (ortholog); protein tyrosine kinase activity (ortholog); INVOLVED IN DNA damage response (ortholog); intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (ortholog); negative regulation of calcineurin-NFAT signaling cascade (ortholog); PARTICIPATES IN p53 signaling pathway; ASSOCIATED WITH gastrointestinal stromal tumor (ortholog); genetic disease (ortholog); FOUND IN cytosol (ortholog); nucleoplasm (ortholog); ribonucleoprotein complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: dual specificity tyrosine-phosphorylation-regulated kinase 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11163,294,035 - 63,308,008 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1163,294,444 - 63,304,080 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037182,403,669 - 182,420,416 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
DYRK2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11163,294,035 - 63,308,008 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1163,294,444 - 63,304,080 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037182,403,669 - 182,420,416 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
DYRK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381267,648,745 - 67,665,406 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1267,648,338 - 67,665,406 (+)EnsemblGRCh38hg38GRCh38
GRCh371268,042,525 - 68,059,186 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361266,328,779 - 66,342,711 (+)NCBINCBI36Build 36hg18NCBI36
Build 341266,329,020 - 66,340,410NCBI
Celera1267,706,515 - 67,720,446 (+)NCBICelera
Cytogenetic Map12q15NCBI
HuRef1265,093,416 - 65,107,347 (+)NCBIHuRef
CHM1_11268,010,112 - 68,024,043 (+)NCBICHM1_1
T2T-CHM13v2.01267,628,264 - 67,644,920 (+)NCBIT2T-CHM13v2.0
Dyrk2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910118,691,507 - 118,725,144 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10118,691,508 - 118,706,114 (-)EnsemblGRCm39 Ensembl
GRCm3810118,855,602 - 118,889,245 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10118,855,603 - 118,870,209 (-)EnsemblGRCm38mm10GRCm38
MGSCv3710118,296,405 - 118,305,959 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3610118,262,342 - 118,271,896 (-)NCBIMGSCv36mm8
Celera10121,236,125 - 121,244,887 (-)NCBICelera
Cytogenetic Map10D2NCBI
cM Map1066.75NCBI
Dyrk2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8756,235,276 - 56,265,741 (-)NCBIGRCr8
mRatBN7.2754,348,724 - 54,381,363 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl754,349,610 - 54,380,106 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx756,256,148 - 56,268,568 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0758,459,275 - 58,471,695 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0758,237,109 - 58,249,529 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0761,785,423 - 61,816,775 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl761,786,309 - 61,798,729 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0761,775,902 - 61,807,168 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4758,114,127 - 58,126,547 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1758,138,697 - 58,149,260 (-)NCBI
Celera751,116,337 - 51,128,757 (-)NCBICelera
Cytogenetic Map7q22NCBI
Dyrk2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545814,193,303 - 14,218,957 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545814,199,912 - 14,201,712 (+)NCBIChiLan1.0ChiLan1.0
DYRK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21026,689,217 - 26,704,660 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11226,685,982 - 26,701,425 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01221,241,325 - 21,260,321 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11221,751,119 - 21,766,602 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1221,757,436 - 21,767,505 (-)Ensemblpanpan1.1panPan2
DYRK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1109,982,245 - 9,994,327 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl109,980,080 - 9,991,934 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha109,915,768 - 9,929,155 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01010,099,203 - 10,112,645 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1010,098,813 - 10,108,970 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1109,974,467 - 9,987,896 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01010,221,581 - 10,234,975 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01010,343,266 - 10,356,687 (+)NCBIUU_Cfam_GSD_1.0
Dyrk2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494548,553,639 - 48,567,246 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365455,542,803 - 5,554,136 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365455,542,873 - 5,555,469 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DYRK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl532,047,643 - 32,064,222 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1532,047,614 - 32,064,231 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.25110,120,816 - 110,124,970 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Dyrk2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624802650,119 - 660,005 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624802643,783 - 660,603 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 18 20 58
Low 18 2
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000002376   ⟹   ENSCSAP00000000689
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl1163,294,444 - 63,304,080 (+)Ensembl
RefSeq Acc Id: XM_008003940   ⟹   XP_008002131
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11163,294,035 - 63,308,008 (+)NCBI
Vero_WHO_p1.0NW_023666037182,403,669 - 182,420,416 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008003941   ⟹   XP_008002132
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11163,294,045 - 63,308,008 (+)NCBI
Vero_WHO_p1.0NW_023666037182,403,669 - 182,420,416 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008003942   ⟹   XP_008002133
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11163,296,076 - 63,308,008 (+)NCBI
Vero_WHO_p1.0NW_023666037182,403,669 - 182,418,346 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008003943   ⟹   XP_008002134
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11163,296,122 - 63,308,008 (+)NCBI
Vero_WHO_p1.0NW_023666037182,403,669 - 182,419,316 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_008002131 (Get FASTA)   NCBI Sequence Viewer  
  XP_008002132 (Get FASTA)   NCBI Sequence Viewer  
  XP_008002133 (Get FASTA)   NCBI Sequence Viewer  
  XP_008002134 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000000689
  ENSCSAP00000000689.1
Reference Protein Sequences
RefSeq Acc Id: XP_008002131   ⟸   XM_008003940
- Peptide Label: isoform X1
- UniProtKB: A0A0D9QWF0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_008002132   ⟸   XM_008003941
- Peptide Label: isoform X2
RefSeq Acc Id: XP_008002133   ⟸   XM_008003942
- Peptide Label: isoform X2
RefSeq Acc Id: XP_008002134   ⟸   XM_008003943
- Peptide Label: isoform X2
RefSeq Acc Id: ENSCSAP00000000689   ⟸   ENSCSAT00000002376


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000004346 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000002376.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.10.30 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro DYRK UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
KEGG Report csab:103238668 UniProtKB/TrEMBL
NCBI Gene DYRK2 ENTREZGENE
PANTHER DUAL SPECIFICITY PROTEIN KINASE UniProtKB/TrEMBL
  DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REGULATED KINASE 2 UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt A0A0D9QWF0 ENTREZGENE, UniProtKB/TrEMBL